Amino acid dipepetide frequency for Actinopolyspora mortivallis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.707AlaAla: 15.707 ± 0.186
0.988AlaCys: 0.988 ± 0.03
6.28AlaAsp: 6.28 ± 0.077
10.454AlaGlu: 10.454 ± 0.112
2.902AlaPhe: 2.902 ± 0.049
11.076AlaGly: 11.076 ± 0.106
2.604AlaHis: 2.604 ± 0.05
2.701AlaIle: 2.701 ± 0.064
1.901AlaLys: 1.901 ± 0.048
12.629AlaLeu: 12.629 ± 0.136
2.131AlaMet: 2.131 ± 0.043
1.931AlaAsn: 1.931 ± 0.048
5.322AlaPro: 5.322 ± 0.069
2.83AlaGln: 2.83 ± 0.056
9.526AlaArg: 9.526 ± 0.107
5.509AlaSer: 5.509 ± 0.066
6.198AlaThr: 6.198 ± 0.067
11.192AlaVal: 11.192 ± 0.123
1.442AlaTrp: 1.442 ± 0.034
1.88AlaTyr: 1.88 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.103CysAla: 1.103 ± 0.034
0.127CysCys: 0.127 ± 0.012
0.484CysAsp: 0.484 ± 0.02
0.46CysGlu: 0.46 ± 0.02
0.237CysPhe: 0.237 ± 0.016
1.047CysGly: 1.047 ± 0.03
0.208CysHis: 0.208 ± 0.014
0.147CysIle: 0.147 ± 0.011
0.091CysLys: 0.091 ± 0.009
0.811CysLeu: 0.811 ± 0.03
0.136CysMet: 0.136 ± 0.011
0.133CysAsn: 0.133 ± 0.011
0.562CysPro: 0.562 ± 0.02
0.153CysGln: 0.153 ± 0.012
0.672CysArg: 0.672 ± 0.029
0.62CysSer: 0.62 ± 0.023
0.493CysThr: 0.493 ± 0.019
0.758CysVal: 0.758 ± 0.024
0.169CysTrp: 0.169 ± 0.011
0.211CysTyr: 0.211 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.252AspAla: 5.252 ± 0.077
0.436AspCys: 0.436 ± 0.022
2.782AspAsp: 2.782 ± 0.054
4.691AspGlu: 4.691 ± 0.077
1.557AspPhe: 1.557 ± 0.038
5.376AspGly: 5.376 ± 0.082
1.322AspHis: 1.322 ± 0.03
1.555AspIle: 1.555 ± 0.038
0.876AspLys: 0.876 ± 0.03
5.329AspLeu: 5.329 ± 0.067
0.891AspMet: 0.891 ± 0.027
1.122AspAsn: 1.122 ± 0.034
4.653AspPro: 4.653 ± 0.067
1.433AspGln: 1.433 ± 0.034
4.939AspArg: 4.939 ± 0.071
3.48AspSer: 3.48 ± 0.064
3.576AspThr: 3.576 ± 0.049
4.683AspVal: 4.683 ± 0.066
0.877AspTrp: 0.877 ± 0.026
1.222AspTyr: 1.222 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.091GluAla: 7.091 ± 0.092
0.477GluCys: 0.477 ± 0.023
3.389GluAsp: 3.389 ± 0.055
4.839GluGlu: 4.839 ± 0.08
1.959GluPhe: 1.959 ± 0.045
4.82GluGly: 4.82 ± 0.068
2.504GluHis: 2.504 ± 0.046
2.681GluIle: 2.681 ± 0.05
1.261GluLys: 1.261 ± 0.041
8.973GluLeu: 8.973 ± 0.104
1.281GluMet: 1.281 ± 0.03
1.495GluAsn: 1.495 ± 0.033
3.883GluPro: 3.883 ± 0.074
3.323GluGln: 3.323 ± 0.06
7.377GluArg: 7.377 ± 0.086
3.625GluSer: 3.625 ± 0.062
3.78GluThr: 3.78 ± 0.06
5.823GluVal: 5.823 ± 0.077
0.956GluTrp: 0.956 ± 0.028
1.359GluTyr: 1.359 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.438PheAla: 3.438 ± 0.057
0.289PheCys: 0.289 ± 0.016
2.073PheAsp: 2.073 ± 0.049
1.636PheGlu: 1.636 ± 0.041
0.828PhePhe: 0.828 ± 0.027
3.375PheGly: 3.375 ± 0.053
0.658PheHis: 0.658 ± 0.025
0.521PheIle: 0.521 ± 0.025
0.323PheLys: 0.323 ± 0.017
2.605PheLeu: 2.605 ± 0.051
0.343PheMet: 0.343 ± 0.019
0.527PheAsn: 0.527 ± 0.02
1.498PhePro: 1.498 ± 0.04
0.533PheGln: 0.533 ± 0.022
2.01PheArg: 2.01 ± 0.041
1.599PheSer: 1.599 ± 0.042
1.865PheThr: 1.865 ± 0.04
2.591PheVal: 2.591 ± 0.047
0.4PheTrp: 0.4 ± 0.02
0.56PheTyr: 0.56 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.407GlyAla: 9.407 ± 0.114
0.899GlyCys: 0.899 ± 0.027
4.587GlyAsp: 4.587 ± 0.073
6.165GlyGlu: 6.165 ± 0.078
3.051GlyPhe: 3.051 ± 0.049
8.624GlyGly: 8.624 ± 0.132
2.179GlyHis: 2.179 ± 0.046
3.394GlyIle: 3.394 ± 0.06
2.068GlyLys: 2.068 ± 0.045
8.879GlyLeu: 8.879 ± 0.106
2.334GlyMet: 2.334 ± 0.045
1.978GlyAsn: 1.978 ± 0.048
4.408GlyPro: 4.408 ± 0.07
2.815GlyGln: 2.815 ± 0.059
7.524GlyArg: 7.524 ± 0.085
5.884GlySer: 5.884 ± 0.084
6.198GlyThr: 6.198 ± 0.072
8.461GlyVal: 8.461 ± 0.095
1.725GlyTrp: 1.725 ± 0.043
2.179GlyTyr: 2.179 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.557HisAla: 2.557 ± 0.048
0.262HisCys: 0.262 ± 0.013
1.366HisAsp: 1.366 ± 0.032
1.662HisGlu: 1.662 ± 0.038
0.585HisPhe: 0.585 ± 0.022
2.736HisGly: 2.736 ± 0.051
0.797HisHis: 0.797 ± 0.03
0.514HisIle: 0.514 ± 0.02
0.293HisLys: 0.293 ± 0.014
2.216HisLeu: 2.216 ± 0.045
0.36HisMet: 0.36 ± 0.018
0.457HisAsn: 0.457 ± 0.021
1.868HisPro: 1.868 ± 0.044
0.648HisGln: 0.648 ± 0.022
2.472HisArg: 2.472 ± 0.045
1.256HisSer: 1.256 ± 0.033
1.535HisThr: 1.535 ± 0.036
1.937HisVal: 1.937 ± 0.044
0.388HisTrp: 0.388 ± 0.019
0.576HisTyr: 0.576 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
3.84IleAla: 3.84 ± 0.058
0.243IleCys: 0.243 ± 0.017
1.988IleAsp: 1.988 ± 0.042
1.91IleGlu: 1.91 ± 0.04
0.605IlePhe: 0.605 ± 0.023
3.143IleGly: 3.143 ± 0.065
0.605IleHis: 0.605 ± 0.021
0.758IleIle: 0.758 ± 0.032
0.529IleLys: 0.529 ± 0.021
2.175IleLeu: 2.175 ± 0.053
0.414IleMet: 0.414 ± 0.019
0.725IleAsn: 0.725 ± 0.029
1.759IlePro: 1.759 ± 0.043
0.589IleGln: 0.589 ± 0.02
2.324IleArg: 2.324 ± 0.042
1.801IleSer: 1.801 ± 0.04
2.216IleThr: 2.216 ± 0.043
2.475IleVal: 2.475 ± 0.052
0.268IleTrp: 0.268 ± 0.017
0.511IleTyr: 0.511 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.805LysAla: 1.805 ± 0.05
0.101LysCys: 0.101 ± 0.009
0.777LysAsp: 0.777 ± 0.03
0.95LysGlu: 0.95 ± 0.036
0.388LysPhe: 0.388 ± 0.021
1.2LysGly: 1.2 ± 0.04
0.447LysHis: 0.447 ± 0.02
0.672LysIle: 0.672 ± 0.026
0.505LysLys: 0.505 ± 0.025
1.78LysLeu: 1.78 ± 0.04
0.299LysMet: 0.299 ± 0.016
0.447LysAsn: 0.447 ± 0.021
1.075LysPro: 1.075 ± 0.032
0.64LysGln: 0.64 ± 0.026
1.434LysArg: 1.434 ± 0.045
1.033LysSer: 1.033 ± 0.034
0.957LysThr: 0.957 ± 0.03
1.384LysVal: 1.384 ± 0.038
0.196LysTrp: 0.196 ± 0.011
0.333LysTyr: 0.333 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
13.297LeuAla: 13.297 ± 0.126
0.938LeuCys: 0.938 ± 0.029
6.745LeuAsp: 6.745 ± 0.09
5.702LeuGlu: 5.702 ± 0.074
2.814LeuPhe: 2.814 ± 0.053
9.816LeuGly: 9.816 ± 0.103
2.367LeuHis: 2.367 ± 0.047
2.597LeuIle: 2.597 ± 0.058
1.21LeuLys: 1.21 ± 0.038
11.537LeuLeu: 11.537 ± 0.141
1.403LeuMet: 1.403 ± 0.039
1.837LeuAsn: 1.837 ± 0.04
6.315LeuPro: 6.315 ± 0.084
1.913LeuGln: 1.913 ± 0.046
10.065LeuArg: 10.065 ± 0.107
6.282LeuSer: 6.282 ± 0.076
5.839LeuThr: 5.839 ± 0.065
10.181LeuVal: 10.181 ± 0.111
1.302LeuTrp: 1.302 ± 0.037
1.725LeuTyr: 1.725 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.011MetAla: 2.011 ± 0.037
0.16MetCys: 0.16 ± 0.013
0.816MetAsp: 0.816 ± 0.028
0.778MetGlu: 0.778 ± 0.025
0.554MetPhe: 0.554 ± 0.019
1.255MetGly: 1.255 ± 0.032
0.368MetHis: 0.368 ± 0.016
0.703MetIle: 0.703 ± 0.023
0.282MetLys: 0.282 ± 0.015
2.026MetLeu: 2.026 ± 0.047
0.297MetMet: 0.297 ± 0.017
0.478MetAsn: 0.478 ± 0.017
1.051MetPro: 1.051 ± 0.032
0.383MetGln: 0.383 ± 0.018
1.669MetArg: 1.669 ± 0.039
1.53MetSer: 1.53 ± 0.037
1.426MetThr: 1.426 ± 0.035
1.416MetVal: 1.416 ± 0.033
0.217MetTrp: 0.217 ± 0.012
0.309MetTyr: 0.309 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.265AsnAla: 2.265 ± 0.045
0.188AsnCys: 0.188 ± 0.014
0.973AsnAsp: 0.973 ± 0.033
1.223AsnGlu: 1.223 ± 0.03
0.495AsnPhe: 0.495 ± 0.019
2.043AsnGly: 2.043 ± 0.047
0.476AsnHis: 0.476 ± 0.02
0.672AsnIle: 0.672 ± 0.021
0.393AsnLys: 0.393 ± 0.022
1.775AsnLeu: 1.775 ± 0.039
0.358AsnMet: 0.358 ± 0.017
0.522AsnAsn: 0.522 ± 0.024
1.542AsnPro: 1.542 ± 0.037
0.605AsnGln: 0.605 ± 0.023
1.679AsnArg: 1.679 ± 0.04
1.203AsnSer: 1.203 ± 0.032
1.37AsnThr: 1.37 ± 0.032
1.457AsnVal: 1.457 ± 0.037
0.306AsnTrp: 0.306 ± 0.018
0.439AsnTyr: 0.439 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
6.293ProAla: 6.293 ± 0.087
0.385ProCys: 0.385 ± 0.017
4.095ProAsp: 4.095 ± 0.059
5.871ProGlu: 5.871 ± 0.076
1.489ProPhe: 1.489 ± 0.036
5.81ProGly: 5.81 ± 0.081
1.432ProHis: 1.432 ± 0.039
1.262ProIle: 1.262 ± 0.036
0.917ProLys: 0.917 ± 0.03
5.067ProLeu: 5.067 ± 0.072
0.877ProMet: 0.877 ± 0.024
1.146ProAsn: 1.146 ± 0.03
3.643ProPro: 3.643 ± 0.082
1.492ProGln: 1.492 ± 0.04
4.361ProArg: 4.361 ± 0.062
3.359ProSer: 3.359 ± 0.06
3.333ProThr: 3.333 ± 0.053
5.426ProVal: 5.426 ± 0.072
0.955ProTrp: 0.955 ± 0.034
1.092ProTyr: 1.092 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.218GlnAla: 3.218 ± 0.066
0.185GlnCys: 0.185 ± 0.012
1.197GlnAsp: 1.197 ± 0.034
1.453GlnGlu: 1.453 ± 0.044
0.658GlnPhe: 0.658 ± 0.026
2.048GlnGly: 2.048 ± 0.042
0.843GlnHis: 0.843 ± 0.028
0.825GlnIle: 0.825 ± 0.027
0.427GlnLys: 0.427 ± 0.022
3.125GlnLeu: 3.125 ± 0.053
0.415GlnMet: 0.415 ± 0.02
0.5GlnAsn: 0.5 ± 0.021
1.747GlnPro: 1.747 ± 0.058
1.554GlnGln: 1.554 ± 0.047
3.373GlnArg: 3.373 ± 0.061
1.222GlnSer: 1.222 ± 0.035
1.123GlnThr: 1.123 ± 0.031
2.088GlnVal: 2.088 ± 0.049
0.505GlnTrp: 0.505 ± 0.023
0.575GlnTyr: 0.575 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.991ArgAla: 9.991 ± 0.123
0.774ArgCys: 0.774 ± 0.029
4.419ArgAsp: 4.419 ± 0.069
6.164ArgGlu: 6.164 ± 0.081
2.473ArgPhe: 2.473 ± 0.047
6.639ArgGly: 6.639 ± 0.085
2.238ArgHis: 2.238 ± 0.048
3.361ArgIle: 3.361 ± 0.047
1.676ArgLys: 1.676 ± 0.043
9.085ArgLeu: 9.085 ± 0.097
2.194ArgMet: 2.194 ± 0.038
1.868ArgAsn: 1.868 ± 0.042
4.464ArgPro: 4.464 ± 0.061
2.792ArgGln: 2.792 ± 0.054
8.807ArgArg: 8.807 ± 0.117
5.278ArgSer: 5.278 ± 0.072
5.339ArgThr: 5.339 ± 0.069
7.437ArgVal: 7.437 ± 0.093
1.485ArgTrp: 1.485 ± 0.036
1.843ArgTyr: 1.843 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.842SerAla: 6.842 ± 0.095
0.548SerCys: 0.548 ± 0.021
3.023SerAsp: 3.023 ± 0.051
4.404SerGlu: 4.404 ± 0.057
1.648SerPhe: 1.648 ± 0.039
7.116SerGly: 7.116 ± 0.095
1.058SerHis: 1.058 ± 0.033
1.375SerIle: 1.375 ± 0.032
0.952SerLys: 0.952 ± 0.032
5.078SerLeu: 5.078 ± 0.062
1.092SerMet: 1.092 ± 0.031
1.065SerAsn: 1.065 ± 0.034
3.543SerPro: 3.543 ± 0.058
1.278SerGln: 1.278 ± 0.031
4.412SerArg: 4.412 ± 0.056
3.705SerSer: 3.705 ± 0.077
3.85SerThr: 3.85 ± 0.068
5.15SerVal: 5.15 ± 0.076
1.04SerTrp: 1.04 ± 0.03
1.268SerTyr: 1.268 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.62ThrAla: 7.62 ± 0.081
0.447ThrCys: 0.447 ± 0.02
3.504ThrAsp: 3.504 ± 0.059
4.515ThrGlu: 4.515 ± 0.065
1.513ThrPhe: 1.513 ± 0.034
6.375ThrGly: 6.375 ± 0.072
1.285ThrHis: 1.285 ± 0.03
1.586ThrIle: 1.586 ± 0.037
0.961ThrLys: 0.961 ± 0.033
5.657ThrLeu: 5.657 ± 0.074
0.988ThrMet: 0.988 ± 0.033
1.126ThrAsn: 1.126 ± 0.034
3.813ThrPro: 3.813 ± 0.056
1.189ThrGln: 1.189 ± 0.035
4.342ThrArg: 4.342 ± 0.057
3.559ThrSer: 3.559 ± 0.063
3.969ThrThr: 3.969 ± 0.081
6.427ThrVal: 6.427 ± 0.088
0.777ThrTrp: 0.777 ± 0.027
1.039ThrTyr: 1.039 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.976ValAla: 9.976 ± 0.114
0.843ValCys: 0.843 ± 0.026
5.649ValAsp: 5.649 ± 0.077
5.997ValGlu: 5.997 ± 0.079
2.703ValPhe: 2.703 ± 0.05
7.281ValGly: 7.281 ± 0.086
2.211ValHis: 2.211 ± 0.041
2.582ValIle: 2.582 ± 0.056
1.189ValLys: 1.189 ± 0.038
11.163ValLeu: 11.163 ± 0.13
1.313ValMet: 1.313 ± 0.034
1.862ValAsn: 1.862 ± 0.034
5.26ValPro: 5.26 ± 0.068
1.799ValGln: 1.799 ± 0.035
8.018ValArg: 8.018 ± 0.102
5.357ValSer: 5.357 ± 0.07
5.626ValThr: 5.626 ± 0.071
8.781ValVal: 8.781 ± 0.11
1.141ValTrp: 1.141 ± 0.03
1.529ValTyr: 1.529 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.395TrpAla: 1.395 ± 0.031
0.151TrpCys: 0.151 ± 0.01
0.682TrpAsp: 0.682 ± 0.024
0.787TrpGlu: 0.787 ± 0.024
0.568TrpPhe: 0.568 ± 0.022
0.996TrpGly: 0.996 ± 0.036
0.385TrpHis: 0.385 ± 0.015
0.571TrpIle: 0.571 ± 0.026
0.296TrpLys: 0.296 ± 0.016
1.854TrpLeu: 1.854 ± 0.047
0.359TrpMet: 0.359 ± 0.019
0.399TrpAsn: 0.399 ± 0.02
0.781TrpPro: 0.781 ± 0.026
0.564TrpGln: 0.564 ± 0.021
1.375TrpArg: 1.375 ± 0.036
1.05TrpSer: 1.05 ± 0.029
0.856TrpThr: 0.856 ± 0.027
1.061TrpVal: 1.061 ± 0.029
0.423TrpTrp: 0.423 ± 0.022
0.317TrpTyr: 0.317 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.096TyrAla: 2.096 ± 0.044
0.179TyrCys: 0.179 ± 0.012
1.224TyrAsp: 1.224 ± 0.045
1.234TyrGlu: 1.234 ± 0.029
0.647TyrPhe: 0.647 ± 0.027
1.982TyrGly: 1.982 ± 0.049
0.498TyrHis: 0.498 ± 0.018
0.398TyrIle: 0.398 ± 0.02
0.276TyrLys: 0.276 ± 0.015
2.122TyrLeu: 2.122 ± 0.043
0.244TyrMet: 0.244 ± 0.015
0.365TyrAsn: 0.365 ± 0.019
1.117TyrPro: 1.117 ± 0.032
0.544TyrGln: 0.544 ± 0.021
1.949TyrArg: 1.949 ± 0.044
1.094TyrSer: 1.094 ± 0.029
1.144TyrThr: 1.144 ± 0.034
1.552TyrVal: 1.552 ± 0.038
0.299TyrTrp: 0.299 ± 0.016
0.445TyrTyr: 0.445 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3817 proteins (1209028 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski