Amino acid dipepetide frequency for Desulfosporosinus orientis (strain ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628 / Singapore I) (Desulfotomaculum orientis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.417AlaAla: 7.417 ± 0.1
1.018AlaCys: 1.018 ± 0.034
3.799AlaAsp: 3.799 ± 0.057
5.384AlaGlu: 5.384 ± 0.08
3.107AlaPhe: 3.107 ± 0.05
6.429AlaGly: 6.429 ± 0.074
1.353AlaHis: 1.353 ± 0.034
5.455AlaIle: 5.455 ± 0.062
4.875AlaLys: 4.875 ± 0.06
8.538AlaLeu: 8.538 ± 0.093
2.243AlaMet: 2.243 ± 0.042
2.862AlaAsn: 2.862 ± 0.048
2.362AlaPro: 2.362 ± 0.039
3.014AlaGln: 3.014 ± 0.049
3.41AlaArg: 3.41 ± 0.058
4.214AlaSer: 4.214 ± 0.061
3.437AlaThr: 3.437 ± 0.076
6.015AlaVal: 6.015 ± 0.072
0.765AlaTrp: 0.765 ± 0.024
2.327AlaTyr: 2.327 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
0.802CysAla: 0.802 ± 0.022
0.228CysCys: 0.228 ± 0.014
0.538CysAsp: 0.538 ± 0.019
0.635CysGlu: 0.635 ± 0.022
0.472CysPhe: 0.472 ± 0.015
1.218CysGly: 1.218 ± 0.038
0.295CysHis: 0.295 ± 0.017
0.76CysIle: 0.76 ± 0.026
0.587CysLys: 0.587 ± 0.023
1.175CysLeu: 1.175 ± 0.027
0.285CysMet: 0.285 ± 0.013
0.44CysAsn: 0.44 ± 0.018
0.671CysPro: 0.671 ± 0.026
0.482CysGln: 0.482 ± 0.016
0.585CysArg: 0.585 ± 0.021
0.852CysSer: 0.852 ± 0.028
0.632CysThr: 0.632 ± 0.021
0.734CysVal: 0.734 ± 0.023
0.12CysTrp: 0.12 ± 0.008
0.388CysTyr: 0.388 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.222AspAla: 3.222 ± 0.049
0.57AspCys: 0.57 ± 0.019
2.143AspAsp: 2.143 ± 0.062
3.465AspGlu: 3.465 ± 0.047
2.307AspPhe: 2.307 ± 0.037
3.262AspGly: 3.262 ± 0.054
0.907AspHis: 0.907 ± 0.022
4.006AspIle: 4.006 ± 0.056
2.986AspLys: 2.986 ± 0.044
5.401AspLeu: 5.401 ± 0.062
1.326AspMet: 1.326 ± 0.03
1.9AspAsn: 1.9 ± 0.036
2.175AspPro: 2.175 ± 0.035
1.885AspGln: 1.885 ± 0.035
2.202AspArg: 2.202 ± 0.039
2.826AspSer: 2.826 ± 0.043
2.259AspThr: 2.259 ± 0.045
3.459AspVal: 3.459 ± 0.048
0.601AspTrp: 0.601 ± 0.022
2.1AspTyr: 2.1 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.379GluAla: 5.379 ± 0.069
0.617GluCys: 0.617 ± 0.024
3.284GluAsp: 3.284 ± 0.054
5.614GluGlu: 5.614 ± 0.082
2.578GluPhe: 2.578 ± 0.04
4.409GluGly: 4.409 ± 0.056
1.211GluHis: 1.211 ± 0.022
5.687GluIle: 5.687 ± 0.065
5.168GluLys: 5.168 ± 0.059
7.059GluLeu: 7.059 ± 0.079
2.02GluMet: 2.02 ± 0.038
3.125GluAsn: 3.125 ± 0.046
1.864GluPro: 1.864 ± 0.035
2.728GluGln: 2.728 ± 0.042
3.454GluArg: 3.454 ± 0.055
3.387GluSer: 3.387 ± 0.051
3.236GluThr: 3.236 ± 0.049
4.902GluVal: 4.902 ± 0.065
0.684GluTrp: 0.684 ± 0.024
2.022GluTyr: 2.022 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.164PheAla: 3.164 ± 0.044
0.53PheCys: 0.53 ± 0.016
2.053PheAsp: 2.053 ± 0.035
2.368PheGlu: 2.368 ± 0.036
1.858PhePhe: 1.858 ± 0.047
3.219PheGly: 3.219 ± 0.048
0.72PheHis: 0.72 ± 0.022
3.025PheIle: 3.025 ± 0.052
2.19PheLys: 2.19 ± 0.037
4.398PheLeu: 4.398 ± 0.061
1.074PheMet: 1.074 ± 0.028
1.752PheAsn: 1.752 ± 0.032
1.663PhePro: 1.663 ± 0.036
1.388PheGln: 1.388 ± 0.033
1.686PheArg: 1.686 ± 0.034
2.988PheSer: 2.988 ± 0.043
2.234PheThr: 2.234 ± 0.037
2.681PheVal: 2.681 ± 0.041
0.487PheTrp: 0.487 ± 0.02
1.526PheTyr: 1.526 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
5.504GlyAla: 5.504 ± 0.085
1.143GlyCys: 1.143 ± 0.035
3.292GlyAsp: 3.292 ± 0.05
4.607GlyGlu: 4.607 ± 0.063
3.353GlyPhe: 3.353 ± 0.046
5.434GlyGly: 5.434 ± 0.081
1.303GlyHis: 1.303 ± 0.029
6.558GlyIle: 6.558 ± 0.081
5.107GlyLys: 5.107 ± 0.063
7.708GlyLeu: 7.708 ± 0.077
2.367GlyMet: 2.367 ± 0.038
2.885GlyAsn: 2.885 ± 0.048
2.032GlyPro: 2.032 ± 0.038
2.671GlyGln: 2.671 ± 0.044
3.16GlyArg: 3.16 ± 0.048
4.348GlySer: 4.348 ± 0.067
4.3GlyThr: 4.3 ± 0.056
5.585GlyVal: 5.585 ± 0.075
0.851GlyTrp: 0.851 ± 0.026
2.904GlyTyr: 2.904 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.186HisAla: 1.186 ± 0.031
0.276HisCys: 0.276 ± 0.012
0.846HisAsp: 0.846 ± 0.022
1.125HisGlu: 1.125 ± 0.029
0.837HisPhe: 0.837 ± 0.021
1.319HisGly: 1.319 ± 0.029
0.488HisHis: 0.488 ± 0.021
1.191HisIle: 1.191 ± 0.029
0.927HisLys: 0.927 ± 0.021
1.856HisLeu: 1.856 ± 0.041
0.44HisMet: 0.44 ± 0.015
0.726HisAsn: 0.726 ± 0.023
1.06HisPro: 1.06 ± 0.028
0.725HisGln: 0.725 ± 0.022
0.829HisArg: 0.829 ± 0.024
1.127HisSer: 1.127 ± 0.025
0.941HisThr: 0.941 ± 0.022
1.046HisVal: 1.046 ± 0.023
0.262HisTrp: 0.262 ± 0.012
0.715HisTyr: 0.715 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.22IleAla: 6.22 ± 0.071
0.88IleCys: 0.88 ± 0.024
3.765IleAsp: 3.765 ± 0.053
4.66IleGlu: 4.66 ± 0.059
3.017IlePhe: 3.017 ± 0.057
5.727IleGly: 5.727 ± 0.077
1.398IleHis: 1.398 ± 0.028
5.708IleIle: 5.708 ± 0.071
4.362IleLys: 4.362 ± 0.056
7.667IleLeu: 7.667 ± 0.085
1.936IleMet: 1.936 ± 0.042
3.404IleAsn: 3.404 ± 0.049
3.6IlePro: 3.6 ± 0.052
2.62IleGln: 2.62 ± 0.043
3.343IleArg: 3.343 ± 0.047
5.242IleSer: 5.242 ± 0.068
4.074IleThr: 4.074 ± 0.057
5.117IleVal: 5.117 ± 0.064
0.62IleTrp: 0.62 ± 0.021
2.318IleTyr: 2.318 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
5.001LysAla: 5.001 ± 0.061
0.574LysCys: 0.574 ± 0.022
3.404LysAsp: 3.404 ± 0.048
5.18LysGlu: 5.18 ± 0.06
1.881LysPhe: 1.881 ± 0.032
4.301LysGly: 4.301 ± 0.056
0.997LysHis: 0.997 ± 0.027
4.686LysIle: 4.686 ± 0.059
4.074LysLys: 4.074 ± 0.065
5.602LysLeu: 5.602 ± 0.07
1.816LysMet: 1.816 ± 0.037
2.821LysAsn: 2.821 ± 0.046
2.334LysPro: 2.334 ± 0.04
2.189LysGln: 2.189 ± 0.039
2.769LysArg: 2.769 ± 0.04
3.342LysSer: 3.342 ± 0.05
3.396LysThr: 3.396 ± 0.045
4.637LysVal: 4.637 ± 0.062
0.539LysTrp: 0.539 ± 0.016
2.071LysTyr: 2.071 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
8.852LeuAla: 8.852 ± 0.08
1.133LeuCys: 1.133 ± 0.027
5.164LeuAsp: 5.164 ± 0.048
6.965LeuGlu: 6.965 ± 0.072
4.084LeuPhe: 4.084 ± 0.067
7.953LeuGly: 7.953 ± 0.077
1.658LeuHis: 1.658 ± 0.035
7.314LeuIle: 7.314 ± 0.087
6.791LeuLys: 6.791 ± 0.06
10.248LeuLeu: 10.248 ± 0.122
2.683LeuMet: 2.683 ± 0.044
4.545LeuAsn: 4.545 ± 0.055
4.357LeuPro: 4.357 ± 0.052
3.598LeuGln: 3.598 ± 0.06
4.687LeuArg: 4.687 ± 0.073
7.008LeuSer: 7.008 ± 0.073
5.876LeuThr: 5.876 ± 0.063
6.606LeuVal: 6.606 ± 0.06
1.018LeuTrp: 1.018 ± 0.03
2.841LeuTyr: 2.841 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.422MetAla: 2.422 ± 0.038
0.251MetCys: 0.251 ± 0.012
1.536MetAsp: 1.536 ± 0.035
1.897MetGlu: 1.897 ± 0.039
0.965MetPhe: 0.965 ± 0.024
2.206MetGly: 2.206 ± 0.041
0.414MetHis: 0.414 ± 0.017
1.976MetIle: 1.976 ± 0.035
1.853MetLys: 1.853 ± 0.032
2.575MetLeu: 2.575 ± 0.046
0.755MetMet: 0.755 ± 0.023
1.343MetAsn: 1.343 ± 0.031
1.089MetPro: 1.089 ± 0.026
0.888MetGln: 0.888 ± 0.024
1.205MetArg: 1.205 ± 0.024
1.769MetSer: 1.769 ± 0.032
1.503MetThr: 1.503 ± 0.03
1.929MetVal: 1.929 ± 0.037
0.182MetTrp: 0.182 ± 0.011
0.645MetTyr: 0.645 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.786AsnAla: 2.786 ± 0.042
0.571AsnCys: 0.571 ± 0.018
1.812AsnAsp: 1.812 ± 0.031
2.456AsnGlu: 2.456 ± 0.042
1.573AsnPhe: 1.573 ± 0.032
2.901AsnGly: 2.901 ± 0.05
0.85AsnHis: 0.85 ± 0.021
3.275AsnIle: 3.275 ± 0.05
2.443AsnLys: 2.443 ± 0.046
4.476AsnLeu: 4.476 ± 0.056
1.081AsnMet: 1.081 ± 0.025
1.905AsnAsn: 1.905 ± 0.041
2.426AsnPro: 2.426 ± 0.036
1.715AsnGln: 1.715 ± 0.034
1.918AsnArg: 1.918 ± 0.033
2.687AsnSer: 2.687 ± 0.044
2.153AsnThr: 2.153 ± 0.041
2.769AsnVal: 2.769 ± 0.046
0.488AsnTrp: 0.488 ± 0.017
1.664AsnTyr: 1.664 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.843ProAla: 2.843 ± 0.042
0.41ProCys: 0.41 ± 0.017
2.2ProAsp: 2.2 ± 0.039
3.378ProGlu: 3.378 ± 0.044
1.718ProPhe: 1.718 ± 0.03
3.013ProGly: 3.013 ± 0.042
0.694ProHis: 0.694 ± 0.018
2.742ProIle: 2.742 ± 0.037
2.163ProLys: 2.163 ± 0.037
3.987ProLeu: 3.987 ± 0.052
0.973ProMet: 0.973 ± 0.024
1.591ProAsn: 1.591 ± 0.028
1.292ProPro: 1.292 ± 0.032
1.562ProGln: 1.562 ± 0.038
1.457ProArg: 1.457 ± 0.03
2.358ProSer: 2.358 ± 0.038
1.888ProThr: 1.888 ± 0.036
3.168ProVal: 3.168 ± 0.051
0.469ProTrp: 0.469 ± 0.016
1.328ProTyr: 1.328 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.232GlnAla: 3.232 ± 0.049
0.359GlnCys: 0.359 ± 0.014
1.782GlnAsp: 1.782 ± 0.035
3.086GlnGlu: 3.086 ± 0.049
1.281GlnPhe: 1.281 ± 0.03
2.895GlnGly: 2.895 ± 0.047
0.569GlnHis: 0.569 ± 0.019
2.68GlnIle: 2.68 ± 0.042
2.4GlnLys: 2.4 ± 0.041
3.477GlnLeu: 3.477 ± 0.054
1.025GlnMet: 1.025 ± 0.027
1.524GlnAsn: 1.524 ± 0.034
1.254GlnPro: 1.254 ± 0.029
1.454GlnGln: 1.454 ± 0.032
1.891GlnArg: 1.891 ± 0.038
2.059GlnSer: 2.059 ± 0.041
1.973GlnThr: 1.973 ± 0.037
2.74GlnVal: 2.74 ± 0.041
0.425GlnTrp: 0.425 ± 0.017
1.102GlnTyr: 1.102 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
3.021ArgAla: 3.021 ± 0.043
0.536ArgCys: 0.536 ± 0.02
2.202ArgAsp: 2.202 ± 0.041
3.584ArgGlu: 3.584 ± 0.059
1.934ArgPhe: 1.934 ± 0.041
2.857ArgGly: 2.857 ± 0.056
0.834ArgHis: 0.834 ± 0.024
3.457ArgIle: 3.457 ± 0.055
3.01ArgLys: 3.01 ± 0.053
4.748ArgLeu: 4.748 ± 0.059
1.303ArgMet: 1.303 ± 0.028
1.83ArgAsn: 1.83 ± 0.034
1.53ArgPro: 1.53 ± 0.034
1.865ArgGln: 1.865 ± 0.04
2.296ArgArg: 2.296 ± 0.05
2.457ArgSer: 2.457 ± 0.044
2.154ArgThr: 2.154 ± 0.036
3.142ArgVal: 3.142 ± 0.043
0.523ArgTrp: 0.523 ± 0.019
1.572ArgTyr: 1.572 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.439SerAla: 4.439 ± 0.063
0.723SerCys: 0.723 ± 0.024
2.858SerAsp: 2.858 ± 0.049
3.82SerGlu: 3.82 ± 0.058
2.744SerPhe: 2.744 ± 0.04
5.085SerGly: 5.085 ± 0.07
1.126SerHis: 1.126 ± 0.024
4.587SerIle: 4.587 ± 0.078
3.437SerLys: 3.437 ± 0.049
6.773SerLeu: 6.773 ± 0.079
1.739SerMet: 1.739 ± 0.03
2.36SerAsn: 2.36 ± 0.044
2.458SerPro: 2.458 ± 0.041
2.402SerGln: 2.402 ± 0.04
2.702SerArg: 2.702 ± 0.042
4.145SerSer: 4.145 ± 0.071
3.002SerThr: 3.002 ± 0.05
4.204SerVal: 4.204 ± 0.067
0.712SerTrp: 0.712 ± 0.023
2.019SerTyr: 2.019 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.156ThrAla: 4.156 ± 0.066
0.565ThrCys: 0.565 ± 0.02
2.49ThrAsp: 2.49 ± 0.045
3.067ThrGlu: 3.067 ± 0.048
2.148ThrPhe: 2.148 ± 0.031
4.558ThrGly: 4.558 ± 0.078
0.99ThrHis: 0.99 ± 0.021
4.066ThrIle: 4.066 ± 0.058
2.729ThrLys: 2.729 ± 0.044
5.581ThrLeu: 5.581 ± 0.066
1.345ThrMet: 1.345 ± 0.033
2.063ThrAsn: 2.063 ± 0.043
2.351ThrPro: 2.351 ± 0.037
1.767ThrGln: 1.767 ± 0.033
1.975ThrArg: 1.975 ± 0.036
3.121ThrSer: 3.121 ± 0.068
2.856ThrThr: 2.856 ± 0.055
4.005ThrVal: 4.005 ± 0.065
0.489ThrTrp: 0.489 ± 0.018
1.592ThrTyr: 1.592 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
5.301ValAla: 5.301 ± 0.059
0.933ValCys: 0.933 ± 0.025
3.563ValAsp: 3.563 ± 0.052
4.427ValGlu: 4.427 ± 0.064
3.117ValPhe: 3.117 ± 0.043
4.913ValGly: 4.913 ± 0.062
1.229ValHis: 1.229 ± 0.025
5.647ValIle: 5.647 ± 0.056
4.172ValLys: 4.172 ± 0.055
7.426ValLeu: 7.426 ± 0.08
2.0ValMet: 2.0 ± 0.038
3.028ValAsn: 3.028 ± 0.052
2.809ValPro: 2.809 ± 0.047
2.344ValGln: 2.344 ± 0.039
3.09ValArg: 3.09 ± 0.044
4.713ValSer: 4.713 ± 0.067
3.874ValThr: 3.874 ± 0.066
5.235ValVal: 5.235 ± 0.068
0.69ValTrp: 0.69 ± 0.023
2.143ValTyr: 2.143 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.749TrpAla: 0.749 ± 0.022
0.101TrpCys: 0.101 ± 0.008
0.529TrpAsp: 0.529 ± 0.021
0.707TrpGlu: 0.707 ± 0.021
0.43TrpPhe: 0.43 ± 0.016
0.835TrpGly: 0.835 ± 0.028
0.198TrpHis: 0.198 ± 0.011
0.744TrpIle: 0.744 ± 0.025
0.596TrpLys: 0.596 ± 0.02
1.193TrpLeu: 1.193 ± 0.029
0.275TrpMet: 0.275 ± 0.013
0.493TrpAsn: 0.493 ± 0.02
0.396TrpPro: 0.396 ± 0.017
0.526TrpGln: 0.526 ± 0.018
0.488TrpArg: 0.488 ± 0.018
0.61TrpSer: 0.61 ± 0.02
0.478TrpThr: 0.478 ± 0.019
0.669TrpVal: 0.669 ± 0.021
0.137TrpTrp: 0.137 ± 0.01
0.307TrpTyr: 0.307 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.327TyrAla: 2.327 ± 0.039
0.48TyrCys: 0.48 ± 0.016
1.742TyrAsp: 1.742 ± 0.038
2.002TyrGlu: 2.002 ± 0.038
1.6TyrPhe: 1.6 ± 0.032
2.58TyrGly: 2.58 ± 0.043
0.689TyrHis: 0.689 ± 0.022
2.113TyrIle: 2.113 ± 0.037
1.748TyrLys: 1.748 ± 0.033
3.495TyrLeu: 3.495 ± 0.049
0.718TyrMet: 0.718 ± 0.021
1.351TyrAsn: 1.351 ± 0.032
1.513TyrPro: 1.513 ± 0.034
1.386TyrGln: 1.386 ± 0.035
1.705TyrArg: 1.705 ± 0.032
2.081TyrSer: 2.081 ± 0.041
1.644TyrThr: 1.644 ± 0.033
2.012TyrVal: 2.012 ± 0.037
0.398TyrTrp: 0.398 ± 0.016
1.341TyrTyr: 1.341 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5217 proteins (1624322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski