Amino acid dipepetide frequency for Erythrobacter insulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.946AlaAla: 15.946 ± 0.196	1.004AlaCys: 1.004 ± 0.036	7.158AlaAsp: 7.158 ± 0.091	7.654AlaGlu: 7.654 ± 0.098	4.21AlaPhe: 4.21 ± 0.083	10.441AlaGly: 10.441 ± 0.155	2.086AlaHis: 2.086 ± 0.054	7.063AlaIle: 7.063 ± 0.104	4.699AlaLys: 4.699 ± 0.099	12.461AlaLeu: 12.461 ± 0.142	3.694AlaMet: 3.694 ± 0.078	3.635AlaAsn: 3.635 ± 0.085	5.54AlaPro: 5.54 ± 0.095	4.615AlaGln: 4.615 ± 0.08	7.791AlaArg: 7.791 ± 0.117	6.875AlaSer: 6.875 ± 0.098	5.479AlaThr: 5.479 ± 0.1	7.624AlaVal: 7.624 ± 0.103	1.388AlaTrp: 1.388 ± 0.045	2.37AlaTyr: 2.37 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.99CysAla: 0.99 ± 0.035	0.078CysCys: 0.078 ± 0.009	0.594CysAsp: 0.594 ± 0.03	0.523CysGlu: 0.523 ± 0.026	0.286CysPhe: 0.286 ± 0.022	0.893CysGly: 0.893 ± 0.036	0.209CysHis: 0.209 ± 0.024	0.379CysIle: 0.379 ± 0.024	0.203CysLys: 0.203 ± 0.015	0.659CysLeu: 0.659 ± 0.026	0.147CysMet: 0.147 ± 0.011	0.238CysAsn: 0.238 ± 0.018	0.412CysPro: 0.412 ± 0.023	0.22CysGln: 0.22 ± 0.015	0.42CysArg: 0.42 ± 0.021	0.455CysSer: 0.455 ± 0.024	0.403CysThr: 0.403 ± 0.021	0.551CysVal: 0.551 ± 0.022	0.105CysTrp: 0.105 ± 0.01	0.156CysTyr: 0.156 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.452AspAla: 7.452 ± 0.098	0.542AspCys: 0.542 ± 0.025	3.808AspAsp: 3.808 ± 0.074	4.132AspGlu: 4.132 ± 0.069	2.456AspPhe: 2.456 ± 0.057	5.602AspGly: 5.602 ± 0.085	1.311AspHis: 1.311 ± 0.042	3.41AspIle: 3.41 ± 0.088	1.983AspLys: 1.983 ± 0.053	6.015AspLeu: 6.015 ± 0.082	1.548AspMet: 1.548 ± 0.043	1.812AspAsn: 1.812 ± 0.051	3.815AspPro: 3.815 ± 0.073	2.115AspGln: 2.115 ± 0.056	4.222AspArg: 4.222 ± 0.075	2.636AspSer: 2.636 ± 0.048	3.05AspThr: 3.05 ± 0.061	3.944AspVal: 3.944 ± 0.071	1.171AspTrp: 1.171 ± 0.035	1.566AspTyr: 1.566 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.75GluAla: 7.75 ± 0.115	0.4GluCys: 0.4 ± 0.025	3.488GluAsp: 3.488 ± 0.07	3.831GluGlu: 3.831 ± 0.076	2.18GluPhe: 2.18 ± 0.055	4.795GluGly: 4.795 ± 0.077	1.16GluHis: 1.16 ± 0.04	3.618GluIle: 3.618 ± 0.063	2.547GluLys: 2.547 ± 0.06	5.71GluLeu: 5.71 ± 0.081	1.805GluMet: 1.805 ± 0.051	2.024GluAsn: 2.024 ± 0.052	2.81GluPro: 2.81 ± 0.07	2.504GluGln: 2.504 ± 0.054	4.798GluArg: 4.798 ± 0.085	2.714GluSer: 2.714 ± 0.058	3.881GluThr: 3.881 ± 0.07	3.75GluVal: 3.75 ± 0.076	0.972GluTrp: 0.972 ± 0.037	1.29GluTyr: 1.29 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	5.089PheAla: 5.089 ± 0.075	0.319PheCys: 0.319 ± 0.018	2.934PheAsp: 2.934 ± 0.068	2.514PheGlu: 2.514 ± 0.057	1.53PhePhe: 1.53 ± 0.05	3.893PheGly: 3.893 ± 0.076	0.663PheHis: 0.663 ± 0.028	1.752PheIle: 1.752 ± 0.048	1.136PheLys: 1.136 ± 0.035	3.197PheLeu: 3.197 ± 0.069	0.856PheMet: 0.856 ± 0.036	1.223PheAsn: 1.223 ± 0.04	1.519PhePro: 1.519 ± 0.048	0.997PheGln: 0.997 ± 0.035	2.057PheArg: 2.057 ± 0.043	2.255PheSer: 2.255 ± 0.058	2.245PheThr: 2.245 ± 0.055	2.694PheVal: 2.694 ± 0.056	0.566PheTrp: 0.566 ± 0.026	0.989PheTyr: 0.989 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.249GlyAla: 9.249 ± 0.112	0.786GlyCys: 0.786 ± 0.032	5.374GlyAsp: 5.374 ± 0.113	5.588GlyGlu: 5.588 ± 0.095	3.881GlyPhe: 3.881 ± 0.075	8.055GlyGly: 8.055 ± 0.172	1.7GlyHis: 1.7 ± 0.043	4.763GlyIle: 4.763 ± 0.076	3.673GlyLys: 3.673 ± 0.09	8.219GlyLeu: 8.219 ± 0.108	2.349GlyMet: 2.349 ± 0.05	2.611GlyAsn: 2.611 ± 0.086	3.395GlyPro: 3.395 ± 0.071	3.019GlyGln: 3.019 ± 0.052	5.139GlyArg: 5.139 ± 0.079	5.317GlySer: 5.317 ± 0.109	4.938GlyThr: 4.938 ± 0.105	5.791GlyVal: 5.791 ± 0.091	1.407GlyTrp: 1.407 ± 0.045	2.213GlyTyr: 2.213 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.028HisAla: 2.028 ± 0.055	0.243HisCys: 0.243 ± 0.016	1.162HisAsp: 1.162 ± 0.036	1.078HisGlu: 1.078 ± 0.034	0.863HisPhe: 0.863 ± 0.033	1.764HisGly: 1.764 ± 0.046	0.53HisHis: 0.53 ± 0.029	0.963HisIle: 0.963 ± 0.036	0.549HisLys: 0.549 ± 0.026	1.66HisLeu: 1.66 ± 0.052	0.451HisMet: 0.451 ± 0.025	0.523HisAsn: 0.523 ± 0.025	1.168HisPro: 1.168 ± 0.036	0.545HisGln: 0.545 ± 0.023	1.235HisArg: 1.235 ± 0.043	1.078HisSer: 1.078 ± 0.04	0.796HisThr: 0.796 ± 0.033	1.237HisVal: 1.237 ± 0.037	0.313HisTrp: 0.313 ± 0.021	0.544HisTyr: 0.544 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	8.365IleAla: 8.365 ± 0.113	0.495IleCys: 0.495 ± 0.026	3.981IleAsp: 3.981 ± 0.079	4.266IleGlu: 4.266 ± 0.078	1.772IlePhe: 1.772 ± 0.038	5.518IleGly: 5.518 ± 0.1	0.895IleHis: 0.895 ± 0.036	2.714IleIle: 2.714 ± 0.068	1.695IleLys: 1.695 ± 0.048	4.169IleLeu: 4.169 ± 0.081	1.095IleMet: 1.095 ± 0.032	1.749IleAsn: 1.749 ± 0.058	2.46IlePro: 2.46 ± 0.052	1.307IleGln: 1.307 ± 0.034	3.055IleArg: 3.055 ± 0.063	3.29IleSer: 3.29 ± 0.063	3.144IleThr: 3.144 ± 0.081	4.077IleVal: 4.077 ± 0.073	0.698IleTrp: 0.698 ± 0.023	1.09IleTyr: 1.09 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.27LysAla: 4.27 ± 0.091	0.201LysCys: 0.201 ± 0.016	1.919LysAsp: 1.919 ± 0.045	1.727LysGlu: 1.727 ± 0.042	1.099LysPhe: 1.099 ± 0.033	2.838LysGly: 2.838 ± 0.059	0.705LysHis: 0.705 ± 0.029	1.736LysIle: 1.736 ± 0.05	1.539LysLys: 1.539 ± 0.064	3.529LysLeu: 3.529 ± 0.071	0.908LysMet: 0.908 ± 0.031	0.967LysAsn: 0.967 ± 0.039	2.12LysPro: 2.12 ± 0.053	1.205LysGln: 1.205 ± 0.036	2.621LysArg: 2.621 ± 0.054	2.023LysSer: 2.023 ± 0.048	2.051LysThr: 2.051 ± 0.047	2.424LysVal: 2.424 ± 0.06	0.442LysTrp: 0.442 ± 0.024	0.709LysTyr: 0.709 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	12.415LeuAla: 12.415 ± 0.151	0.722LeuCys: 0.722 ± 0.031	5.959LeuAsp: 5.959 ± 0.097	5.508LeuGlu: 5.508 ± 0.088	3.578LeuPhe: 3.578 ± 0.07	8.043LeuGly: 8.043 ± 0.102	1.654LeuHis: 1.654 ± 0.048	5.354LeuIle: 5.354 ± 0.09	3.35LeuLys: 3.35 ± 0.072	8.357LeuLeu: 8.357 ± 0.138	2.188LeuMet: 2.188 ± 0.05	2.706LeuAsn: 2.706 ± 0.055	5.014LeuPro: 5.014 ± 0.08	2.559LeuGln: 2.559 ± 0.046	5.713LeuArg: 5.713 ± 0.09	6.244LeuSer: 6.244 ± 0.096	5.43LeuThr: 5.43 ± 0.092	6.523LeuVal: 6.523 ± 0.097	1.077LeuTrp: 1.077 ± 0.04	1.88LeuTyr: 1.88 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.159MetAla: 3.159 ± 0.063	0.157MetCys: 0.157 ± 0.011	1.268MetAsp: 1.268 ± 0.037	1.236MetGlu: 1.236 ± 0.036	0.769MetPhe: 0.769 ± 0.025	1.98MetGly: 1.98 ± 0.051	0.472MetHis: 0.472 ± 0.025	1.553MetIle: 1.553 ± 0.042	1.056MetLys: 1.056 ± 0.035	2.711MetLeu: 2.711 ± 0.061	0.758MetMet: 0.758 ± 0.028	0.8MetAsn: 0.8 ± 0.033	1.521MetPro: 1.521 ± 0.041	0.847MetGln: 0.847 ± 0.031	1.794MetArg: 1.794 ± 0.037	1.548MetSer: 1.548 ± 0.041	1.642MetThr: 1.642 ± 0.048	1.649MetVal: 1.649 ± 0.041	0.235MetTrp: 0.235 ± 0.017	0.293MetTyr: 0.293 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.704AsnAla: 3.704 ± 0.083	0.273AsnCys: 0.273 ± 0.02	1.768AsnAsp: 1.768 ± 0.042	1.574AsnGlu: 1.574 ± 0.05	1.18AsnPhe: 1.18 ± 0.044	2.693AsnGly: 2.693 ± 0.073	0.538AsnHis: 0.538 ± 0.024	1.648AsnIle: 1.648 ± 0.064	0.787AsnLys: 0.787 ± 0.031	2.809AsnLeu: 2.809 ± 0.064	0.664AsnMet: 0.664 ± 0.027	0.801AsnAsn: 0.801 ± 0.032	2.026AsnPro: 2.026 ± 0.059	0.892AsnGln: 0.892 ± 0.031	2.11AsnArg: 2.11 ± 0.05	1.661AsnSer: 1.661 ± 0.05	1.48AsnThr: 1.48 ± 0.042	2.12AsnVal: 2.12 ± 0.063	0.454AsnTrp: 0.454 ± 0.023	0.746AsnTyr: 0.746 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.926ProAla: 5.926 ± 0.104	0.285ProCys: 0.285 ± 0.02	3.928ProAsp: 3.928 ± 0.076	3.837ProGlu: 3.837 ± 0.076	1.988ProPhe: 1.988 ± 0.047	4.088ProGly: 4.088 ± 0.067	0.941ProHis: 0.941 ± 0.036	2.642ProIle: 2.642 ± 0.055	1.716ProLys: 1.716 ± 0.047	4.332ProLeu: 4.332 ± 0.079	1.142ProMet: 1.142 ± 0.037	1.468ProAsn: 1.468 ± 0.047	2.24ProPro: 2.24 ± 0.069	1.763ProGln: 1.763 ± 0.049	2.585ProArg: 2.585 ± 0.059	2.851ProSer: 2.851 ± 0.056	2.346ProThr: 2.346 ± 0.053	3.98ProVal: 3.98 ± 0.069	0.629ProTrp: 0.629 ± 0.028	1.08ProTyr: 1.08 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.715GlnAla: 3.715 ± 0.068	0.247GlnCys: 0.247 ± 0.016	1.764GlnAsp: 1.764 ± 0.043	1.573GlnGlu: 1.573 ± 0.044	1.328GlnPhe: 1.328 ± 0.041	2.381GlnGly: 2.381 ± 0.053	0.649GlnHis: 0.649 ± 0.027	2.151GlnIle: 2.151 ± 0.052	1.05GlnLys: 1.05 ± 0.033	3.279GlnLeu: 3.279 ± 0.064	0.939GlnMet: 0.939 ± 0.031	1.036GlnAsn: 1.036 ± 0.037	1.685GlnPro: 1.685 ± 0.046	1.277GlnGln: 1.277 ± 0.048	2.284GlnArg: 2.284 ± 0.061	2.232GlnSer: 2.232 ± 0.051	1.851GlnThr: 1.851 ± 0.041	2.211GlnVal: 2.211 ± 0.055	0.483GlnTrp: 0.483 ± 0.022	0.71GlnTyr: 0.71 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.121ArgAla: 7.121 ± 0.107	0.434ArgCys: 0.434 ± 0.023	4.026ArgAsp: 4.026 ± 0.075	4.26ArgGlu: 4.26 ± 0.075	2.885ArgPhe: 2.885 ± 0.068	4.704ArgGly: 4.704 ± 0.084	1.28ArgHis: 1.28 ± 0.042	3.959ArgIle: 3.959 ± 0.069	2.321ArgLys: 2.321 ± 0.051	6.438ArgLeu: 6.438 ± 0.096	1.76ArgMet: 1.76 ± 0.046	1.821ArgAsn: 1.821 ± 0.048	2.838ArgPro: 2.838 ± 0.058	2.108ArgGln: 2.108 ± 0.051	4.242ArgArg: 4.242 ± 0.084	3.765ArgSer: 3.765 ± 0.064	2.989ArgThr: 2.989 ± 0.056	4.085ArgVal: 4.085 ± 0.073	0.973ArgTrp: 0.973 ± 0.037	1.598ArgTyr: 1.598 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.887SerAla: 6.887 ± 0.106	0.423SerCys: 0.423 ± 0.024	3.91SerAsp: 3.91 ± 0.068	3.621SerGlu: 3.621 ± 0.071	2.25SerPhe: 2.25 ± 0.056	6.11SerGly: 6.11 ± 0.118	0.996SerHis: 0.996 ± 0.031	3.079SerIle: 3.079 ± 0.077	1.779SerLys: 1.779 ± 0.049	5.311SerLeu: 5.311 ± 0.082	1.382SerMet: 1.382 ± 0.039	1.743SerAsn: 1.743 ± 0.046	2.849SerPro: 2.849 ± 0.063	1.948SerGln: 1.948 ± 0.055	3.38SerArg: 3.38 ± 0.068	3.355SerSer: 3.355 ± 0.081	2.796SerThr: 2.796 ± 0.055	4.007SerVal: 4.007 ± 0.076	0.789SerTrp: 0.789 ± 0.032	1.319SerTyr: 1.319 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.258ThrAla: 6.258 ± 0.102	0.398ThrCys: 0.398 ± 0.021	3.109ThrAsp: 3.109 ± 0.064	2.777ThrGlu: 2.777 ± 0.057	2.094ThrPhe: 2.094 ± 0.047	5.445ThrGly: 5.445 ± 0.112	0.971ThrHis: 0.971 ± 0.036	3.143ThrIle: 3.143 ± 0.063	1.66ThrLys: 1.66 ± 0.043	5.325ThrLeu: 5.325 ± 0.093	1.189ThrMet: 1.189 ± 0.039	1.53ThrAsn: 1.53 ± 0.044	3.145ThrPro: 3.145 ± 0.068	1.636ThrGln: 1.636 ± 0.042	3.183ThrArg: 3.183 ± 0.062	2.96ThrSer: 2.96 ± 0.064	2.508ThrThr: 2.508 ± 0.069	4.018ThrVal: 4.018 ± 0.067	0.611ThrTrp: 0.611 ± 0.029	1.226ThrTyr: 1.226 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.642ValAla: 7.642 ± 0.099	0.563ValCys: 0.563 ± 0.028	4.107ValAsp: 4.107 ± 0.069	4.401ValGlu: 4.401 ± 0.073	2.53ValPhe: 2.53 ± 0.054	5.182ValGly: 5.182 ± 0.096	1.187ValHis: 1.187 ± 0.036	4.175ValIle: 4.175 ± 0.081	2.218ValLys: 2.218 ± 0.064	6.403ValLeu: 6.403 ± 0.103	1.806ValMet: 1.806 ± 0.047	2.103ValAsn: 2.103 ± 0.053	3.592ValPro: 3.592 ± 0.057	1.985ValGln: 1.985 ± 0.041	4.166ValArg: 4.166 ± 0.07	4.362ValSer: 4.362 ± 0.078	4.317ValThr: 4.317 ± 0.092	4.543ValVal: 4.543 ± 0.091	0.873ValTrp: 0.873 ± 0.029	1.313ValTyr: 1.313 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.308TrpAla: 1.308 ± 0.042	0.108TrpCys: 0.108 ± 0.01	0.785TrpAsp: 0.785 ± 0.029	0.665TrpGlu: 0.665 ± 0.029	0.612TrpPhe: 0.612 ± 0.027	0.961TrpGly: 0.961 ± 0.037	0.328TrpHis: 0.328 ± 0.019	0.738TrpIle: 0.738 ± 0.029	0.479TrpLys: 0.479 ± 0.02	1.653TrpLeu: 1.653 ± 0.051	0.358TrpMet: 0.358 ± 0.022	0.479TrpAsn: 0.479 ± 0.023	0.606TrpPro: 0.606 ± 0.029	0.615TrpGln: 0.615 ± 0.029	1.13TrpArg: 1.13 ± 0.038	0.872TrpSer: 0.872 ± 0.033	0.747TrpThr: 0.747 ± 0.031	0.796TrpVal: 0.796 ± 0.031	0.261TrpTrp: 0.261 ± 0.017	0.29TrpTyr: 0.29 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.455TyrAla: 2.455 ± 0.056	0.243TyrCys: 0.243 ± 0.017	1.552TyrAsp: 1.552 ± 0.044	1.26TyrGlu: 1.26 ± 0.042	0.939TyrPhe: 0.939 ± 0.037	2.082TyrGly: 2.082 ± 0.053	0.455TyrHis: 0.455 ± 0.022	0.994TyrIle: 0.994 ± 0.039	0.591TyrLys: 0.591 ± 0.025	2.041TyrLeu: 2.041 ± 0.05	0.408TyrMet: 0.408 ± 0.021	0.663TyrAsn: 0.663 ± 0.029	1.01TyrPro: 1.01 ± 0.033	0.686TyrGln: 0.686 ± 0.033	1.682TyrArg: 1.682 ± 0.044	1.439TyrSer: 1.439 ± 0.038	1.094TyrThr: 1.094 ± 0.037	1.444TyrVal: 1.444 ± 0.039	0.343TyrTrp: 0.343 ± 0.019	0.601TyrTyr: 0.601 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2737 proteins (904613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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