Amino acid dipepetide frequency for Halomonas heilongjiangensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.725AlaAla: 13.725 ± 0.135	1.298AlaCys: 1.298 ± 0.03	6.073AlaAsp: 6.073 ± 0.067	8.271AlaGlu: 8.271 ± 0.094	4.185AlaPhe: 4.185 ± 0.057	10.26AlaGly: 10.26 ± 0.088	2.475AlaHis: 2.475 ± 0.044	5.52AlaIle: 5.52 ± 0.074	2.2AlaLys: 2.2 ± 0.047	14.734AlaLeu: 14.734 ± 0.152	3.453AlaMet: 3.453 ± 0.043	2.34AlaAsn: 2.34 ± 0.042	5.311AlaPro: 5.311 ± 0.067	3.438AlaGln: 3.438 ± 0.048	9.366AlaArg: 9.366 ± 0.098	6.074AlaSer: 6.074 ± 0.065	5.497AlaThr: 5.497 ± 0.075	8.173AlaVal: 8.173 ± 0.087	2.099AlaTrp: 2.099 ± 0.047	2.403AlaTyr: 2.403 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.939CysAla: 0.939 ± 0.03	0.131CysCys: 0.131 ± 0.011	0.574CysAsp: 0.574 ± 0.021	0.531CysGlu: 0.531 ± 0.019	0.327CysPhe: 0.327 ± 0.014	0.939CysGly: 0.939 ± 0.024	0.334CysHis: 0.334 ± 0.018	0.36CysIle: 0.36 ± 0.017	0.167CysLys: 0.167 ± 0.012	1.066CysLeu: 1.066 ± 0.029	0.197CysMet: 0.197 ± 0.013	0.22CysAsn: 0.22 ± 0.012	0.519CysPro: 0.519 ± 0.022	0.341CysGln: 0.341 ± 0.016	0.88CysArg: 0.88 ± 0.024	0.462CysSer: 0.462 ± 0.018	0.415CysThr: 0.415 ± 0.018	0.638CysVal: 0.638 ± 0.023	0.136CysTrp: 0.136 ± 0.009	0.244CysTyr: 0.244 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.717AspAla: 6.717 ± 0.085	0.463AspCys: 0.463 ± 0.019	3.954AspAsp: 3.954 ± 0.065	4.215AspGlu: 4.215 ± 0.059	2.192AspPhe: 2.192 ± 0.039	4.999AspGly: 4.999 ± 0.073	1.47AspHis: 1.47 ± 0.033	2.593AspIle: 2.593 ± 0.052	1.311AspLys: 1.311 ± 0.031	5.648AspLeu: 5.648 ± 0.067	1.236AspMet: 1.236 ± 0.035	1.294AspAsn: 1.294 ± 0.037	3.316AspPro: 3.316 ± 0.057	1.794AspGln: 1.794 ± 0.042	4.053AspArg: 4.053 ± 0.059	2.448AspSer: 2.448 ± 0.048	2.723AspThr: 2.723 ± 0.038	3.611AspVal: 3.611 ± 0.061	1.039AspTrp: 1.039 ± 0.027	1.672AspTyr: 1.672 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	9.474GluAla: 9.474 ± 0.119	0.495GluCys: 0.495 ± 0.021	2.845GluAsp: 2.845 ± 0.047	4.339GluGlu: 4.339 ± 0.076	1.674GluPhe: 1.674 ± 0.038	5.188GluGly: 5.188 ± 0.062	1.814GluHis: 1.814 ± 0.037	3.048GluIle: 3.048 ± 0.053	1.576GluLys: 1.576 ± 0.042	7.362GluLeu: 7.362 ± 0.087	1.458GluMet: 1.458 ± 0.03	1.34GluAsn: 1.34 ± 0.035	3.019GluPro: 3.019 ± 0.053	2.956GluGln: 2.956 ± 0.054	6.726GluArg: 6.726 ± 0.089	3.05GluSer: 3.05 ± 0.049	3.28GluThr: 3.28 ± 0.048	5.019GluVal: 5.019 ± 0.064	0.869GluTrp: 0.869 ± 0.028	1.178GluTyr: 1.178 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.848PheAla: 3.848 ± 0.055	0.391PheCys: 0.391 ± 0.017	2.526PheAsp: 2.526 ± 0.046	2.155PheGlu: 2.155 ± 0.042	1.372PhePhe: 1.372 ± 0.034	3.244PheGly: 3.244 ± 0.052	0.886PheHis: 0.886 ± 0.027	1.555PheIle: 1.555 ± 0.035	0.783PheLys: 0.783 ± 0.026	3.385PheLeu: 3.385 ± 0.05	0.833PheMet: 0.833 ± 0.024	0.944PheAsn: 0.944 ± 0.025	1.54PhePro: 1.54 ± 0.035	1.108PheGln: 1.108 ± 0.026	2.205PheArg: 2.205 ± 0.043	2.069PheSer: 2.069 ± 0.04	1.923PheThr: 1.923 ± 0.04	2.61PheVal: 2.61 ± 0.049	0.483PheTrp: 0.483 ± 0.02	0.881PheTyr: 0.881 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.028GlyAla: 8.028 ± 0.091	0.942GlyCys: 0.942 ± 0.025	4.857GlyAsp: 4.857 ± 0.066	6.397GlyGlu: 6.397 ± 0.073	3.309GlyPhe: 3.309 ± 0.049	7.19GlyGly: 7.19 ± 0.088	2.273GlyHis: 2.273 ± 0.05	4.468GlyIle: 4.468 ± 0.058	2.367GlyLys: 2.367 ± 0.05	9.865GlyLeu: 9.865 ± 0.104	2.468GlyMet: 2.468 ± 0.04	2.009GlyAsn: 2.009 ± 0.04	3.104GlyPro: 3.104 ± 0.051	3.083GlyGln: 3.083 ± 0.055	6.524GlyArg: 6.524 ± 0.082	4.42GlySer: 4.42 ± 0.066	3.786GlyThr: 3.786 ± 0.051	6.641GlyVal: 6.641 ± 0.076	1.497GlyTrp: 1.497 ± 0.032	2.389GlyTyr: 2.389 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.698HisAla: 2.698 ± 0.05	0.328HisCys: 0.328 ± 0.015	1.574HisAsp: 1.574 ± 0.036	1.459HisGlu: 1.459 ± 0.029	1.074HisPhe: 1.074 ± 0.029	2.475HisGly: 2.475 ± 0.043	0.871HisHis: 0.871 ± 0.027	0.852HisIle: 0.852 ± 0.024	0.453HisLys: 0.453 ± 0.019	2.828HisLeu: 2.828 ± 0.05	0.46HisMet: 0.46 ± 0.018	0.533HisAsn: 0.533 ± 0.022	1.74HisPro: 1.74 ± 0.038	0.902HisGln: 0.902 ± 0.025	2.172HisArg: 2.172 ± 0.047	1.092HisSer: 1.092 ± 0.03	0.95HisThr: 0.95 ± 0.027	1.55HisVal: 1.55 ± 0.036	0.462HisTrp: 0.462 ± 0.019	0.804HisTyr: 0.804 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.677IleAla: 5.677 ± 0.075	0.434IleCys: 0.434 ± 0.021	3.282IleAsp: 3.282 ± 0.049	3.416IleGlu: 3.416 ± 0.056	1.457IlePhe: 1.457 ± 0.037	4.339IleGly: 4.339 ± 0.064	1.076IleHis: 1.076 ± 0.028	1.865IleIle: 1.865 ± 0.047	1.093IleLys: 1.093 ± 0.031	4.037IleLeu: 4.037 ± 0.062	0.853IleMet: 0.853 ± 0.026	1.34IleAsn: 1.34 ± 0.033	2.246IlePro: 2.246 ± 0.04	1.309IleGln: 1.309 ± 0.032	3.027IleArg: 3.027 ± 0.045	2.27IleSer: 2.27 ± 0.04	2.487IleThr: 2.487 ± 0.049	3.227IleVal: 3.227 ± 0.054	0.487IleTrp: 0.487 ± 0.019	0.919IleTyr: 0.919 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.768LysAla: 2.768 ± 0.05	0.163LysCys: 0.163 ± 0.012	1.018LysAsp: 1.018 ± 0.026	1.282LysGlu: 1.282 ± 0.035	0.544LysPhe: 0.544 ± 0.021	1.956LysGly: 1.956 ± 0.044	0.54LysHis: 0.54 ± 0.021	0.955LysIle: 0.955 ± 0.032	0.782LysLys: 0.782 ± 0.034	2.344LysLeu: 2.344 ± 0.046	0.484LysMet: 0.484 ± 0.019	0.508LysAsn: 0.508 ± 0.022	1.314LysPro: 1.314 ± 0.033	0.865LysGln: 0.865 ± 0.033	1.997LysArg: 1.997 ± 0.04	1.205LysSer: 1.205 ± 0.031	1.154LysThr: 1.154 ± 0.031	1.804LysVal: 1.804 ± 0.041	0.257LysTrp: 0.257 ± 0.014	0.469LysTyr: 0.469 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.211LeuAla: 16.211 ± 0.173	1.159LeuCys: 1.159 ± 0.03	7.279LeuAsp: 7.279 ± 0.087	8.139LeuGlu: 8.139 ± 0.093	3.924LeuPhe: 3.924 ± 0.067	10.04LeuGly: 10.04 ± 0.108	2.57LeuHis: 2.57 ± 0.05	5.108LeuIle: 5.108 ± 0.075	2.814LeuLys: 2.814 ± 0.047	12.836LeuLeu: 12.836 ± 0.178	2.774LeuMet: 2.774 ± 0.047	2.469LeuAsn: 2.469 ± 0.037	6.521LeuPro: 6.521 ± 0.075	3.206LeuGln: 3.206 ± 0.051	7.461LeuArg: 7.461 ± 0.08	6.208LeuSer: 6.208 ± 0.079	5.846LeuThr: 5.846 ± 0.074	8.861LeuVal: 8.861 ± 0.099	1.526LeuTrp: 1.526 ± 0.039	2.432LeuTyr: 2.432 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.169MetAla: 3.169 ± 0.05	0.144MetCys: 0.144 ± 0.009	1.057MetAsp: 1.057 ± 0.031	1.202MetGlu: 1.202 ± 0.031	0.657MetPhe: 0.657 ± 0.023	1.859MetGly: 1.859 ± 0.043	0.537MetHis: 0.537 ± 0.019	1.142MetIle: 1.142 ± 0.031	0.76MetLys: 0.76 ± 0.023	2.737MetLeu: 2.737 ± 0.051	0.613MetMet: 0.613 ± 0.025	0.727MetAsn: 0.727 ± 0.023	1.398MetPro: 1.398 ± 0.031	0.897MetGln: 0.897 ± 0.024	1.631MetArg: 1.631 ± 0.036	1.642MetSer: 1.642 ± 0.032	1.674MetThr: 1.674 ± 0.034	1.709MetVal: 1.709 ± 0.033	0.198MetTrp: 0.198 ± 0.011	0.323MetTyr: 0.323 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.607AsnAla: 2.607 ± 0.039	0.204AsnCys: 0.204 ± 0.013	1.266AsnAsp: 1.266 ± 0.033	1.176AsnGlu: 1.176 ± 0.029	0.759AsnPhe: 0.759 ± 0.023	1.937AsnGly: 1.937 ± 0.042	0.546AsnHis: 0.546 ± 0.019	1.096AsnIle: 1.096 ± 0.034	0.48AsnLys: 0.48 ± 0.02	2.589AsnLeu: 2.589 ± 0.046	0.487AsnMet: 0.487 ± 0.021	0.579AsnAsn: 0.579 ± 0.022	1.528AsnPro: 1.528 ± 0.036	0.777AsnGln: 0.777 ± 0.023	1.801AsnArg: 1.801 ± 0.038	0.944AsnSer: 0.944 ± 0.029	1.077AsnThr: 1.077 ± 0.035	1.643AsnVal: 1.643 ± 0.038	0.306AsnTrp: 0.306 ± 0.015	0.567AsnTyr: 0.567 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.864ProAla: 5.864 ± 0.077	0.372ProCys: 0.372 ± 0.017	3.392ProAsp: 3.392 ± 0.054	4.186ProGlu: 4.186 ± 0.053	1.822ProPhe: 1.822 ± 0.037	4.911ProGly: 4.911 ± 0.065	1.232ProHis: 1.232 ± 0.033	1.962ProIle: 1.962 ± 0.039	0.922ProLys: 0.922 ± 0.029	6.078ProLeu: 6.078 ± 0.071	1.283ProMet: 1.283 ± 0.032	1.024ProAsn: 1.024 ± 0.028	2.657ProPro: 2.657 ± 0.055	1.503ProGln: 1.503 ± 0.037	3.641ProArg: 3.641 ± 0.048	2.574ProSer: 2.574 ± 0.046	2.211ProThr: 2.211 ± 0.037	4.052ProVal: 4.052 ± 0.052	0.906ProTrp: 0.906 ± 0.025	1.08ProTyr: 1.08 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.023GlnAla: 5.023 ± 0.071	0.269GlnCys: 0.269 ± 0.014	1.499GlnAsp: 1.499 ± 0.036	1.926GlnGlu: 1.926 ± 0.042	0.955GlnPhe: 0.955 ± 0.029	3.102GlnGly: 3.102 ± 0.045	0.852GlnHis: 0.852 ± 0.023	1.27GlnIle: 1.27 ± 0.029	0.737GlnLys: 0.737 ± 0.026	3.793GlnLeu: 3.793 ± 0.063	0.743GlnMet: 0.743 ± 0.024	0.641GlnAsn: 0.641 ± 0.027	1.733GlnPro: 1.733 ± 0.035	1.685GlnGln: 1.685 ± 0.041	3.245GlnArg: 3.245 ± 0.051	1.492GlnSer: 1.492 ± 0.03	1.395GlnThr: 1.395 ± 0.032	2.676GlnVal: 2.676 ± 0.046	0.524GlnTrp: 0.524 ± 0.02	0.627GlnTyr: 0.627 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.318ArgAla: 7.318 ± 0.081	0.694ArgCys: 0.694 ± 0.02	4.573ArgAsp: 4.573 ± 0.073	5.804ArgGlu: 5.804 ± 0.077	3.025ArgPhe: 3.025 ± 0.044	5.376ArgGly: 5.376 ± 0.078	2.706ArgHis: 2.706 ± 0.042	3.466ArgIle: 3.466 ± 0.052	1.572ArgLys: 1.572 ± 0.04	11.384ArgLeu: 11.384 ± 0.124	1.769ArgMet: 1.769 ± 0.038	1.565ArgAsn: 1.565 ± 0.035	3.57ArgPro: 3.57 ± 0.05	3.368ArgGln: 3.368 ± 0.055	7.078ArgArg: 7.078 ± 0.099	3.247ArgSer: 3.247 ± 0.045	3.0ArgThr: 3.0 ± 0.053	5.604ArgVal: 5.604 ± 0.076	1.228ArgTrp: 1.228 ± 0.036	2.126ArgTyr: 2.126 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.138SerAla: 5.138 ± 0.066	0.41SerCys: 0.41 ± 0.017	2.623SerAsp: 2.623 ± 0.049	2.803SerGlu: 2.803 ± 0.047	1.795SerPhe: 1.795 ± 0.039	4.821SerGly: 4.821 ± 0.057	1.262SerHis: 1.262 ± 0.03	2.185SerIle: 2.185 ± 0.046	0.975SerLys: 0.975 ± 0.029	6.378SerLeu: 6.378 ± 0.068	1.215SerMet: 1.215 ± 0.029	1.116SerAsn: 1.116 ± 0.031	2.998SerPro: 2.998 ± 0.05	1.638SerGln: 1.638 ± 0.031	4.399SerArg: 4.399 ± 0.058	2.599SerSer: 2.599 ± 0.046	2.34SerThr: 2.34 ± 0.041	3.532SerVal: 3.532 ± 0.051	0.712SerTrp: 0.712 ± 0.022	1.096SerTyr: 1.096 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.177ThrAla: 5.177 ± 0.064	0.414ThrCys: 0.414 ± 0.019	2.347ThrAsp: 2.347 ± 0.041	2.466ThrGlu: 2.466 ± 0.042	1.748ThrPhe: 1.748 ± 0.04	4.406ThrGly: 4.406 ± 0.065	1.119ThrHis: 1.119 ± 0.031	2.057ThrIle: 2.057 ± 0.039	0.779ThrLys: 0.779 ± 0.023	6.986ThrLeu: 6.986 ± 0.086	0.95ThrMet: 0.95 ± 0.03	1.014ThrAsn: 1.014 ± 0.028	3.459ThrPro: 3.459 ± 0.048	1.386ThrGln: 1.386 ± 0.036	3.87ThrArg: 3.87 ± 0.053	2.391ThrSer: 2.391 ± 0.04	2.542ThrThr: 2.542 ± 0.05	3.321ThrVal: 3.321 ± 0.052	0.714ThrTrp: 0.714 ± 0.022	0.975ThrTyr: 0.975 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.899ValAla: 8.899 ± 0.093	0.687ValCys: 0.687 ± 0.024	4.197ValAsp: 4.197 ± 0.063	5.108ValGlu: 5.108 ± 0.063	2.548ValPhe: 2.548 ± 0.048	5.683ValGly: 5.683 ± 0.064	1.543ValHis: 1.543 ± 0.032	3.884ValIle: 3.884 ± 0.054	1.838ValLys: 1.838 ± 0.042	7.967ValLeu: 7.967 ± 0.086	1.987ValMet: 1.987 ± 0.04	1.82ValAsn: 1.82 ± 0.039	3.674ValPro: 3.674 ± 0.054	2.089ValGln: 2.089 ± 0.039	4.764ValArg: 4.764 ± 0.062	3.993ValSer: 3.993 ± 0.062	4.151ValThr: 4.151 ± 0.057	6.139ValVal: 6.139 ± 0.082	0.881ValTrp: 0.881 ± 0.025	1.48ValTyr: 1.48 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.282TrpAla: 1.282 ± 0.031	0.18TrpCys: 0.18 ± 0.012	0.563TrpAsp: 0.563 ± 0.023	0.731TrpGlu: 0.731 ± 0.023	0.496TrpPhe: 0.496 ± 0.023	0.958TrpGly: 0.958 ± 0.023	0.484TrpHis: 0.484 ± 0.02	0.641TrpIle: 0.641 ± 0.022	0.364TrpLys: 0.364 ± 0.018	2.483TrpLeu: 2.483 ± 0.049	0.382TrpMet: 0.382 ± 0.015	0.354TrpAsn: 0.354 ± 0.018	0.788TrpPro: 0.788 ± 0.025	0.925TrpGln: 0.925 ± 0.029	1.359TrpArg: 1.359 ± 0.032	0.753TrpSer: 0.753 ± 0.025	0.629TrpThr: 0.629 ± 0.021	0.984TrpVal: 0.984 ± 0.029	0.32TrpTrp: 0.32 ± 0.015	0.342TrpTyr: 0.342 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.334TyrAla: 2.334 ± 0.045	0.241TyrCys: 0.241 ± 0.013	1.247TyrAsp: 1.247 ± 0.029	1.103TyrGlu: 1.103 ± 0.034	0.882TyrPhe: 0.882 ± 0.027	1.934TyrGly: 1.934 ± 0.04	0.685TyrHis: 0.685 ± 0.023	0.815TyrIle: 0.815 ± 0.023	0.439TyrLys: 0.439 ± 0.02	2.884TyrLeu: 2.884 ± 0.047	0.429TyrMet: 0.429 ± 0.016	0.53TyrAsn: 0.53 ± 0.021	1.238TyrPro: 1.238 ± 0.03	0.919TyrGln: 0.919 ± 0.025	2.275TyrArg: 2.275 ± 0.04	1.103TyrSer: 1.103 ± 0.028	1.036TyrThr: 1.036 ± 0.03	1.54TyrVal: 1.54 ± 0.036	0.373TyrTrp: 0.373 ± 0.02	0.663TyrTyr: 0.663 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4329 proteins (1413880 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---