Amino acid dipepetide frequency for Human adenovirus 4a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.17AlaAla: 9.17 ± 1.505
1.166AlaCys: 1.166 ± 0.267
2.875AlaAsp: 2.875 ± 0.39
3.419AlaGlu: 3.419 ± 0.585
2.487AlaPhe: 2.487 ± 0.47
4.507AlaGly: 4.507 ± 0.708
2.021AlaHis: 2.021 ± 0.353
3.963AlaIle: 3.963 ± 0.642
1.943AlaLys: 1.943 ± 0.401
8.393AlaLeu: 8.393 ± 0.771
1.554AlaMet: 1.554 ± 0.384
3.652AlaAsn: 3.652 ± 0.717
4.818AlaPro: 4.818 ± 0.785
2.254AlaGln: 2.254 ± 0.389
5.129AlaArg: 5.129 ± 0.851
5.751AlaSer: 5.751 ± 0.588
4.585AlaThr: 4.585 ± 0.473
6.217AlaVal: 6.217 ± 0.549
0.699AlaTrp: 0.699 ± 0.187
2.953AlaTyr: 2.953 ± 0.533
0.0AlaXaa: 0.0 ± 0.0
Cys
1.321CysAla: 1.321 ± 0.3
1.01CysCys: 1.01 ± 0.385
0.855CysAsp: 0.855 ± 0.244
1.01CysGlu: 1.01 ± 0.255
0.699CysPhe: 0.699 ± 0.226
1.477CysGly: 1.477 ± 0.342
0.777CysHis: 0.777 ± 0.246
0.699CysIle: 0.699 ± 0.241
0.777CysLys: 0.777 ± 0.209
2.021CysLeu: 2.021 ± 0.407
0.622CysMet: 0.622 ± 0.296
1.399CysAsn: 1.399 ± 0.346
0.855CysPro: 0.855 ± 0.218
0.622CysGln: 0.622 ± 0.18
0.933CysArg: 0.933 ± 0.242
0.777CysSer: 0.777 ± 0.214
1.088CysThr: 1.088 ± 0.248
1.321CysVal: 1.321 ± 0.282
0.311CysTrp: 0.311 ± 0.151
1.399CysTyr: 1.399 ± 0.3
0.0CysXaa: 0.0 ± 0.0
Asp
3.886AspAla: 3.886 ± 0.525
0.855AspCys: 0.855 ± 0.252
3.031AspAsp: 3.031 ± 0.731
4.196AspGlu: 4.196 ± 0.592
1.71AspPhe: 1.71 ± 0.465
3.186AspGly: 3.186 ± 0.627
1.399AspHis: 1.399 ± 0.329
1.632AspIle: 1.632 ± 0.372
2.254AspLys: 2.254 ± 0.409
6.295AspLeu: 6.295 ± 0.878
1.943AspMet: 1.943 ± 0.347
1.399AspAsn: 1.399 ± 0.385
4.041AspPro: 4.041 ± 0.499
1.01AspGln: 1.01 ± 0.253
3.186AspArg: 3.186 ± 0.686
2.875AspSer: 2.875 ± 0.475
2.021AspThr: 2.021 ± 0.576
2.798AspVal: 2.798 ± 0.374
0.699AspTrp: 0.699 ± 0.183
1.71AspTyr: 1.71 ± 0.399
0.0AspXaa: 0.0 ± 0.0
Glu
4.43GluAla: 4.43 ± 0.6
1.632GluCys: 1.632 ± 0.365
4.196GluAsp: 4.196 ± 0.73
7.46GluGlu: 7.46 ± 1.463
1.71GluPhe: 1.71 ± 0.324
3.575GluGly: 3.575 ± 0.53
1.243GluHis: 1.243 ± 0.253
2.565GluIle: 2.565 ± 0.399
2.409GluLys: 2.409 ± 0.392
5.906GluLeu: 5.906 ± 0.764
1.554GluMet: 1.554 ± 0.342
2.098GluAsn: 2.098 ± 0.445
2.331GluPro: 2.331 ± 0.437
2.176GluGln: 2.176 ± 0.383
3.963GluArg: 3.963 ± 0.66
3.73GluSer: 3.73 ± 0.646
3.73GluThr: 3.73 ± 0.469
4.352GluVal: 4.352 ± 0.597
0.622GluTrp: 0.622 ± 0.237
