Amino acid dipepetide frequency for Marine RNA virus PAL438

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.313AlaAla: 2.313 ± 0.377
1.85AlaCys: 1.85 ± 2.444
3.238AlaAsp: 3.238 ± 0.871
3.238AlaGlu: 3.238 ± 0.871
3.238AlaPhe: 3.238 ± 0.871
5.088AlaGly: 5.088 ± 1.002
1.85AlaHis: 1.85 ± 0.988
2.775AlaIle: 2.775 ± 0.234
4.625AlaLys: 4.625 ± 0.755
5.088AlaLeu: 5.088 ± 1.002
2.775AlaMet: 2.775 ± 0.624
1.85AlaAsn: 1.85 ± 0.13
2.775AlaPro: 2.775 ± 0.234
2.313AlaGln: 2.313 ± 0.481
2.775AlaArg: 2.775 ± 0.624
4.625AlaSer: 4.625 ± 0.755
2.775AlaThr: 2.775 ± 0.234
1.388AlaVal: 1.388 ± 0.117
0.463AlaTrp: 0.463 ± 0.247
2.313AlaTyr: 2.313 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.463CysAla: 0.463 ± 0.247
0.463CysCys: 0.463 ± 0.611
0.463CysAsp: 0.463 ± 0.247
0.925CysGlu: 0.925 ± 0.364
2.313CysPhe: 2.313 ± 1.339
2.775CysGly: 2.775 ± 0.624
0.463CysHis: 0.463 ± 0.611
1.85CysIle: 1.85 ± 1.586
0.0CysLys: 0.0 ± 0.0
0.463CysLeu: 0.463 ± 0.247
1.388CysMet: 1.388 ± 0.312
0.463CysAsn: 0.463 ± 0.247
1.388CysPro: 1.388 ± 0.117
1.388CysGln: 1.388 ± 0.741
0.463CysArg: 0.463 ± 0.611
1.85CysSer: 1.85 ± 0.728
2.313CysThr: 2.313 ± 0.481
0.925CysVal: 0.925 ± 1.222
0.0CysTrp: 0.0 ± 0.0
0.925CysTyr: 0.925 ± 0.364
0.0CysXaa: 0.0 ± 0.0
Asp
2.775AspAla: 2.775 ± 0.624
1.388AspCys: 1.388 ± 0.117
4.625AspAsp: 4.625 ± 0.104
6.013AspGlu: 6.013 ± 0.22
3.7AspPhe: 3.7 ± 1.456
2.313AspGly: 2.313 ± 0.377
1.388AspHis: 1.388 ± 0.117
4.163AspIle: 4.163 ± 1.366
3.7AspLys: 3.7 ± 1.456
6.013AspLeu: 6.013 ± 0.22
1.388AspMet: 1.388 ± 0.117
1.85AspAsn: 1.85 ± 0.13
0.925AspPro: 0.925 ± 0.364
2.775AspGln: 2.775 ± 0.624
3.238AspArg: 3.238 ± 0.013
3.7AspSer: 3.7 ± 0.26
3.238AspThr: 3.238 ± 0.013
5.088AspVal: 5.088 ± 0.715
0.463AspTrp: 0.463 ± 0.247
3.7AspTyr: 3.7 ± 0.26
0.0AspXaa: 0.0 ± 0.0
Glu
2.313GluAla: 2.313 ± 0.377
1.85GluCys: 1.85 ± 0.13
3.7GluAsp: 3.7 ± 0.26
6.475GluGlu: 6.475 ± 3.459
5.55GluPhe: 5.55 ± 0.391
4.163GluGly: 4.163 ± 0.507
1.85GluHis: 1.85 ± 0.728
4.163GluIle: 4.163 ± 1.366
4.163GluLys: 4.163 ± 1.366
3.238GluLeu: 3.238 ± 0.013
1.388GluMet: 1.388 ± 0.117
3.238GluAsn: 3.238 ± 0.013
3.7GluPro: 3.7 ± 0.26
2.775GluGln: 2.775 ± 1.092
3.238GluArg: 3.238 ± 0.871
4.625GluSer: 4.625 ± 0.755
4.163GluThr: 4.163 ± 0.351
2.313GluVal: 2.313 ± 0.481
0.925GluTrp: 0.925 ± 0.364
1.85GluTyr: 1.85 ± 1.586
0.0GluXaa: 0.0 ± 0.0
Phe
4.163PheAla: 4.163 ± 0.351
2.313PheCys: 2.313 ± 1.339
5.55PheAsp: 5.55 ± 0.391
2.313PheGlu: 2.313 ± 1.235
1.85PhePhe: 1.85 ± 0.13
4.163PheGly: 4.163 ± 1.366
1.85PheHis: 1.85 ± 1.586
2.313PheIle: 2.313 ± 1.339
2.775PheLys: 2.775 ± 0.624
4.163PheLeu: 4.163 ± 1.209
0.463PheMet: 0.463 ± 0.247
0.925PheAsn: 0.925 ± 0.364
3.238PhePro: 3.238 ± 0.013
2.313PheGln: 2.313 ± 0.481
2.775PheArg: 2.775 ± 0.624
5.55PheSer: 5.55 ± 0.468
3.238PheThr: 3.238 ± 1.729
4.163PheVal: 4.163 ± 0.507
0.0PheTrp: 0.0 ± 0.0
4.163PheTyr: 4.163 ± 2.224
0.0PheXaa: 0.0 ± 0.0
Gly
4.163GlyAla: 4.163 ± 0.351
1.388GlyCys: 1.388 ± 0.741
3.7GlyAsp: 3.7 ± 0.26
6.013GlyGlu: 6.013 ± 1.496
5.088GlyPhe: 5.088 ± 1.002
2.313GlyGly: 2.313 ± 0.377
0.0GlyHis: 0.0 ± 0.0
2.775GlyIle: 2.775 ± 0.624
2.313GlyLys: 2.313 ± 0.481
3.238GlyLeu: 3.238 ± 0.871
0.925GlyMet: 0.925 ± 0.494
2.313GlyAsn: 2.313 ± 0.377
0.463GlyPro: 0.463 ± 0.611
1.85GlyGln: 1.85 ± 0.13
2.775GlyArg: 2.775 ± 0.234
2.775GlySer: 2.775 ± 0.624
4.625GlyThr: 4.625 ± 1.613
4.163GlyVal: 4.163 ± 0.507
0.463GlyTrp: 0.463 ± 0.247
2.775GlyTyr: 2.775 ± 0.234
0.0GlyXaa: 0.0 ± 0.0
His
1.388HisAla: 1.388 ± 0.117
0.0HisCys: 0.0 ± 0.0
1.85HisAsp: 1.85 ± 0.13
0.463HisGlu: 0.463 ± 0.611
0.0HisPhe: 0.0 ± 0.0
0.463HisGly: 0.463 ± 0.247
1.388HisHis: 1.388 ± 0.741
1.388HisIle: 1.388 ± 0.975
2.313HisLys: 2.313 ± 1.339
1.85HisLeu: 1.85 ± 0.728
0.0HisMet: 0.0 ± 0.0
1.388HisAsn: 1.388 ± 0.117
1.85HisPro: 1.85 ± 0.13
0.925HisGln: 0.925 ± 0.494
1.388HisArg: 1.388 ± 0.975
0.463HisSer: 0.463 ± 0.247
2.775HisThr: 2.775 ± 1.092
1.85HisVal: 1.85 ± 0.988
0.463HisTrp: 0.463 ± 0.247
0.925HisTyr: 0.925 ± 0.494
0.0HisXaa: 0.0 ± 0.0
Ile
5.088IleAla: 5.088 ± 1.002
0.925IleCys: 0.925 ± 0.494
4.625IleAsp: 4.625 ± 1.82
5.088IleGlu: 5.088 ± 0.715
1.388IlePhe: 1.388 ± 0.117
3.7IleGly: 3.7 ± 1.977
0.925IleHis: 0.925 ± 0.364
4.163IleIle: 4.163 ± 2.067
4.625IleLys: 4.625 ± 0.104
4.625IleLeu: 4.625 ± 0.755
1.388IleMet: 1.388 ± 0.117
4.625IleAsn: 4.625 ± 0.104
2.313IlePro: 2.313 ± 1.235
0.463IleGln: 0.463 ± 0.247
3.7IleArg: 3.7 ± 2.314
3.238IleSer: 3.238 ± 1.703
3.7IleThr: 3.7 ± 0.598
5.088IleVal: 5.088 ± 0.715
0.0IleTrp: 0.0 ± 0.0
1.388IleTyr: 1.388 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
5.088LysAla: 5.088 ± 0.143
0.925LysCys: 0.925 ± 1.222
4.625LysAsp: 4.625 ± 0.755
4.163LysGlu: 4.163 ± 0.507
3.238LysPhe: 3.238 ± 0.871
4.163LysGly: 4.163 ± 0.507
1.85LysHis: 1.85 ± 0.13
3.7LysIle: 3.7 ± 0.26
5.088LysLys: 5.088 ± 1.002
3.7LysLeu: 3.7 ± 0.26
0.925LysMet: 0.925 ± 1.222
0.925LysAsn: 0.925 ± 0.364
3.238LysPro: 3.238 ± 0.013
0.925LysGln: 0.925 ± 0.494
2.313LysArg: 2.313 ± 0.377
6.475LysSer: 6.475 ± 0.885
4.625LysThr: 4.625 ± 0.755
4.625LysVal: 4.625 ± 0.104
0.463LysTrp: 0.463 ± 0.247
3.238LysTyr: 3.238 ± 0.845
0.0LysXaa: 0.0 ± 0.0
Leu
3.7LeuAla: 3.7 ± 0.26
0.925LeuCys: 0.925 ± 0.494
5.55LeuAsp: 5.55 ± 0.468
6.013LeuGlu: 6.013 ± 2.795
6.475LeuPhe: 6.475 ± 0.885
3.238LeuGly: 3.238 ± 0.013
2.313LeuHis: 2.313 ± 0.377
5.55LeuIle: 5.55 ± 0.468
6.938LeuLys: 6.938 ± 1.132
5.55LeuLeu: 5.55 ± 1.326
1.85LeuMet: 1.85 ± 0.13
4.163LeuAsn: 4.163 ± 1.209
3.238LeuPro: 3.238 ± 0.013
2.775LeuGln: 2.775 ± 0.234
5.088LeuArg: 5.088 ± 0.715
6.013LeuSer: 6.013 ± 1.079
6.475LeuThr: 6.475 ± 0.831
3.7LeuVal: 3.7 ± 1.118
1.85LeuTrp: 1.85 ± 0.988
0.925LeuTyr: 0.925 ± 0.494
0.0LeuXaa: 0.0 ± 0.0
Met
2.313MetAla: 2.313 ± 0.481
1.388MetCys: 1.388 ± 0.117
1.388MetAsp: 1.388 ± 0.117
0.925MetGlu: 0.925 ± 0.364
0.925MetPhe: 0.925 ± 0.364
0.463MetGly: 0.463 ± 0.611
0.463MetHis: 0.463 ± 0.247
0.925MetIle: 0.925 ± 0.494
1.388MetLys: 1.388 ± 0.741
0.925MetLeu: 0.925 ± 0.494
0.925MetMet: 0.925 ± 0.494
0.925MetAsn: 0.925 ± 0.364
0.463MetPro: 0.463 ± 0.247
0.463MetGln: 0.463 ± 0.611
1.85MetArg: 1.85 ± 0.728
2.775MetSer: 2.775 ± 0.624
1.388MetThr: 1.388 ± 0.741
1.85MetVal: 1.85 ± 0.988
0.463MetTrp: 0.463 ± 0.247
0.925MetTyr: 0.925 ± 0.494
0.0MetXaa: 0.0 ± 0.0
Asn
4.625AsnAla: 4.625 ± 1.613
0.925AsnCys: 0.925 ± 1.222
3.7AsnAsp: 3.7 ± 1.118
2.313AsnGlu: 2.313 ± 0.481
2.313AsnPhe: 2.313 ± 0.377
1.85AsnGly: 1.85 ± 0.988
0.0AsnHis: 0.0 ± 0.0
4.625AsnIle: 4.625 ± 1.82
1.85AsnLys: 1.85 ± 0.988
3.7AsnLeu: 3.7 ± 0.26
1.388AsnMet: 1.388 ± 0.741
2.313AsnAsn: 2.313 ± 0.481
2.775AsnPro: 2.775 ± 1.95
0.0AsnGln: 0.0 ± 0.0
0.925AsnArg: 0.925 ± 0.364
3.238AsnSer: 3.238 ± 2.561
1.388AsnThr: 1.388 ± 0.117
3.7AsnVal: 3.7 ± 0.26
0.0AsnTrp: 0.0 ± 0.0
1.85AsnTyr: 1.85 ± 0.13
0.0AsnXaa: 0.0 ± 0.0
Pro
1.388ProAla: 1.388 ± 0.117
0.0ProCys: 0.0 ± 0.0
2.775ProAsp: 2.775 ± 1.95
2.313ProGlu: 2.313 ± 0.377
2.775ProPhe: 2.775 ± 0.624
3.238ProGly: 3.238 ± 0.871
1.85ProHis: 1.85 ± 0.728
2.313ProIle: 2.313 ± 0.481
2.775ProLys: 2.775 ± 0.234
3.7ProLeu: 3.7 ± 0.598
0.925ProMet: 0.925 ± 0.494
4.163ProAsn: 4.163 ± 1.209
1.85ProPro: 1.85 ± 0.728
0.925ProGln: 0.925 ± 0.364
2.775ProArg: 2.775 ± 0.624
2.313ProSer: 2.313 ± 0.377
3.238ProThr: 3.238 ± 0.871
2.775ProVal: 2.775 ± 1.092
0.463ProTrp: 0.463 ± 0.611
2.313ProTyr: 2.313 ± 0.481
0.0ProXaa: 0.0 ± 0.0
Gln
2.775GlnAla: 2.775 ± 0.624
0.0GlnCys: 0.0 ± 0.0
1.85GlnAsp: 1.85 ± 0.988
2.775GlnGlu: 2.775 ± 0.234
2.775GlnPhe: 2.775 ± 1.482
0.925GlnGly: 0.925 ± 0.364
0.925GlnHis: 0.925 ± 0.364
2.313GlnIle: 2.313 ± 0.377
2.313GlnLys: 2.313 ± 0.481
2.775GlnLeu: 2.775 ± 1.092
0.0GlnMet: 0.0 ± 0.0
1.388GlnAsn: 1.388 ± 0.117
0.925GlnPro: 0.925 ± 0.364
1.85GlnGln: 1.85 ± 1.586
1.85GlnArg: 1.85 ± 0.728
0.463GlnSer: 0.463 ± 0.611
2.775GlnThr: 2.775 ± 0.234
2.775GlnVal: 2.775 ± 0.234
0.925GlnTrp: 0.925 ± 0.494
0.925GlnTyr: 0.925 ± 1.222
0.0GlnXaa: 0.0 ± 0.0
Arg
1.85ArgAla: 1.85 ± 0.988
2.313ArgCys: 2.313 ± 0.481
6.475ArgAsp: 6.475 ± 0.027
2.775ArgGlu: 2.775 ± 1.482
5.088ArgPhe: 5.088 ± 0.143
1.85ArgGly: 1.85 ± 0.728
0.925ArgHis: 0.925 ± 0.494
2.775ArgIle: 2.775 ± 0.234
3.238ArgLys: 3.238 ± 0.845
6.475ArgLeu: 6.475 ± 1.69
1.388ArgMet: 1.388 ± 0.741
0.925ArgAsn: 0.925 ± 0.494
1.85ArgPro: 1.85 ± 0.728
0.463ArgGln: 0.463 ± 0.611
4.163ArgArg: 4.163 ± 1.209
4.163ArgSer: 4.163 ± 0.351
3.238ArgThr: 3.238 ± 0.013
2.775ArgVal: 2.775 ± 0.234
0.0ArgTrp: 0.0 ± 0.0
1.85ArgTyr: 1.85 ± 0.13
0.0ArgXaa: 0.0 ± 0.0
Ser
3.7SerAla: 3.7 ± 0.26
1.85SerCys: 1.85 ± 0.988
1.85SerAsp: 1.85 ± 0.728
4.163SerGlu: 4.163 ± 0.351
5.088SerPhe: 5.088 ± 0.715
2.775SerGly: 2.775 ± 0.234
0.925SerHis: 0.925 ± 0.364
2.775SerIle: 2.775 ± 0.624
4.625SerLys: 4.625 ± 0.755
12.026SerLeu: 12.026 ± 2.157
1.85SerMet: 1.85 ± 0.13
4.163SerAsn: 4.163 ± 0.351
2.775SerPro: 2.775 ± 1.482
2.313SerGln: 2.313 ± 0.481
4.163SerArg: 4.163 ± 0.507
6.475SerSer: 6.475 ± 1.69
3.7SerThr: 3.7 ± 0.598
5.088SerVal: 5.088 ± 1.002
1.388SerTrp: 1.388 ± 0.741
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
0.925ThrAla: 0.925 ± 0.494
1.388ThrCys: 1.388 ± 0.975
1.388ThrAsp: 1.388 ± 1.833
4.163ThrGlu: 4.163 ± 1.366
2.313ThrPhe: 2.313 ± 0.377
2.775ThrGly: 2.775 ± 1.092
1.388ThrHis: 1.388 ± 0.741
3.7ThrIle: 3.7 ± 0.26
3.7ThrLys: 3.7 ± 0.598
6.938ThrLeu: 6.938 ± 1.132
0.925ThrMet: 0.925 ± 0.494
2.313ThrAsn: 2.313 ± 0.377
5.088ThrPro: 5.088 ± 0.715
3.238ThrGln: 3.238 ± 0.013
4.163ThrArg: 4.163 ± 0.507
6.013ThrSer: 6.013 ± 0.22
5.55ThrThr: 5.55 ± 0.468
5.55ThrVal: 5.55 ± 2.107
1.388ThrTrp: 1.388 ± 1.833
2.313ThrTyr: 2.313 ± 1.235
0.0ThrXaa: 0.0 ± 0.0
Val
5.088ValAla: 5.088 ± 1.002
1.388ValCys: 1.388 ± 0.741
2.313ValAsp: 2.313 ± 0.481
2.313ValGlu: 2.313 ± 0.481
1.85ValPhe: 1.85 ± 0.728
3.7ValGly: 3.7 ± 0.598
1.85ValHis: 1.85 ± 0.13
5.088ValIle: 5.088 ± 0.715
4.163ValLys: 4.163 ± 0.351
6.475ValLeu: 6.475 ± 0.885
1.85ValMet: 1.85 ± 0.13
2.313ValAsn: 2.313 ± 0.377
3.7ValPro: 3.7 ± 1.456
3.238ValGln: 3.238 ± 0.871
3.238ValArg: 3.238 ± 1.729
3.7ValSer: 3.7 ± 1.977
3.7ValThr: 3.7 ± 0.26
5.088ValVal: 5.088 ± 1.573
0.463ValTrp: 0.463 ± 0.247
2.775ValTyr: 2.775 ± 0.234
0.0ValXaa: 0.0 ± 0.0
Trp
0.463TrpAla: 0.463 ± 0.247
0.0TrpCys: 0.0 ± 0.0
1.388TrpAsp: 1.388 ± 0.741
0.463TrpGlu: 0.463 ± 0.247
0.925TrpPhe: 0.925 ± 0.364
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.85TrpLys: 1.85 ± 0.988
0.0TrpLeu: 0.0 ± 0.0
0.925TrpMet: 0.925 ± 1.222
0.463TrpAsn: 0.463 ± 0.247
0.463TrpPro: 0.463 ± 0.611
0.925TrpGln: 0.925 ± 0.364
0.463TrpArg: 0.463 ± 0.611
0.925TrpSer: 0.925 ± 0.494
0.463TrpThr: 0.463 ± 0.247
0.463TrpVal: 0.463 ± 0.247
0.0TrpTrp: 0.0 ± 0.0
0.925TrpTyr: 0.925 ± 0.494
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.775TyrAla: 2.775 ± 1.092
0.463TyrCys: 0.463 ± 0.611
1.388TyrAsp: 1.388 ± 0.741
2.775TyrGlu: 2.775 ± 0.624
1.388TyrPhe: 1.388 ± 0.117
4.163TyrGly: 4.163 ± 2.224
0.925TyrHis: 0.925 ± 1.222
3.7TyrIle: 3.7 ± 0.598
1.85TyrLys: 1.85 ± 0.988
1.388TyrLeu: 1.388 ± 0.117
0.0TyrMet: 0.0 ± 0.0
2.775TyrAsn: 2.775 ± 0.234
1.85TyrPro: 1.85 ± 0.13
1.388TyrGln: 1.388 ± 0.975
3.238TyrArg: 3.238 ± 0.013
2.313TyrSer: 2.313 ± 1.235
1.85TyrThr: 1.85 ± 0.13
0.925TyrVal: 0.925 ± 0.494
0.925TyrTrp: 0.925 ± 0.364
2.313TyrTyr: 2.313 ± 0.377
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2163 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski