Amino acid dipepetide frequency for Candidatus Methylomirabilis lanthanidiphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.582AlaAla: 11.582 ± 0.14	1.221AlaCys: 1.221 ± 0.044	5.206AlaAsp: 5.206 ± 0.076	6.437AlaGlu: 6.437 ± 0.103	3.749AlaPhe: 3.749 ± 0.068	8.182AlaGly: 8.182 ± 0.107	2.197AlaHis: 2.197 ± 0.049	5.984AlaIle: 5.984 ± 0.085	3.95AlaLys: 3.95 ± 0.081	11.504AlaLeu: 11.504 ± 0.127	2.666AlaMet: 2.666 ± 0.064	2.22AlaAsn: 2.22 ± 0.055	4.187AlaPro: 4.187 ± 0.077	3.501AlaGln: 3.501 ± 0.06	7.072AlaArg: 7.072 ± 0.101	5.146AlaSer: 5.146 ± 0.086	5.108AlaThr: 5.108 ± 0.082	7.867AlaVal: 7.867 ± 0.097	1.284AlaTrp: 1.284 ± 0.047	2.58AlaTyr: 2.58 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.039	0.156CysCys: 0.156 ± 0.014	0.537CysAsp: 0.537 ± 0.024	0.61CysGlu: 0.61 ± 0.028	0.348CysPhe: 0.348 ± 0.021	1.061CysGly: 1.061 ± 0.036	0.451CysHis: 0.451 ± 0.039	0.435CysIle: 0.435 ± 0.024	0.3CysLys: 0.3 ± 0.019	1.084CysLeu: 1.084 ± 0.035	0.184CysMet: 0.184 ± 0.015	0.29CysAsn: 0.29 ± 0.016	0.622CysPro: 0.622 ± 0.029	0.324CysGln: 0.324 ± 0.019	0.894CysArg: 0.894 ± 0.034	0.567CysSer: 0.567 ± 0.026	0.529CysThr: 0.529 ± 0.031	0.776CysVal: 0.776 ± 0.029	0.126CysTrp: 0.126 ± 0.01	0.308CysTyr: 0.308 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.861AspAla: 4.861 ± 0.073	0.529AspCys: 0.529 ± 0.028	2.426AspAsp: 2.426 ± 0.049	3.402AspGlu: 3.402 ± 0.065	1.895AspPhe: 1.895 ± 0.052	4.205AspGly: 4.205 ± 0.074	1.172AspHis: 1.172 ± 0.039	2.574AspIle: 2.574 ± 0.053	1.584AspLys: 1.584 ± 0.048	6.422AspLeu: 6.422 ± 0.096	0.896AspMet: 0.896 ± 0.031	1.175AspAsn: 1.175 ± 0.04	3.269AspPro: 3.269 ± 0.069	1.817AspGln: 1.817 ± 0.046	4.33AspArg: 4.33 ± 0.075	2.195AspSer: 2.195 ± 0.055	2.335AspThr: 2.335 ± 0.054	3.767AspVal: 3.767 ± 0.063	0.749AspTrp: 0.749 ± 0.031	1.53AspTyr: 1.53 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.255GluAla: 7.255 ± 0.114	0.51GluCys: 0.51 ± 0.023	2.584GluAsp: 2.584 ± 0.055	4.576GluGlu: 4.576 ± 0.08	2.059GluPhe: 2.059 ± 0.048	4.681GluGly: 4.681 ± 0.071	1.323GluHis: 1.323 ± 0.035	3.986GluIle: 3.986 ± 0.074	2.561GluLys: 2.561 ± 0.059	6.72GluLeu: 6.72 ± 0.091	1.507GluMet: 1.507 ± 0.04	1.256GluAsn: 1.256 ± 0.041	2.582GluPro: 2.582 ± 0.055	2.82GluGln: 2.82 ± 0.051	5.786GluArg: 5.786 ± 0.092	2.97GluSer: 2.97 ± 0.059	3.313GluThr: 3.313 ± 0.063	4.915GluVal: 4.915 ± 0.068	0.71GluTrp: 0.71 ± 0.03	1.409GluTyr: 1.409 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.372PheAla: 3.372 ± 0.068	0.435PheCys: 0.435 ± 0.024	2.207PheAsp: 2.207 ± 0.053	2.239PheGlu: 2.239 ± 0.042	1.507PhePhe: 1.507 ± 0.049	3.281PheGly: 3.281 ± 0.072	0.819PheHis: 0.819 ± 0.032	1.77PheIle: 1.77 ± 0.049	1.132PheLys: 1.132 ± 0.034	3.824PheLeu: 3.824 ± 0.076	0.706PheMet: 0.706 ± 0.028	1.018PheAsn: 1.018 ± 0.035	1.739PhePro: 1.739 ± 0.043	1.149PheGln: 1.149 ± 0.037	2.466PheArg: 2.466 ± 0.061	2.083PheSer: 2.083 ± 0.046	2.121PheThr: 2.121 ± 0.055	2.843PheVal: 2.843 ± 0.061	0.531PheTrp: 0.531 ± 0.028	1.058PheTyr: 1.058 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.188GlyAla: 7.188 ± 0.096	1.078GlyCys: 1.078 ± 0.045	3.746GlyAsp: 3.746 ± 0.075	4.794GlyGlu: 4.794 ± 0.069	3.072GlyPhe: 3.072 ± 0.062	6.681GlyGly: 6.681 ± 0.104	1.822GlyHis: 1.822 ± 0.053	4.971GlyIle: 4.971 ± 0.071	3.559GlyLys: 3.559 ± 0.066	8.51GlyLeu: 8.51 ± 0.113	2.061GlyMet: 2.061 ± 0.057	2.001GlyAsn: 2.001 ± 0.058	3.2GlyPro: 3.2 ± 0.07	2.734GlyGln: 2.734 ± 0.055	6.307GlyArg: 6.307 ± 0.086	4.681GlySer: 4.681 ± 0.076	4.509GlyThr: 4.509 ± 0.078	6.266GlyVal: 6.266 ± 0.09	1.231GlyTrp: 1.231 ± 0.044	2.411GlyTyr: 2.411 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.122HisAla: 2.122 ± 0.051	0.298HisCys: 0.298 ± 0.02	1.125HisAsp: 1.125 ± 0.037	1.298HisGlu: 1.298 ± 0.044	0.817HisPhe: 0.817 ± 0.032	2.017HisGly: 2.017 ± 0.05	0.659HisHis: 0.659 ± 0.032	1.034HisIle: 1.034 ± 0.036	0.659HisLys: 0.659 ± 0.025	2.62HisLeu: 2.62 ± 0.054	0.396HisMet: 0.396 ± 0.021	0.567HisAsn: 0.567 ± 0.026	1.556HisPro: 1.556 ± 0.042	0.777HisGln: 0.777 ± 0.025	1.826HisArg: 1.826 ± 0.047	1.071HisSer: 1.071 ± 0.039	1.139HisThr: 1.139 ± 0.037	1.514HisVal: 1.514 ± 0.042	0.324HisTrp: 0.324 ± 0.019	0.642HisTyr: 0.642 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.069IleAla: 6.069 ± 0.088	0.543IleCys: 0.543 ± 0.025	3.38IleAsp: 3.38 ± 0.065	3.958IleGlu: 3.958 ± 0.075	1.891IlePhe: 1.891 ± 0.048	4.804IleGly: 4.804 ± 0.075	1.207IleHis: 1.207 ± 0.036	2.635IleIle: 2.635 ± 0.064	1.892IleLys: 1.892 ± 0.047	5.521IleLeu: 5.521 ± 0.076	0.9IleMet: 0.9 ± 0.036	1.4IleAsn: 1.4 ± 0.038	3.11IlePro: 3.11 ± 0.07	1.732IleGln: 1.732 ± 0.044	4.309IleArg: 4.309 ± 0.07	2.962IleSer: 2.962 ± 0.064	2.981IleThr: 2.981 ± 0.066	4.55IleVal: 4.55 ± 0.08	0.555IleTrp: 0.555 ± 0.026	1.323IleTyr: 1.323 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.127LysAla: 4.127 ± 0.078	0.275LysCys: 0.275 ± 0.016	1.931LysAsp: 1.931 ± 0.058	2.698LysGlu: 2.698 ± 0.056	0.921LysPhe: 0.921 ± 0.035	3.206LysGly: 3.206 ± 0.064	0.722LysHis: 0.722 ± 0.03	2.145LysIle: 2.145 ± 0.048	1.632LysLys: 1.632 ± 0.053	3.39LysLeu: 3.39 ± 0.061	0.807LysMet: 0.807 ± 0.029	0.915LysAsn: 0.915 ± 0.035	1.937LysPro: 1.937 ± 0.044	1.334LysGln: 1.334 ± 0.042	3.063LysArg: 3.063 ± 0.064	1.851LysSer: 1.851 ± 0.047	2.154LysThr: 2.154 ± 0.049	2.844LysVal: 2.844 ± 0.063	0.378LysTrp: 0.378 ± 0.021	0.76LysTyr: 0.76 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.592LeuAla: 11.592 ± 0.116	1.131LeuCys: 1.131 ± 0.037	5.722LeuAsp: 5.722 ± 0.077	6.372LeuGlu: 6.372 ± 0.087	4.039LeuPhe: 4.039 ± 0.072	8.099LeuGly: 8.099 ± 0.097	2.352LeuHis: 2.352 ± 0.047	5.912LeuIle: 5.912 ± 0.087	4.221LeuLys: 4.221 ± 0.073	11.988LeuLeu: 11.988 ± 0.176	2.22LeuMet: 2.22 ± 0.049	2.797LeuAsn: 2.797 ± 0.057	5.545LeuPro: 5.545 ± 0.097	3.734LeuGln: 3.734 ± 0.066	8.145LeuArg: 8.145 ± 0.106	6.503LeuSer: 6.503 ± 0.093	6.425LeuThr: 6.425 ± 0.095	7.752LeuVal: 7.752 ± 0.115	1.225LeuTrp: 1.225 ± 0.042	2.693LeuTyr: 2.693 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.687MetAla: 2.687 ± 0.059	0.144MetCys: 0.144 ± 0.012	0.987MetAsp: 0.987 ± 0.034	1.168MetGlu: 1.168 ± 0.038	0.588MetPhe: 0.588 ± 0.028	1.714MetGly: 1.714 ± 0.049	0.328MetHis: 0.328 ± 0.021	1.207MetIle: 1.207 ± 0.034	1.122MetLys: 1.122 ± 0.037	2.158MetLeu: 2.158 ± 0.048	0.564MetMet: 0.564 ± 0.029	0.673MetAsn: 0.673 ± 0.028	1.126MetPro: 1.126 ± 0.038	0.672MetGln: 0.672 ± 0.034	1.821MetArg: 1.821 ± 0.049	1.24MetSer: 1.24 ± 0.04	1.592MetThr: 1.592 ± 0.043	1.674MetVal: 1.674 ± 0.045	0.175MetTrp: 0.175 ± 0.014	0.357MetTyr: 0.357 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.202AsnAla: 2.202 ± 0.049	0.256AsnCys: 0.256 ± 0.017	1.232AsnAsp: 1.232 ± 0.043	1.303AsnGlu: 1.303 ± 0.043	0.854AsnPhe: 0.854 ± 0.035	2.031AsnGly: 2.031 ± 0.053	0.552AsnHis: 0.552 ± 0.026	1.352AsnIle: 1.352 ± 0.039	0.743AsnLys: 0.743 ± 0.03	2.84AsnLeu: 2.84 ± 0.06	0.462AsnMet: 0.462 ± 0.024	0.674AsnAsn: 0.674 ± 0.034	1.921AsnPro: 1.921 ± 0.051	0.84AsnGln: 0.84 ± 0.034	2.029AsnArg: 2.029 ± 0.046	1.121AsnSer: 1.121 ± 0.039	1.259AsnThr: 1.259 ± 0.052	1.869AsnVal: 1.869 ± 0.054	0.352AsnTrp: 0.352 ± 0.021	0.726AsnTyr: 0.726 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.795ProAla: 4.795 ± 0.078	0.441ProCys: 0.441 ± 0.02	3.24ProAsp: 3.24 ± 0.068	3.608ProGlu: 3.608 ± 0.061	2.137ProPhe: 2.137 ± 0.049	4.113ProGly: 4.113 ± 0.078	1.29ProHis: 1.29 ± 0.044	2.65ProIle: 2.65 ± 0.054	1.741ProLys: 1.741 ± 0.045	5.043ProLeu: 5.043 ± 0.09	1.13ProMet: 1.13 ± 0.036	1.247ProAsn: 1.247 ± 0.033	2.802ProPro: 2.802 ± 0.07	1.645ProGln: 1.645 ± 0.048	2.927ProArg: 2.927 ± 0.058	2.994ProSer: 2.994 ± 0.06	2.834ProThr: 2.834 ± 0.058	3.887ProVal: 3.887 ± 0.066	0.741ProTrp: 0.741 ± 0.032	1.306ProTyr: 1.306 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.058GlnAla: 4.058 ± 0.079	0.339GlnCys: 0.339 ± 0.021	1.552GlnAsp: 1.552 ± 0.043	2.463GlnGlu: 2.463 ± 0.055	1.133GlnPhe: 1.133 ± 0.032	2.552GlnGly: 2.552 ± 0.045	0.759GlnHis: 0.759 ± 0.026	2.17GlnIle: 2.17 ± 0.049	1.232GlnLys: 1.232 ± 0.039	3.29GlnLeu: 3.29 ± 0.066	0.885GlnMet: 0.885 ± 0.036	0.728GlnAsn: 0.728 ± 0.032	1.706GlnPro: 1.706 ± 0.043	1.581GlnGln: 1.581 ± 0.048	2.873GlnArg: 2.873 ± 0.064	1.699GlnSer: 1.699 ± 0.045	1.918GlnThr: 1.918 ± 0.05	2.95GlnVal: 2.95 ± 0.061	0.454GlnTrp: 0.454 ± 0.023	0.822GlnTyr: 0.822 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.784ArgAla: 6.784 ± 0.093	0.775ArgCys: 0.775 ± 0.035	3.762ArgAsp: 3.762 ± 0.057	5.253ArgGlu: 5.253 ± 0.086	3.108ArgPhe: 3.108 ± 0.066	5.077ArgGly: 5.077 ± 0.084	1.876ArgHis: 1.876 ± 0.047	4.65ArgIle: 4.65 ± 0.076	2.726ArgLys: 2.726 ± 0.065	9.25ArgLeu: 9.25 ± 0.107	1.815ArgMet: 1.815 ± 0.045	1.778ArgAsn: 1.778 ± 0.049	3.493ArgPro: 3.493 ± 0.07	3.191ArgGln: 3.191 ± 0.067	6.483ArgArg: 6.483 ± 0.099	4.058ArgSer: 4.058 ± 0.064	3.873ArgThr: 3.873 ± 0.06	5.488ArgVal: 5.488 ± 0.091	1.107ArgTrp: 1.107 ± 0.034	2.365ArgTyr: 2.365 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.083SerAla: 5.083 ± 0.079	0.606SerCys: 0.606 ± 0.029	2.724SerAsp: 2.724 ± 0.054	3.049SerGlu: 3.049 ± 0.065	2.018SerPhe: 2.018 ± 0.044	4.907SerGly: 4.907 ± 0.089	1.25SerHis: 1.25 ± 0.035	2.725SerIle: 2.725 ± 0.053	1.804SerLys: 1.804 ± 0.051	5.923SerLeu: 5.923 ± 0.101	1.288SerMet: 1.288 ± 0.036	1.385SerAsn: 1.385 ± 0.037	2.954SerPro: 2.954 ± 0.066	1.757SerGln: 1.757 ± 0.048	4.086SerArg: 4.086 ± 0.07	3.114SerSer: 3.114 ± 0.077	2.804SerThr: 2.804 ± 0.07	3.933SerVal: 3.933 ± 0.066	0.676SerTrp: 0.676 ± 0.032	1.314SerTyr: 1.314 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.455ThrAla: 5.455 ± 0.081	0.576ThrCys: 0.576 ± 0.035	2.675ThrAsp: 2.675 ± 0.057	2.846ThrGlu: 2.846 ± 0.056	2.063ThrPhe: 2.063 ± 0.052	4.891ThrGly: 4.891 ± 0.086	1.226ThrHis: 1.226 ± 0.037	3.25ThrIle: 3.25 ± 0.063	1.858ThrLys: 1.858 ± 0.043	6.184ThrLeu: 6.184 ± 0.091	1.154ThrMet: 1.154 ± 0.034	1.355ThrAsn: 1.355 ± 0.042	3.239ThrPro: 3.239 ± 0.057	1.61ThrGln: 1.61 ± 0.041	3.476ThrArg: 3.476 ± 0.059	2.85ThrSer: 2.85 ± 0.066	2.935ThrThr: 2.935 ± 0.059	4.553ThrVal: 4.553 ± 0.08	0.621ThrTrp: 0.621 ± 0.032	1.396ThrTyr: 1.396 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.923ValAla: 7.923 ± 0.093	0.845ValCys: 0.845 ± 0.03	4.018ValAsp: 4.018 ± 0.075	5.183ValGlu: 5.183 ± 0.083	2.566ValPhe: 2.566 ± 0.055	6.153ValGly: 6.153 ± 0.09	1.462ValHis: 1.462 ± 0.038	4.461ValIle: 4.461 ± 0.079	3.121ValLys: 3.121 ± 0.06	7.633ValLeu: 7.633 ± 0.124	1.619ValMet: 1.619 ± 0.045	2.04ValAsn: 2.04 ± 0.056	3.671ValPro: 3.671 ± 0.064	2.427ValGln: 2.427 ± 0.054	5.617ValArg: 5.617 ± 0.083	4.264ValSer: 4.264 ± 0.068	4.337ValThr: 4.337 ± 0.07	6.54ValVal: 6.54 ± 0.099	0.935ValTrp: 0.935 ± 0.036	1.786ValTyr: 1.786 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.076TrpAla: 1.076 ± 0.036	0.141TrpCys: 0.141 ± 0.014	0.595TrpAsp: 0.595 ± 0.029	0.764TrpGlu: 0.764 ± 0.03	0.501TrpPhe: 0.501 ± 0.025	0.962TrpGly: 0.962 ± 0.035	0.326TrpHis: 0.326 ± 0.021	0.715TrpIle: 0.715 ± 0.03	0.504TrpLys: 0.504 ± 0.026	1.462TrpLeu: 1.462 ± 0.051	0.329TrpMet: 0.329 ± 0.021	0.402TrpAsn: 0.402 ± 0.023	0.532TrpPro: 0.532 ± 0.025	0.536TrpGln: 0.536 ± 0.027	1.024TrpArg: 1.024 ± 0.041	0.736TrpSer: 0.736 ± 0.029	0.735TrpThr: 0.735 ± 0.032	0.886TrpVal: 0.886 ± 0.034	0.215TrpTrp: 0.215 ± 0.017	0.329TrpTyr: 0.329 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.424TyrAla: 2.424 ± 0.053	0.29TyrCys: 0.29 ± 0.02	1.484TyrAsp: 1.484 ± 0.04	1.502TyrGlu: 1.502 ± 0.044	1.034TyrPhe: 1.034 ± 0.038	2.202TyrGly: 2.202 ± 0.059	0.665TyrHis: 0.665 ± 0.026	1.098TyrIle: 1.098 ± 0.039	0.75TyrLys: 0.75 ± 0.028	3.101TyrLeu: 3.101 ± 0.062	0.407TyrMet: 0.407 ± 0.023	0.698TyrAsn: 0.698 ± 0.033	1.379TyrPro: 1.379 ± 0.042	0.984TyrGln: 0.984 ± 0.032	2.379TyrArg: 2.379 ± 0.059	1.295TyrSer: 1.295 ± 0.044	1.312TyrThr: 1.312 ± 0.04	1.729TyrVal: 1.729 ± 0.044	0.383TyrTrp: 0.383 ± 0.022	0.88TyrTyr: 0.88 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3012 proteins (889585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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