1.243GluTyr: 1.243 ± 0.244
0.0GluXaa: 0.0 ± 0.0
Phe
2.487PheAla: 2.487 ± 0.432
0.622PheCys: 0.622 ± 0.214
2.875PheAsp: 2.875 ± 0.536
1.943PheGlu: 1.943 ± 0.321
1.71PhePhe: 1.71 ± 0.364
1.632PheGly: 1.632 ± 0.382
1.01PheHis: 1.01 ± 0.211
1.943PheIle: 1.943 ± 0.381
1.243PheLys: 1.243 ± 0.292
3.419PheLeu: 3.419 ± 0.573
1.243PheMet: 1.243 ± 0.259
1.787PheAsn: 1.787 ± 0.29
2.409PhePro: 2.409 ± 0.307
1.943PheGln: 1.943 ± 0.342
2.098PheArg: 2.098 ± 0.369
3.419PheSer: 3.419 ± 0.433
1.865PheThr: 1.865 ± 0.337
2.798PheVal: 2.798 ± 0.391
0.078PheTrp: 0.078 ± 0.077
1.321PheTyr: 1.321 ± 0.326
0.0PheXaa: 0.0 ± 0.0
Gly
4.74GlyAla: 4.74 ± 0.59
1.399GlyCys: 1.399 ± 0.367
3.031GlyAsp: 3.031 ± 0.45
3.342GlyGlu: 3.342 ± 0.531
2.875GlyPhe: 2.875 ± 0.418
6.139GlyGly: 6.139 ± 0.978
1.787GlyHis: 1.787 ± 0.359
2.331GlyIle: 2.331 ± 0.329
2.254GlyLys: 2.254 ± 0.422
6.372GlyLeu: 6.372 ± 0.71
1.166GlyMet: 1.166 ± 0.411
2.487GlyAsn: 2.487 ± 0.585
2.72GlyPro: 2.72 ± 0.468
2.254GlyGln: 2.254 ± 0.439
5.44GlyArg: 5.44 ± 0.577
5.207GlySer: 5.207 ± 0.643
3.886GlyThr: 3.886 ± 0.672
5.44GlyVal: 5.44 ± 0.876
0.699GlyTrp: 0.699 ± 0.206
1.787GlyTyr: 1.787 ± 0.388
0.0GlyXaa: 0.0 ± 0.0
His
1.632HisAla: 1.632 ± 0.328
1.321HisCys: 1.321 ± 0.345
0.699HisAsp: 0.699 ± 0.189
1.166HisGlu: 1.166 ± 0.29
1.01HisPhe: 1.01 ± 0.358
2.409HisGly: 2.409 ± 0.376
0.933HisHis: 0.933 ± 0.276
0.544HisIle: 0.544 ± 0.248
1.01HisLys: 1.01 ± 0.371
2.642HisLeu: 2.642 ± 0.444
0.622HisMet: 0.622 ± 0.243
1.088HisAsn: 1.088 ± 0.3
2.642HisPro: 2.642 ± 0.504
0.933HisGln: 0.933 ± 0.212
2.098HisArg: 2.098 ± 0.347
1.477HisSer: 1.477 ± 0.349
1.166HisThr: 1.166 ± 0.27
1.399HisVal: 1.399 ± 0.281
0.389HisTrp: 0.389 ± 0.197
0.389HisTyr: 0.389 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
2.875IleAla: 2.875 ± 0.506
0.777IleCys: 0.777 ± 0.208
1.399IleAsp: 1.399 ± 0.282
1.399IleGlu: 1.399 ± 0.302
1.399IlePhe: 1.399 ± 0.412
2.176IleGly: 2.176 ± 0.45
0.855IleHis: 0.855 ± 0.285
2.565IleIle: 2.565 ± 0.622
1.787IleLys: 1.787 ± 0.443
3.264IleLeu: 3.264 ± 0.524
1.399IleMet: 1.399 ± 0.316
1.71IleAsn: 1.71 ± 0.368
2.875IlePro: 2.875 ± 0.605
2.098IleGln: 2.098 ± 0.327
2.331IleArg: 2.331 ± 0.375
2.875IleSer: 2.875 ± 0.422
3.031IleThr: 3.031 ± 0.472
2.798IleVal: 2.798 ± 0.348
0.466IleTrp: 0.466 ± 0.212
1.088IleTyr: 1.088 ± 0.307
0.0IleXaa: 0.0 ± 0.0
Lys
2.021LysAla: 2.021 ± 0.442
0.855LysCys: 0.855 ± 0.269
1.71LysAsp: 1.71 ± 0.542
2.642LysGlu: 2.642 ± 0.414
1.554LysPhe: 1.554 ± 0.36
2.176LysGly: 2.176 ± 0.473
0.777LysHis: 0.777 ± 0.247
2.565LysIle: 2.565 ± 0.435
2.409LysLys: 2.409 ± 0.42
3.652LysLeu: 3.652 ± 0.767
1.01LysMet: 1.01 ± 0.324
2.176LysAsn: 2.176 ± 0.29
2.098LysPro: 2.098 ± 0.373
1.71LysGln: 1.71 ± 0.389
2.798LysArg: 2.798 ± 0.584
2.254LysSer: 2.254 ± 0.388
2.098LysThr: 2.098 ± 0.322
1.632LysVal: 1.632 ± 0.339
0.466LysTrp: 0.466 ± 0.156
1.321LysTyr: 1.321 ± 0.25
0.0LysXaa: 0.0 ± 0.0
Leu
7.616LeuAla: 7.616 ± 0.807
2.254LeuCys: 2.254 ± 0.417
4.585LeuAsp: 4.585 ± 0.644
5.518LeuGlu: 5.518 ± 0.772
2.487LeuPhe: 2.487 ± 0.42
5.44LeuGly: 5.44 ± 0.836
3.264LeuHis: 3.264 ± 0.634
2.798LeuIle: 2.798 ± 0.498
4.352LeuLys: 4.352 ± 0.66
9.714LeuLeu: 9.714 ± 0.97
2.565LeuMet: 2.565 ± 0.481
3.963LeuAsn: 3.963 ± 0.601
7.694LeuPro: 7.694 ± 0.76
4.041LeuGln: 4.041 ± 0.454
7.771LeuArg: 7.771 ± 0.781
5.595LeuSer: 5.595 ± 0.678
6.994LeuThr: 6.994 ± 0.574
5.906LeuVal: 5.906 ± 0.616
1.71LeuTrp: 1.71 ± 0.361
3.108LeuTyr: 3.108 ± 0.469
0.0LeuXaa: 0.0 ± 0.0
Met
2.331MetAla: 2.331 ± 0.405
0.233MetCys: 0.233 ± 0.119
1.166MetAsp: 1.166 ± 0.196
1.943MetGlu: 1.943 ± 0.326
0.389MetPhe: 0.389 ± 0.176
1.632MetGly: 1.632 ± 0.312
1.477MetHis: 1.477 ± 0.399
0.777MetIle: 0.777 ± 0.232
0.622MetLys: 0.622 ± 0.191
2.254MetLeu: 2.254 ± 0.49
0.855MetMet: 0.855 ± 0.293
1.71MetAsn: 1.71 ± 0.381
1.865MetPro: 1.865 ± 0.329
1.166MetGln: 1.166 ± 0.306
1.71MetArg: 1.71 ± 0.34
1.943MetSer: 1.943 ± 0.455
0.933MetThr: 0.933 ± 0.18
1.321MetVal: 1.321 ± 0.361
0.466MetTrp: 0.466 ± 0.177
1.088MetTyr: 1.088 ± 0.266
0.0MetXaa: 0.0 ± 0.0
Asn
3.264AsnAla: 3.264 ± 0.502
0.544AsnCys: 0.544 ± 0.177
2.254AsnAsp: 2.254 ± 0.57
1.787AsnGlu: 1.787 ± 0.289
2.642AsnPhe: 2.642 ± 0.526
2.565AsnGly: 2.565 ± 0.486
1.088AsnHis: 1.088 ± 0.292
2.409AsnIle: 2.409 ± 0.475
1.321AsnLys: 1.321 ± 0.263
3.808AsnLeu: 3.808 ± 0.673
1.399AsnMet: 1.399 ± 0.446
1.787AsnAsn: 1.787 ± 0.459
3.031AsnPro: 3.031 ± 0.368
1.399AsnGln: 1.399 ± 0.342
2.098AsnArg: 2.098 ± 0.384
2.642AsnSer: 2.642 ± 0.524
2.487AsnThr: 2.487 ± 0.596
2.487AsnVal: 2.487 ± 0.41
0.933AsnTrp: 0.933 ± 0.258
2.098AsnTyr: 2.098 ± 0.56
0.0AsnXaa: 0.0 ± 0.0
Pro
5.284ProAla: 5.284 ± 0.523
0.699ProCys: 0.699 ± 0.244
3.73ProAsp: 3.73 ± 0.471
4.585ProGlu: 4.585 ± 0.561
2.72ProPhe: 2.72 ± 0.458
4.818ProGly: 4.818 ± 0.485
1.166ProHis: 1.166 ± 0.251
1.943ProIle: 1.943 ± 0.398
1.865ProLys: 1.865 ± 0.32
5.673ProLeu: 5.673 ± 0.773
1.088ProMet: 1.088 ± 0.346
2.409ProAsn: 2.409 ± 0.383
7.694ProPro: 7.694 ± 1.343
3.419ProGln: 3.419 ± 0.546
5.518ProArg: 5.518 ± 0.826
4.43ProSer: 4.43 ± 0.561
4.274ProThr: 4.274 ± 0.599
4.974ProVal: 4.974 ± 0.716
0.855ProTrp: 0.855 ± 0.241
1.632ProTyr: 1.632 ± 0.376
0.0ProXaa: 0.0 ± 0.0
Gln
4.352GlnAla: 4.352 ± 0.542
0.544GlnCys: 0.544 ± 0.186
2.331GlnAsp: 2.331 ± 0.365
3.264GlnGlu: 3.264 ± 0.627
1.321GlnPhe: 1.321 ± 0.37
3.264GlnGly: 3.264 ± 0.5
0.933GlnHis: 0.933 ± 0.234
1.321GlnIle: 1.321 ± 0.283
1.01GlnLys: 1.01 ± 0.217
3.73GlnLeu: 3.73 ± 0.516
1.399GlnMet: 1.399 ± 0.276
1.865GlnAsn: 1.865 ± 0.475
3.497GlnPro: 3.497 ± 0.446
3.497GlnGln: 3.497 ± 0.711
3.031GlnArg: 3.031 ± 0.502
2.798GlnSer: 2.798 ± 0.531
2.254GlnThr: 2.254 ± 0.39
2.254GlnVal: 2.254 ± 0.437
0.466GlnTrp: 0.466 ± 0.194
0.699GlnTyr: 0.699 ± 0.193
0.0GlnXaa: 0.0 ± 0.0
Arg
7.227ArgAla: 7.227 ± 0.956
1.787ArgCys: 1.787 ± 0.382
2.875ArgAsp: 2.875 ± 0.443
3.342ArgGlu: 3.342 ± 0.544
2.798ArgPhe: 2.798 ± 0.415
5.984ArgGly: 5.984 ± 0.506
2.331ArgHis: 2.331 ± 0.501
3.108ArgIle: 3.108 ± 0.534
2.487ArgLys: 2.487 ± 0.557
5.284ArgLeu: 5.284 ± 0.77
1.243ArgMet: 1.243 ± 0.235
2.953ArgAsn: 2.953 ± 0.479
4.74ArgPro: 4.74 ± 0.786
3.497ArgGln: 3.497 ± 0.53
8.237ArgArg: 8.237 ± 1.636
4.507ArgSer: 4.507 ± 0.624
3.497ArgThr: 3.497 ± 0.622
3.497ArgVal: 3.497 ± 0.562
1.088ArgTrp: 1.088 ± 0.21
1.399ArgTyr: 1.399 ± 0.275
0.0ArgXaa: 0.0 ± 0.0
Ser
3.886SerAla: 3.886 ± 0.505
1.088SerCys: 1.088 ± 0.258
3.031SerAsp: 3.031 ± 0.529
2.953SerGlu: 2.953 ± 0.458
3.264SerPhe: 3.264 ± 0.441
5.673SerGly: 5.673 ± 0.8
1.399SerHis: 1.399 ± 0.392
2.798SerIle: 2.798 ± 0.414
2.487SerLys: 2.487 ± 0.46
6.217SerLeu: 6.217 ± 0.478
1.71SerMet: 1.71 ± 0.352
2.331SerAsn: 2.331 ± 0.429
4.119SerPro: 4.119 ± 0.595
2.798SerGln: 2.798 ± 0.432
5.518SerArg: 5.518 ± 0.722
6.994SerSer: 6.994 ± 1.101
4.74SerThr: 4.74 ± 0.755
3.264SerVal: 3.264 ± 0.447
0.855SerTrp: 0.855 ± 0.226
2.254SerTyr: 2.254 ± 0.365
0.0SerXaa: 0.0 ± 0.0
Thr
3.963ThrAla: 3.963 ± 0.619
1.554ThrCys: 1.554 ± 0.26
2.331ThrAsp: 2.331 ± 0.394
3.652ThrGlu: 3.652 ± 0.468
2.72ThrPhe: 2.72 ± 0.532
3.575ThrGly: 3.575 ± 0.643
1.243ThrHis: 1.243 ± 0.272
1.554ThrIle: 1.554 ± 0.438
2.176ThrLys: 2.176 ± 0.526
7.15ThrLeu: 7.15 ± 0.588
1.399ThrMet: 1.399 ± 0.37
2.487ThrAsn: 2.487 ± 0.514
4.818ThrPro: 4.818 ± 0.592
2.642ThrGln: 2.642 ± 0.41
3.497ThrArg: 3.497 ± 0.484
2.798ThrSer: 2.798 ± 0.444
4.896ThrThr: 4.896 ± 0.809
4.74ThrVal: 4.74 ± 0.556
0.699ThrTrp: 0.699 ± 0.197
1.943ThrTyr: 1.943 ± 0.46
0.0ThrXaa: 0.0 ± 0.0
Val
4.896ValAla: 4.896 ± 0.6
1.088ValCys: 1.088 ± 0.307
3.963ValAsp: 3.963 ± 0.57
4.507ValGlu: 4.507 ± 0.573
2.331ValPhe: 2.331 ± 0.276
2.875ValGly: 2.875 ± 0.607
0.544ValHis: 0.544 ± 0.206
2.331ValIle: 2.331 ± 0.556
2.565ValLys: 2.565 ± 0.51
6.839ValLeu: 6.839 ± 0.816
1.554ValMet: 1.554 ± 0.323
2.875ValAsn: 2.875 ± 0.428
4.352ValPro: 4.352 ± 0.408
3.575ValGln: 3.575 ± 0.508
3.808ValArg: 3.808 ± 0.622
3.963ValSer: 3.963 ± 0.459
3.264ValThr: 3.264 ± 0.546
4.818ValVal: 4.818 ± 0.558
0.855ValTrp: 0.855 ± 0.261
2.875ValTyr: 2.875 ± 0.454
0.0ValXaa: 0.0 ± 0.0
Trp
0.389TrpAla: 0.389 ± 0.16
0.078TrpCys: 0.078 ± 0.08
1.01TrpAsp: 1.01 ± 0.295
0.933TrpGlu: 0.933 ± 0.259
0.389TrpPhe: 0.389 ± 0.155
0.855TrpGly: 0.855 ± 0.243
0.233TrpHis: 0.233 ± 0.108
0.233TrpIle: 0.233 ± 0.108
1.166TrpLys: 1.166 ± 0.357
1.321TrpLeu: 1.321 ± 0.28
0.466TrpMet: 0.466 ± 0.179
0.699TrpAsn: 0.699 ± 0.257
0.466TrpPro: 0.466 ± 0.166
0.622TrpGln: 0.622 ± 0.226
0.699TrpArg: 0.699 ± 0.271
1.166TrpSer: 1.166 ± 0.301
1.166TrpThr: 1.166 ± 0.356
0.466TrpVal: 0.466 ± 0.17
0.155TrpTrp: 0.155 ± 0.088
0.389TrpTyr: 0.389 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.787TyrAla: 1.787 ± 0.39
0.466TyrCys: 0.466 ± 0.182
2.176TyrAsp: 2.176 ± 0.405
1.865TyrGlu: 1.865 ± 0.404
1.632TyrPhe: 1.632 ± 0.41
1.399TyrGly: 1.399 ± 0.383
1.088TyrHis: 1.088 ± 0.335
1.166TyrIle: 1.166 ± 0.259
1.787TyrLys: 1.787 ± 0.414
3.419TyrLeu: 3.419 ± 0.697
1.01TyrMet: 1.01 ± 0.225
1.166TyrAsn: 1.166 ± 0.322
1.71TyrPro: 1.71 ± 0.407
2.176TyrGln: 2.176 ± 0.496
2.021TyrArg: 2.021 ± 0.397
2.176TyrSer: 2.176 ± 0.463
1.865TyrThr: 1.865 ± 0.421
1.399TyrVal: 1.399 ± 0.333
0.389TyrTrp: 0.389 ± 0.16
1.088TyrTyr: 1.088 ± 0.438
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (12869 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski