Amino acid dipepetide frequency for Parasporobacterium paucivorans DSM 15970

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.805AlaAla: 6.805 ± 0.128
1.076AlaCys: 1.076 ± 0.042
4.244AlaAsp: 4.244 ± 0.078
4.787AlaGlu: 4.787 ± 0.086
3.079AlaPhe: 3.079 ± 0.068
6.357AlaGly: 6.357 ± 0.108
1.065AlaHis: 1.065 ± 0.042
5.442AlaIle: 5.442 ± 0.088
4.357AlaLys: 4.357 ± 0.078
6.957AlaLeu: 6.957 ± 0.117
2.249AlaMet: 2.249 ± 0.06
2.434AlaAsn: 2.434 ± 0.065
1.928AlaPro: 1.928 ± 0.05
2.14AlaGln: 2.14 ± 0.066
3.063AlaArg: 3.063 ± 0.061
4.321AlaSer: 4.321 ± 0.081
3.102AlaThr: 3.102 ± 0.073
6.047AlaVal: 6.047 ± 0.088
0.506AlaTrp: 0.506 ± 0.026
2.511AlaTyr: 2.511 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.873CysAla: 0.873 ± 0.034
0.223CysCys: 0.223 ± 0.017
0.736CysAsp: 0.736 ± 0.034
0.856CysGlu: 0.856 ± 0.039
0.608CysPhe: 0.608 ± 0.03
1.443CysGly: 1.443 ± 0.054
0.309CysHis: 0.309 ± 0.02
1.154CysIle: 1.154 ± 0.041
0.678CysLys: 0.678 ± 0.031
1.123CysLeu: 1.123 ± 0.036
0.408CysMet: 0.408 ± 0.026
0.531CysAsn: 0.531 ± 0.023
0.671CysPro: 0.671 ± 0.033
0.336CysGln: 0.336 ± 0.021
0.732CysArg: 0.732 ± 0.032
0.905CysSer: 0.905 ± 0.035
0.68CysThr: 0.68 ± 0.031
0.896CysVal: 0.896 ± 0.037
0.095CysTrp: 0.095 ± 0.01
0.47CysTyr: 0.47 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.837AspAla: 3.837 ± 0.073
0.79AspCys: 0.79 ± 0.038
2.607AspAsp: 2.607 ± 0.059
4.429AspGlu: 4.429 ± 0.082
2.792AspPhe: 2.792 ± 0.059
3.952AspGly: 3.952 ± 0.081
0.764AspHis: 0.764 ± 0.033
5.235AspIle: 5.235 ± 0.077
3.823AspLys: 3.823 ± 0.073
4.67AspLeu: 4.67 ± 0.078
1.891AspMet: 1.891 ± 0.051
2.417AspAsn: 2.417 ± 0.066
1.774AspPro: 1.774 ± 0.053
1.069AspGln: 1.069 ± 0.043
2.624AspArg: 2.624 ± 0.06
3.236AspSer: 3.236 ± 0.062
2.87AspThr: 2.87 ± 0.065
3.769AspVal: 3.769 ± 0.082
0.494AspTrp: 0.494 ± 0.03
2.41AspTyr: 2.41 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.203GluAla: 5.203 ± 0.093
0.811GluCys: 0.811 ± 0.038
3.96GluAsp: 3.96 ± 0.089
6.73GluGlu: 6.73 ± 0.126
2.803GluPhe: 2.803 ± 0.065
4.57GluGly: 4.57 ± 0.08
1.121GluHis: 1.121 ± 0.045
6.483GluIle: 6.483 ± 0.092
6.557GluLys: 6.557 ± 0.112
6.321GluLeu: 6.321 ± 0.119
2.653GluMet: 2.653 ± 0.061
4.276GluAsn: 4.276 ± 0.092
1.796GluPro: 1.796 ± 0.055
2.184GluGln: 2.184 ± 0.063
3.04GluArg: 3.04 ± 0.063
3.768GluSer: 3.768 ± 0.081
3.854GluThr: 3.854 ± 0.08
4.338GluVal: 4.338 ± 0.087
0.618GluTrp: 0.618 ± 0.027
3.079GluTyr: 3.079 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.051PheAla: 3.051 ± 0.071
0.644PheCys: 0.644 ± 0.03
2.558PheAsp: 2.558 ± 0.064
3.036PheGlu: 3.036 ± 0.071
1.929PhePhe: 1.929 ± 0.061
3.252PheGly: 3.252 ± 0.071
0.714PheHis: 0.714 ± 0.033
3.371PheIle: 3.371 ± 0.079
2.406PheLys: 2.406 ± 0.06
3.926PheLeu: 3.926 ± 0.087
1.311PheMet: 1.311 ± 0.044
1.829PheAsn: 1.829 ± 0.053
1.486PhePro: 1.486 ± 0.042
1.119PheGln: 1.119 ± 0.034
1.76PheArg: 1.76 ± 0.05
3.209PheSer: 3.209 ± 0.079
2.323PheThr: 2.323 ± 0.06
2.87PheVal: 2.87 ± 0.068
0.394PheTrp: 0.394 ± 0.021
1.558PheTyr: 1.558 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.019GlyAla: 5.019 ± 0.093
1.245GlyCys: 1.245 ± 0.047
3.499GlyAsp: 3.499 ± 0.07
4.643GlyGlu: 4.643 ± 0.084
3.418GlyPhe: 3.418 ± 0.068
5.185GlyGly: 5.185 ± 0.124
1.273GlyHis: 1.273 ± 0.046
6.977GlyIle: 6.977 ± 0.103
5.37GlyLys: 5.37 ± 0.083
6.342GlyLeu: 6.342 ± 0.093
2.531GlyMet: 2.531 ± 0.063
3.186GlyAsn: 3.186 ± 0.066
1.625GlyPro: 1.625 ± 0.048
1.886GlyGln: 1.886 ± 0.056
3.363GlyArg: 3.363 ± 0.069
4.35GlySer: 4.35 ± 0.08
4.348GlyThr: 4.348 ± 0.08
4.999GlyVal: 4.999 ± 0.084
0.618GlyTrp: 0.618 ± 0.032
3.232GlyTyr: 3.232 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.049HisAla: 1.049 ± 0.042
0.284HisCys: 0.284 ± 0.021
0.853HisAsp: 0.853 ± 0.04
1.125HisGlu: 1.125 ± 0.043
0.774HisPhe: 0.774 ± 0.03
1.2HisGly: 1.2 ± 0.046
0.428HisHis: 0.428 ± 0.027
1.389HisIle: 1.389 ± 0.048
0.967HisLys: 0.967 ± 0.033
1.399HisLeu: 1.399 ± 0.043
0.487HisMet: 0.487 ± 0.025
0.744HisAsn: 0.744 ± 0.034
0.879HisPro: 0.879 ± 0.041
0.413HisGln: 0.413 ± 0.024
0.72HisArg: 0.72 ± 0.027
1.06HisSer: 1.06 ± 0.039
0.911HisThr: 0.911 ± 0.035
1.021HisVal: 1.021 ± 0.037
0.153HisTrp: 0.153 ± 0.015
0.684HisTyr: 0.684 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.183IleAla: 6.183 ± 0.119
1.254IleCys: 1.254 ± 0.042
4.35IleAsp: 4.35 ± 0.083
5.368IleGlu: 5.368 ± 0.084
3.433IlePhe: 3.433 ± 0.069
5.626IleGly: 5.626 ± 0.095
1.439IleHis: 1.439 ± 0.047
7.111IleIle: 7.111 ± 0.118
5.102IleLys: 5.102 ± 0.089
8.099IleLeu: 8.099 ± 0.134
2.283IleMet: 2.283 ± 0.051
3.675IleAsn: 3.675 ± 0.071
3.484IlePro: 3.484 ± 0.073
2.445IleGln: 2.445 ± 0.06
4.217IleArg: 4.217 ± 0.075
5.874IleSer: 5.874 ± 0.1
4.535IleThr: 4.535 ± 0.082
5.342IleVal: 5.342 ± 0.094
0.56IleTrp: 0.56 ± 0.027
2.75IleTyr: 2.75 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
4.859LysAla: 4.859 ± 0.087
0.733LysCys: 0.733 ± 0.036
3.88LysAsp: 3.88 ± 0.074
6.022LysGlu: 6.022 ± 0.111
2.086LysPhe: 2.086 ± 0.05
4.389LysGly: 4.389 ± 0.071
1.034LysHis: 1.034 ± 0.041
5.458LysIle: 5.458 ± 0.089
5.729LysLys: 5.729 ± 0.088
5.311LysLeu: 5.311 ± 0.088
2.329LysMet: 2.329 ± 0.052
3.902LysAsn: 3.902 ± 0.067
2.029LysPro: 2.029 ± 0.054
1.901LysGln: 1.901 ± 0.049
2.993LysArg: 2.993 ± 0.067
3.719LysSer: 3.719 ± 0.075
3.808LysThr: 3.808 ± 0.074
4.263LysVal: 4.263 ± 0.079
0.562LysTrp: 0.562 ± 0.026
2.89LysTyr: 2.89 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.803LeuAla: 6.803 ± 0.11
1.216LeuCys: 1.216 ± 0.042
5.242LeuAsp: 5.242 ± 0.092
6.634LeuGlu: 6.634 ± 0.127
3.838LeuPhe: 3.838 ± 0.084
6.332LeuGly: 6.332 ± 0.104
1.531LeuHis: 1.531 ± 0.041
6.811LeuIle: 6.811 ± 0.102
6.302LeuLys: 6.302 ± 0.097
8.214LeuLeu: 8.214 ± 0.149
2.581LeuMet: 2.581 ± 0.071
4.077LeuAsn: 4.077 ± 0.084
3.351LeuPro: 3.351 ± 0.067
2.543LeuGln: 2.543 ± 0.063
3.765LeuArg: 3.765 ± 0.076
6.38LeuSer: 6.38 ± 0.096
4.764LeuThr: 4.764 ± 0.076
5.883LeuVal: 5.883 ± 0.106
0.678LeuTrp: 0.678 ± 0.035
3.032LeuTyr: 3.032 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.367MetAla: 2.367 ± 0.06
0.305MetCys: 0.305 ± 0.022
2.022MetAsp: 2.022 ± 0.057
2.728MetGlu: 2.728 ± 0.068
1.081MetPhe: 1.081 ± 0.038
2.31MetGly: 2.31 ± 0.06
0.501MetHis: 0.501 ± 0.026
2.313MetIle: 2.313 ± 0.057
2.429MetLys: 2.429 ± 0.059
2.773MetLeu: 2.773 ± 0.057
0.925MetMet: 0.925 ± 0.039
1.656MetAsn: 1.656 ± 0.048
1.131MetPro: 1.131 ± 0.039
0.952MetGln: 0.952 ± 0.033
1.127MetArg: 1.127 ± 0.033
1.868MetSer: 1.868 ± 0.048
1.733MetThr: 1.733 ± 0.045
1.917MetVal: 1.917 ± 0.058
0.155MetTrp: 0.155 ± 0.015
0.818MetTyr: 0.818 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.216AsnAla: 3.216 ± 0.069
0.563AsnCys: 0.563 ± 0.028
2.152AsnAsp: 2.152 ± 0.058
3.015AsnGlu: 3.015 ± 0.069
1.701AsnPhe: 1.701 ± 0.046
3.329AsnGly: 3.329 ± 0.068
0.791AsnHis: 0.791 ± 0.033
4.211AsnIle: 4.211 ± 0.079
2.919AsnLys: 2.919 ± 0.07
4.173AsnLeu: 4.173 ± 0.084
1.428AsnMet: 1.428 ± 0.038
2.086AsnAsn: 2.086 ± 0.051
2.323AsnPro: 2.323 ± 0.054
1.35AsnGln: 1.35 ± 0.042
2.225AsnArg: 2.225 ± 0.066
2.619AsnSer: 2.619 ± 0.059
2.4AsnThr: 2.4 ± 0.062
3.059AsnVal: 3.059 ± 0.07
0.366AsnTrp: 0.366 ± 0.024
1.674AsnTyr: 1.674 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.48ProAla: 2.48 ± 0.074
0.459ProCys: 0.459 ± 0.025
2.388ProAsp: 2.388 ± 0.058
3.248ProGlu: 3.248 ± 0.068
1.643ProPhe: 1.643 ± 0.053
2.662ProGly: 2.662 ± 0.059
0.617ProHis: 0.617 ± 0.033
2.238ProIle: 2.238 ± 0.057
1.821ProLys: 1.821 ± 0.048
2.9ProLeu: 2.9 ± 0.064
0.905ProMet: 0.905 ± 0.031
1.216ProAsn: 1.216 ± 0.04
0.83ProPro: 0.83 ± 0.037
0.944ProGln: 0.944 ± 0.036
1.108ProArg: 1.108 ± 0.043
1.964ProSer: 1.964 ± 0.052
1.509ProThr: 1.509 ± 0.048
3.046ProVal: 3.046 ± 0.063
0.315ProTrp: 0.315 ± 0.026
1.362ProTyr: 1.362 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
1.989GlnAla: 1.989 ± 0.055
0.319GlnCys: 0.319 ± 0.023
1.5GlnAsp: 1.5 ± 0.047
2.322GlnGlu: 2.322 ± 0.055
1.026GlnPhe: 1.026 ± 0.033
1.828GlnGly: 1.828 ± 0.048
0.425GlnHis: 0.425 ± 0.027
2.442GlnIle: 2.442 ± 0.054
2.192GlnLys: 2.192 ± 0.053
2.442GlnLeu: 2.442 ± 0.068
0.998GlnMet: 0.998 ± 0.033
1.374GlnAsn: 1.374 ± 0.044
0.771GlnPro: 0.771 ± 0.029
0.838GlnGln: 0.838 ± 0.036
1.191GlnArg: 1.191 ± 0.051
1.53GlnSer: 1.53 ± 0.041
1.497GlnThr: 1.497 ± 0.046
1.817GlnVal: 1.817 ± 0.05
0.227GlnTrp: 0.227 ± 0.023
1.03GlnTyr: 1.03 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.485ArgAla: 2.485 ± 0.059
0.547ArgCys: 0.547 ± 0.03
2.408ArgAsp: 2.408 ± 0.065
3.741ArgGlu: 3.741 ± 0.074
1.975ArgPhe: 1.975 ± 0.049
2.628ArgGly: 2.628 ± 0.064
0.775ArgHis: 0.775 ± 0.033
3.993ArgIle: 3.993 ± 0.079
3.607ArgLys: 3.607 ± 0.074
4.108ArgLeu: 4.108 ± 0.068
1.58ArgMet: 1.58 ± 0.046
2.322ArgAsn: 2.322 ± 0.062
1.411ArgPro: 1.411 ± 0.062
1.424ArgGln: 1.424 ± 0.041
2.036ArgArg: 2.036 ± 0.061
2.207ArgSer: 2.207 ± 0.057
2.29ArgThr: 2.29 ± 0.054
2.691ArgVal: 2.691 ± 0.057
0.347ArgTrp: 0.347 ± 0.021
1.814ArgTyr: 1.814 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.413SerAla: 4.413 ± 0.079
0.849SerCys: 0.849 ± 0.041
3.407SerAsp: 3.407 ± 0.064
4.097SerGlu: 4.097 ± 0.078
2.889SerPhe: 2.889 ± 0.067
5.445SerGly: 5.445 ± 0.089
1.052SerHis: 1.052 ± 0.038
4.938SerIle: 4.938 ± 0.096
3.395SerLys: 3.395 ± 0.068
5.682SerLeu: 5.682 ± 0.118
1.797SerMet: 1.797 ± 0.052
2.429SerAsn: 2.429 ± 0.059
2.063SerPro: 2.063 ± 0.051
1.744SerGln: 1.744 ± 0.054
3.067SerArg: 3.067 ± 0.059
3.926SerSer: 3.926 ± 0.07
2.907SerThr: 2.907 ± 0.072
4.558SerVal: 4.558 ± 0.087
0.528SerTrp: 0.528 ± 0.027
2.371SerTyr: 2.371 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.138ThrAla: 4.138 ± 0.087
0.664ThrCys: 0.664 ± 0.03
3.212ThrAsp: 3.212 ± 0.063
3.603ThrGlu: 3.603 ± 0.078
2.147ThrPhe: 2.147 ± 0.057
5.042ThrGly: 5.042 ± 0.085
0.861ThrHis: 0.861 ± 0.03
3.977ThrIle: 3.977 ± 0.08
2.95ThrLys: 2.95 ± 0.062
4.541ThrLeu: 4.541 ± 0.075
1.413ThrMet: 1.413 ± 0.048
2.117ThrAsn: 2.117 ± 0.06
2.084ThrPro: 2.084 ± 0.055
1.412ThrGln: 1.412 ± 0.046
2.171ThrArg: 2.171 ± 0.049
3.077ThrSer: 3.077 ± 0.067
2.715ThrThr: 2.715 ± 0.078
4.142ThrVal: 4.142 ± 0.089
0.41ThrTrp: 0.41 ± 0.023
1.81ThrTyr: 1.81 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.705ValAla: 4.705 ± 0.092
1.085ValCys: 1.085 ± 0.044
3.744ValAsp: 3.744 ± 0.068
4.444ValGlu: 4.444 ± 0.079
3.318ValPhe: 3.318 ± 0.077
4.168ValGly: 4.168 ± 0.087
1.034ValHis: 1.034 ± 0.035
5.99ValIle: 5.99 ± 0.1
4.34ValLys: 4.34 ± 0.068
6.707ValLeu: 6.707 ± 0.102
2.024ValMet: 2.024 ± 0.054
3.085ValAsn: 3.085 ± 0.063
2.48ValPro: 2.48 ± 0.059
1.748ValGln: 1.748 ± 0.053
3.056ValArg: 3.056 ± 0.069
4.614ValSer: 4.614 ± 0.089
3.792ValThr: 3.792 ± 0.071
4.833ValVal: 4.833 ± 0.1
0.497ValTrp: 0.497 ± 0.025
2.58ValTyr: 2.58 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.483TrpAla: 0.483 ± 0.025
0.1TrpCys: 0.1 ± 0.012
0.456TrpAsp: 0.456 ± 0.025
0.579TrpGlu: 0.579 ± 0.03
0.375TrpPhe: 0.375 ± 0.023
0.575TrpGly: 0.575 ± 0.028
0.142TrpHis: 0.142 ± 0.016
0.676TrpIle: 0.676 ± 0.03
0.61TrpLys: 0.61 ± 0.027
0.743TrpLeu: 0.743 ± 0.037
0.242TrpMet: 0.242 ± 0.018
0.45TrpAsn: 0.45 ± 0.023
0.186TrpPro: 0.186 ± 0.018
0.292TrpGln: 0.292 ± 0.024
0.315TrpArg: 0.315 ± 0.022
0.435TrpSer: 0.435 ± 0.023
0.444TrpThr: 0.444 ± 0.023
0.419TrpVal: 0.419 ± 0.027
0.095TrpTrp: 0.095 ± 0.011
0.297TrpTyr: 0.297 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.514TyrAla: 2.514 ± 0.06
0.559TyrCys: 0.559 ± 0.032
2.234TyrAsp: 2.234 ± 0.052
2.755TyrGlu: 2.755 ± 0.066
1.833TyrPhe: 1.833 ± 0.049
2.819TyrGly: 2.819 ± 0.066
0.662TyrHis: 0.662 ± 0.035
2.919TyrIle: 2.919 ± 0.062
2.345TyrLys: 2.345 ± 0.064
3.548TyrLeu: 3.548 ± 0.082
1.077TyrMet: 1.077 ± 0.036
1.796TyrAsn: 1.796 ± 0.054
1.353TyrPro: 1.353 ± 0.049
1.017TyrGln: 1.017 ± 0.036
1.816TyrArg: 1.816 ± 0.057
2.495TyrSer: 2.495 ± 0.064
2.002TyrThr: 2.002 ± 0.057
2.336TyrVal: 2.336 ± 0.056
0.296TyrTrp: 0.296 ± 0.019
1.69TyrTyr: 1.69 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2361 proteins (740729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski