Amino acid dipepetide frequency for Acinetobacter sp. CAG:196

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.562AlaAla: 5.562 ± 0.136
0.828AlaCys: 0.828 ± 0.04
3.866AlaAsp: 3.866 ± 0.086
5.107AlaGlu: 5.107 ± 0.112
2.634AlaPhe: 2.634 ± 0.074
5.233AlaGly: 5.233 ± 0.112
1.014AlaHis: 1.014 ± 0.041
5.371AlaIle: 5.371 ± 0.109
5.9AlaLys: 5.9 ± 0.122
6.778AlaLeu: 6.778 ± 0.119
1.848AlaMet: 1.848 ± 0.061
3.576AlaAsn: 3.576 ± 0.087
2.02AlaPro: 2.02 ± 0.068
2.626AlaGln: 2.626 ± 0.067
2.649AlaArg: 2.649 ± 0.068
4.339AlaSer: 4.339 ± 0.101
2.902AlaThr: 2.902 ± 0.089
4.999AlaVal: 4.999 ± 0.101
0.374AlaTrp: 0.374 ± 0.026
2.502AlaTyr: 2.502 ± 0.069
0.002AlaXaa: 0.002 ± 0.002
Cys
0.873CysAla: 0.873 ± 0.04
0.215CysCys: 0.215 ± 0.021
0.755CysAsp: 0.755 ± 0.034
0.824CysGlu: 0.824 ± 0.043
0.581CysPhe: 0.581 ± 0.034
1.084CysGly: 1.084 ± 0.044
0.181CysHis: 0.181 ± 0.017
0.966CysIle: 0.966 ± 0.046
0.945CysLys: 0.945 ± 0.041
0.967CysLeu: 0.967 ± 0.039
0.303CysMet: 0.303 ± 0.019
0.581CysAsn: 0.581 ± 0.032
0.564CysPro: 0.564 ± 0.033
0.314CysGln: 0.314 ± 0.02
0.399CysArg: 0.399 ± 0.025
0.846CysSer: 0.846 ± 0.043
0.601CysThr: 0.601 ± 0.033
0.733CysVal: 0.733 ± 0.035
0.116CysTrp: 0.116 ± 0.016
0.587CysTyr: 0.587 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
3.854AspAla: 3.854 ± 0.092
0.755AspCys: 0.755 ± 0.041
2.91AspAsp: 2.91 ± 0.083
4.325AspGlu: 4.325 ± 0.099
3.226AspPhe: 3.226 ± 0.074
3.543AspGly: 3.543 ± 0.094
0.429AspHis: 0.429 ± 0.025
5.523AspIle: 5.523 ± 0.095
5.211AspLys: 5.211 ± 0.101
5.118AspLeu: 5.118 ± 0.098
1.461AspMet: 1.461 ± 0.052
3.37AspAsn: 3.37 ± 0.084
1.222AspPro: 1.222 ± 0.047
0.724AspGln: 0.724 ± 0.041
1.833AspArg: 1.833 ± 0.065
2.981AspSer: 2.981 ± 0.076
2.874AspThr: 2.874 ± 0.073
3.675AspVal: 3.675 ± 0.084
0.466AspTrp: 0.466 ± 0.029
2.808AspTyr: 2.808 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.051GluAla: 5.051 ± 0.118
0.735GluCys: 0.735 ± 0.038
3.634GluAsp: 3.634 ± 0.085
5.669GluGlu: 5.669 ± 0.155
3.229GluPhe: 3.229 ± 0.075
3.375GluGly: 3.375 ± 0.089
1.117GluHis: 1.117 ± 0.043
6.352GluIle: 6.352 ± 0.119
7.028GluLys: 7.028 ± 0.115
6.897GluLeu: 6.897 ± 0.116
1.757GluMet: 1.757 ± 0.057
4.845GluAsn: 4.845 ± 0.093
1.781GluPro: 1.781 ± 0.071
2.458GluGln: 2.458 ± 0.08
2.552GluArg: 2.552 ± 0.063
2.764GluSer: 2.764 ± 0.067
3.601GluThr: 3.601 ± 0.09
4.115GluVal: 4.115 ± 0.09
0.484GluTrp: 0.484 ± 0.028
3.084GluTyr: 3.084 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
3.081PheAla: 3.081 ± 0.085
0.633PheCys: 0.633 ± 0.033
2.902PheAsp: 2.902 ± 0.073
3.08PheGlu: 3.08 ± 0.068
2.01PhePhe: 2.01 ± 0.068
2.744PheGly: 2.744 ± 0.077
0.559PheHis: 0.559 ± 0.034
3.687PheIle: 3.687 ± 0.093
3.522PheLys: 3.522 ± 0.076
3.957PheLeu: 3.957 ± 0.1
1.054PheMet: 1.054 ± 0.04
2.715PheAsn: 2.715 ± 0.076
1.266PhePro: 1.266 ± 0.043
1.186PheGln: 1.186 ± 0.046
1.464PheArg: 1.464 ± 0.054
3.175PheSer: 3.175 ± 0.069
2.302PheThr: 2.302 ± 0.062
2.935PheVal: 2.935 ± 0.072
0.386PheTrp: 0.386 ± 0.025
1.724PheTyr: 1.724 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.342GlyAla: 4.342 ± 0.117
0.95GlyCys: 0.95 ± 0.043
3.193GlyAsp: 3.193 ± 0.1
3.722GlyGlu: 3.722 ± 0.09
3.0GlyPhe: 3.0 ± 0.072
4.305GlyGly: 4.305 ± 0.152
1.029GlyHis: 1.029 ± 0.042
5.379GlyIle: 5.379 ± 0.1
4.977GlyLys: 4.977 ± 0.097
5.575GlyLeu: 5.575 ± 0.106
1.826GlyMet: 1.826 ± 0.061
3.318GlyAsn: 3.318 ± 0.128
0.949GlyPro: 0.949 ± 0.042
1.519GlyGln: 1.519 ± 0.056
2.184GlyArg: 2.184 ± 0.062
3.623GlySer: 3.623 ± 0.12
3.469GlyThr: 3.469 ± 0.138
4.465GlyVal: 4.465 ± 0.095
0.531GlyTrp: 0.531 ± 0.031
2.718GlyTyr: 2.718 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.04
0.215HisCys: 0.215 ± 0.018
0.711HisAsp: 0.711 ± 0.036
0.851HisGlu: 0.851 ± 0.038
0.674HisPhe: 0.674 ± 0.038
0.886HisGly: 0.886 ± 0.04
0.3HisHis: 0.3 ± 0.022
1.242HisIle: 1.242 ± 0.045
1.084HisLys: 1.084 ± 0.042
1.165HisLeu: 1.165 ± 0.048
0.327HisMet: 0.327 ± 0.022
0.843HisAsn: 0.843 ± 0.037
0.733HisPro: 0.733 ± 0.034
0.405HisGln: 0.405 ± 0.026
0.556HisArg: 0.556 ± 0.027
0.975HisSer: 0.975 ± 0.041
0.754HisThr: 0.754 ± 0.036
0.738HisVal: 0.738 ± 0.031
0.115HisTrp: 0.115 ± 0.015
0.63HisTyr: 0.63 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.908IleAla: 5.908 ± 0.105
1.063IleCys: 1.063 ± 0.041
5.074IleAsp: 5.074 ± 0.093
6.023IleGlu: 6.023 ± 0.099
3.431IlePhe: 3.431 ± 0.093
4.589IleGly: 4.589 ± 0.109
1.043IleHis: 1.043 ± 0.042
6.552IleIle: 6.552 ± 0.138
7.332IleLys: 7.332 ± 0.111
7.573IleLeu: 7.573 ± 0.13
1.875IleMet: 1.875 ± 0.063
5.539IleAsn: 5.539 ± 0.121
3.237IlePro: 3.237 ± 0.086
2.597IleGln: 2.597 ± 0.068
2.806IleArg: 2.806 ± 0.075
5.899IleSer: 5.899 ± 0.112
4.969IleThr: 4.969 ± 0.124
4.87IleVal: 4.87 ± 0.091
0.415IleTrp: 0.415 ± 0.025
2.861IleTyr: 2.861 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
5.564LysAla: 5.564 ± 0.104
0.884LysCys: 0.884 ± 0.041
5.325LysAsp: 5.325 ± 0.083
6.692LysGlu: 6.692 ± 0.131
3.45LysPhe: 3.45 ± 0.081
4.226LysGly: 4.226 ± 0.09
1.259LysHis: 1.259 ± 0.046
7.372LysIle: 7.372 ± 0.126
7.292LysLys: 7.292 ± 0.131
7.706LysLeu: 7.706 ± 0.116
2.172LysMet: 2.172 ± 0.061
5.997LysAsn: 5.997 ± 0.112
2.742LysPro: 2.742 ± 0.07
2.886LysGln: 2.886 ± 0.068
3.028LysArg: 3.028 ± 0.071
4.787LysSer: 4.787 ± 0.099
4.882LysThr: 4.882 ± 0.1
4.678LysVal: 4.678 ± 0.084
0.506LysTrp: 0.506 ± 0.03
3.94LysTyr: 3.94 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
6.649LeuAla: 6.649 ± 0.112
1.186LeuCys: 1.186 ± 0.046
5.076LeuAsp: 5.076 ± 0.092
6.368LeuGlu: 6.368 ± 0.113
3.767LeuPhe: 3.767 ± 0.114
5.715LeuGly: 5.715 ± 0.111
1.245LeuHis: 1.245 ± 0.04
6.893LeuIle: 6.893 ± 0.12
8.311LeuLys: 8.311 ± 0.137
7.701LeuLeu: 7.701 ± 0.149
2.351LeuMet: 2.351 ± 0.063
5.763LeuAsn: 5.763 ± 0.107
3.265LeuPro: 3.265 ± 0.087
2.839LeuGln: 2.839 ± 0.058
3.279LeuArg: 3.279 ± 0.078
6.436LeuSer: 6.436 ± 0.114
5.244LeuThr: 5.244 ± 0.111
4.785LeuVal: 4.785 ± 0.086
0.523LeuTrp: 0.523 ± 0.028
3.073LeuTyr: 3.073 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.834MetAla: 1.834 ± 0.056
0.258MetCys: 0.258 ± 0.019
1.347MetAsp: 1.347 ± 0.048
1.435MetGlu: 1.435 ± 0.049
1.102MetPhe: 1.102 ± 0.042
1.559MetGly: 1.559 ± 0.056
0.36MetHis: 0.36 ± 0.025
1.771MetIle: 1.771 ± 0.061
2.18MetLys: 2.18 ± 0.063
2.447MetLeu: 2.447 ± 0.068
0.735MetMet: 0.735 ± 0.038
1.572MetAsn: 1.572 ± 0.049
1.051MetPro: 1.051 ± 0.037
1.027MetGln: 1.027 ± 0.044
0.936MetArg: 0.936 ± 0.038
1.727MetSer: 1.727 ± 0.049
1.489MetThr: 1.489 ± 0.048
1.286MetVal: 1.286 ± 0.048
0.143MetTrp: 0.143 ± 0.017
0.887MetTyr: 0.887 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.925AsnAla: 3.925 ± 0.102
0.798AsnCys: 0.798 ± 0.043
2.951AsnAsp: 2.951 ± 0.085
3.527AsnGlu: 3.527 ± 0.082
2.874AsnPhe: 2.874 ± 0.07
3.794AsnGly: 3.794 ± 0.115
0.77AsnHis: 0.77 ± 0.036
5.983AsnIle: 5.983 ± 0.133
4.958AsnLys: 4.958 ± 0.099
5.661AsnLeu: 5.661 ± 0.124
1.456AsnMet: 1.456 ± 0.049
4.276AsnAsn: 4.276 ± 0.138
2.849AsnPro: 2.849 ± 0.069
1.817AsnGln: 1.817 ± 0.056
2.043AsnArg: 2.043 ± 0.058
4.127AsnSer: 4.127 ± 0.121
3.411AsnThr: 3.411 ± 0.105
3.61AsnVal: 3.61 ± 0.093
0.49AsnTrp: 0.49 ± 0.029
2.835AsnTyr: 2.835 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
2.335ProAla: 2.335 ± 0.073
0.353ProCys: 0.353 ± 0.029
2.326ProAsp: 2.326 ± 0.065
3.18ProGlu: 3.18 ± 0.076
1.537ProPhe: 1.537 ± 0.054
1.418ProGly: 1.418 ± 0.059
0.51ProHis: 0.51 ± 0.03
2.285ProIle: 2.285 ± 0.062
2.395ProLys: 2.395 ± 0.063
2.695ProLeu: 2.695 ± 0.072
0.737ProMet: 0.737 ± 0.034
1.671ProAsn: 1.671 ± 0.046
0.908ProPro: 0.908 ± 0.042
1.445ProGln: 1.445 ± 0.051
0.867ProArg: 0.867 ± 0.042
1.908ProSer: 1.908 ± 0.054
1.432ProThr: 1.432 ± 0.053
2.663ProVal: 2.663 ± 0.075
0.229ProTrp: 0.229 ± 0.02
1.305ProTyr: 1.305 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.521GlnAla: 2.521 ± 0.075
0.234GlnCys: 0.234 ± 0.021
1.589GlnAsp: 1.589 ± 0.049
2.293GlnGlu: 2.293 ± 0.066
1.066GlnPhe: 1.066 ± 0.042
1.671GlnGly: 1.671 ± 0.05
0.408GlnHis: 0.408 ± 0.027
2.69GlnIle: 2.69 ± 0.062
3.185GlnLys: 3.185 ± 0.072
2.547GlnLeu: 2.547 ± 0.069
0.925GlnMet: 0.925 ± 0.038
2.199GlnAsn: 2.199 ± 0.063
0.905GlnPro: 0.905 ± 0.043
1.241GlnGln: 1.241 ± 0.054
1.223GlnArg: 1.223 ± 0.05
1.754GlnSer: 1.754 ± 0.055
1.76GlnThr: 1.76 ± 0.047
1.748GlnVal: 1.748 ± 0.059
0.166GlnTrp: 0.166 ± 0.015
1.192GlnTyr: 1.192 ± 0.048
0.002GlnXaa: 0.002 ± 0.001
Arg
2.382ArgAla: 2.382 ± 0.07
0.435ArgCys: 0.435 ± 0.032
1.74ArgAsp: 1.74 ± 0.056
2.806ArgGlu: 2.806 ± 0.088
1.712ArgPhe: 1.712 ± 0.048
1.99ArgGly: 1.99 ± 0.058
0.605ArgHis: 0.605 ± 0.033
3.24ArgIle: 3.24 ± 0.078
3.012ArgLys: 3.012 ± 0.072
3.359ArgLeu: 3.359 ± 0.08
0.999ArgMet: 0.999 ± 0.039
2.101ArgAsn: 2.101 ± 0.058
0.991ArgPro: 0.991 ± 0.044
1.19ArgGln: 1.19 ± 0.044
1.429ArgArg: 1.429 ± 0.053
1.71ArgSer: 1.71 ± 0.058
1.754ArgThr: 1.754 ± 0.058
2.232ArgVal: 2.232 ± 0.062
0.281ArgTrp: 0.281 ± 0.02
1.395ArgTyr: 1.395 ± 0.044
0.002ArgXaa: 0.002 ± 0.002
Ser
4.419SerAla: 4.419 ± 0.111
0.79SerCys: 0.79 ± 0.038
3.554SerAsp: 3.554 ± 0.077
4.05SerGlu: 4.05 ± 0.083
2.915SerPhe: 2.915 ± 0.076
4.637SerGly: 4.637 ± 0.155
0.908SerHis: 0.908 ± 0.037
5.291SerIle: 5.291 ± 0.115
4.791SerLys: 4.791 ± 0.085
5.501SerLeu: 5.501 ± 0.099
1.567SerMet: 1.567 ± 0.05
3.59SerAsn: 3.59 ± 0.097
1.955SerPro: 1.955 ± 0.06
1.982SerGln: 1.982 ± 0.061
2.318SerArg: 2.318 ± 0.064
4.735SerSer: 4.735 ± 0.139
3.419SerThr: 3.419 ± 0.101
3.747SerVal: 3.747 ± 0.095
0.465SerTrp: 0.465 ± 0.025
2.389SerTyr: 2.389 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
4.151ThrAla: 4.151 ± 0.099
0.521ThrCys: 0.521 ± 0.028
2.864ThrAsp: 2.864 ± 0.077
3.268ThrGlu: 3.268 ± 0.072
2.247ThrPhe: 2.247 ± 0.071
3.975ThrGly: 3.975 ± 0.131
0.837ThrHis: 0.837 ± 0.035
4.264ThrIle: 4.264 ± 0.107
3.931ThrLys: 3.931 ± 0.088
5.157ThrLeu: 5.157 ± 0.108
1.157ThrMet: 1.157 ± 0.041
3.081ThrAsn: 3.081 ± 0.133
2.44ThrPro: 2.44 ± 0.072
1.677ThrGln: 1.677 ± 0.05
1.917ThrArg: 1.917 ± 0.061
3.607ThrSer: 3.607 ± 0.095
3.15ThrThr: 3.15 ± 0.11
3.625ThrVal: 3.625 ± 0.09
0.284ThrTrp: 0.284 ± 0.024
1.905ThrTyr: 1.905 ± 0.062
0.002ThrXaa: 0.002 ± 0.002
Val
3.705ValAla: 3.705 ± 0.089
0.916ValCys: 0.916 ± 0.04
3.631ValAsp: 3.631 ± 0.079
4.256ValGlu: 4.256 ± 0.083
2.764ValPhe: 2.764 ± 0.074
3.482ValGly: 3.482 ± 0.099
0.777ValHis: 0.777 ± 0.035
5.154ValIle: 5.154 ± 0.108
5.443ValLys: 5.443 ± 0.095
5.497ValLeu: 5.497 ± 0.094
1.611ValMet: 1.611 ± 0.053
3.848ValAsn: 3.848 ± 0.085
1.853ValPro: 1.853 ± 0.06
1.896ValGln: 1.896 ± 0.057
2.092ValArg: 2.092 ± 0.066
4.372ValSer: 4.372 ± 0.09
3.518ValThr: 3.518 ± 0.1
3.857ValVal: 3.857 ± 0.104
0.369ValTrp: 0.369 ± 0.024
2.241ValTyr: 2.241 ± 0.059
0.002ValXaa: 0.002 ± 0.002
Trp
0.503TrpAla: 0.503 ± 0.031
0.118TrpCys: 0.118 ± 0.012
0.394TrpAsp: 0.394 ± 0.023
0.454TrpGlu: 0.454 ± 0.029
0.341TrpPhe: 0.341 ± 0.023
0.523TrpGly: 0.523 ± 0.026
0.154TrpHis: 0.154 ± 0.016
0.539TrpIle: 0.539 ± 0.026
0.4TrpLys: 0.4 ± 0.024
0.721TrpLeu: 0.721 ± 0.037
0.159TrpMet: 0.159 ± 0.015
0.399TrpAsn: 0.399 ± 0.025
0.105TrpPro: 0.105 ± 0.015
0.265TrpGln: 0.265 ± 0.023
0.243TrpArg: 0.243 ± 0.017
0.32TrpSer: 0.32 ± 0.022
0.314TrpThr: 0.314 ± 0.023
0.408TrpVal: 0.408 ± 0.029
0.068TrpTrp: 0.068 ± 0.01
0.284TrpTyr: 0.284 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.547TyrAla: 2.547 ± 0.071
0.551TyrCys: 0.551 ± 0.033
2.462TyrAsp: 2.462 ± 0.071
2.596TyrGlu: 2.596 ± 0.071
1.822TyrPhe: 1.822 ± 0.063
2.326TyrGly: 2.326 ± 0.063
0.622TyrHis: 0.622 ± 0.033
3.1TyrIle: 3.1 ± 0.074
3.493TyrLys: 3.493 ± 0.076
3.444TyrLeu: 3.444 ± 0.081
0.826TyrMet: 0.826 ± 0.042
2.869TyrAsn: 2.869 ± 0.077
1.366TyrPro: 1.366 ± 0.056
1.225TyrGln: 1.225 ± 0.048
1.545TyrArg: 1.545 ± 0.053
2.937TyrSer: 2.937 ± 0.081
2.216TyrThr: 2.216 ± 0.06
2.114TyrVal: 2.114 ± 0.057
0.302TyrTrp: 0.302 ± 0.024
1.853TyrTyr: 1.853 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.002XaaPhe: 0.002 ± 0.002
0.0XaaGly: 0.0 ± 0.0
0.002XaaHis: 0.002 ± 0.001
0.002XaaIle: 0.002 ± 0.002
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.002XaaTyr: 0.002 ± 0.002
0.014XaaXaa: 0.014 ± 0.008
Statistics based on 2085 proteins (636768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski