Amino acid dipepetide frequency for Bacteroidales bacterium Barb6XT

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.479AlaAla: 8.479 ± 0.149	1.112AlaCys: 1.112 ± 0.038	5.374AlaAsp: 5.374 ± 0.091	5.709AlaGlu: 5.709 ± 0.093	4.112AlaPhe: 4.112 ± 0.097	7.374AlaGly: 7.374 ± 0.11	1.315AlaHis: 1.315 ± 0.044	4.173AlaIle: 4.173 ± 0.08	4.409AlaLys: 4.409 ± 0.079	7.519AlaLeu: 7.519 ± 0.12	1.656AlaMet: 1.656 ± 0.043	3.324AlaAsn: 3.324 ± 0.073	2.325AlaPro: 2.325 ± 0.049	2.482AlaGln: 2.482 ± 0.051	3.644AlaArg: 3.644 ± 0.069	4.86AlaSer: 4.86 ± 0.08	4.079AlaThr: 4.079 ± 0.085	7.049AlaVal: 7.049 ± 0.109	0.817AlaTrp: 0.817 ± 0.032	3.118AlaTyr: 3.118 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.031	0.265CysCys: 0.265 ± 0.018	0.528CysAsp: 0.528 ± 0.026	0.587CysGlu: 0.587 ± 0.027	0.663CysPhe: 0.663 ± 0.025	0.938CysGly: 0.938 ± 0.036	0.334CysHis: 0.334 ± 0.02	0.719CysIle: 0.719 ± 0.029	0.613CysLys: 0.613 ± 0.027	1.191CysLeu: 1.191 ± 0.039	0.271CysMet: 0.271 ± 0.02	0.475CysAsn: 0.475 ± 0.022	0.577CysPro: 0.577 ± 0.027	0.327CysGln: 0.327 ± 0.019	0.807CysArg: 0.807 ± 0.037	0.689CysSer: 0.689 ± 0.03	0.755CysThr: 0.755 ± 0.039	0.616CysVal: 0.616 ± 0.029	0.133CysTrp: 0.133 ± 0.014	0.42CysTyr: 0.42 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.342AspAla: 4.342 ± 0.065	0.631AspCys: 0.631 ± 0.029	2.58AspAsp: 2.58 ± 0.051	3.471AspGlu: 3.471 ± 0.07	2.942AspPhe: 2.942 ± 0.056	4.279AspGly: 4.279 ± 0.083	0.748AspHis: 0.748 ± 0.034	4.139AspIle: 4.139 ± 0.076	3.541AspLys: 3.541 ± 0.06	4.77AspLeu: 4.77 ± 0.08	1.445AspMet: 1.445 ± 0.043	2.795AspAsn: 2.795 ± 0.061	2.019AspPro: 2.019 ± 0.056	0.961AspGln: 0.961 ± 0.036	2.913AspArg: 2.913 ± 0.055	3.174AspSer: 3.174 ± 0.086	3.124AspThr: 3.124 ± 0.069	3.512AspVal: 3.512 ± 0.066	0.712AspTrp: 0.712 ± 0.03	2.85AspTyr: 2.85 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.788GluAla: 5.788 ± 0.103	0.571GluCys: 0.571 ± 0.027	3.093GluAsp: 3.093 ± 0.059	4.831GluGlu: 4.831 ± 0.106	2.094GluPhe: 2.094 ± 0.047	4.412GluGly: 4.412 ± 0.082	1.214GluHis: 1.214 ± 0.036	4.256GluIle: 4.256 ± 0.078	4.822GluLys: 4.822 ± 0.082	5.669GluLeu: 5.669 ± 0.085	1.639GluMet: 1.639 ± 0.045	3.229GluAsn: 3.229 ± 0.07	1.762GluPro: 1.762 ± 0.05	2.367GluGln: 2.367 ± 0.06	3.36GluArg: 3.36 ± 0.068	3.286GluSer: 3.286 ± 0.058	3.857GluThr: 3.857 ± 0.069	3.868GluVal: 3.868 ± 0.071	0.823GluTrp: 0.823 ± 0.033	2.509GluTyr: 2.509 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.882PheAla: 3.882 ± 0.08	0.595PheCys: 0.595 ± 0.026	2.815PheAsp: 2.815 ± 0.061	2.588PheGlu: 2.588 ± 0.054	2.156PhePhe: 2.156 ± 0.064	3.394PheGly: 3.394 ± 0.072	0.933PheHis: 0.933 ± 0.032	2.836PheIle: 2.836 ± 0.063	2.228PheLys: 2.228 ± 0.062	4.14PheLeu: 4.14 ± 0.075	1.056PheMet: 1.056 ± 0.035	2.245PheAsn: 2.245 ± 0.051	1.884PhePro: 1.884 ± 0.052	1.333PheGln: 1.333 ± 0.034	2.481PheArg: 2.481 ± 0.052	3.159PheSer: 3.159 ± 0.066	3.084PheThr: 3.084 ± 0.062	2.822PheVal: 2.822 ± 0.069	0.452PheTrp: 0.452 ± 0.023	1.681PheTyr: 1.681 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.002GlyAla: 5.002 ± 0.088	1.05GlyCys: 1.05 ± 0.044	4.013GlyAsp: 4.013 ± 0.08	4.476GlyGlu: 4.476 ± 0.07	3.372GlyPhe: 3.372 ± 0.065	5.94GlyGly: 5.94 ± 0.126	1.332GlyHis: 1.332 ± 0.042	5.795GlyIle: 5.795 ± 0.098	5.264GlyLys: 5.264 ± 0.076	6.083GlyLeu: 6.083 ± 0.084	2.008GlyMet: 2.008 ± 0.048	3.797GlyAsn: 3.797 ± 0.088	0.948GlyPro: 0.948 ± 0.028	2.151GlyGln: 2.151 ± 0.051	3.75GlyArg: 3.75 ± 0.069	4.587GlySer: 4.587 ± 0.079	4.652GlyThr: 4.652 ± 0.086	4.86GlyVal: 4.86 ± 0.083	0.888GlyTrp: 0.888 ± 0.034	3.429GlyTyr: 3.429 ± 0.085	0.0GlyXaa: 0.0 ± 0.0
His	1.394HisAla: 1.394 ± 0.041	0.255HisCys: 0.255 ± 0.016	0.83HisAsp: 0.83 ± 0.03	0.942HisGlu: 0.942 ± 0.031	1.26HisPhe: 1.26 ± 0.059	1.246HisGly: 1.246 ± 0.041	0.436HisHis: 0.436 ± 0.027	1.597HisIle: 1.597 ± 0.047	0.912HisLys: 0.912 ± 0.031	1.828HisLeu: 1.828 ± 0.039	0.283HisMet: 0.283 ± 0.017	0.827HisAsn: 0.827 ± 0.029	1.15HisPro: 1.15 ± 0.039	0.483HisGln: 0.483 ± 0.023	0.994HisArg: 0.994 ± 0.031	1.232HisSer: 1.232 ± 0.035	1.209HisThr: 1.209 ± 0.034	1.115HisVal: 1.115 ± 0.04	0.224HisTrp: 0.224 ± 0.017	0.859HisTyr: 0.859 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.454IleAla: 5.454 ± 0.09	0.761IleCys: 0.761 ± 0.031	3.937IleAsp: 3.937 ± 0.079	4.096IleGlu: 4.096 ± 0.08	2.374IlePhe: 2.374 ± 0.045	4.657IleGly: 4.657 ± 0.076	1.255IleHis: 1.255 ± 0.039	4.051IleIle: 4.051 ± 0.076	3.774IleLys: 3.774 ± 0.067	5.275IleLeu: 5.275 ± 0.09	1.184IleMet: 1.184 ± 0.036	3.056IleAsn: 3.056 ± 0.065	3.278IlePro: 3.278 ± 0.076	1.903IleGln: 1.903 ± 0.041	3.79IleArg: 3.79 ± 0.064	4.055IleSer: 4.055 ± 0.068	4.138IleThr: 4.138 ± 0.073	4.172IleVal: 4.172 ± 0.079	0.515IleTrp: 0.515 ± 0.026	2.39IleTyr: 2.39 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	5.243LysAla: 5.243 ± 0.085	0.436LysCys: 0.436 ± 0.026	3.609LysAsp: 3.609 ± 0.065	5.203LysGlu: 5.203 ± 0.098	1.923LysPhe: 1.923 ± 0.039	4.636LysGly: 4.636 ± 0.082	1.198LysHis: 1.198 ± 0.035	3.643LysIle: 3.643 ± 0.067	4.163LysLys: 4.163 ± 0.075	4.746LysLeu: 4.746 ± 0.068	1.553LysMet: 1.553 ± 0.04	2.892LysAsn: 2.892 ± 0.064	2.196LysPro: 2.196 ± 0.053	2.318LysGln: 2.318 ± 0.058	3.147LysArg: 3.147 ± 0.057	3.535LysSer: 3.535 ± 0.069	3.678LysThr: 3.678 ± 0.066	3.831LysVal: 3.831 ± 0.071	0.779LysTrp: 0.779 ± 0.041	2.399LysTyr: 2.399 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.696LeuAla: 6.696 ± 0.107	1.255LeuCys: 1.255 ± 0.04	4.46LeuAsp: 4.46 ± 0.078	4.901LeuGlu: 4.901 ± 0.089	4.513LeuPhe: 4.513 ± 0.088	5.172LeuGly: 5.172 ± 0.088	2.054LeuHis: 2.054 ± 0.051	5.26LeuIle: 5.26 ± 0.081	6.045LeuLys: 6.045 ± 0.088	8.818LeuLeu: 8.818 ± 0.132	1.986LeuMet: 1.986 ± 0.049	4.317LeuAsn: 4.317 ± 0.072	4.566LeuPro: 4.566 ± 0.087	3.295LeuGln: 3.295 ± 0.063	4.616LeuArg: 4.616 ± 0.083	7.358LeuSer: 7.358 ± 0.102	6.016LeuThr: 6.016 ± 0.084	4.843LeuVal: 4.843 ± 0.079	0.836LeuTrp: 0.836 ± 0.032	3.464LeuTyr: 3.464 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.814MetAla: 1.814 ± 0.053	0.18MetCys: 0.18 ± 0.014	1.255MetAsp: 1.255 ± 0.035	1.597MetGlu: 1.597 ± 0.041	0.833MetPhe: 0.833 ± 0.034	1.436MetGly: 1.436 ± 0.045	0.412MetHis: 0.412 ± 0.021	1.376MetIle: 1.376 ± 0.045	1.984MetLys: 1.984 ± 0.04	2.083MetLeu: 2.083 ± 0.052	0.59MetMet: 0.59 ± 0.03	1.257MetAsn: 1.257 ± 0.04	1.097MetPro: 1.097 ± 0.033	0.948MetGln: 0.948 ± 0.033	1.183MetArg: 1.183 ± 0.035	1.297MetSer: 1.297 ± 0.042	1.333MetThr: 1.333 ± 0.034	1.229MetVal: 1.229 ± 0.037	0.165MetTrp: 0.165 ± 0.013	0.766MetTyr: 0.766 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.8AsnAla: 3.8 ± 0.07	0.449AsnCys: 0.449 ± 0.022	2.358AsnAsp: 2.358 ± 0.052	2.641AsnGlu: 2.641 ± 0.055	1.931AsnPhe: 1.931 ± 0.047	3.726AsnGly: 3.726 ± 0.09	0.847AsnHis: 0.847 ± 0.028	3.255AsnIle: 3.255 ± 0.074	2.612AsnLys: 2.612 ± 0.053	3.985AsnLeu: 3.985 ± 0.065	1.107AsnMet: 1.107 ± 0.035	2.357AsnAsn: 2.357 ± 0.058	2.78AsnPro: 2.78 ± 0.066	1.289AsnGln: 1.289 ± 0.036	2.682AsnArg: 2.682 ± 0.058	2.726AsnSer: 2.726 ± 0.069	2.885AsnThr: 2.885 ± 0.062	2.916AsnVal: 2.916 ± 0.062	0.517AsnTrp: 0.517 ± 0.023	2.142AsnTyr: 2.142 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	3.962ProAla: 3.962 ± 0.069	0.419ProCys: 0.419 ± 0.022	2.912ProAsp: 2.912 ± 0.057	3.246ProGlu: 3.246 ± 0.064	1.99ProPhe: 1.99 ± 0.054	2.321ProGly: 2.321 ± 0.051	0.806ProHis: 0.806 ± 0.03	1.712ProIle: 1.712 ± 0.042	1.856ProLys: 1.856 ± 0.044	3.48ProLeu: 3.48 ± 0.061	0.704ProMet: 0.704 ± 0.028	1.617ProAsn: 1.617 ± 0.045	1.298ProPro: 1.298 ± 0.045	1.325ProGln: 1.325 ± 0.037	1.409ProArg: 1.409 ± 0.046	2.562ProSer: 2.562 ± 0.056	1.699ProThr: 1.699 ± 0.043	3.632ProVal: 3.632 ± 0.064	0.396ProTrp: 0.396 ± 0.023	1.736ProTyr: 1.736 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	2.78GlnAla: 2.78 ± 0.067	0.249GlnCys: 0.249 ± 0.02	1.354GlnAsp: 1.354 ± 0.039	2.121GlnGlu: 2.121 ± 0.053	1.197GlnPhe: 1.197 ± 0.034	2.104GlnGly: 2.104 ± 0.062	0.616GlnHis: 0.616 ± 0.024	2.044GlnIle: 2.044 ± 0.049	2.094GlnLys: 2.094 ± 0.047	2.963GlnLeu: 2.963 ± 0.062	0.872GlnMet: 0.872 ± 0.031	1.391GlnAsn: 1.391 ± 0.044	1.252GlnPro: 1.252 ± 0.036	1.375GlnGln: 1.375 ± 0.046	1.67GlnArg: 1.67 ± 0.051	2.012GlnSer: 2.012 ± 0.059	2.254GlnThr: 2.254 ± 0.059	1.806GlnVal: 1.806 ± 0.047	0.402GlnTrp: 0.402 ± 0.024	1.234GlnTyr: 1.234 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.38ArgAla: 3.38 ± 0.058	0.506ArgCys: 0.506 ± 0.022	2.39ArgAsp: 2.39 ± 0.056	3.442ArgGlu: 3.442 ± 0.073	2.625ArgPhe: 2.625 ± 0.052	2.878ArgGly: 2.878 ± 0.061	1.088ArgHis: 1.088 ± 0.034	3.945ArgIle: 3.945 ± 0.072	3.55ArgLys: 3.55 ± 0.073	5.21ArgLeu: 5.21 ± 0.083	1.534ArgMet: 1.534 ± 0.039	2.517ArgAsn: 2.517 ± 0.05	1.814ArgPro: 1.814 ± 0.05	2.176ArgGln: 2.176 ± 0.05	2.806ArgArg: 2.806 ± 0.072	2.661ArgSer: 2.661 ± 0.054	2.845ArgThr: 2.845 ± 0.061	3.009ArgVal: 3.009 ± 0.06	0.599ArgTrp: 0.599 ± 0.026	2.227ArgTyr: 2.227 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.205SerAla: 5.205 ± 0.087	0.843SerCys: 0.843 ± 0.035	3.615SerAsp: 3.615 ± 0.066	3.302SerGlu: 3.302 ± 0.061	3.192SerPhe: 3.192 ± 0.063	5.563SerGly: 5.563 ± 0.093	1.103SerHis: 1.103 ± 0.033	3.983SerIle: 3.983 ± 0.074	3.051SerLys: 3.051 ± 0.063	6.521SerLeu: 6.521 ± 0.104	1.244SerMet: 1.244 ± 0.037	2.523SerAsn: 2.523 ± 0.056	2.674SerPro: 2.674 ± 0.058	1.692SerGln: 1.692 ± 0.045	3.201SerArg: 3.201 ± 0.065	4.087SerSer: 4.087 ± 0.092	2.998SerThr: 2.998 ± 0.061	4.898SerVal: 4.898 ± 0.091	0.656SerTrp: 0.656 ± 0.027	2.64SerTyr: 2.64 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	5.994ThrAla: 5.994 ± 0.11	0.575ThrCys: 0.575 ± 0.024	4.026ThrAsp: 4.026 ± 0.078	3.592ThrGlu: 3.592 ± 0.069	2.914ThrPhe: 2.914 ± 0.067	5.407ThrGly: 5.407 ± 0.092	0.959ThrHis: 0.959 ± 0.029	3.633ThrIle: 3.633 ± 0.08	2.766ThrLys: 2.766 ± 0.058	5.65ThrLeu: 5.65 ± 0.093	1.031ThrMet: 1.031 ± 0.036	2.335ThrAsn: 2.335 ± 0.057	2.727ThrPro: 2.727 ± 0.055	1.616ThrGln: 1.616 ± 0.048	2.313ThrArg: 2.313 ± 0.044	3.286ThrSer: 3.286 ± 0.071	3.056ThrThr: 3.056 ± 0.068	5.313ThrVal: 5.313 ± 0.1	0.532ThrTrp: 0.532 ± 0.023	2.188ThrTyr: 2.188 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.962ValAla: 4.962 ± 0.071	0.977ValCys: 0.977 ± 0.036	2.786ValAsp: 2.786 ± 0.061	3.78ValGlu: 3.78 ± 0.063	3.287ValPhe: 3.287 ± 0.069	3.969ValGly: 3.969 ± 0.078	1.188ValHis: 1.188 ± 0.038	4.524ValIle: 4.524 ± 0.088	4.354ValLys: 4.354 ± 0.089	6.065ValLeu: 6.065 ± 0.087	1.464ValMet: 1.464 ± 0.04	3.234ValAsn: 3.234 ± 0.068	2.789ValPro: 2.789 ± 0.054	2.006ValGln: 2.006 ± 0.041	3.641ValArg: 3.641 ± 0.065	5.226ValSer: 5.226 ± 0.083	4.651ValThr: 4.651 ± 0.112	4.565ValVal: 4.565 ± 0.083	0.695ValTrp: 0.695 ± 0.028	2.554ValTyr: 2.554 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.731TrpAla: 0.731 ± 0.031	0.102TrpCys: 0.102 ± 0.01	0.58TrpAsp: 0.58 ± 0.026	0.71TrpGlu: 0.71 ± 0.03	0.455TrpPhe: 0.455 ± 0.02	0.845TrpGly: 0.845 ± 0.035	0.25TrpHis: 0.25 ± 0.016	0.624TrpIle: 0.624 ± 0.024	0.775TrpLys: 0.775 ± 0.03	1.012TrpLeu: 1.012 ± 0.037	0.296TrpMet: 0.296 ± 0.02	0.598TrpAsn: 0.598 ± 0.026	0.194TrpPro: 0.194 ± 0.019	0.519TrpGln: 0.519 ± 0.024	0.513TrpArg: 0.513 ± 0.022	0.592TrpSer: 0.592 ± 0.025	0.803TrpThr: 0.803 ± 0.041	0.551TrpVal: 0.551 ± 0.024	0.114TrpTrp: 0.114 ± 0.011	0.414TrpTyr: 0.414 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.243TyrAla: 3.243 ± 0.076	0.458TyrCys: 0.458 ± 0.024	2.431TyrAsp: 2.431 ± 0.057	2.216TyrGlu: 2.216 ± 0.05	1.931TyrPhe: 1.931 ± 0.045	3.1TyrGly: 3.1 ± 0.066	0.988TyrHis: 0.988 ± 0.042	2.548TyrIle: 2.548 ± 0.058	2.316TyrLys: 2.316 ± 0.047	3.462TyrLeu: 3.462 ± 0.058	0.913TyrMet: 0.913 ± 0.03	2.219TyrAsn: 2.219 ± 0.061	1.753TyrPro: 1.753 ± 0.047	1.223TyrGln: 1.223 ± 0.046	2.284TyrArg: 2.284 ± 0.056	2.606TyrSer: 2.606 ± 0.067	2.795TyrThr: 2.795 ± 0.079	2.111TyrVal: 2.111 ± 0.044	0.421TyrTrp: 0.421 ± 0.023	1.808TyrTyr: 1.808 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3068 proteins (929218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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