Amino acid dipepetide frequency for Clostridium sp. CAG:352

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.407AlaAla: 5.407 ± 0.138
0.979AlaCys: 0.979 ± 0.046
4.346AlaAsp: 4.346 ± 0.102
5.642AlaGlu: 5.642 ± 0.115
2.895AlaPhe: 2.895 ± 0.079
4.57AlaGly: 4.57 ± 0.098
0.952AlaHis: 0.952 ± 0.039
6.142AlaIle: 6.142 ± 0.111
5.388AlaLys: 5.388 ± 0.109
6.492AlaLeu: 6.492 ± 0.119
2.144AlaMet: 2.144 ± 0.057
3.103AlaAsn: 3.103 ± 0.073
1.811AlaPro: 1.811 ± 0.066
2.08AlaGln: 2.08 ± 0.06
2.586AlaArg: 2.586 ± 0.08
4.058AlaSer: 4.058 ± 0.083
3.571AlaThr: 3.571 ± 0.089
5.857AlaVal: 5.857 ± 0.123
0.425AlaTrp: 0.425 ± 0.03
2.476AlaTyr: 2.476 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.988CysAla: 0.988 ± 0.044
0.323CysCys: 0.323 ± 0.021
1.078CysAsp: 1.078 ± 0.046
1.129CysGlu: 1.129 ± 0.044
0.634CysPhe: 0.634 ± 0.03
1.637CysGly: 1.637 ± 0.057
0.251CysHis: 0.251 ± 0.022
1.113CysIle: 1.113 ± 0.038
1.06CysLys: 1.06 ± 0.043
1.044CysLeu: 1.044 ± 0.042
0.351CysMet: 0.351 ± 0.024
0.74CysAsn: 0.74 ± 0.036
0.555CysPro: 0.555 ± 0.031
0.293CysGln: 0.293 ± 0.025
0.588CysArg: 0.588 ± 0.032
0.999CysSer: 0.999 ± 0.042
0.756CysThr: 0.756 ± 0.034
1.014CysVal: 1.014 ± 0.039
0.087CysTrp: 0.087 ± 0.011
0.568CysTyr: 0.568 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.465AspAla: 3.465 ± 0.082
0.879AspCys: 0.879 ± 0.04
3.512AspAsp: 3.512 ± 0.08
5.291AspGlu: 5.291 ± 0.098
2.943AspPhe: 2.943 ± 0.075
4.532AspGly: 4.532 ± 0.099
0.579AspHis: 0.579 ± 0.031
5.628AspIle: 5.628 ± 0.088
4.928AspLys: 4.928 ± 0.088
3.786AspLeu: 3.786 ± 0.079
1.722AspMet: 1.722 ± 0.057
3.307AspAsn: 3.307 ± 0.084
1.338AspPro: 1.338 ± 0.056
0.729AspGln: 0.729 ± 0.037
1.944AspArg: 1.944 ± 0.062
3.795AspSer: 3.795 ± 0.083
3.12AspThr: 3.12 ± 0.075
3.602AspVal: 3.602 ± 0.088
0.471AspTrp: 0.471 ± 0.032
2.771AspTyr: 2.771 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
4.618GluAla: 4.618 ± 0.088
0.874GluCys: 0.874 ± 0.042
3.65GluAsp: 3.65 ± 0.084
5.117GluGlu: 5.117 ± 0.119
2.725GluPhe: 2.725 ± 0.056
3.435GluGly: 3.435 ± 0.076
1.135GluHis: 1.135 ± 0.048
6.213GluIle: 6.213 ± 0.11
6.703GluLys: 6.703 ± 0.114
6.928GluLeu: 6.928 ± 0.133
1.989GluMet: 1.989 ± 0.06
5.149GluAsn: 5.149 ± 0.101
2.004GluPro: 2.004 ± 0.089
2.487GluGln: 2.487 ± 0.074
3.134GluArg: 3.134 ± 0.075
4.311GluSer: 4.311 ± 0.103
3.683GluThr: 3.683 ± 0.087
3.824GluVal: 3.824 ± 0.083
0.53GluTrp: 0.53 ± 0.032
3.296GluTyr: 3.296 ± 0.092
0.0GluXaa: 0.0 ± 0.0
Phe
3.096PheAla: 3.096 ± 0.07
0.852PheCys: 0.852 ± 0.039
2.861PheAsp: 2.861 ± 0.066
2.85PheGlu: 2.85 ± 0.082
1.917PhePhe: 1.917 ± 0.075
3.142PheGly: 3.142 ± 0.078
0.579PheHis: 0.579 ± 0.033
3.528PheIle: 3.528 ± 0.102
2.809PheLys: 2.809 ± 0.061
3.441PheLeu: 3.441 ± 0.09
1.218PheMet: 1.218 ± 0.05
2.225PheAsn: 2.225 ± 0.062
1.262PhePro: 1.262 ± 0.044
0.816PheGln: 0.816 ± 0.035
1.483PheArg: 1.483 ± 0.049
3.221PheSer: 3.221 ± 0.088
2.481PheThr: 2.481 ± 0.059
2.698PheVal: 2.698 ± 0.064
0.324PheTrp: 0.324 ± 0.024
1.743PheTyr: 1.743 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.521GlyAla: 4.521 ± 0.095
1.161GlyCys: 1.161 ± 0.046
3.61GlyAsp: 3.61 ± 0.084
4.436GlyGlu: 4.436 ± 0.091
2.941GlyPhe: 2.941 ± 0.073
4.41GlyGly: 4.41 ± 0.1
1.009GlyHis: 1.009 ± 0.042
6.084GlyIle: 6.084 ± 0.113
5.623GlyLys: 5.623 ± 0.103
5.141GlyLeu: 5.141 ± 0.097
1.907GlyMet: 1.907 ± 0.061
3.207GlyAsn: 3.207 ± 0.07
0.884GlyPro: 0.884 ± 0.039
1.428GlyGln: 1.428 ± 0.053
2.518GlyArg: 2.518 ± 0.074
4.063GlySer: 4.063 ± 0.093
3.805GlyThr: 3.805 ± 0.097
4.559GlyVal: 4.559 ± 0.086
0.549GlyTrp: 0.549 ± 0.031
2.943GlyTyr: 2.943 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.901HisAla: 0.901 ± 0.044
0.296HisCys: 0.296 ± 0.02
0.742HisAsp: 0.742 ± 0.039
0.922HisGlu: 0.922 ± 0.041
0.71HisPhe: 0.71 ± 0.037
0.922HisGly: 0.922 ± 0.038
0.31HisHis: 0.31 ± 0.033
1.381HisIle: 1.381 ± 0.049
1.058HisLys: 1.058 ± 0.042
1.071HisLeu: 1.071 ± 0.047
0.378HisMet: 0.378 ± 0.024
0.865HisAsn: 0.865 ± 0.04
0.642HisPro: 0.642 ± 0.034
0.373HisGln: 0.373 ± 0.022
0.735HisArg: 0.735 ± 0.038
1.06HisSer: 1.06 ± 0.041
0.849HisThr: 0.849 ± 0.039
0.536HisVal: 0.536 ± 0.034
0.125HisTrp: 0.125 ± 0.015
0.609HisTyr: 0.609 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.314IleAla: 6.314 ± 0.1
1.466IleCys: 1.466 ± 0.05
5.283IleAsp: 5.283 ± 0.096
5.883IleGlu: 5.883 ± 0.103
3.745IlePhe: 3.745 ± 0.101
5.207IleGly: 5.207 ± 0.105
1.128IleHis: 1.128 ± 0.049
7.567IleIle: 7.567 ± 0.151
6.414IleLys: 6.414 ± 0.108
7.099IleLeu: 7.099 ± 0.132
2.228IleMet: 2.228 ± 0.057
4.297IleAsn: 4.297 ± 0.083
3.308IlePro: 3.308 ± 0.067
1.85IleGln: 1.85 ± 0.054
3.134IleArg: 3.134 ± 0.07
6.86IleSer: 6.86 ± 0.134
5.1IleThr: 5.1 ± 0.1
5.298IleVal: 5.298 ± 0.095
0.522IleTrp: 0.522 ± 0.028
3.071IleTyr: 3.071 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
5.786LysAla: 5.786 ± 0.101
0.818LysCys: 0.818 ± 0.04
4.088LysAsp: 4.088 ± 0.081
5.834LysGlu: 5.834 ± 0.115
2.654LysPhe: 2.654 ± 0.074
4.15LysGly: 4.15 ± 0.081
1.161LysHis: 1.161 ± 0.046
6.387LysIle: 6.387 ± 0.11
6.949LysLys: 6.949 ± 0.143
7.135LysLeu: 7.135 ± 0.131
2.149LysMet: 2.149 ± 0.058
5.201LysAsn: 5.201 ± 0.088
2.543LysPro: 2.543 ± 0.074
2.352LysGln: 2.352 ± 0.071
3.365LysArg: 3.365 ± 0.076
5.067LysSer: 5.067 ± 0.103
4.586LysThr: 4.586 ± 0.086
4.21LysVal: 4.21 ± 0.096
0.577LysTrp: 0.577 ± 0.031
3.561LysTyr: 3.561 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
6.18LeuAla: 6.18 ± 0.121
1.561LeuCys: 1.561 ± 0.051
5.018LeuAsp: 5.018 ± 0.093
5.549LeuGlu: 5.549 ± 0.113
3.631LeuPhe: 3.631 ± 0.087
5.306LeuGly: 5.306 ± 0.098
1.196LeuHis: 1.196 ± 0.045
6.737LeuIle: 6.737 ± 0.129
6.52LeuLys: 6.52 ± 0.097
7.138LeuLeu: 7.138 ± 0.159
2.288LeuMet: 2.288 ± 0.063
4.327LeuAsn: 4.327 ± 0.091
3.34LeuPro: 3.34 ± 0.076
1.961LeuGln: 1.961 ± 0.061
3.47LeuArg: 3.47 ± 0.076
6.65LeuSer: 6.65 ± 0.113
4.731LeuThr: 4.731 ± 0.083
4.788LeuVal: 4.788 ± 0.081
0.544LeuTrp: 0.544 ± 0.033
3.065LeuTyr: 3.065 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
2.029MetAla: 2.029 ± 0.051
0.296MetCys: 0.296 ± 0.026
1.281MetAsp: 1.281 ± 0.047
1.472MetGlu: 1.472 ± 0.051
1.102MetPhe: 1.102 ± 0.045
1.702MetGly: 1.702 ± 0.056
0.338MetHis: 0.338 ± 0.021
2.04MetIle: 2.04 ± 0.055
2.363MetLys: 2.363 ± 0.063
2.677MetLeu: 2.677 ± 0.071
0.686MetMet: 0.686 ± 0.035
1.602MetAsn: 1.602 ± 0.048
1.034MetPro: 1.034 ± 0.037
0.846MetGln: 0.846 ± 0.037
1.173MetArg: 1.173 ± 0.046
1.953MetSer: 1.953 ± 0.06
1.641MetThr: 1.641 ± 0.049
1.469MetVal: 1.469 ± 0.048
0.188MetTrp: 0.188 ± 0.016
0.856MetTyr: 0.856 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.795AsnAla: 3.795 ± 0.093
0.857AsnCys: 0.857 ± 0.04
3.098AsnAsp: 3.098 ± 0.08
3.737AsnGlu: 3.737 ± 0.078
2.103AsnPhe: 2.103 ± 0.069
4.309AsnGly: 4.309 ± 0.105
0.729AsnHis: 0.729 ± 0.037
5.238AsnIle: 5.238 ± 0.1
3.999AsnLys: 3.999 ± 0.077
4.091AsnLeu: 4.091 ± 0.08
1.341AsnMet: 1.341 ± 0.043
3.324AsnAsn: 3.324 ± 0.1
2.268AsnPro: 2.268 ± 0.069
1.322AsnGln: 1.322 ± 0.048
1.931AsnArg: 1.931 ± 0.049
3.825AsnSer: 3.825 ± 0.092
2.954AsnThr: 2.954 ± 0.068
3.074AsnVal: 3.074 ± 0.085
0.376AsnTrp: 0.376 ± 0.029
2.098AsnTyr: 2.098 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.035ProAla: 2.035 ± 0.062
0.449ProCys: 0.449 ± 0.026
2.231ProAsp: 2.231 ± 0.062
2.88ProGlu: 2.88 ± 0.081
1.562ProPhe: 1.562 ± 0.055
1.382ProGly: 1.382 ± 0.05
0.5ProHis: 0.5 ± 0.031
2.574ProIle: 2.574 ± 0.063
2.344ProLys: 2.344 ± 0.06
2.442ProLeu: 2.442 ± 0.07
0.783ProMet: 0.783 ± 0.036
1.531ProAsn: 1.531 ± 0.053
0.9ProPro: 0.9 ± 0.049
1.105ProGln: 1.105 ± 0.051
0.914ProArg: 0.914 ± 0.038
2.102ProSer: 2.102 ± 0.065
1.709ProThr: 1.709 ± 0.058
2.299ProVal: 2.299 ± 0.071
0.217ProTrp: 0.217 ± 0.02
1.404ProTyr: 1.404 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.962GlnAla: 1.962 ± 0.068
0.316GlnCys: 0.316 ± 0.024
1.116GlnAsp: 1.116 ± 0.043
1.728GlnGlu: 1.728 ± 0.059
0.919GlnPhe: 0.919 ± 0.04
1.471GlnGly: 1.471 ± 0.053
0.395GlnHis: 0.395 ± 0.026
2.114GlnIle: 2.114 ± 0.059
2.412GlnLys: 2.412 ± 0.072
2.244GlnLeu: 2.244 ± 0.062
0.783GlnMet: 0.783 ± 0.035
1.705GlnAsn: 1.705 ± 0.05
0.825GlnPro: 0.825 ± 0.046
1.094GlnGln: 1.094 ± 0.064
1.232GlnArg: 1.232 ± 0.046
1.725GlnSer: 1.725 ± 0.059
1.412GlnThr: 1.412 ± 0.052
1.314GlnVal: 1.314 ± 0.046
0.237GlnTrp: 0.237 ± 0.021
1.216GlnTyr: 1.216 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.506ArgAla: 2.506 ± 0.075
0.572ArgCys: 0.572 ± 0.03
2.034ArgAsp: 2.034 ± 0.067
2.937ArgGlu: 2.937 ± 0.071
1.768ArgPhe: 1.768 ± 0.057
2.298ArgGly: 2.298 ± 0.072
0.648ArgHis: 0.648 ± 0.035
3.425ArgIle: 3.425 ± 0.085
3.182ArgLys: 3.182 ± 0.065
3.561ArgLeu: 3.561 ± 0.076
1.093ArgMet: 1.093 ± 0.042
2.018ArgAsn: 2.018 ± 0.061
1.129ArgPro: 1.129 ± 0.045
1.213ArgGln: 1.213 ± 0.046
1.913ArgArg: 1.913 ± 0.065
2.168ArgSer: 2.168 ± 0.064
2.043ArgThr: 2.043 ± 0.058
2.42ArgVal: 2.42 ± 0.078
0.294ArgTrp: 0.294 ± 0.022
1.621ArgTyr: 1.621 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.016SerAla: 5.016 ± 0.119
0.901SerCys: 0.901 ± 0.036
4.409SerAsp: 4.409 ± 0.097
5.41SerGlu: 5.41 ± 0.117
3.147SerPhe: 3.147 ± 0.07
5.132SerGly: 5.132 ± 0.104
1.007SerHis: 1.007 ± 0.038
5.288SerIle: 5.288 ± 0.101
5.184SerLys: 5.184 ± 0.114
5.519SerLeu: 5.519 ± 0.096
1.66SerMet: 1.66 ± 0.05
3.327SerAsn: 3.327 ± 0.102
1.906SerPro: 1.906 ± 0.061
1.826SerGln: 1.826 ± 0.057
2.476SerArg: 2.476 ± 0.075
5.304SerSer: 5.304 ± 0.156
3.504SerThr: 3.504 ± 0.101
4.769SerVal: 4.769 ± 0.103
0.468SerTrp: 0.468 ± 0.024
2.831SerTyr: 2.831 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
4.807ThrAla: 4.807 ± 0.095
0.61ThrCys: 0.61 ± 0.029
3.302ThrAsp: 3.302 ± 0.082
3.878ThrGlu: 3.878 ± 0.09
2.089ThrPhe: 2.089 ± 0.061
3.976ThrGly: 3.976 ± 0.09
0.878ThrHis: 0.878 ± 0.037
4.724ThrIle: 4.724 ± 0.105
3.618ThrLys: 3.618 ± 0.084
4.89ThrLeu: 4.89 ± 0.091
1.27ThrMet: 1.27 ± 0.051
2.563ThrAsn: 2.563 ± 0.077
2.08ThrPro: 2.08 ± 0.064
1.531ThrGln: 1.531 ± 0.054
1.746ThrArg: 1.746 ± 0.052
3.765ThrSer: 3.765 ± 0.099
3.115ThrThr: 3.115 ± 0.078
4.518ThrVal: 4.518 ± 0.109
0.312ThrTrp: 0.312 ± 0.024
2.029ThrTyr: 2.029 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
4.564ValAla: 4.564 ± 0.094
1.135ValCys: 1.135 ± 0.049
3.571ValAsp: 3.571 ± 0.088
3.958ValGlu: 3.958 ± 0.074
2.79ValPhe: 2.79 ± 0.068
3.887ValGly: 3.887 ± 0.093
0.89ValHis: 0.89 ± 0.036
5.483ValIle: 5.483 ± 0.088
4.518ValLys: 4.518 ± 0.085
5.592ValLeu: 5.592 ± 0.103
1.638ValMet: 1.638 ± 0.053
2.992ValAsn: 2.992 ± 0.076
2.136ValPro: 2.136 ± 0.058
1.534ValGln: 1.534 ± 0.057
2.563ValArg: 2.563 ± 0.073
4.932ValSer: 4.932 ± 0.083
3.824ValThr: 3.824 ± 0.092
4.229ValVal: 4.229 ± 0.096
0.481ValTrp: 0.481 ± 0.032
2.421ValTyr: 2.421 ± 0.075
0.0ValXaa: 0.0 ± 0.0
Trp
0.392TrpAla: 0.392 ± 0.027
0.15TrpCys: 0.15 ± 0.015
0.397TrpAsp: 0.397 ± 0.024
0.438TrpGlu: 0.438 ± 0.026
0.349TrpPhe: 0.349 ± 0.025
0.517TrpGly: 0.517 ± 0.03
0.139TrpHis: 0.139 ± 0.015
0.576TrpIle: 0.576 ± 0.032
0.47TrpLys: 0.47 ± 0.028
0.688TrpLeu: 0.688 ± 0.037
0.16TrpMet: 0.16 ± 0.018
0.422TrpAsn: 0.422 ± 0.027
0.111TrpPro: 0.111 ± 0.015
0.275TrpGln: 0.275 ± 0.022
0.297TrpArg: 0.297 ± 0.019
0.441TrpSer: 0.441 ± 0.033
0.4TrpThr: 0.4 ± 0.03
0.436TrpVal: 0.436 ± 0.026
0.089TrpTrp: 0.089 ± 0.012
0.346TrpTyr: 0.346 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.538TyrAla: 2.538 ± 0.065
0.712TyrCys: 0.712 ± 0.034
2.715TyrAsp: 2.715 ± 0.069
2.715TyrGlu: 2.715 ± 0.068
1.921TyrPhe: 1.921 ± 0.059
2.815TyrGly: 2.815 ± 0.069
0.659TyrHis: 0.659 ± 0.032
3.534TyrIle: 3.534 ± 0.075
3.031TyrLys: 3.031 ± 0.08
3.02TyrLeu: 3.02 ± 0.071
0.958TyrMet: 0.958 ± 0.046
2.567TyrAsn: 2.567 ± 0.08
1.289TyrPro: 1.289 ± 0.05
1.107TyrGln: 1.107 ± 0.045
1.64TyrArg: 1.64 ± 0.055
2.786TyrSer: 2.786 ± 0.087
2.413TyrThr: 2.413 ± 0.074
2.223TyrVal: 2.223 ± 0.057
0.278TyrTrp: 0.278 ± 0.022
1.964TyrTyr: 1.964 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2097 proteins (632363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski