Amino acid dipepetide frequency for Trypanosoma cruzi marinkellei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.906AlaAla: 9.906 ± 0.074	1.668AlaCys: 1.668 ± 0.021	3.423AlaAsp: 3.423 ± 0.026	5.643AlaGlu: 5.643 ± 0.045	3.0AlaPhe: 3.0 ± 0.026	5.065AlaGly: 5.065 ± 0.042	1.779AlaHis: 1.779 ± 0.021	3.18AlaIle: 3.18 ± 0.027	3.317AlaLys: 3.317 ± 0.032	8.757AlaLeu: 8.757 ± 0.057	2.344AlaMet: 2.344 ± 0.022	2.504AlaAsn: 2.504 ± 0.023	3.727AlaPro: 3.727 ± 0.032	2.813AlaGln: 2.813 ± 0.03	4.671AlaArg: 4.671 ± 0.04	6.904AlaSer: 6.904 ± 0.043	5.176AlaThr: 5.176 ± 0.035	7.189AlaVal: 7.189 ± 0.044	0.894AlaTrp: 0.894 ± 0.013	1.764AlaTyr: 1.764 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.742CysAla: 1.742 ± 0.02	0.654CysCys: 0.654 ± 0.012	1.059CysAsp: 1.059 ± 0.016	1.105CysGlu: 1.105 ± 0.017	1.005CysPhe: 1.005 ± 0.016	1.808CysGly: 1.808 ± 0.023	0.496CysHis: 0.496 ± 0.01	0.905CysIle: 0.905 ± 0.014	0.659CysLys: 0.659 ± 0.013	1.838CysLeu: 1.838 ± 0.019	0.485CysMet: 0.485 ± 0.011	0.732CysAsn: 0.732 ± 0.013	0.868CysPro: 0.868 ± 0.014	0.535CysGln: 0.535 ± 0.01	1.407CysArg: 1.407 ± 0.017	1.592CysSer: 1.592 ± 0.02	1.175CysThr: 1.175 ± 0.018	2.082CysVal: 2.082 ± 0.026	0.225CysTrp: 0.225 ± 0.007	0.541CysTyr: 0.541 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.146AspAla: 5.146 ± 0.035	0.853AspCys: 0.853 ± 0.013	3.574AspAsp: 3.574 ± 0.039	4.003AspGlu: 4.003 ± 0.033	1.619AspPhe: 1.619 ± 0.022	4.593AspGly: 4.593 ± 0.037	0.867AspHis: 0.867 ± 0.013	2.117AspIle: 2.117 ± 0.02	1.772AspLys: 1.772 ± 0.02	3.493AspLeu: 3.493 ± 0.037	1.145AspMet: 1.145 ± 0.015	1.767AspAsn: 1.767 ± 0.021	2.235AspPro: 2.235 ± 0.024	0.975AspGln: 0.975 ± 0.013	2.382AspArg: 2.382 ± 0.028	3.189AspSer: 3.189 ± 0.026	2.677AspThr: 2.677 ± 0.025	4.474AspVal: 4.474 ± 0.029	0.518AspTrp: 0.518 ± 0.011	1.1AspTyr: 1.1 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.919GluAla: 5.919 ± 0.045	1.074GluCys: 1.074 ± 0.018	3.661GluAsp: 3.661 ± 0.031	8.131GluGlu: 8.131 ± 0.081	1.937GluPhe: 1.937 ± 0.022	4.745GluGly: 4.745 ± 0.038	1.369GluHis: 1.369 ± 0.018	2.385GluIle: 2.385 ± 0.024	4.623GluLys: 4.623 ± 0.039	6.307GluLeu: 6.307 ± 0.05	1.936GluMet: 1.936 ± 0.02	2.843GluAsn: 2.843 ± 0.028	2.131GluPro: 2.131 ± 0.022	2.549GluGln: 2.549 ± 0.03	5.186GluArg: 5.186 ± 0.049	4.342GluSer: 4.342 ± 0.035	3.536GluThr: 3.536 ± 0.03	4.616GluVal: 4.616 ± 0.036	0.866GluTrp: 0.866 ± 0.014	1.615GluTyr: 1.615 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.968PheAla: 2.968 ± 0.026	0.97PheCys: 0.97 ± 0.014	1.897PheAsp: 1.897 ± 0.022	1.771PheGlu: 1.771 ± 0.02	2.479PhePhe: 2.479 ± 0.036	2.282PheGly: 2.282 ± 0.025	0.975PheHis: 0.975 ± 0.014	1.692PheIle: 1.692 ± 0.023	1.011PheLys: 1.011 ± 0.016	4.364PheLeu: 4.364 ± 0.036	0.848PheMet: 0.848 ± 0.015	1.107PheAsn: 1.107 ± 0.017	1.916PhePro: 1.916 ± 0.022	1.128PheGln: 1.128 ± 0.016	2.099PheArg: 2.099 ± 0.024	3.475PheSer: 3.475 ± 0.031	2.123PheThr: 2.123 ± 0.022	3.032PheVal: 3.032 ± 0.025	0.411PheTrp: 0.411 ± 0.011	1.195PheTyr: 1.195 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.427GlyAla: 5.427 ± 0.039	1.511GlyCys: 1.511 ± 0.019	3.819GlyAsp: 3.819 ± 0.026	4.539GlyGlu: 4.539 ± 0.031	2.25GlyPhe: 2.25 ± 0.026	6.982GlyGly: 6.982 ± 0.072	1.365GlyHis: 1.365 ± 0.019	2.788GlyIle: 2.788 ± 0.026	3.285GlyLys: 3.285 ± 0.029	4.741GlyLeu: 4.741 ± 0.032	1.646GlyMet: 1.646 ± 0.02	3.157GlyAsn: 3.157 ± 0.032	2.296GlyPro: 2.296 ± 0.028	1.675GlyGln: 1.675 ± 0.022	4.138GlyArg: 4.138 ± 0.037	5.674GlySer: 5.674 ± 0.042	4.096GlyThr: 4.096 ± 0.034	5.735GlyVal: 5.735 ± 0.042	0.734GlyTrp: 0.734 ± 0.013	1.499GlyTyr: 1.499 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.146HisAla: 2.146 ± 0.024	0.613HisCys: 0.613 ± 0.012	1.2HisAsp: 1.2 ± 0.018	1.565HisGlu: 1.565 ± 0.018	1.071HisPhe: 1.071 ± 0.015	1.75HisGly: 1.75 ± 0.019	0.909HisHis: 0.909 ± 0.016	1.054HisIle: 1.054 ± 0.016	0.795HisLys: 0.795 ± 0.013	2.353HisLeu: 2.353 ± 0.023	0.575HisMet: 0.575 ± 0.011	0.886HisAsn: 0.886 ± 0.014	1.353HisPro: 1.353 ± 0.017	0.885HisGln: 0.885 ± 0.014	1.798HisArg: 1.798 ± 0.019	1.917HisSer: 1.917 ± 0.019	1.432HisThr: 1.432 ± 0.017	2.086HisVal: 2.086 ± 0.024	0.319HisTrp: 0.319 ± 0.008	0.69HisTyr: 0.69 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.316IleAla: 3.316 ± 0.026	0.786IleCys: 0.786 ± 0.013	1.928IleAsp: 1.928 ± 0.023	2.258IleGlu: 2.258 ± 0.025	1.605IlePhe: 1.605 ± 0.021	2.414IleGly: 2.414 ± 0.027	1.109IleHis: 1.109 ± 0.014	1.829IleIle: 1.829 ± 0.021	1.41IleLys: 1.41 ± 0.018	3.675IleLeu: 3.675 ± 0.033	0.852IleMet: 0.852 ± 0.014	1.333IleAsn: 1.333 ± 0.016	2.251IlePro: 2.251 ± 0.024	1.403IleGln: 1.403 ± 0.019	2.441IleArg: 2.441 ± 0.026	3.125IleSer: 3.125 ± 0.026	2.384IleThr: 2.384 ± 0.025	3.064IleVal: 3.064 ± 0.027	0.35IleTrp: 0.35 ± 0.009	1.122IleTyr: 1.122 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.121LysAla: 3.121 ± 0.031	0.692LysCys: 0.692 ± 0.014	2.346LysAsp: 2.346 ± 0.027	4.133LysGlu: 4.133 ± 0.031	1.095LysPhe: 1.095 ± 0.015	3.007LysGly: 3.007 ± 0.026	0.997LysHis: 0.997 ± 0.015	1.576LysIle: 1.576 ± 0.019	3.618LysLys: 3.618 ± 0.04	3.673LysLeu: 3.673 ± 0.031	1.147LysMet: 1.147 ± 0.017	1.951LysAsn: 1.951 ± 0.024	1.693LysPro: 1.693 ± 0.018	1.748LysGln: 1.748 ± 0.022	3.418LysArg: 3.418 ± 0.032	2.866LysSer: 2.866 ± 0.025	2.525LysThr: 2.525 ± 0.023	2.438LysVal: 2.438 ± 0.024	0.558LysTrp: 0.558 ± 0.012	1.121LysTyr: 1.121 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	6.781LeuAla: 6.781 ± 0.044	2.341LeuCys: 2.341 ± 0.024	3.961LeuAsp: 3.961 ± 0.032	6.055LeuGlu: 6.055 ± 0.052	4.011LeuPhe: 4.011 ± 0.037	4.9LeuGly: 4.9 ± 0.036	2.892LeuHis: 2.892 ± 0.032	3.223LeuIle: 3.223 ± 0.03	3.711LeuLys: 3.711 ± 0.036	12.036LeuLeu: 12.036 ± 0.085	2.329LeuMet: 2.329 ± 0.02	3.032LeuAsn: 3.032 ± 0.029	5.357LeuPro: 5.357 ± 0.035	4.842LeuGln: 4.842 ± 0.044	7.919LeuArg: 7.919 ± 0.049	8.064LeuSer: 8.064 ± 0.04	5.162LeuThr: 5.162 ± 0.037	6.361LeuVal: 6.361 ± 0.047	1.314LeuTrp: 1.314 ± 0.015	2.694LeuTyr: 2.694 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.934MetAla: 1.934 ± 0.021	0.495MetCys: 0.495 ± 0.009	1.343MetAsp: 1.343 ± 0.017	1.982MetGlu: 1.982 ± 0.021	0.731MetPhe: 0.731 ± 0.013	1.422MetGly: 1.422 ± 0.018	0.727MetHis: 0.727 ± 0.013	0.803MetIle: 0.803 ± 0.012	1.169MetLys: 1.169 ± 0.017	2.41MetLeu: 2.41 ± 0.022	0.93MetMet: 0.93 ± 0.015	1.016MetAsn: 1.016 ± 0.014	1.235MetPro: 1.235 ± 0.018	1.152MetGln: 1.152 ± 0.018	1.993MetArg: 1.993 ± 0.021	1.848MetSer: 1.848 ± 0.019	1.494MetThr: 1.494 ± 0.017	1.407MetVal: 1.407 ± 0.019	0.313MetTrp: 0.313 ± 0.008	0.647MetTyr: 0.647 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.255AsnAla: 3.255 ± 0.03	0.725AsnCys: 0.725 ± 0.012	2.16AsnAsp: 2.16 ± 0.021	2.595AsnGlu: 2.595 ± 0.023	1.257AsnPhe: 1.257 ± 0.017	2.933AsnGly: 2.933 ± 0.028	0.726AsnHis: 0.726 ± 0.012	1.599AsnIle: 1.599 ± 0.021	1.708AsnLys: 1.708 ± 0.02	2.513AsnLeu: 2.513 ± 0.025	0.91AsnMet: 0.91 ± 0.014	2.062AsnAsn: 2.062 ± 0.035	1.624AsnPro: 1.624 ± 0.016	0.947AsnGln: 0.947 ± 0.014	2.038AsnArg: 2.038 ± 0.021	2.91AsnSer: 2.91 ± 0.029	2.415AsnThr: 2.415 ± 0.025	2.816AsnVal: 2.816 ± 0.026	0.38AsnTrp: 0.38 ± 0.009	0.93AsnTyr: 0.93 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	3.558ProAla: 3.558 ± 0.03	0.862ProCys: 0.862 ± 0.013	1.769ProAsp: 1.769 ± 0.02	2.727ProGlu: 2.727 ± 0.027	2.029ProPhe: 2.029 ± 0.021	2.365ProGly: 2.365 ± 0.03	1.431ProHis: 1.431 ± 0.021	1.737ProIle: 1.737 ± 0.017	1.805ProLys: 1.805 ± 0.021	5.137ProLeu: 5.137 ± 0.04	1.032ProMet: 1.032 ± 0.014	1.574ProAsn: 1.574 ± 0.018	4.209ProPro: 4.209 ± 0.055	2.061ProGln: 2.061 ± 0.024	2.982ProArg: 2.982 ± 0.029	4.737ProSer: 4.737 ± 0.038	3.127ProThr: 3.127 ± 0.03	3.576ProVal: 3.576 ± 0.03	0.544ProTrp: 0.544 ± 0.011	1.112ProTyr: 1.112 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	2.324GlnAla: 2.324 ± 0.026	0.704GlnCys: 0.704 ± 0.014	1.228GlnAsp: 1.228 ± 0.017	2.863GlnGlu: 2.863 ± 0.032	1.135GlnPhe: 1.135 ± 0.017	1.895GlnGly: 1.895 ± 0.022	1.219GlnHis: 1.219 ± 0.016	1.253GlnIle: 1.253 ± 0.016	2.039GlnLys: 2.039 ± 0.026	4.15GlnLeu: 4.15 ± 0.037	0.931GlnMet: 0.931 ± 0.015	1.302GlnAsn: 1.302 ± 0.016	1.672GlnPro: 1.672 ± 0.022	3.217GlnGln: 3.217 ± 0.053	3.671GlnArg: 3.671 ± 0.033	2.459GlnSer: 2.459 ± 0.021	1.833GlnThr: 1.833 ± 0.023	1.918GlnVal: 1.918 ± 0.019	0.528GlnTrp: 0.528 ± 0.011	0.936GlnTyr: 0.936 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.825ArgAla: 4.825 ± 0.04	1.616ArgCys: 1.616 ± 0.021	3.333ArgAsp: 3.333 ± 0.03	5.179ArgGlu: 5.179 ± 0.045	2.359ArgPhe: 2.359 ± 0.021	4.427ArgGly: 4.427 ± 0.036	2.207ArgHis: 2.207 ± 0.022	2.748ArgIle: 2.748 ± 0.026	3.022ArgLys: 3.022 ± 0.029	6.572ArgLeu: 6.572 ± 0.042	1.714ArgMet: 1.714 ± 0.02	2.448ArgAsn: 2.448 ± 0.024	2.785ArgPro: 2.785 ± 0.027	3.038ArgGln: 3.038 ± 0.031	6.784ArgArg: 6.784 ± 0.061	4.751ArgSer: 4.751 ± 0.037	3.185ArgThr: 3.185 ± 0.024	5.134ArgVal: 5.134 ± 0.032	0.937ArgTrp: 0.937 ± 0.013	1.76ArgTyr: 1.76 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.332SerAla: 6.332 ± 0.04	1.666SerCys: 1.666 ± 0.019	3.557SerAsp: 3.557 ± 0.028	4.077SerGlu: 4.077 ± 0.032	3.226SerPhe: 3.226 ± 0.029	5.894SerGly: 5.894 ± 0.043	2.056SerHis: 2.056 ± 0.021	3.179SerIle: 3.179 ± 0.032	2.812SerLys: 2.812 ± 0.026	7.979SerLeu: 7.979 ± 0.044	1.862SerMet: 1.862 ± 0.021	2.711SerAsn: 2.711 ± 0.025	4.373SerPro: 4.373 ± 0.036	2.644SerGln: 2.644 ± 0.024	4.936SerArg: 4.936 ± 0.036	8.624SerSer: 8.624 ± 0.066	5.038SerThr: 5.038 ± 0.041	6.228SerVal: 6.228 ± 0.042	1.013SerTrp: 1.013 ± 0.016	1.669SerTyr: 1.669 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.583ThrAla: 5.583 ± 0.04	0.989ThrCys: 0.989 ± 0.014	2.538ThrAsp: 2.538 ± 0.024	3.726ThrGlu: 3.726 ± 0.028	2.094ThrPhe: 2.094 ± 0.022	3.641ThrGly: 3.641 ± 0.031	1.521ThrHis: 1.521 ± 0.018	2.308ThrIle: 2.308 ± 0.024	2.288ThrLys: 2.288 ± 0.026	5.713ThrLeu: 5.713 ± 0.036	1.297ThrMet: 1.297 ± 0.016	2.089ThrAsn: 2.089 ± 0.024	3.422ThrPro: 3.422 ± 0.032	1.971ThrGln: 1.971 ± 0.022	3.356ThrArg: 3.356 ± 0.029	4.694ThrSer: 4.694 ± 0.039	4.466ThrThr: 4.466 ± 0.051	4.828ThrVal: 4.828 ± 0.038	0.727ThrTrp: 0.727 ± 0.013	1.132ThrTyr: 1.132 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	6.658ValAla: 6.658 ± 0.048	1.78ValCys: 1.78 ± 0.022	3.859ValAsp: 3.859 ± 0.027	5.062ValGlu: 5.062 ± 0.035	3.247ValPhe: 3.247 ± 0.029	4.78ValGly: 4.78 ± 0.039	1.774ValHis: 1.774 ± 0.02	2.659ValIle: 2.659 ± 0.03	3.038ValLys: 3.038 ± 0.028	7.895ValLeu: 7.895 ± 0.056	1.944ValMet: 1.944 ± 0.018	2.466ValAsn: 2.466 ± 0.024	3.781ValPro: 3.781 ± 0.031	2.476ValGln: 2.476 ± 0.026	4.779ValArg: 4.779 ± 0.034	6.093ValSer: 6.093 ± 0.038	4.557ValThr: 4.557 ± 0.035	6.583ValVal: 6.583 ± 0.047	0.901ValTrp: 0.901 ± 0.015	1.928ValTyr: 1.928 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.772TrpAla: 0.772 ± 0.013	0.367TrpCys: 0.367 ± 0.008	0.55TrpAsp: 0.55 ± 0.011	0.805TrpGlu: 0.805 ± 0.014	0.367TrpPhe: 0.367 ± 0.009	0.769TrpGly: 0.769 ± 0.013	0.323TrpHis: 0.323 ± 0.008	0.462TrpIle: 0.462 ± 0.01	0.753TrpLys: 0.753 ± 0.015	1.147TrpLeu: 1.147 ± 0.015	0.408TrpMet: 0.408 ± 0.009	0.506TrpAsn: 0.506 ± 0.011	0.423TrpPro: 0.423 ± 0.009	0.457TrpGln: 0.457 ± 0.01	1.166TrpArg: 1.166 ± 0.015	0.903TrpSer: 0.903 ± 0.013	0.665TrpThr: 0.665 ± 0.013	0.732TrpVal: 0.732 ± 0.013	0.225TrpTrp: 0.225 ± 0.008	0.305TrpTyr: 0.305 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.009TyrAla: 2.009 ± 0.024	0.546TyrCys: 0.546 ± 0.011	1.295TyrAsp: 1.295 ± 0.016	1.551TyrGlu: 1.551 ± 0.018	1.227TyrPhe: 1.227 ± 0.019	1.683TyrGly: 1.683 ± 0.02	0.654TyrHis: 0.654 ± 0.012	1.158TyrIle: 1.158 ± 0.016	0.888TyrLys: 0.888 ± 0.012	2.234TyrLeu: 2.234 ± 0.022	0.716TyrMet: 0.716 ± 0.013	1.018TyrAsn: 1.018 ± 0.017	1.023TyrPro: 1.023 ± 0.016	0.76TyrGln: 0.76 ± 0.013	1.659TyrArg: 1.659 ± 0.019	1.71TyrSer: 1.71 ± 0.022	1.32TyrThr: 1.32 ± 0.015	1.961TyrVal: 1.961 ± 0.023	0.348TyrTrp: 0.348 ± 0.01	0.818TyrTyr: 0.818 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10052 proteins (4945837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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