Amino acid dipepetide frequency for Friedmanniomyces simplex

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.091AlaAla: 11.091 ± 0.062	1.083AlaCys: 1.083 ± 0.016	4.918AlaAsp: 4.918 ± 0.032	6.322AlaGlu: 6.322 ± 0.047	3.309AlaPhe: 3.309 ± 0.027	7.255AlaGly: 7.255 ± 0.044	2.014AlaHis: 2.014 ± 0.02	3.943AlaIle: 3.943 ± 0.033	4.464AlaLys: 4.464 ± 0.031	8.245AlaLeu: 8.245 ± 0.045	2.25AlaMet: 2.25 ± 0.018	3.132AlaAsn: 3.132 ± 0.023	5.53AlaPro: 5.53 ± 0.044	4.043AlaGln: 4.043 ± 0.029	5.724AlaArg: 5.724 ± 0.042	7.75AlaSer: 7.75 ± 0.041	5.989AlaThr: 5.989 ± 0.032	6.128AlaVal: 6.128 ± 0.036	1.247AlaTrp: 1.247 ± 0.014	2.398AlaTyr: 2.398 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.945CysAla: 0.945 ± 0.012	0.218CysCys: 0.218 ± 0.007	0.596CysAsp: 0.596 ± 0.012	0.59CysGlu: 0.59 ± 0.008	0.491CysPhe: 0.491 ± 0.01	0.921CysGly: 0.921 ± 0.014	0.298CysHis: 0.298 ± 0.007	0.578CysIle: 0.578 ± 0.01	0.464CysLys: 0.464 ± 0.008	1.114CysLeu: 1.114 ± 0.015	0.245CysMet: 0.245 ± 0.007	0.36CysAsn: 0.36 ± 0.008	0.583CysPro: 0.583 ± 0.011	0.388CysGln: 0.388 ± 0.007	0.685CysArg: 0.685 ± 0.01	0.745CysSer: 0.745 ± 0.011	0.634CysThr: 0.634 ± 0.012	0.755CysVal: 0.755 ± 0.012	0.175CysTrp: 0.175 ± 0.006	0.34CysTyr: 0.34 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.315AspAla: 5.315 ± 0.03	0.586AspCys: 0.586 ± 0.012	4.321AspAsp: 4.321 ± 0.033	4.789AspGlu: 4.789 ± 0.037	2.199AspPhe: 2.199 ± 0.02	4.605AspGly: 4.605 ± 0.031	1.234AspHis: 1.234 ± 0.014	2.528AspIle: 2.528 ± 0.024	2.08AspLys: 2.08 ± 0.019	4.922AspLeu: 4.922 ± 0.032	1.274AspMet: 1.274 ± 0.014	1.564AspAsn: 1.564 ± 0.016	3.288AspPro: 3.288 ± 0.026	1.82AspGln: 1.82 ± 0.019	3.136AspArg: 3.136 ± 0.027	3.668AspSer: 3.668 ± 0.028	2.962AspThr: 2.962 ± 0.024	3.942AspVal: 3.942 ± 0.028	0.862AspTrp: 0.862 ± 0.013	1.549AspTyr: 1.549 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	6.339GluAla: 6.339 ± 0.046	0.584GluCys: 0.584 ± 0.01	4.394GluAsp: 4.394 ± 0.029	6.139GluGlu: 6.139 ± 0.05	1.643GluPhe: 1.643 ± 0.018	4.791GluGly: 4.791 ± 0.031	1.56GluHis: 1.56 ± 0.019	2.525GluIle: 2.525 ± 0.021	3.509GluLys: 3.509 ± 0.03	5.326GluLeu: 5.326 ± 0.041	1.661GluMet: 1.661 ± 0.017	1.778GluAsn: 1.778 ± 0.015	2.809GluPro: 2.809 ± 0.029	2.928GluGln: 2.928 ± 0.025	4.754GluArg: 4.754 ± 0.039	3.868GluSer: 3.868 ± 0.027	3.425GluThr: 3.425 ± 0.027	4.022GluVal: 4.022 ± 0.03	0.89GluTrp: 0.89 ± 0.013	1.662GluTyr: 1.662 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.293PheAla: 3.293 ± 0.022	0.49PheCys: 0.49 ± 0.008	2.153PheAsp: 2.153 ± 0.018	2.033PheGlu: 2.033 ± 0.02	1.357PhePhe: 1.357 ± 0.018	2.868PheGly: 2.868 ± 0.027	0.81PheHis: 0.81 ± 0.012	1.378PheIle: 1.378 ± 0.017	1.244PheLys: 1.244 ± 0.012	2.986PheLeu: 2.986 ± 0.027	0.724PheMet: 0.724 ± 0.011	1.235PheAsn: 1.235 ± 0.019	1.682PhePro: 1.682 ± 0.018	1.164PheGln: 1.164 ± 0.015	1.871PheArg: 1.871 ± 0.018	2.472PheSer: 2.472 ± 0.022	2.056PheThr: 2.056 ± 0.02	2.23PheVal: 2.23 ± 0.019	0.578PheTrp: 0.578 ± 0.011	0.985PheTyr: 0.985 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.385GlyAla: 6.385 ± 0.041	0.833GlyCys: 0.833 ± 0.012	3.964GlyAsp: 3.964 ± 0.027	4.682GlyGlu: 4.682 ± 0.033	2.763GlyPhe: 2.763 ± 0.024	8.219GlyGly: 8.219 ± 0.079	1.763GlyHis: 1.763 ± 0.019	3.211GlyIle: 3.211 ± 0.028	3.832GlyLys: 3.832 ± 0.027	6.316GlyLeu: 6.316 ± 0.036	2.114GlyMet: 2.114 ± 0.023	2.536GlyAsn: 2.536 ± 0.023	3.335GlyPro: 3.335 ± 0.029	2.869GlyGln: 2.869 ± 0.026	4.689GlyArg: 4.689 ± 0.029	6.023GlySer: 6.023 ± 0.037	4.303GlyThr: 4.303 ± 0.028	5.043GlyVal: 5.043 ± 0.029	1.263GlyTrp: 1.263 ± 0.016	2.246GlyTyr: 2.246 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.206HisAla: 2.206 ± 0.022	0.308HisCys: 0.308 ± 0.007	1.437HisAsp: 1.437 ± 0.017	1.446HisGlu: 1.446 ± 0.016	0.9HisPhe: 0.9 ± 0.013	1.813HisGly: 1.813 ± 0.019	0.896HisHis: 0.896 ± 0.014	1.046HisIle: 1.046 ± 0.013	0.885HisLys: 0.885 ± 0.012	2.245HisLeu: 2.245 ± 0.019	0.49HisMet: 0.49 ± 0.009	0.786HisAsn: 0.786 ± 0.011	1.66HisPro: 1.66 ± 0.019	1.008HisGln: 1.008 ± 0.014	1.508HisArg: 1.508 ± 0.019	1.713HisSer: 1.713 ± 0.018	1.314HisThr: 1.314 ± 0.015	1.484HisVal: 1.484 ± 0.016	0.349HisTrp: 0.349 ± 0.007	0.693HisTyr: 0.693 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.037IleAla: 4.037 ± 0.026	0.617IleCys: 0.617 ± 0.011	2.505IleAsp: 2.505 ± 0.02	2.508IleGlu: 2.508 ± 0.021	1.539IlePhe: 1.539 ± 0.017	2.888IleGly: 2.888 ± 0.027	0.972IleHis: 0.972 ± 0.014	1.865IleIle: 1.865 ± 0.022	1.736IleLys: 1.736 ± 0.018	3.632IleLeu: 3.632 ± 0.027	0.867IleMet: 0.867 ± 0.01	1.493IleAsn: 1.493 ± 0.017	2.523IlePro: 2.523 ± 0.019	1.476IleGln: 1.476 ± 0.017	2.43IleArg: 2.43 ± 0.018	2.992IleSer: 2.992 ± 0.023	2.581IleThr: 2.581 ± 0.021	2.775IleVal: 2.775 ± 0.024	0.612IleTrp: 0.612 ± 0.01	1.21IleTyr: 1.21 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.58LysAla: 4.58 ± 0.027	0.407LysCys: 0.407 ± 0.009	2.53LysAsp: 2.53 ± 0.026	3.136LysGlu: 3.136 ± 0.025	1.147LysPhe: 1.147 ± 0.014	3.204LysGly: 3.204 ± 0.028	1.173LysHis: 1.173 ± 0.016	1.733LysIle: 1.733 ± 0.019	2.951LysLys: 2.951 ± 0.035	3.863LysLeu: 3.863 ± 0.029	1.01LysMet: 1.01 ± 0.014	1.316LysAsn: 1.316 ± 0.015	2.711LysPro: 2.711 ± 0.028	1.978LysGln: 1.978 ± 0.02	3.775LysArg: 3.775 ± 0.031	2.919LysSer: 2.919 ± 0.023	2.613LysThr: 2.613 ± 0.024	2.765LysVal: 2.765 ± 0.022	0.607LysTrp: 0.607 ± 0.01	1.223LysTyr: 1.223 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.473LeuAla: 8.473 ± 0.042	1.1LeuCys: 1.1 ± 0.015	5.046LeuAsp: 5.046 ± 0.029	5.357LeuGlu: 5.357 ± 0.038	2.936LeuPhe: 2.936 ± 0.022	6.004LeuGly: 6.004 ± 0.037	2.297LeuHis: 2.297 ± 0.021	3.263LeuIle: 3.263 ± 0.027	3.804LeuLys: 3.804 ± 0.03	8.178LeuLeu: 8.178 ± 0.054	1.764LeuMet: 1.764 ± 0.017	2.771LeuAsn: 2.771 ± 0.022	5.667LeuPro: 5.667 ± 0.031	3.943LeuGln: 3.943 ± 0.031	5.971LeuArg: 5.971 ± 0.034	6.464LeuSer: 6.464 ± 0.041	4.82LeuThr: 4.82 ± 0.034	5.216LeuVal: 5.216 ± 0.035	1.112LeuTrp: 1.112 ± 0.016	2.18LeuTyr: 2.18 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.462MetAla: 2.462 ± 0.022	0.24MetCys: 0.24 ± 0.007	1.275MetAsp: 1.275 ± 0.014	1.395MetGlu: 1.395 ± 0.015	0.698MetPhe: 0.698 ± 0.011	1.679MetGly: 1.679 ± 0.02	0.545MetHis: 0.545 ± 0.009	0.846MetIle: 0.846 ± 0.012	0.972MetLys: 0.972 ± 0.014	2.013MetLeu: 2.013 ± 0.02	0.624MetMet: 0.624 ± 0.011	0.752MetAsn: 0.752 ± 0.011	1.448MetPro: 1.448 ± 0.017	1.051MetGln: 1.051 ± 0.014	1.467MetArg: 1.467 ± 0.016	1.845MetSer: 1.845 ± 0.018	1.26MetThr: 1.26 ± 0.015	1.345MetVal: 1.345 ± 0.015	0.259MetTrp: 0.259 ± 0.007	0.543MetTyr: 0.543 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.281AsnAla: 3.281 ± 0.022	0.353AsnCys: 0.353 ± 0.009	1.778AsnAsp: 1.778 ± 0.017	1.793AsnGlu: 1.793 ± 0.02	1.164AsnPhe: 1.164 ± 0.015	3.285AsnGly: 3.285 ± 0.031	0.744AsnHis: 0.744 ± 0.012	1.583AsnIle: 1.583 ± 0.018	1.268AsnLys: 1.268 ± 0.014	2.742AsnLeu: 2.742 ± 0.02	0.734AsnMet: 0.734 ± 0.012	1.33AsnAsn: 1.33 ± 0.017	2.066AsnPro: 2.066 ± 0.019	1.127AsnGln: 1.127 ± 0.015	1.648AsnArg: 1.648 ± 0.016	2.206AsnSer: 2.206 ± 0.022	2.115AsnThr: 2.115 ± 0.021	2.186AsnVal: 2.186 ± 0.022	0.452AsnTrp: 0.452 ± 0.01	0.928AsnTyr: 0.928 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.195ProAla: 6.195 ± 0.047	0.453ProCys: 0.453 ± 0.01	3.132ProAsp: 3.132 ± 0.021	3.777ProGlu: 3.777 ± 0.026	1.88ProPhe: 1.88 ± 0.017	4.136ProGly: 4.136 ± 0.03	1.372ProHis: 1.372 ± 0.017	2.208ProIle: 2.208 ± 0.02	2.553ProLys: 2.553 ± 0.024	4.655ProLeu: 4.655 ± 0.028	1.147ProMet: 1.147 ± 0.014	2.0ProAsn: 2.0 ± 0.019	5.842ProPro: 5.842 ± 0.065	2.641ProGln: 2.641 ± 0.026	3.421ProArg: 3.421 ± 0.033	5.786ProSer: 5.786 ± 0.046	4.286ProThr: 4.286 ± 0.032	3.49ProVal: 3.49 ± 0.029	0.706ProTrp: 0.706 ± 0.013	1.517ProTyr: 1.517 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	4.127GlnAla: 4.127 ± 0.036	0.421GlnCys: 0.421 ± 0.009	2.066GlnAsp: 2.066 ± 0.017	2.399GlnGlu: 2.399 ± 0.021	1.101GlnPhe: 1.101 ± 0.014	2.682GlnGly: 2.682 ± 0.026	1.343GlnHis: 1.343 ± 0.016	1.624GlnIle: 1.624 ± 0.016	1.858GlnLys: 1.858 ± 0.019	3.52GlnLeu: 3.52 ± 0.028	0.977GlnMet: 0.977 ± 0.014	1.33GlnAsn: 1.33 ± 0.015	2.876GlnPro: 2.876 ± 0.029	3.563GlnGln: 3.563 ± 0.059	3.065GlnArg: 3.065 ± 0.027	3.018GlnSer: 3.018 ± 0.027	2.469GlnThr: 2.469 ± 0.02	2.179GlnVal: 2.179 ± 0.02	0.595GlnTrp: 0.595 ± 0.01	1.272GlnTyr: 1.272 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.355ArgAla: 5.355 ± 0.037	0.668ArgCys: 0.668 ± 0.012	3.491ArgAsp: 3.491 ± 0.025	4.465ArgGlu: 4.465 ± 0.039	2.032ArgPhe: 2.032 ± 0.019	4.098ArgGly: 4.098 ± 0.032	1.598ArgHis: 1.598 ± 0.02	2.6ArgIle: 2.6 ± 0.022	3.715ArgLys: 3.715 ± 0.027	5.516ArgLeu: 5.516 ± 0.035	1.526ArgMet: 1.526 ± 0.016	2.103ArgAsn: 2.103 ± 0.02	3.633ArgPro: 3.633 ± 0.032	2.957ArgGln: 2.957 ± 0.024	5.517ArgArg: 5.517 ± 0.047	4.79ArgSer: 4.79 ± 0.036	3.525ArgThr: 3.525 ± 0.024	3.562ArgVal: 3.562 ± 0.025	0.953ArgTrp: 0.953 ± 0.012	1.665ArgTyr: 1.665 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	7.31SerAla: 7.31 ± 0.045	0.693SerCys: 0.693 ± 0.012	3.879SerAsp: 3.879 ± 0.032	3.975SerGlu: 3.975 ± 0.03	2.491SerPhe: 2.491 ± 0.019	5.87SerGly: 5.87 ± 0.035	1.748SerHis: 1.748 ± 0.018	3.237SerIle: 3.237 ± 0.024	3.247SerLys: 3.247 ± 0.026	6.339SerLeu: 6.339 ± 0.036	1.688SerMet: 1.688 ± 0.017	2.596SerAsn: 2.596 ± 0.022	5.252SerPro: 5.252 ± 0.047	2.988SerGln: 2.988 ± 0.028	4.591SerArg: 4.591 ± 0.037	7.839SerSer: 7.839 ± 0.068	5.516SerThr: 5.516 ± 0.037	4.376SerVal: 4.376 ± 0.028	0.971SerTrp: 0.971 ± 0.014	1.938SerTyr: 1.938 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	6.222ThrAla: 6.222 ± 0.035	0.689ThrCys: 0.689 ± 0.012	2.852ThrAsp: 2.852 ± 0.022	3.084ThrGlu: 3.084 ± 0.023	2.171ThrPhe: 2.171 ± 0.021	4.43ThrGly: 4.43 ± 0.028	1.324ThrHis: 1.324 ± 0.015	2.72ThrIle: 2.72 ± 0.021	2.43ThrLys: 2.43 ± 0.022	5.381ThrLeu: 5.381 ± 0.037	1.231ThrMet: 1.231 ± 0.015	2.086ThrAsn: 2.086 ± 0.02	4.566ThrPro: 4.566 ± 0.038	2.238ThrGln: 2.238 ± 0.017	3.09ThrArg: 3.09 ± 0.027	5.224ThrSer: 5.224 ± 0.039	4.688ThrThr: 4.688 ± 0.038	3.831ThrVal: 3.831 ± 0.032	0.779ThrTrp: 0.779 ± 0.011	1.622ThrTyr: 1.622 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.731ValAla: 5.731 ± 0.033	0.811ValCys: 0.811 ± 0.011	3.767ValAsp: 3.767 ± 0.026	4.295ValGlu: 4.295 ± 0.03	2.217ValPhe: 2.217 ± 0.022	4.537ValGly: 4.537 ± 0.035	1.419ValHis: 1.419 ± 0.015	2.506ValIle: 2.506 ± 0.022	2.957ValLys: 2.957 ± 0.025	5.548ValLeu: 5.548 ± 0.036	1.421ValMet: 1.421 ± 0.016	2.075ValAsn: 2.075 ± 0.02	3.654ValPro: 3.654 ± 0.023	2.571ValGln: 2.571 ± 0.022	3.809ValArg: 3.809 ± 0.027	4.337ValSer: 4.337 ± 0.027	3.527ValThr: 3.527 ± 0.023	4.457ValVal: 4.457 ± 0.031	0.871ValTrp: 0.871 ± 0.012	1.713ValTyr: 1.713 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.099TrpAla: 1.099 ± 0.015	0.188TrpCys: 0.188 ± 0.006	0.835TrpAsp: 0.835 ± 0.013	0.836TrpGlu: 0.836 ± 0.011	0.488TrpPhe: 0.488 ± 0.008	0.87TrpGly: 0.87 ± 0.014	0.37TrpHis: 0.37 ± 0.009	0.653TrpIle: 0.653 ± 0.01	0.689TrpLys: 0.689 ± 0.011	1.335TrpLeu: 1.335 ± 0.018	0.376TrpMet: 0.376 ± 0.008	0.505TrpAsn: 0.505 ± 0.009	0.619TrpPro: 0.619 ± 0.01	0.649TrpGln: 0.649 ± 0.011	1.035TrpArg: 1.035 ± 0.015	1.015TrpSer: 1.015 ± 0.013	0.89TrpThr: 0.89 ± 0.014	0.83TrpVal: 0.83 ± 0.011	0.253TrpTrp: 0.253 ± 0.007	0.417TrpTyr: 0.417 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.39TyrAla: 2.39 ± 0.02	0.383TyrCys: 0.383 ± 0.007	1.703TyrAsp: 1.703 ± 0.018	1.587TyrGlu: 1.587 ± 0.018	1.082TyrPhe: 1.082 ± 0.015	2.234TyrGly: 2.234 ± 0.023	0.708TyrHis: 0.708 ± 0.012	1.209TyrIle: 1.209 ± 0.014	0.984TyrLys: 0.984 ± 0.013	2.491TyrLeu: 2.491 ± 0.021	0.596TyrMet: 0.596 ± 0.009	1.034TyrAsn: 1.034 ± 0.016	1.451TyrPro: 1.451 ± 0.017	1.084TyrGln: 1.084 ± 0.016	1.583TyrArg: 1.583 ± 0.016	1.871TyrSer: 1.871 ± 0.02	1.686TyrThr: 1.686 ± 0.019	1.608TyrVal: 1.608 ± 0.016	0.417TyrTrp: 0.417 ± 0.01	0.911TyrTyr: 0.911 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13631 proteins (6101469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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