Amino acid dipepetide frequency for Prevotella sp. CAG:592

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.531AlaAla: 6.531 ± 0.124	1.069AlaCys: 1.069 ± 0.044	5.347AlaAsp: 5.347 ± 0.104	4.939AlaGlu: 4.939 ± 0.09	3.269AlaPhe: 3.269 ± 0.062	5.287AlaGly: 5.287 ± 0.088	1.322AlaHis: 1.322 ± 0.038	4.887AlaIle: 4.887 ± 0.086	4.869AlaLys: 4.869 ± 0.088	6.802AlaLeu: 6.802 ± 0.098	2.415AlaMet: 2.415 ± 0.067	3.391AlaAsn: 3.391 ± 0.085	2.29AlaPro: 2.29 ± 0.047	2.67AlaGln: 2.67 ± 0.063	3.125AlaArg: 3.125 ± 0.066	4.474AlaSer: 4.474 ± 0.09	4.546AlaThr: 4.546 ± 0.101	5.052AlaVal: 5.052 ± 0.085	0.754AlaTrp: 0.754 ± 0.032	2.974AlaTyr: 2.974 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.035	0.247CysCys: 0.247 ± 0.018	0.825CysAsp: 0.825 ± 0.035	0.709CysGlu: 0.709 ± 0.031	0.601CysPhe: 0.601 ± 0.028	1.355CysGly: 1.355 ± 0.043	0.379CysHis: 0.379 ± 0.024	0.947CysIle: 0.947 ± 0.037	0.749CysLys: 0.749 ± 0.034	1.192CysLeu: 1.192 ± 0.042	0.384CysMet: 0.384 ± 0.024	0.65CysAsn: 0.65 ± 0.033	0.603CysPro: 0.603 ± 0.033	0.403CysGln: 0.403 ± 0.023	0.778CysArg: 0.778 ± 0.036	0.912CysSer: 0.912 ± 0.038	0.685CysThr: 0.685 ± 0.033	0.945CysVal: 0.945 ± 0.039	0.186CysTrp: 0.186 ± 0.014	0.602CysTyr: 0.602 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	4.474AspAla: 4.474 ± 0.096	0.782AspCys: 0.782 ± 0.034	3.699AspAsp: 3.699 ± 0.082	4.133AspGlu: 4.133 ± 0.083	3.107AspPhe: 3.107 ± 0.062	4.853AspGly: 4.853 ± 0.108	1.021AspHis: 1.021 ± 0.04	4.364AspIle: 4.364 ± 0.086	4.409AspLys: 4.409 ± 0.077	4.331AspLeu: 4.331 ± 0.069	1.965AspMet: 1.965 ± 0.057	3.399AspAsn: 3.399 ± 0.071	1.822AspPro: 1.822 ± 0.05	1.371AspGln: 1.371 ± 0.042	2.665AspArg: 2.665 ± 0.054	3.348AspSer: 3.348 ± 0.077	3.088AspThr: 3.088 ± 0.072	3.925AspVal: 3.925 ± 0.069	0.804AspTrp: 0.804 ± 0.032	2.834AspTyr: 2.834 ± 0.062	0.003AspXaa: 0.003 ± 0.002
Glu	4.721GluAla: 4.721 ± 0.09	0.764GluCys: 0.764 ± 0.033	3.237GluAsp: 3.237 ± 0.074	4.579GluGlu: 4.579 ± 0.099	2.375GluPhe: 2.375 ± 0.055	4.153GluGly: 4.153 ± 0.076	1.172GluHis: 1.172 ± 0.045	4.065GluIle: 4.065 ± 0.089	5.026GluLys: 5.026 ± 0.113	5.28GluLeu: 5.28 ± 0.092	2.181GluMet: 2.181 ± 0.051	3.38GluAsn: 3.38 ± 0.077	1.737GluPro: 1.737 ± 0.045	2.379GluGln: 2.379 ± 0.062	3.159GluArg: 3.159 ± 0.067	2.954GluSer: 2.954 ± 0.055	3.271GluThr: 3.271 ± 0.067	3.845GluVal: 3.845 ± 0.078	0.842GluTrp: 0.842 ± 0.037	2.758GluTyr: 2.758 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.193PheAla: 3.193 ± 0.071	0.852PheCys: 0.852 ± 0.032	2.858PheAsp: 2.858 ± 0.058	2.273PheGlu: 2.273 ± 0.064	2.063PhePhe: 2.063 ± 0.051	3.271PheGly: 3.271 ± 0.067	0.846PheHis: 0.846 ± 0.033	2.921PheIle: 2.921 ± 0.073	2.408PheLys: 2.408 ± 0.058	3.52PheLeu: 3.52 ± 0.082	1.342PheMet: 1.342 ± 0.052	2.282PheAsn: 2.282 ± 0.056	1.517PhePro: 1.517 ± 0.044	1.085PheGln: 1.085 ± 0.037	2.059PheArg: 2.059 ± 0.053	3.301PheSer: 3.301 ± 0.074	2.681PheThr: 2.681 ± 0.055	3.1PheVal: 3.1 ± 0.068	0.49PheTrp: 0.49 ± 0.025	1.657PheTyr: 1.657 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.789GlyAla: 4.789 ± 0.089	1.104GlyCys: 1.104 ± 0.04	4.065GlyAsp: 4.065 ± 0.078	4.233GlyGlu: 4.233 ± 0.086	3.148GlyPhe: 3.148 ± 0.072	5.138GlyGly: 5.138 ± 0.103	1.287GlyHis: 1.287 ± 0.045	5.174GlyIle: 5.174 ± 0.087	5.699GlyLys: 5.699 ± 0.093	5.508GlyLeu: 5.508 ± 0.086	2.565GlyMet: 2.565 ± 0.057	3.657GlyAsn: 3.657 ± 0.09	1.298GlyPro: 1.298 ± 0.041	2.039GlyGln: 2.039 ± 0.057	3.177GlyArg: 3.177 ± 0.06	4.094GlySer: 4.094 ± 0.085	4.064GlyThr: 4.064 ± 0.084	5.204GlyVal: 5.204 ± 0.108	0.976GlyTrp: 0.976 ± 0.045	3.215GlyTyr: 3.215 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.195HisAla: 1.195 ± 0.041	0.342HisCys: 0.342 ± 0.022	1.14HisAsp: 1.14 ± 0.035	1.023HisGlu: 1.023 ± 0.041	0.973HisPhe: 0.973 ± 0.035	1.415HisGly: 1.415 ± 0.049	0.527HisHis: 0.527 ± 0.026	1.41HisIle: 1.41 ± 0.039	1.143HisLys: 1.143 ± 0.047	1.619HisLeu: 1.619 ± 0.051	0.36HisMet: 0.36 ± 0.019	0.979HisAsn: 0.979 ± 0.038	0.965HisPro: 0.965 ± 0.035	0.563HisGln: 0.563 ± 0.029	0.922HisArg: 0.922 ± 0.032	1.149HisSer: 1.149 ± 0.036	1.092HisThr: 1.092 ± 0.042	1.236HisVal: 1.236 ± 0.039	0.203HisTrp: 0.203 ± 0.016	0.852HisTyr: 0.852 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.224IleAla: 5.224 ± 0.091	1.083IleCys: 1.083 ± 0.039	4.507IleAsp: 4.507 ± 0.078	4.081IleGlu: 4.081 ± 0.084	2.611IlePhe: 2.611 ± 0.067	4.516IleGly: 4.516 ± 0.083	1.232IleHis: 1.232 ± 0.047	4.361IleIle: 4.361 ± 0.09	4.203IleLys: 4.203 ± 0.076	5.18IleLeu: 5.18 ± 0.099	1.691IleMet: 1.691 ± 0.052	3.248IleAsn: 3.248 ± 0.066	2.753IlePro: 2.753 ± 0.057	1.804IleGln: 1.804 ± 0.052	2.984IleArg: 2.984 ± 0.068	4.416IleSer: 4.416 ± 0.081	4.017IleThr: 4.017 ± 0.083	4.714IleVal: 4.714 ± 0.096	0.631IleTrp: 0.631 ± 0.033	2.524IleTyr: 2.524 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	5.532LysAla: 5.532 ± 0.092	0.674LysCys: 0.674 ± 0.033	4.22LysAsp: 4.22 ± 0.077	5.24LysGlu: 5.24 ± 0.096	2.364LysPhe: 2.364 ± 0.055	4.656LysGly: 4.656 ± 0.072	1.187LysHis: 1.187 ± 0.037	4.004LysIle: 4.004 ± 0.081	5.469LysLys: 5.469 ± 0.108	5.42LysLeu: 5.42 ± 0.1	2.458LysMet: 2.458 ± 0.063	3.336LysAsn: 3.336 ± 0.072	2.355LysPro: 2.355 ± 0.06	2.374LysGln: 2.374 ± 0.058	3.378LysArg: 3.378 ± 0.076	3.689LysSer: 3.689 ± 0.072	4.01LysThr: 4.01 ± 0.077	4.506LysVal: 4.506 ± 0.091	0.836LysTrp: 0.836 ± 0.038	2.86LysTyr: 2.86 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.764LeuAla: 6.764 ± 0.105	1.331LeuCys: 1.331 ± 0.049	4.703LeuAsp: 4.703 ± 0.082	4.287LeuGlu: 4.287 ± 0.087	3.755LeuPhe: 3.755 ± 0.075	5.651LeuGly: 5.651 ± 0.093	1.796LeuHis: 1.796 ± 0.049	4.789LeuIle: 4.789 ± 0.102	5.867LeuLys: 5.867 ± 0.097	7.718LeuLeu: 7.718 ± 0.12	2.611LeuMet: 2.611 ± 0.067	4.156LeuAsn: 4.156 ± 0.084	3.649LeuPro: 3.649 ± 0.064	3.016LeuGln: 3.016 ± 0.065	4.24LeuArg: 4.24 ± 0.091	6.093LeuSer: 6.093 ± 0.094	5.178LeuThr: 5.178 ± 0.07	5.11LeuVal: 5.11 ± 0.092	0.89LeuTrp: 0.89 ± 0.041	3.168LeuTyr: 3.168 ± 0.072	0.001LeuXaa: 0.001 ± 0.001
Met	2.787MetAla: 2.787 ± 0.073	0.326MetCys: 0.326 ± 0.02	1.458MetAsp: 1.458 ± 0.05	1.916MetGlu: 1.916 ± 0.053	1.214MetPhe: 1.214 ± 0.042	2.077MetGly: 2.077 ± 0.058	0.519MetHis: 0.519 ± 0.027	1.718MetIle: 1.718 ± 0.061	2.742MetLys: 2.742 ± 0.06	2.806MetLeu: 2.806 ± 0.064	1.081MetMet: 1.081 ± 0.038	1.606MetAsn: 1.606 ± 0.05	1.481MetPro: 1.481 ± 0.041	1.263MetGln: 1.263 ± 0.045	1.601MetArg: 1.601 ± 0.054	1.87MetSer: 1.87 ± 0.053	1.989MetThr: 1.989 ± 0.049	1.937MetVal: 1.937 ± 0.054	0.248MetTrp: 0.248 ± 0.017	0.93MetTyr: 0.93 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	3.817AsnAla: 3.817 ± 0.078	0.614AsnCys: 0.614 ± 0.036	2.985AsnAsp: 2.985 ± 0.077	2.73AsnGlu: 2.73 ± 0.069	2.044AsnPhe: 2.044 ± 0.054	4.333AsnGly: 4.333 ± 0.095	0.91AsnHis: 0.91 ± 0.039	3.922AsnIle: 3.922 ± 0.077	3.157AsnLys: 3.157 ± 0.069	3.765AsnLeu: 3.765 ± 0.078	1.431AsnMet: 1.431 ± 0.042	2.486AsnAsn: 2.486 ± 0.068	2.208AsnPro: 2.208 ± 0.051	1.318AsnGln: 1.318 ± 0.046	2.33AsnArg: 2.33 ± 0.065	2.677AsnSer: 2.677 ± 0.064	2.761AsnThr: 2.761 ± 0.066	3.715AsnVal: 3.715 ± 0.075	0.559AsnTrp: 0.559 ± 0.03	1.988AsnTyr: 1.988 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.691ProAla: 2.691 ± 0.064	0.429ProCys: 0.429 ± 0.024	2.384ProAsp: 2.384 ± 0.054	2.921ProGlu: 2.921 ± 0.065	1.702ProPhe: 1.702 ± 0.046	2.283ProGly: 2.283 ± 0.062	0.697ProHis: 0.697 ± 0.031	2.033ProIle: 2.033 ± 0.055	2.115ProLys: 2.115 ± 0.057	3.037ProLeu: 3.037 ± 0.067	1.08ProMet: 1.08 ± 0.039	1.571ProAsn: 1.571 ± 0.049	0.725ProPro: 0.725 ± 0.034	1.408ProGln: 1.408 ± 0.045	1.288ProArg: 1.288 ± 0.04	2.171ProSer: 2.171 ± 0.053	2.059ProThr: 2.059 ± 0.057	2.793ProVal: 2.793 ± 0.07	0.434ProTrp: 0.434 ± 0.029	1.65ProTyr: 1.65 ± 0.05	0.001ProXaa: 0.001 ± 0.001
Gln	2.294GlnAla: 2.294 ± 0.06	0.372GlnCys: 0.372 ± 0.023	1.495GlnAsp: 1.495 ± 0.046	1.982GlnGlu: 1.982 ± 0.054	1.298GlnPhe: 1.298 ± 0.047	1.789GlnGly: 1.789 ± 0.044	0.653GlnHis: 0.653 ± 0.028	2.036GlnIle: 2.036 ± 0.062	2.415GlnLys: 2.415 ± 0.052	3.057GlnLeu: 3.057 ± 0.06	1.171GlnMet: 1.171 ± 0.041	1.694GlnAsn: 1.694 ± 0.051	1.24GlnPro: 1.24 ± 0.044	1.539GlnGln: 1.539 ± 0.054	1.754GlnArg: 1.754 ± 0.053	1.714GlnSer: 1.714 ± 0.048	2.051GlnThr: 2.051 ± 0.049	1.929GlnVal: 1.929 ± 0.054	0.447GlnTrp: 0.447 ± 0.028	1.386GlnTyr: 1.386 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	2.638ArgAla: 2.638 ± 0.066	0.614ArgCys: 0.614 ± 0.032	2.347ArgAsp: 2.347 ± 0.061	2.949ArgGlu: 2.949 ± 0.065	2.176ArgPhe: 2.176 ± 0.055	2.657ArgGly: 2.657 ± 0.063	1.137ArgHis: 1.137 ± 0.045	3.447ArgIle: 3.447 ± 0.071	3.383ArgLys: 3.383 ± 0.079	4.54ArgLeu: 4.54 ± 0.09	1.842ArgMet: 1.842 ± 0.053	2.482ArgAsn: 2.482 ± 0.062	1.609ArgPro: 1.609 ± 0.053	2.101ArgGln: 2.101 ± 0.064	2.766ArgArg: 2.766 ± 0.082	2.476ArgSer: 2.476 ± 0.061	2.398ArgThr: 2.398 ± 0.057	2.594ArgVal: 2.594 ± 0.061	0.583ArgTrp: 0.583 ± 0.027	2.205ArgTyr: 2.205 ± 0.066	0.003ArgXaa: 0.003 ± 0.002
Ser	4.55SerAla: 4.55 ± 0.087	0.89SerCys: 0.89 ± 0.038	3.667SerAsp: 3.667 ± 0.073	3.463SerGlu: 3.463 ± 0.065	3.016SerPhe: 3.016 ± 0.07	4.444SerGly: 4.444 ± 0.075	1.275SerHis: 1.275 ± 0.042	4.01SerIle: 4.01 ± 0.081	3.567SerLys: 3.567 ± 0.069	5.647SerLeu: 5.647 ± 0.094	1.749SerMet: 1.749 ± 0.049	2.598SerAsn: 2.598 ± 0.062	2.147SerPro: 2.147 ± 0.057	1.998SerGln: 1.998 ± 0.05	2.646SerArg: 2.646 ± 0.06	3.773SerSer: 3.773 ± 0.097	3.117SerThr: 3.117 ± 0.074	4.428SerVal: 4.428 ± 0.083	0.729SerTrp: 0.729 ± 0.033	2.554SerTyr: 2.554 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	4.571ThrAla: 4.571 ± 0.087	0.672ThrCys: 0.672 ± 0.035	3.829ThrAsp: 3.829 ± 0.074	3.2ThrGlu: 3.2 ± 0.07	2.706ThrPhe: 2.706 ± 0.061	4.275ThrGly: 4.275 ± 0.084	0.997ThrHis: 0.997 ± 0.04	4.094ThrIle: 4.094 ± 0.073	3.22ThrLys: 3.22 ± 0.069	5.332ThrLeu: 5.332 ± 0.085	1.541ThrMet: 1.541 ± 0.049	2.467ThrAsn: 2.467 ± 0.06	2.662ThrPro: 2.662 ± 0.059	1.601ThrGln: 1.601 ± 0.047	2.236ThrArg: 2.236 ± 0.059	3.337ThrSer: 3.337 ± 0.071	3.612ThrThr: 3.612 ± 0.09	4.351ThrVal: 4.351 ± 0.079	0.621ThrTrp: 0.621 ± 0.032	2.344ThrTyr: 2.344 ± 0.063	0.003ThrXaa: 0.003 ± 0.002
Val	5.572ValAla: 5.572 ± 0.096	1.115ValCys: 1.115 ± 0.041	4.14ValAsp: 4.14 ± 0.083	4.432ValGlu: 4.432 ± 0.08	2.964ValPhe: 2.964 ± 0.068	4.516ValGly: 4.516 ± 0.096	1.044ValHis: 1.044 ± 0.042	4.291ValIle: 4.291 ± 0.084	4.672ValLys: 4.672 ± 0.088	5.413ValLeu: 5.413 ± 0.103	2.143ValMet: 2.143 ± 0.056	3.315ValAsn: 3.315 ± 0.076	2.528ValPro: 2.528 ± 0.055	1.633ValGln: 1.633 ± 0.042	3.188ValArg: 3.188 ± 0.069	4.47ValSer: 4.47 ± 0.084	3.896ValThr: 3.896 ± 0.088	5.337ValVal: 5.337 ± 0.101	0.738ValTrp: 0.738 ± 0.031	2.651ValTyr: 2.651 ± 0.065	0.003ValXaa: 0.003 ± 0.002
Trp	0.773TrpAla: 0.773 ± 0.033	0.184TrpCys: 0.184 ± 0.017	0.696TrpAsp: 0.696 ± 0.035	0.546TrpGlu: 0.546 ± 0.027	0.495TrpPhe: 0.495 ± 0.024	0.829TrpGly: 0.829 ± 0.035	0.312TrpHis: 0.312 ± 0.018	0.738TrpIle: 0.738 ± 0.037	0.856TrpLys: 0.856 ± 0.038	1.108TrpLeu: 1.108 ± 0.038	0.399TrpMet: 0.399 ± 0.024	0.726TrpAsn: 0.726 ± 0.037	0.254TrpPro: 0.254 ± 0.02	0.513TrpGln: 0.513 ± 0.024	0.571TrpArg: 0.571 ± 0.029	0.623TrpSer: 0.623 ± 0.03	0.694TrpThr: 0.694 ± 0.033	0.678TrpVal: 0.678 ± 0.029	0.174TrpTrp: 0.174 ± 0.017	0.478TrpTyr: 0.478 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.96TyrAla: 2.96 ± 0.057	0.623TyrCys: 0.623 ± 0.029	2.793TyrAsp: 2.793 ± 0.068	2.241TyrGlu: 2.241 ± 0.057	1.838TyrPhe: 1.838 ± 0.047	2.933TyrGly: 2.933 ± 0.069	0.794TyrHis: 0.794 ± 0.034	2.57TyrIle: 2.57 ± 0.055	2.597TyrLys: 2.597 ± 0.064	3.498TyrLeu: 3.498 ± 0.08	1.159TyrMet: 1.159 ± 0.039	2.328TyrAsn: 2.328 ± 0.057	1.63TyrPro: 1.63 ± 0.05	1.239TyrGln: 1.239 ± 0.042	2.079TyrArg: 2.079 ± 0.05	2.726TyrSer: 2.726 ± 0.058	2.462TyrThr: 2.462 ± 0.065	2.659TyrVal: 2.659 ± 0.062	0.502TyrTrp: 0.502 ± 0.026	1.889TyrTyr: 1.889 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.004

Statistics based on 2159 proteins (749068 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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