Amino acid dipepetide frequency for Alistipes sp. CAG:157

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.203AlaAla: 11.203 ± 0.196
1.247AlaCys: 1.247 ± 0.044
5.86AlaAsp: 5.86 ± 0.117
6.864AlaGlu: 6.864 ± 0.106
3.424AlaPhe: 3.424 ± 0.071
8.58AlaGly: 8.58 ± 0.148
1.289AlaHis: 1.289 ± 0.049
4.346AlaIle: 4.346 ± 0.085
3.42AlaLys: 3.42 ± 0.084
8.139AlaLeu: 8.139 ± 0.117
2.353AlaMet: 2.353 ± 0.067
2.536AlaAsn: 2.536 ± 0.059
3.422AlaPro: 3.422 ± 0.079
2.472AlaGln: 2.472 ± 0.06
5.24AlaArg: 5.24 ± 0.117
5.001AlaSer: 5.001 ± 0.097
4.288AlaThr: 4.288 ± 0.094
8.075AlaVal: 8.075 ± 0.143
0.87AlaTrp: 0.87 ± 0.04
2.947AlaTyr: 2.947 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.942CysAla: 0.942 ± 0.047
0.233CysCys: 0.233 ± 0.022
0.69CysAsp: 0.69 ± 0.034
0.653CysGlu: 0.653 ± 0.035
0.5CysPhe: 0.5 ± 0.031
1.401CysGly: 1.401 ± 0.056
0.243CysHis: 0.243 ± 0.024
0.752CysIle: 0.752 ± 0.035
0.386CysLys: 0.386 ± 0.029
0.822CysLeu: 0.822 ± 0.041
0.355CysMet: 0.355 ± 0.026
0.389CysAsn: 0.389 ± 0.026
0.582CysPro: 0.582 ± 0.035
0.231CysGln: 0.231 ± 0.02
0.995CysArg: 0.995 ± 0.048
0.775CysSer: 0.775 ± 0.034
0.792CysThr: 0.792 ± 0.037
0.739CysVal: 0.739 ± 0.038
0.125CysTrp: 0.125 ± 0.016
0.396CysTyr: 0.396 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.971AspAla: 4.971 ± 0.093
0.582AspCys: 0.582 ± 0.035
3.227AspAsp: 3.227 ± 0.074
3.689AspGlu: 3.689 ± 0.085
2.788AspPhe: 2.788 ± 0.075
5.46AspGly: 5.46 ± 0.12
0.739AspHis: 0.739 ± 0.037
4.054AspIle: 4.054 ± 0.085
2.519AspLys: 2.519 ± 0.077
4.151AspLeu: 4.151 ± 0.092
1.638AspMet: 1.638 ± 0.049
2.391AspAsn: 2.391 ± 0.075
1.977AspPro: 1.977 ± 0.064
0.84AspGln: 0.84 ± 0.039
3.81AspArg: 3.81 ± 0.089
2.876AspSer: 2.876 ± 0.065
3.349AspThr: 3.349 ± 0.082
3.607AspVal: 3.607 ± 0.079
0.683AspTrp: 0.683 ± 0.032
2.698AspTyr: 2.698 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
6.131GluAla: 6.131 ± 0.108
0.625GluCys: 0.625 ± 0.036
2.858GluAsp: 2.858 ± 0.071
5.691GluGlu: 5.691 ± 0.111
2.602GluPhe: 2.602 ± 0.063
5.43GluGly: 5.43 ± 0.119
1.196GluHis: 1.196 ± 0.049
4.151GluIle: 4.151 ± 0.085
3.645GluLys: 3.645 ± 0.092
6.235GluLeu: 6.235 ± 0.122
2.112GluMet: 2.112 ± 0.066
2.948GluAsn: 2.948 ± 0.071
2.427GluPro: 2.427 ± 0.063
2.217GluGln: 2.217 ± 0.057
5.047GluArg: 5.047 ± 0.104
3.103GluSer: 3.103 ± 0.07
3.727GluThr: 3.727 ± 0.095
4.831GluVal: 4.831 ± 0.092
0.944GluTrp: 0.944 ± 0.045
2.851GluTyr: 2.851 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.796PheAla: 3.796 ± 0.089
0.533PheCys: 0.533 ± 0.03
2.925PheAsp: 2.925 ± 0.068
2.288PheGlu: 2.288 ± 0.057
1.774PhePhe: 1.774 ± 0.062
3.833PheGly: 3.833 ± 0.085
0.676PheHis: 0.676 ± 0.03
2.523PheIle: 2.523 ± 0.071
1.338PheLys: 1.338 ± 0.047
3.402PheLeu: 3.402 ± 0.093
1.127PheMet: 1.127 ± 0.048
1.698PheAsn: 1.698 ± 0.061
1.789PhePro: 1.789 ± 0.057
0.861PheGln: 0.861 ± 0.042
2.963PheArg: 2.963 ± 0.074
2.82PheSer: 2.82 ± 0.071
2.722PheThr: 2.722 ± 0.073
3.105PheVal: 3.105 ± 0.074
0.488PheTrp: 0.488 ± 0.031
1.617PheTyr: 1.617 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
6.514GlyAla: 6.514 ± 0.126
1.127GlyCys: 1.127 ± 0.052
4.338GlyAsp: 4.338 ± 0.112
5.653GlyGlu: 5.653 ± 0.113
3.476GlyPhe: 3.476 ± 0.079
6.534GlyGly: 6.534 ± 0.13
1.492GlyHis: 1.492 ± 0.047
5.76GlyIle: 5.76 ± 0.105
4.143GlyLys: 4.143 ± 0.089
6.421GlyLeu: 6.421 ± 0.108
2.62GlyMet: 2.62 ± 0.067
3.179GlyAsn: 3.179 ± 0.08
1.935GlyPro: 1.935 ± 0.061
2.104GlyGln: 2.104 ± 0.059
5.644GlyArg: 5.644 ± 0.127
4.706GlySer: 4.706 ± 0.098
5.539GlyThr: 5.539 ± 0.098
5.813GlyVal: 5.813 ± 0.124
0.944GlyTrp: 0.944 ± 0.042
3.633GlyTyr: 3.633 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
1.388HisAla: 1.388 ± 0.055
0.264HisCys: 0.264 ± 0.021
0.935HisAsp: 0.935 ± 0.034
0.964HisGlu: 0.964 ± 0.051
0.787HisPhe: 0.787 ± 0.036
1.338HisGly: 1.338 ± 0.045
0.373HisHis: 0.373 ± 0.029
1.244HisIle: 1.244 ± 0.046
0.683HisLys: 0.683 ± 0.035
1.492HisLeu: 1.492 ± 0.06
0.429HisMet: 0.429 ± 0.028
0.678HisAsn: 0.678 ± 0.032
1.086HisPro: 1.086 ± 0.041
0.391HisGln: 0.391 ± 0.024
1.206HisArg: 1.206 ± 0.044
0.967HisSer: 0.967 ± 0.042
1.122HisThr: 1.122 ± 0.047
1.094HisVal: 1.094 ± 0.042
0.165HisTrp: 0.165 ± 0.018
0.777HisTyr: 0.777 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.71IleAla: 5.71 ± 0.107
0.749IleCys: 0.749 ± 0.037
3.884IleAsp: 3.884 ± 0.094
3.943IleGlu: 3.943 ± 0.087
2.321IlePhe: 2.321 ± 0.062
4.582IleGly: 4.582 ± 0.088
1.066IleHis: 1.066 ± 0.039
3.493IleIle: 3.493 ± 0.096
2.496IleLys: 2.496 ± 0.063
5.003IleLeu: 5.003 ± 0.109
1.237IleMet: 1.237 ± 0.051
2.241IleAsn: 2.241 ± 0.067
2.991IlePro: 2.991 ± 0.069
1.353IleGln: 1.353 ± 0.046
3.793IleArg: 3.793 ± 0.091
3.562IleSer: 3.562 ± 0.079
3.627IleThr: 3.627 ± 0.086
4.668IleVal: 4.668 ± 0.087
0.478IleTrp: 0.478 ± 0.028
2.178IleTyr: 2.178 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
3.613LysAla: 3.613 ± 0.079
0.361LysCys: 0.361 ± 0.028
2.013LysAsp: 2.013 ± 0.058
3.605LysGlu: 3.605 ± 0.094
1.511LysPhe: 1.511 ± 0.042
3.424LysGly: 3.424 ± 0.089
0.719LysHis: 0.719 ± 0.035
2.825LysIle: 2.825 ± 0.073
2.533LysLys: 2.533 ± 0.078
3.584LysLeu: 3.584 ± 0.081
1.447LysMet: 1.447 ± 0.049
1.784LysAsn: 1.784 ± 0.061
1.727LysPro: 1.727 ± 0.049
1.32LysGln: 1.32 ± 0.045
3.075LysArg: 3.075 ± 0.08
2.224LysSer: 2.224 ± 0.064
2.506LysThr: 2.506 ± 0.061
3.346LysVal: 3.346 ± 0.09
0.487LysTrp: 0.487 ± 0.027
1.924LysTyr: 1.924 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
8.144LeuAla: 8.144 ± 0.132
1.231LeuCys: 1.231 ± 0.048
4.699LeuAsp: 4.699 ± 0.097
5.057LeuGlu: 5.057 ± 0.101
4.191LeuPhe: 4.191 ± 0.094
6.238LeuGly: 6.238 ± 0.114
1.772LeuHis: 1.772 ± 0.057
4.357LeuIle: 4.357 ± 0.092
3.861LeuLys: 3.861 ± 0.1
8.705LeuLeu: 8.705 ± 0.163
2.226LeuMet: 2.226 ± 0.061
3.118LeuAsn: 3.118 ± 0.087
4.593LeuPro: 4.593 ± 0.109
2.442LeuGln: 2.442 ± 0.063
5.856LeuArg: 5.856 ± 0.111
6.025LeuSer: 6.025 ± 0.098
5.049LeuThr: 5.049 ± 0.103
5.648LeuVal: 5.648 ± 0.106
0.934LeuTrp: 0.934 ± 0.042
3.277LeuTyr: 3.277 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.572MetAla: 2.572 ± 0.068
0.254MetCys: 0.254 ± 0.021
1.358MetAsp: 1.358 ± 0.046
2.12MetGlu: 2.12 ± 0.051
0.988MetPhe: 0.988 ± 0.046
1.785MetGly: 1.785 ± 0.056
0.447MetHis: 0.447 ± 0.03
1.247MetIle: 1.247 ± 0.045
1.975MetLys: 1.975 ± 0.058
2.686MetLeu: 2.686 ± 0.066
0.714MetMet: 0.714 ± 0.038
1.176MetAsn: 1.176 ± 0.048
1.429MetPro: 1.429 ± 0.054
0.944MetGln: 0.944 ± 0.038
1.709MetArg: 1.709 ± 0.053
1.549MetSer: 1.549 ± 0.046
1.648MetThr: 1.648 ± 0.052
1.708MetVal: 1.708 ± 0.058
0.277MetTrp: 0.277 ± 0.024
0.764MetTyr: 0.764 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.014AsnAla: 3.014 ± 0.063
0.375AsnCys: 0.375 ± 0.027
2.081AsnAsp: 2.081 ± 0.055
2.052AsnGlu: 2.052 ± 0.064
1.467AsnPhe: 1.467 ± 0.053
3.468AsnGly: 3.468 ± 0.087
0.64AsnHis: 0.64 ± 0.031
2.787AsnIle: 2.787 ± 0.079
1.528AsnLys: 1.528 ± 0.056
3.102AsnLeu: 3.102 ± 0.084
1.051AsnMet: 1.051 ± 0.039
1.556AsnAsn: 1.556 ± 0.061
2.338AsnPro: 2.338 ± 0.06
0.879AsnGln: 0.879 ± 0.043
2.351AsnArg: 2.351 ± 0.065
1.805AsnSer: 1.805 ± 0.057
2.104AsnThr: 2.104 ± 0.057
2.749AsnVal: 2.749 ± 0.076
0.393AsnTrp: 0.393 ± 0.028
1.584AsnTyr: 1.584 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
4.557ProAla: 4.557 ± 0.089
0.46ProCys: 0.46 ± 0.03
3.226ProAsp: 3.226 ± 0.077
3.993ProGlu: 3.993 ± 0.086
1.859ProPhe: 1.859 ± 0.054
3.231ProGly: 3.231 ± 0.085
0.762ProHis: 0.762 ± 0.037
1.845ProIle: 1.845 ± 0.055
1.538ProLys: 1.538 ± 0.05
3.81ProLeu: 3.81 ± 0.091
0.992ProMet: 0.992 ± 0.045
1.338ProAsn: 1.338 ± 0.048
1.368ProPro: 1.368 ± 0.064
1.521ProGln: 1.521 ± 0.056
1.899ProArg: 1.899 ± 0.066
2.496ProSer: 2.496 ± 0.069
1.97ProThr: 1.97 ± 0.062
3.935ProVal: 3.935 ± 0.07
0.414ProTrp: 0.414 ± 0.026
1.665ProTyr: 1.665 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
2.468GlnAla: 2.468 ± 0.062
0.252GlnCys: 0.252 ± 0.02
1.084GlnAsp: 1.084 ± 0.041
2.039GlnGlu: 2.039 ± 0.071
1.011GlnPhe: 1.011 ± 0.043
1.817GlnGly: 1.817 ± 0.06
0.525GlnHis: 0.525 ± 0.03
1.549GlnIle: 1.549 ± 0.047
1.373GlnLys: 1.373 ± 0.055
2.407GlnLeu: 2.407 ± 0.062
0.851GlnMet: 0.851 ± 0.035
1.048GlnAsn: 1.048 ± 0.04
1.315GlnPro: 1.315 ± 0.048
1.145GlnGln: 1.145 ± 0.049
1.757GlnArg: 1.757 ± 0.063
1.35GlnSer: 1.35 ± 0.051
1.612GlnThr: 1.612 ± 0.056
1.807GlnVal: 1.807 ± 0.056
0.409GlnTrp: 0.409 ± 0.023
1.133GlnTyr: 1.133 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
4.491ArgAla: 4.491 ± 0.096
0.719ArgCys: 0.719 ± 0.036
2.894ArgAsp: 2.894 ± 0.071
4.803ArgGlu: 4.803 ± 0.098
2.935ArgPhe: 2.935 ± 0.065
3.874ArgGly: 3.874 ± 0.094
1.356ArgHis: 1.356 ± 0.042
4.772ArgIle: 4.772 ± 0.1
3.158ArgLys: 3.158 ± 0.072
6.011ArgLeu: 6.011 ± 0.128
2.237ArgMet: 2.237 ± 0.058
2.77ArgAsn: 2.77 ± 0.074
2.828ArgPro: 2.828 ± 0.074
2.104ArgGln: 2.104 ± 0.072
5.024ArgArg: 5.024 ± 0.124
3.438ArgSer: 3.438 ± 0.087
3.721ArgThr: 3.721 ± 0.077
3.777ArgVal: 3.777 ± 0.076
0.756ArgTrp: 0.756 ± 0.037
3.14ArgTyr: 3.14 ± 0.084
0.0ArgXaa: 0.0 ± 0.0
Ser
5.186SerAla: 5.186 ± 0.103
0.775SerCys: 0.775 ± 0.034
3.397SerAsp: 3.397 ± 0.079
3.287SerGlu: 3.287 ± 0.078
2.749SerPhe: 2.749 ± 0.07
5.412SerGly: 5.412 ± 0.109
1.006SerHis: 1.006 ± 0.042
3.14SerIle: 3.14 ± 0.083
1.93SerLys: 1.93 ± 0.06
5.313SerLeu: 5.313 ± 0.099
1.366SerMet: 1.366 ± 0.05
1.822SerAsn: 1.822 ± 0.066
2.627SerPro: 2.627 ± 0.072
1.543SerGln: 1.543 ± 0.052
3.376SerArg: 3.376 ± 0.082
3.221SerSer: 3.221 ± 0.092
2.618SerThr: 2.618 ± 0.065
4.846SerVal: 4.846 ± 0.103
0.714SerTrp: 0.714 ± 0.037
2.298SerTyr: 2.298 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
5.854ThrAla: 5.854 ± 0.11
0.497ThrCys: 0.497 ± 0.029
3.648ThrAsp: 3.648 ± 0.086
3.999ThrGlu: 3.999 ± 0.089
2.561ThrPhe: 2.561 ± 0.066
5.384ThrGly: 5.384 ± 0.108
0.896ThrHis: 0.896 ± 0.037
3.011ThrIle: 3.011 ± 0.076
1.973ThrLys: 1.973 ± 0.069
5.296ThrLeu: 5.296 ± 0.102
1.183ThrMet: 1.183 ± 0.046
1.609ThrAsn: 1.609 ± 0.055
2.998ThrPro: 2.998 ± 0.072
1.419ThrGln: 1.419 ± 0.046
2.571ThrArg: 2.571 ± 0.067
2.803ThrSer: 2.803 ± 0.069
2.938ThrThr: 2.938 ± 0.08
6.021ThrVal: 6.021 ± 0.119
0.602ThrTrp: 0.602 ± 0.034
2.092ThrTyr: 2.092 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
6.784ValAla: 6.784 ± 0.135
1.087ValCys: 1.087 ± 0.048
3.536ValAsp: 3.536 ± 0.081
4.9ValGlu: 4.9 ± 0.096
3.099ValPhe: 3.099 ± 0.082
5.394ValGly: 5.394 ± 0.123
1.272ValHis: 1.272 ± 0.053
4.381ValIle: 4.381 ± 0.094
3.485ValLys: 3.485 ± 0.083
6.299ValLeu: 6.299 ± 0.113
2.028ValMet: 2.028 ± 0.054
2.869ValAsn: 2.869 ± 0.061
3.391ValPro: 3.391 ± 0.08
1.963ValGln: 1.963 ± 0.054
5.009ValArg: 5.009 ± 0.092
5.146ValSer: 5.146 ± 0.113
5.052ValThr: 5.052 ± 0.121
5.976ValVal: 5.976 ± 0.125
0.784ValTrp: 0.784 ± 0.041
2.77ValTyr: 2.77 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.747TrpAla: 0.747 ± 0.04
0.163TrpCys: 0.163 ± 0.016
0.566TrpAsp: 0.566 ± 0.032
0.754TrpGlu: 0.754 ± 0.033
0.474TrpPhe: 0.474 ± 0.03
0.833TrpGly: 0.833 ± 0.039
0.246TrpHis: 0.246 ± 0.02
0.736TrpIle: 0.736 ± 0.039
0.551TrpLys: 0.551 ± 0.033
1.171TrpLeu: 1.171 ± 0.043
0.346TrpMet: 0.346 ± 0.025
0.561TrpAsn: 0.561 ± 0.031
0.272TrpPro: 0.272 ± 0.022
0.368TrpGln: 0.368 ± 0.026
0.617TrpArg: 0.617 ± 0.036
0.615TrpSer: 0.615 ± 0.032
0.591TrpThr: 0.591 ± 0.036
0.736TrpVal: 0.736 ± 0.042
0.137TrpTrp: 0.137 ± 0.015
0.525TrpTyr: 0.525 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.486TyrAla: 3.486 ± 0.085
0.465TyrCys: 0.465 ± 0.03
2.831TyrAsp: 2.831 ± 0.087
2.417TyrGlu: 2.417 ± 0.062
1.762TyrPhe: 1.762 ± 0.062
3.561TyrGly: 3.561 ± 0.088
0.667TyrHis: 0.667 ± 0.035
2.404TyrIle: 2.404 ± 0.069
1.493TyrLys: 1.493 ± 0.057
3.374TyrLeu: 3.374 ± 0.075
1.038TyrMet: 1.038 ± 0.042
1.612TyrAsn: 1.612 ± 0.053
1.784TyrPro: 1.784 ± 0.058
0.837TyrGln: 0.837 ± 0.038
2.864TyrArg: 2.864 ± 0.069
2.142TyrSer: 2.142 ± 0.069
2.379TyrThr: 2.379 ± 0.072
2.747TyrVal: 2.747 ± 0.066
0.406TyrTrp: 0.406 ± 0.027
1.751TyrTyr: 1.751 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1828 proteins (606094 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski