Amino acid dipepetide frequency for Clostridium sp. CAG:264

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.704AlaAla: 6.704 ± 0.137
1.149AlaCys: 1.149 ± 0.044
5.125AlaAsp: 5.125 ± 0.099
5.669AlaGlu: 5.669 ± 0.114
3.112AlaPhe: 3.112 ± 0.074
6.162AlaGly: 6.162 ± 0.11
1.067AlaHis: 1.067 ± 0.043
5.199AlaIle: 5.199 ± 0.085
4.991AlaLys: 4.991 ± 0.098
6.008AlaLeu: 6.008 ± 0.097
2.262AlaMet: 2.262 ± 0.065
2.805AlaAsn: 2.805 ± 0.073
1.819AlaPro: 1.819 ± 0.056
1.865AlaGln: 1.865 ± 0.05
2.694AlaArg: 2.694 ± 0.068
4.047AlaSer: 4.047 ± 0.08
3.597AlaThr: 3.597 ± 0.078
6.217AlaVal: 6.217 ± 0.103
0.576AlaTrp: 0.576 ± 0.035
3.046AlaTyr: 3.046 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.92CysAla: 0.92 ± 0.042
0.26CysCys: 0.26 ± 0.023
0.918CysAsp: 0.918 ± 0.037
0.901CysGlu: 0.901 ± 0.035
0.58CysPhe: 0.58 ± 0.031
1.484CysGly: 1.484 ± 0.051
0.303CysHis: 0.303 ± 0.023
1.236CysIle: 1.236 ± 0.052
0.9CysLys: 0.9 ± 0.036
1.119CysLeu: 1.119 ± 0.044
0.508CysMet: 0.508 ± 0.027
0.61CysAsn: 0.61 ± 0.029
0.532CysPro: 0.532 ± 0.035
0.375CysGln: 0.375 ± 0.022
0.576CysArg: 0.576 ± 0.028
0.934CysSer: 0.934 ± 0.035
0.746CysThr: 0.746 ± 0.036
1.038CysVal: 1.038 ± 0.038
0.092CysTrp: 0.092 ± 0.011
0.685CysTyr: 0.685 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
4.651AspAla: 4.651 ± 0.08
0.796AspCys: 0.796 ± 0.039
3.779AspAsp: 3.779 ± 0.088
5.055AspGlu: 5.055 ± 0.1
2.507AspPhe: 2.507 ± 0.057
4.617AspGly: 4.617 ± 0.09
0.996AspHis: 0.996 ± 0.041
5.486AspIle: 5.486 ± 0.102
4.371AspLys: 4.371 ± 0.091
4.63AspLeu: 4.63 ± 0.086
2.071AspMet: 2.071 ± 0.064
2.525AspAsn: 2.525 ± 0.067
1.853AspPro: 1.853 ± 0.056
1.641AspGln: 1.641 ± 0.047
2.628AspArg: 2.628 ± 0.072
3.596AspSer: 3.596 ± 0.08
3.562AspThr: 3.562 ± 0.089
4.275AspVal: 4.275 ± 0.084
0.54AspTrp: 0.54 ± 0.032
3.149AspTyr: 3.149 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
5.417GluAla: 5.417 ± 0.12
0.85GluCys: 0.85 ± 0.036
4.583GluAsp: 4.583 ± 0.104
6.321GluGlu: 6.321 ± 0.119
2.521GluPhe: 2.521 ± 0.069
3.616GluGly: 3.616 ± 0.088
1.464GluHis: 1.464 ± 0.047
5.445GluIle: 5.445 ± 0.095
6.275GluLys: 6.275 ± 0.108
6.554GluLeu: 6.554 ± 0.112
2.439GluMet: 2.439 ± 0.061
4.016GluAsn: 4.016 ± 0.079
1.713GluPro: 1.713 ± 0.053
2.958GluGln: 2.958 ± 0.076
2.957GluArg: 2.957 ± 0.07
3.153GluSer: 3.153 ± 0.066
3.985GluThr: 3.985 ± 0.082
4.156GluVal: 4.156 ± 0.08
0.564GluTrp: 0.564 ± 0.031
3.382GluTyr: 3.382 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.023PheAla: 3.023 ± 0.06
0.669PheCys: 0.669 ± 0.029
2.744PheAsp: 2.744 ± 0.068
2.474PheGlu: 2.474 ± 0.07
1.753PhePhe: 1.753 ± 0.066
2.967PheGly: 2.967 ± 0.076
0.801PheHis: 0.801 ± 0.032
2.972PheIle: 2.972 ± 0.077
2.139PheLys: 2.139 ± 0.062
3.395PheLeu: 3.395 ± 0.091
1.177PheMet: 1.177 ± 0.04
1.603PheAsn: 1.603 ± 0.049
1.228PhePro: 1.228 ± 0.041
0.999PheGln: 0.999 ± 0.035
1.528PheArg: 1.528 ± 0.049
2.604PheSer: 2.604 ± 0.059
2.327PheThr: 2.327 ± 0.065
2.873PheVal: 2.873 ± 0.069
0.344PheTrp: 0.344 ± 0.024
1.695PheTyr: 1.695 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.888GlyAla: 4.888 ± 0.102
1.279GlyCys: 1.279 ± 0.041
3.667GlyAsp: 3.667 ± 0.077
4.206GlyGlu: 4.206 ± 0.085
2.882GlyPhe: 2.882 ± 0.072
4.487GlyGly: 4.487 ± 0.1
1.279GlyHis: 1.279 ± 0.047
6.282GlyIle: 6.282 ± 0.106
5.66GlyLys: 5.66 ± 0.107
5.462GlyLeu: 5.462 ± 0.099
2.395GlyMet: 2.395 ± 0.067
3.235GlyAsn: 3.235 ± 0.077
1.123GlyPro: 1.123 ± 0.041
1.879GlyGln: 1.879 ± 0.048
2.942GlyArg: 2.942 ± 0.072
4.214GlySer: 4.214 ± 0.09
4.517GlyThr: 4.517 ± 0.098
4.835GlyVal: 4.835 ± 0.093
0.613GlyTrp: 0.613 ± 0.033
3.575GlyTyr: 3.575 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
1.094HisAla: 1.094 ± 0.046
0.239HisCys: 0.239 ± 0.021
0.973HisAsp: 0.973 ± 0.042
1.05HisGlu: 1.05 ± 0.039
0.754HisPhe: 0.754 ± 0.034
1.33HisGly: 1.33 ± 0.045
0.361HisHis: 0.361 ± 0.034
1.507HisIle: 1.507 ± 0.046
0.929HisLys: 0.929 ± 0.041
1.33HisLeu: 1.33 ± 0.038
0.57HisMet: 0.57 ± 0.027
0.784HisAsn: 0.784 ± 0.035
0.784HisPro: 0.784 ± 0.038
0.453HisGln: 0.453 ± 0.025
0.692HisArg: 0.692 ± 0.031
0.925HisSer: 0.925 ± 0.04
1.067HisThr: 1.067 ± 0.036
1.12HisVal: 1.12 ± 0.037
0.12HisTrp: 0.12 ± 0.012
0.679HisTyr: 0.679 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.875IleAla: 5.875 ± 0.104
1.533IleCys: 1.533 ± 0.051
4.721IleAsp: 4.721 ± 0.074
4.898IleGlu: 4.898 ± 0.093
2.984IlePhe: 2.984 ± 0.079
5.356IleGly: 5.356 ± 0.104
1.374IleHis: 1.374 ± 0.042
5.785IleIle: 5.785 ± 0.118
5.036IleLys: 5.036 ± 0.091
7.124IleLeu: 7.124 ± 0.138
2.17IleMet: 2.17 ± 0.065
3.503IleAsn: 3.503 ± 0.083
3.044IlePro: 3.044 ± 0.066
2.112IleGln: 2.112 ± 0.06
3.732IleArg: 3.732 ± 0.073
5.124IleSer: 5.124 ± 0.1
4.685IleThr: 4.685 ± 0.102
5.363IleVal: 5.363 ± 0.101
0.654IleTrp: 0.654 ± 0.031
3.247IleTyr: 3.247 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.248LysAla: 5.248 ± 0.106
0.771LysCys: 0.771 ± 0.037
4.565LysAsp: 4.565 ± 0.086
6.404LysGlu: 6.404 ± 0.107
1.812LysPhe: 1.812 ± 0.059
4.207LysGly: 4.207 ± 0.091
1.133LysHis: 1.133 ± 0.045
5.038LysIle: 5.038 ± 0.102
7.37LysLys: 7.37 ± 0.148
5.848LysLeu: 5.848 ± 0.104
2.35LysMet: 2.35 ± 0.059
4.196LysAsn: 4.196 ± 0.088
2.033LysPro: 2.033 ± 0.061
2.562LysGln: 2.562 ± 0.063
3.026LysArg: 3.026 ± 0.075
3.547LysSer: 3.547 ± 0.085
4.2LysThr: 4.2 ± 0.096
4.598LysVal: 4.598 ± 0.116
0.573LysTrp: 0.573 ± 0.03
3.165LysTyr: 3.165 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
6.669LeuAla: 6.669 ± 0.115
1.364LeuCys: 1.364 ± 0.05
5.131LeuAsp: 5.131 ± 0.086
5.272LeuGlu: 5.272 ± 0.098
3.558LeuPhe: 3.558 ± 0.101
5.328LeuGly: 5.328 ± 0.099
1.427LeuHis: 1.427 ± 0.05
6.049LeuIle: 6.049 ± 0.117
5.694LeuLys: 5.694 ± 0.092
7.544LeuLeu: 7.544 ± 0.145
2.529LeuMet: 2.529 ± 0.065
3.733LeuAsn: 3.733 ± 0.075
3.143LeuPro: 3.143 ± 0.075
2.494LeuGln: 2.494 ± 0.065
3.135LeuArg: 3.135 ± 0.063
5.7LeuSer: 5.7 ± 0.096
4.97LeuThr: 4.97 ± 0.079
5.623LeuVal: 5.623 ± 0.119
0.566LeuTrp: 0.566 ± 0.029
3.477LeuTyr: 3.477 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.473MetAla: 2.473 ± 0.064
0.407MetCys: 0.407 ± 0.022
1.976MetAsp: 1.976 ± 0.058
2.399MetGlu: 2.399 ± 0.063
1.065MetPhe: 1.065 ± 0.039
2.036MetGly: 2.036 ± 0.058
0.461MetHis: 0.461 ± 0.029
2.493MetIle: 2.493 ± 0.061
2.604MetLys: 2.604 ± 0.059
2.701MetLeu: 2.701 ± 0.063
0.989MetMet: 0.989 ± 0.035
1.659MetAsn: 1.659 ± 0.046
1.092MetPro: 1.092 ± 0.039
1.082MetGln: 1.082 ± 0.041
1.101MetArg: 1.101 ± 0.035
1.791MetSer: 1.791 ± 0.055
1.737MetThr: 1.737 ± 0.053
2.014MetVal: 2.014 ± 0.061
0.191MetTrp: 0.191 ± 0.014
1.047MetTyr: 1.047 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.182AsnAla: 3.182 ± 0.067
0.703AsnCys: 0.703 ± 0.035
2.602AsnAsp: 2.602 ± 0.06
3.06AsnGlu: 3.06 ± 0.071
1.491AsnPhe: 1.491 ± 0.058
3.784AsnGly: 3.784 ± 0.101
0.784AsnHis: 0.784 ± 0.037
3.87AsnIle: 3.87 ± 0.083
3.265AsnLys: 3.265 ± 0.082
3.654AsnLeu: 3.654 ± 0.078
1.45AsnMet: 1.45 ± 0.047
2.278AsnAsn: 2.278 ± 0.075
1.797AsnPro: 1.797 ± 0.053
1.402AsnGln: 1.402 ± 0.048
2.159AsnArg: 2.159 ± 0.06
2.61AsnSer: 2.61 ± 0.064
2.611AsnThr: 2.611 ± 0.075
3.159AsnVal: 3.159 ± 0.074
0.39AsnTrp: 0.39 ± 0.026
2.016AsnTyr: 2.016 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.258ProAla: 2.258 ± 0.058
0.43ProCys: 0.43 ± 0.021
2.48ProAsp: 2.48 ± 0.069
3.206ProGlu: 3.206 ± 0.077
1.375ProPhe: 1.375 ± 0.05
2.116ProGly: 2.116 ± 0.056
0.488ProHis: 0.488 ± 0.03
1.971ProIle: 1.971 ± 0.053
1.763ProLys: 1.763 ± 0.053
2.268ProLeu: 2.268 ± 0.054
0.813ProMet: 0.813 ± 0.035
1.154ProAsn: 1.154 ± 0.036
0.572ProPro: 0.572 ± 0.032
0.779ProGln: 0.779 ± 0.045
0.794ProArg: 0.794 ± 0.04
1.659ProSer: 1.659 ± 0.047
1.474ProThr: 1.474 ± 0.053
2.928ProVal: 2.928 ± 0.069
0.256ProTrp: 0.256 ± 0.021
1.491ProTyr: 1.491 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.296GlnAla: 2.296 ± 0.054
0.263GlnCys: 0.263 ± 0.02
1.501GlnAsp: 1.501 ± 0.047
2.105GlnGlu: 2.105 ± 0.055
1.099GlnPhe: 1.099 ± 0.041
1.702GlnGly: 1.702 ± 0.054
0.355GlnHis: 0.355 ± 0.021
2.665GlnIle: 2.665 ± 0.057
2.344GlnLys: 2.344 ± 0.057
2.456GlnLeu: 2.456 ± 0.058
1.236GlnMet: 1.236 ± 0.057
1.558GlnAsn: 1.558 ± 0.043
0.908GlnPro: 0.908 ± 0.04
0.914GlnGln: 0.914 ± 0.045
1.011GlnArg: 1.011 ± 0.042
1.477GlnSer: 1.477 ± 0.052
1.809GlnThr: 1.809 ± 0.056
2.048GlnVal: 2.048 ± 0.052
0.192GlnTrp: 0.192 ± 0.016
1.317GlnTyr: 1.317 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
2.402ArgAla: 2.402 ± 0.06
0.509ArgCys: 0.509 ± 0.027
2.204ArgAsp: 2.204 ± 0.064
3.066ArgGlu: 3.066 ± 0.083
1.746ArgPhe: 1.746 ± 0.051
2.071ArgGly: 2.071 ± 0.054
0.707ArgHis: 0.707 ± 0.032
3.5ArgIle: 3.5 ± 0.069
3.439ArgLys: 3.439 ± 0.079
3.525ArgLeu: 3.525 ± 0.075
1.494ArgMet: 1.494 ± 0.049
2.029ArgAsn: 2.029 ± 0.065
1.214ArgPro: 1.214 ± 0.046
1.457ArgGln: 1.457 ± 0.05
1.91ArgArg: 1.91 ± 0.06
2.142ArgSer: 2.142 ± 0.061
2.16ArgThr: 2.16 ± 0.061
2.416ArgVal: 2.416 ± 0.062
0.28ArgTrp: 0.28 ± 0.021
1.925ArgTyr: 1.925 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.955SerAla: 3.955 ± 0.088
0.751SerCys: 0.751 ± 0.038
3.842SerAsp: 3.842 ± 0.075
3.902SerGlu: 3.902 ± 0.091
2.637SerPhe: 2.637 ± 0.058
5.13SerGly: 5.13 ± 0.093
0.975SerHis: 0.975 ± 0.036
4.425SerIle: 4.425 ± 0.087
3.654SerLys: 3.654 ± 0.08
4.694SerLeu: 4.694 ± 0.082
1.746SerMet: 1.746 ± 0.048
2.512SerAsn: 2.512 ± 0.059
1.487SerPro: 1.487 ± 0.049
1.569SerGln: 1.569 ± 0.053
2.406SerArg: 2.406 ± 0.056
3.493SerSer: 3.493 ± 0.085
3.036SerThr: 3.036 ± 0.08
4.295SerVal: 4.295 ± 0.085
0.474SerTrp: 0.474 ± 0.03
2.894SerTyr: 2.894 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.52ThrAla: 4.52 ± 0.089
0.747ThrCys: 0.747 ± 0.029
4.025ThrAsp: 4.025 ± 0.093
4.32ThrGlu: 4.32 ± 0.102
2.394ThrPhe: 2.394 ± 0.068
5.046ThrGly: 5.046 ± 0.096
0.785ThrHis: 0.785 ± 0.031
4.565ThrIle: 4.565 ± 0.104
3.426ThrLys: 3.426 ± 0.077
4.518ThrLeu: 4.518 ± 0.074
1.376ThrMet: 1.376 ± 0.046
2.244ThrAsn: 2.244 ± 0.058
1.997ThrPro: 1.997 ± 0.061
1.296ThrGln: 1.296 ± 0.05
1.846ThrArg: 1.846 ± 0.048
3.122ThrSer: 3.122 ± 0.075
3.416ThrThr: 3.416 ± 0.118
4.882ThrVal: 4.882 ± 0.108
0.478ThrTrp: 0.478 ± 0.029
2.648ThrTyr: 2.648 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
5.155ValAla: 5.155 ± 0.112
1.235ValCys: 1.235 ± 0.043
4.275ValAsp: 4.275 ± 0.087
4.493ValGlu: 4.493 ± 0.089
2.89ValPhe: 2.89 ± 0.074
4.207ValGly: 4.207 ± 0.088
0.98ValHis: 0.98 ± 0.037
5.755ValIle: 5.755 ± 0.097
5.015ValLys: 5.015 ± 0.095
6.24ValLeu: 6.24 ± 0.107
2.092ValMet: 2.092 ± 0.061
3.109ValAsn: 3.109 ± 0.069
2.437ValPro: 2.437 ± 0.064
1.655ValGln: 1.655 ± 0.051
2.766ValArg: 2.766 ± 0.069
4.666ValSer: 4.666 ± 0.079
4.745ValThr: 4.745 ± 0.107
5.202ValVal: 5.202 ± 0.101
0.526ValTrp: 0.526 ± 0.031
3.012ValTyr: 3.012 ± 0.075
0.001ValXaa: 0.001 ± 0.002
Trp
0.453TrpAla: 0.453 ± 0.025
0.11TrpCys: 0.11 ± 0.012
0.463TrpAsp: 0.463 ± 0.03
0.471TrpGlu: 0.471 ± 0.027
0.369TrpPhe: 0.369 ± 0.026
0.543TrpGly: 0.543 ± 0.029
0.175TrpHis: 0.175 ± 0.015
0.601TrpIle: 0.601 ± 0.027
0.662TrpLys: 0.662 ± 0.03
0.746TrpLeu: 0.746 ± 0.031
0.279TrpMet: 0.279 ± 0.018
0.482TrpAsn: 0.482 ± 0.029
0.137TrpPro: 0.137 ± 0.014
0.307TrpGln: 0.307 ± 0.021
0.3TrpArg: 0.3 ± 0.021
0.429TrpSer: 0.429 ± 0.027
0.373TrpThr: 0.373 ± 0.022
0.431TrpVal: 0.431 ± 0.024
0.078TrpTrp: 0.078 ± 0.012
0.42TrpTyr: 0.42 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.933TyrAla: 2.933 ± 0.067
0.648TyrCys: 0.648 ± 0.034
3.156TyrAsp: 3.156 ± 0.078
3.102TyrGlu: 3.102 ± 0.073
1.787TyrPhe: 1.787 ± 0.052
3.231TyrGly: 3.231 ± 0.071
0.845TyrHis: 0.845 ± 0.036
3.474TyrIle: 3.474 ± 0.083
3.107TyrLys: 3.107 ± 0.07
3.59TyrLeu: 3.59 ± 0.075
1.371TyrMet: 1.371 ± 0.045
2.231TyrAsn: 2.231 ± 0.063
1.361TyrPro: 1.361 ± 0.042
1.46TyrGln: 1.46 ± 0.049
1.995TyrArg: 1.995 ± 0.053
2.644TyrSer: 2.644 ± 0.068
2.633TyrThr: 2.633 ± 0.071
2.981TyrVal: 2.981 ± 0.073
0.323TyrTrp: 0.323 ± 0.021
2.2TyrTyr: 2.2 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.005
Statistics based on 2136 proteins (706887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski