Amino acid dipepetide frequency for Pseudonocardia hydrocarbonoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.551AlaAla: 25.551 ± 0.269	1.075AlaCys: 1.075 ± 0.026	9.43AlaAsp: 9.43 ± 0.099	8.484AlaGlu: 8.484 ± 0.081	3.481AlaPhe: 3.481 ± 0.053	15.308AlaGly: 15.308 ± 0.137	2.959AlaHis: 2.959 ± 0.05	3.526AlaIle: 3.526 ± 0.053	1.705AlaLys: 1.705 ± 0.039	15.976AlaLeu: 15.976 ± 0.132	2.493AlaMet: 2.493 ± 0.044	1.62AlaAsn: 1.62 ± 0.039	8.138AlaPro: 8.138 ± 0.106	3.617AlaGln: 3.617 ± 0.045	11.804AlaArg: 11.804 ± 0.104	5.283AlaSer: 5.283 ± 0.056	7.538AlaThr: 7.538 ± 0.072	14.922AlaVal: 14.922 ± 0.125	1.87AlaTrp: 1.87 ± 0.038	2.179AlaTyr: 2.179 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.026	0.098CysCys: 0.098 ± 0.008	0.453CysAsp: 0.453 ± 0.02	0.376CysGlu: 0.376 ± 0.016	0.191CysPhe: 0.191 ± 0.011	0.945CysGly: 0.945 ± 0.024	0.17CysHis: 0.17 ± 0.01	0.16CysIle: 0.16 ± 0.01	0.063CysLys: 0.063 ± 0.006	0.628CysLeu: 0.628 ± 0.021	0.111CysMet: 0.111 ± 0.008	0.108CysAsn: 0.108 ± 0.008	0.494CysPro: 0.494 ± 0.019	0.128CysGln: 0.128 ± 0.009	0.618CysArg: 0.618 ± 0.022	0.396CysSer: 0.396 ± 0.017	0.508CysThr: 0.508 ± 0.017	0.687CysVal: 0.687 ± 0.022	0.121CysTrp: 0.121 ± 0.009	0.156CysTyr: 0.156 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.581AspAla: 9.581 ± 0.104	0.377AspCys: 0.377 ± 0.018	4.549AspAsp: 4.549 ± 0.057	3.998AspGlu: 3.998 ± 0.054	1.319AspPhe: 1.319 ± 0.028	7.368AspGly: 7.368 ± 0.077	1.401AspHis: 1.401 ± 0.033	1.479AspIle: 1.479 ± 0.034	0.664AspLys: 0.664 ± 0.023	6.884AspLeu: 6.884 ± 0.058	0.743AspMet: 0.743 ± 0.025	0.685AspAsn: 0.685 ± 0.022	5.581AspPro: 5.581 ± 0.066	1.22AspGln: 1.22 ± 0.031	5.531AspArg: 5.531 ± 0.071	1.956AspSer: 1.956 ± 0.039	3.072AspThr: 3.072 ± 0.045	6.15AspVal: 6.15 ± 0.062	0.841AspTrp: 0.841 ± 0.023	0.97AspTyr: 0.97 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.207GluAla: 6.207 ± 0.074	0.338GluCys: 0.338 ± 0.014	2.359GluAsp: 2.359 ± 0.039	2.528GluGlu: 2.528 ± 0.047	1.562GluPhe: 1.562 ± 0.031	3.616GluGly: 3.616 ± 0.053	1.606GluHis: 1.606 ± 0.036	2.329GluIle: 2.329 ± 0.045	0.948GluLys: 0.948 ± 0.032	7.037GluLeu: 7.037 ± 0.074	0.855GluMet: 0.855 ± 0.023	0.753GluAsn: 0.753 ± 0.023	3.584GluPro: 3.584 ± 0.054	2.097GluGln: 2.097 ± 0.04	5.351GluArg: 5.351 ± 0.064	2.17GluSer: 2.17 ± 0.042	2.457GluThr: 2.457 ± 0.044	5.041GluVal: 5.041 ± 0.064	0.739GluTrp: 0.739 ± 0.02	0.868GluTyr: 0.868 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.744PheAla: 3.744 ± 0.045	0.28PheCys: 0.28 ± 0.013	2.059PheAsp: 2.059 ± 0.038	1.173PheGlu: 1.173 ± 0.029	0.781PhePhe: 0.781 ± 0.029	3.076PheGly: 3.076 ± 0.051	0.544PheHis: 0.544 ± 0.018	0.468PheIle: 0.468 ± 0.017	0.282PheLys: 0.282 ± 0.015	2.458PheLeu: 2.458 ± 0.043	0.29PheMet: 0.29 ± 0.015	0.406PheAsn: 0.406 ± 0.015	1.336PhePro: 1.336 ± 0.03	0.466PheGln: 0.466 ± 0.018	1.78PheArg: 1.78 ± 0.035	1.287PheSer: 1.287 ± 0.029	1.809PheThr: 1.809 ± 0.039	2.534PheVal: 2.534 ± 0.045	0.374PheTrp: 0.374 ± 0.016	0.534PheTyr: 0.534 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	12.313GlyAla: 12.313 ± 0.1	0.888GlyCys: 0.888 ± 0.024	5.551GlyAsp: 5.551 ± 0.065	5.201GlyGlu: 5.201 ± 0.063	2.916GlyPhe: 2.916 ± 0.048	9.325GlyGly: 9.325 ± 0.085	2.231GlyHis: 2.231 ± 0.041	3.45GlyIle: 3.45 ± 0.055	1.492GlyLys: 1.492 ± 0.037	9.987GlyLeu: 9.987 ± 0.1	2.123GlyMet: 2.123 ± 0.034	1.378GlyAsn: 1.378 ± 0.03	6.271GlyPro: 6.271 ± 0.073	2.317GlyGln: 2.317 ± 0.047	8.693GlyArg: 8.693 ± 0.085	5.099GlySer: 5.099 ± 0.063	6.119GlyThr: 6.119 ± 0.063	9.069GlyVal: 9.069 ± 0.086	1.879GlyTrp: 1.879 ± 0.035	2.173GlyTyr: 2.173 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.867HisAla: 2.867 ± 0.045	0.195HisCys: 0.195 ± 0.012	1.502HisAsp: 1.502 ± 0.034	1.103HisGlu: 1.103 ± 0.024	0.499HisPhe: 0.499 ± 0.019	2.391HisGly: 2.391 ± 0.038	0.664HisHis: 0.664 ± 0.022	0.44HisIle: 0.44 ± 0.017	0.204HisLys: 0.204 ± 0.013	2.44HisLeu: 2.44 ± 0.04	0.248HisMet: 0.248 ± 0.014	0.297HisAsn: 0.297 ± 0.014	1.791HisPro: 1.791 ± 0.036	0.465HisGln: 0.465 ± 0.019	2.266HisArg: 2.266 ± 0.038	0.835HisSer: 0.835 ± 0.023	1.147HisThr: 1.147 ± 0.026	2.003HisVal: 2.003 ± 0.038	0.321HisTrp: 0.321 ± 0.014	0.403HisTyr: 0.403 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.681IleAla: 4.681 ± 0.064	0.234IleCys: 0.234 ± 0.013	2.273IleAsp: 2.273 ± 0.043	1.767IleGlu: 1.767 ± 0.037	0.56IlePhe: 0.56 ± 0.021	3.559IleGly: 3.559 ± 0.058	0.468IleHis: 0.468 ± 0.019	0.697IleIle: 0.697 ± 0.026	0.419IleLys: 0.419 ± 0.018	2.022IleLeu: 2.022 ± 0.044	0.359IleMet: 0.359 ± 0.014	0.557IleAsn: 0.557 ± 0.021	1.631IlePro: 1.631 ± 0.031	0.522IleGln: 0.522 ± 0.016	2.052IleArg: 2.052 ± 0.034	1.408IleSer: 1.408 ± 0.033	2.014IleThr: 2.014 ± 0.039	2.975IleVal: 2.975 ± 0.046	0.322IleTrp: 0.322 ± 0.016	0.476IleTyr: 0.476 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.638LysAla: 1.638 ± 0.041	0.07LysCys: 0.07 ± 0.007	0.716LysAsp: 0.716 ± 0.024	0.619LysGlu: 0.619 ± 0.024	0.294LysPhe: 0.294 ± 0.015	1.033LysGly: 1.033 ± 0.028	0.275LysHis: 0.275 ± 0.015	0.629LysIle: 0.629 ± 0.024	0.369LysLys: 0.369 ± 0.02	1.266LysLeu: 1.266 ± 0.033	0.249LysMet: 0.249 ± 0.014	0.238LysAsn: 0.238 ± 0.013	0.788LysPro: 0.788 ± 0.027	0.394LysGln: 0.394 ± 0.017	1.013LysArg: 1.013 ± 0.03	0.627LysSer: 0.627 ± 0.02	0.776LysThr: 0.776 ± 0.024	1.172LysVal: 1.172 ± 0.035	0.147LysTrp: 0.147 ± 0.009	0.27LysTyr: 0.27 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	17.017LeuAla: 17.017 ± 0.137	0.703LeuCys: 0.703 ± 0.022	7.766LeuAsp: 7.766 ± 0.081	4.415LeuGlu: 4.415 ± 0.057	2.498LeuPhe: 2.498 ± 0.051	10.169LeuGly: 10.169 ± 0.101	2.393LeuHis: 2.393 ± 0.037	2.686LeuIle: 2.686 ± 0.044	1.042LeuLys: 1.042 ± 0.034	11.91LeuLeu: 11.91 ± 0.128	1.321LeuMet: 1.321 ± 0.027	1.255LeuAsn: 1.255 ± 0.029	6.525LeuPro: 6.525 ± 0.07	2.044LeuGln: 2.044 ± 0.042	9.363LeuArg: 9.363 ± 0.087	4.67LeuSer: 4.67 ± 0.059	6.272LeuThr: 6.272 ± 0.069	10.915LeuVal: 10.915 ± 0.104	1.184LeuTrp: 1.184 ± 0.028	1.467LeuTyr: 1.467 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.11MetAla: 2.11 ± 0.038	0.126MetCys: 0.126 ± 0.009	0.81MetAsp: 0.81 ± 0.025	0.664MetGlu: 0.664 ± 0.019	0.426MetPhe: 0.426 ± 0.016	1.25MetGly: 1.25 ± 0.033	0.346MetHis: 0.346 ± 0.015	0.661MetIle: 0.661 ± 0.02	0.274MetLys: 0.274 ± 0.013	1.677MetLeu: 1.677 ± 0.03	0.244MetMet: 0.244 ± 0.015	0.345MetAsn: 0.345 ± 0.014	1.049MetPro: 1.049 ± 0.027	0.404MetGln: 0.404 ± 0.017	1.393MetArg: 1.393 ± 0.032	1.134MetSer: 1.134 ± 0.027	1.655MetThr: 1.655 ± 0.033	1.292MetVal: 1.292 ± 0.029	0.183MetTrp: 0.183 ± 0.01	0.225MetTyr: 0.225 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.799AsnAla: 1.799 ± 0.034	0.127AsnCys: 0.127 ± 0.009	0.767AsnAsp: 0.767 ± 0.025	0.58AsnGlu: 0.58 ± 0.02	0.355AsnPhe: 0.355 ± 0.015	1.359AsnGly: 1.359 ± 0.037	0.282AsnHis: 0.282 ± 0.014	0.485AsnIle: 0.485 ± 0.019	0.234AsnLys: 0.234 ± 0.013	1.425AsnLeu: 1.425 ± 0.029	0.224AsnMet: 0.224 ± 0.011	0.271AsnAsn: 0.271 ± 0.014	1.175AsnPro: 1.175 ± 0.025	0.331AsnGln: 0.331 ± 0.015	1.065AsnArg: 1.065 ± 0.029	0.628AsnSer: 0.628 ± 0.021	0.784AsnThr: 0.784 ± 0.023	1.213AsnVal: 1.213 ± 0.025	0.21AsnTrp: 0.21 ± 0.012	0.293AsnTyr: 0.293 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.202ProAla: 10.202 ± 0.118	0.325ProCys: 0.325 ± 0.018	5.335ProAsp: 5.335 ± 0.063	3.936ProGlu: 3.936 ± 0.05	1.546ProPhe: 1.546 ± 0.03	7.544ProGly: 7.544 ± 0.071	1.338ProHis: 1.338 ± 0.028	1.396ProIle: 1.396 ± 0.031	0.693ProLys: 0.693 ± 0.024	5.414ProLeu: 5.414 ± 0.059	1.03ProMet: 1.03 ± 0.021	0.725ProAsn: 0.725 ± 0.019	4.44ProPro: 4.44 ± 0.078	1.401ProGln: 1.401 ± 0.029	4.518ProArg: 4.518 ± 0.063	2.904ProSer: 2.904 ± 0.046	3.487ProThr: 3.487 ± 0.052	6.64ProVal: 6.64 ± 0.077	0.935ProTrp: 0.935 ± 0.028	1.015ProTyr: 1.015 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.203GlnAla: 3.203 ± 0.053	0.149GlnCys: 0.149 ± 0.01	1.098GlnAsp: 1.098 ± 0.025	1.118GlnGlu: 1.118 ± 0.024	0.609GlnPhe: 0.609 ± 0.02	1.795GlnGly: 1.795 ± 0.041	0.535GlnHis: 0.535 ± 0.02	0.899GlnIle: 0.899 ± 0.024	0.343GlnLys: 0.343 ± 0.016	2.705GlnLeu: 2.705 ± 0.042	0.414GlnMet: 0.414 ± 0.015	0.394GlnAsn: 0.394 ± 0.017	1.375GlnPro: 1.375 ± 0.032	0.85GlnGln: 0.85 ± 0.027	2.316GlnArg: 2.316 ± 0.046	0.886GlnSer: 0.886 ± 0.024	1.046GlnThr: 1.046 ± 0.023	2.452GlnVal: 2.452 ± 0.041	0.357GlnTrp: 0.357 ± 0.015	0.419GlnTyr: 0.419 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.623ArgAla: 11.623 ± 0.117	0.668ArgCys: 0.668 ± 0.021	4.841ArgAsp: 4.841 ± 0.055	4.581ArgGlu: 4.581 ± 0.06	2.488ArgPhe: 2.488 ± 0.045	6.568ArgGly: 6.568 ± 0.064	2.105ArgHis: 2.105 ± 0.037	3.144ArgIle: 3.144 ± 0.046	1.084ArgLys: 1.084 ± 0.031	8.858ArgLeu: 8.858 ± 0.091	1.915ArgMet: 1.915 ± 0.034	1.169ArgAsn: 1.169 ± 0.027	5.525ArgPro: 5.525 ± 0.07	1.784ArgGln: 1.784 ± 0.035	9.077ArgArg: 9.077 ± 0.092	4.309ArgSer: 4.309 ± 0.056	5.291ArgThr: 5.291 ± 0.059	7.2ArgVal: 7.2 ± 0.068	1.485ArgTrp: 1.485 ± 0.031	1.741ArgTyr: 1.741 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.142SerAla: 6.142 ± 0.069	0.392SerCys: 0.392 ± 0.015	2.428SerAsp: 2.428 ± 0.043	1.968SerGlu: 1.968 ± 0.031	1.282SerPhe: 1.282 ± 0.029	5.324SerGly: 5.324 ± 0.062	0.8SerHis: 0.8 ± 0.023	1.385SerIle: 1.385 ± 0.028	0.555SerLys: 0.555 ± 0.022	4.028SerLeu: 4.028 ± 0.054	1.011SerMet: 1.011 ± 0.026	0.64SerAsn: 0.64 ± 0.021	3.037SerPro: 3.037 ± 0.054	0.942SerGln: 0.942 ± 0.026	3.444SerArg: 3.444 ± 0.048	2.274SerSer: 2.274 ± 0.04	2.943SerThr: 2.943 ± 0.046	4.092SerVal: 4.092 ± 0.052	0.75SerTrp: 0.75 ± 0.021	0.86SerTyr: 0.86 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.697ThrAla: 8.697 ± 0.082	0.418ThrCys: 0.418 ± 0.018	3.612ThrAsp: 3.612 ± 0.049	2.898ThrGlu: 2.898 ± 0.041	1.532ThrPhe: 1.532 ± 0.036	6.666ThrGly: 6.666 ± 0.065	1.11ThrHis: 1.11 ± 0.027	1.743ThrIle: 1.743 ± 0.034	0.685ThrLys: 0.685 ± 0.026	5.494ThrLeu: 5.494 ± 0.057	0.98ThrMet: 0.98 ± 0.024	0.799ThrAsn: 0.799 ± 0.021	4.087ThrPro: 4.087 ± 0.056	1.085ThrGln: 1.085 ± 0.024	4.168ThrArg: 4.168 ± 0.053	2.643ThrSer: 2.643 ± 0.049	3.632ThrThr: 3.632 ± 0.054	6.31ThrVal: 6.31 ± 0.061	0.847ThrTrp: 0.847 ± 0.025	1.001ThrTyr: 1.001 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	14.488ValAla: 14.488 ± 0.128	0.739ValCys: 0.739 ± 0.023	6.862ValAsp: 6.862 ± 0.07	5.501ValGlu: 5.501 ± 0.06	2.38ValPhe: 2.38 ± 0.045	8.406ValGly: 8.406 ± 0.084	2.178ValHis: 2.178 ± 0.041	2.596ValIle: 2.596 ± 0.044	1.093ValLys: 1.093 ± 0.028	11.712ValLeu: 11.712 ± 0.12	1.209ValMet: 1.209 ± 0.03	1.412ValAsn: 1.412 ± 0.033	6.186ValPro: 6.186 ± 0.063	2.037ValGln: 2.037 ± 0.037	7.961ValArg: 7.961 ± 0.092	4.106ValSer: 4.106 ± 0.058	5.943ValThr: 5.943 ± 0.063	10.877ValVal: 10.877 ± 0.111	1.121ValTrp: 1.121 ± 0.026	1.351ValTyr: 1.351 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.738TrpAla: 1.738 ± 0.034	0.142TrpCys: 0.142 ± 0.01	0.771TrpAsp: 0.771 ± 0.02	0.653TrpGlu: 0.653 ± 0.019	0.499TrpPhe: 0.499 ± 0.018	0.99TrpGly: 0.99 ± 0.028	0.333TrpHis: 0.333 ± 0.016	0.488TrpIle: 0.488 ± 0.019	0.199TrpLys: 0.199 ± 0.01	1.727TrpLeu: 1.727 ± 0.035	0.282TrpMet: 0.282 ± 0.014	0.284TrpAsn: 0.284 ± 0.015	0.83TrpPro: 0.83 ± 0.028	0.426TrpGln: 0.426 ± 0.02	1.337TrpArg: 1.337 ± 0.034	0.87TrpSer: 0.87 ± 0.022	0.985TrpThr: 0.985 ± 0.029	1.113TrpVal: 1.113 ± 0.029	0.356TrpTrp: 0.356 ± 0.017	0.276TrpTyr: 0.276 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.272TyrAla: 2.272 ± 0.043	0.154TyrCys: 0.154 ± 0.008	1.188TyrAsp: 1.188 ± 0.027	0.883TyrGlu: 0.883 ± 0.022	0.463TyrPhe: 0.463 ± 0.018	1.782TyrGly: 1.782 ± 0.033	0.342TyrHis: 0.342 ± 0.015	0.34TyrIle: 0.34 ± 0.015	0.233TyrLys: 0.233 ± 0.013	1.967TyrLeu: 1.967 ± 0.036	0.169TyrMet: 0.169 ± 0.01	0.271TyrAsn: 0.271 ± 0.014	0.98TyrPro: 0.98 ± 0.029	0.431TyrGln: 0.431 ± 0.019	1.704TyrArg: 1.704 ± 0.036	0.808TyrSer: 0.808 ± 0.023	0.932TyrThr: 0.932 ± 0.024	1.5TyrVal: 1.5 ± 0.034	0.256TyrTrp: 0.256 ± 0.012	0.346TyrTyr: 0.346 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5254 proteins (1607864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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