Amino acid dipepetide frequency for Prevotella sp. CAG:755

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.0AlaAla: 10.0 ± 0.157	1.459AlaCys: 1.459 ± 0.048	6.365AlaAsp: 6.365 ± 0.104	5.859AlaGlu: 5.859 ± 0.113	3.828AlaPhe: 3.828 ± 0.089	7.167AlaGly: 7.167 ± 0.118	1.88AlaHis: 1.88 ± 0.054	4.425AlaIle: 4.425 ± 0.092	3.459AlaLys: 3.459 ± 0.078	8.978AlaLeu: 8.978 ± 0.143	2.392AlaMet: 2.392 ± 0.065	2.811AlaAsn: 2.811 ± 0.068	3.462AlaPro: 3.462 ± 0.079	3.412AlaGln: 3.412 ± 0.094	5.698AlaArg: 5.698 ± 0.126	4.942AlaSer: 4.942 ± 0.094	5.242AlaThr: 5.242 ± 0.1	7.014AlaVal: 7.014 ± 0.129	1.114AlaTrp: 1.114 ± 0.048	3.292AlaTyr: 3.292 ± 0.071	0.002AlaXaa: 0.002 ± 0.002
Cys	1.103CysAla: 1.103 ± 0.046	0.226CysCys: 0.226 ± 0.024	0.816CysAsp: 0.816 ± 0.038	0.715CysGlu: 0.715 ± 0.037	0.615CysPhe: 0.615 ± 0.033	1.346CysGly: 1.346 ± 0.052	0.414CysHis: 0.414 ± 0.026	0.76CysIle: 0.76 ± 0.034	0.453CysLys: 0.453 ± 0.027	1.342CysLeu: 1.342 ± 0.042	0.333CysMet: 0.333 ± 0.022	0.473CysAsn: 0.473 ± 0.031	0.763CysPro: 0.763 ± 0.034	0.378CysGln: 0.378 ± 0.024	1.082CysArg: 1.082 ± 0.046	0.726CysSer: 0.726 ± 0.032	0.769CysThr: 0.769 ± 0.04	1.073CysVal: 1.073 ± 0.041	0.179CysTrp: 0.179 ± 0.017	0.531CysTyr: 0.531 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	5.532AspAla: 5.532 ± 0.103	0.802AspCys: 0.802 ± 0.037	3.408AspAsp: 3.408 ± 0.075	4.39AspGlu: 4.39 ± 0.101	2.855AspPhe: 2.855 ± 0.068	5.107AspGly: 5.107 ± 0.115	1.056AspHis: 1.056 ± 0.04	3.362AspIle: 3.362 ± 0.082	2.634AspLys: 2.634 ± 0.077	4.89AspLeu: 4.89 ± 0.095	1.444AspMet: 1.444 ± 0.051	2.221AspAsn: 2.221 ± 0.059	2.154AspPro: 2.154 ± 0.055	1.266AspGln: 1.266 ± 0.046	3.679AspArg: 3.679 ± 0.073	3.157AspSer: 3.157 ± 0.077	3.38AspThr: 3.38 ± 0.088	4.488AspVal: 4.488 ± 0.1	0.772AspTrp: 0.772 ± 0.035	2.796AspTyr: 2.796 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	6.261GluAla: 6.261 ± 0.115	0.595GluCys: 0.595 ± 0.032	2.799GluAsp: 2.799 ± 0.074	4.108GluGlu: 4.108 ± 0.09	2.003GluPhe: 2.003 ± 0.062	4.281GluGly: 4.281 ± 0.082	1.43GluHis: 1.43 ± 0.044	3.266GluIle: 3.266 ± 0.088	3.347GluLys: 3.347 ± 0.073	5.619GluLeu: 5.619 ± 0.101	1.813GluMet: 1.813 ± 0.055	2.409GluAsn: 2.409 ± 0.068	1.951GluPro: 1.951 ± 0.056	2.445GluGln: 2.445 ± 0.068	4.599GluArg: 4.599 ± 0.099	2.549GluSer: 2.549 ± 0.063	3.35GluThr: 3.35 ± 0.064	4.093GluVal: 4.093 ± 0.074	0.822GluTrp: 0.822 ± 0.034	1.811GluTyr: 1.811 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.484PheAla: 3.484 ± 0.079	0.726PheCys: 0.726 ± 0.037	2.923PheAsp: 2.923 ± 0.065	2.219PheGlu: 2.219 ± 0.054	2.025PhePhe: 2.025 ± 0.072	3.334PheGly: 3.334 ± 0.077	0.952PheHis: 0.952 ± 0.036	2.317PheIle: 2.317 ± 0.069	1.68PheLys: 1.68 ± 0.061	3.621PheLeu: 3.621 ± 0.074	1.089PheMet: 1.089 ± 0.047	1.847PheAsn: 1.847 ± 0.057	1.607PhePro: 1.607 ± 0.054	1.065PheGln: 1.065 ± 0.044	2.719PheArg: 2.719 ± 0.076	2.757PheSer: 2.757 ± 0.071	2.699PheThr: 2.699 ± 0.075	3.207PheVal: 3.207 ± 0.074	0.494PheTrp: 0.494 ± 0.026	1.659PheTyr: 1.659 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	5.868GlyAla: 5.868 ± 0.107	1.218GlyCys: 1.218 ± 0.044	3.979GlyAsp: 3.979 ± 0.088	4.183GlyGlu: 4.183 ± 0.091	3.202GlyPhe: 3.202 ± 0.072	5.716GlyGly: 5.716 ± 0.115	1.902GlyHis: 1.902 ± 0.059	4.551GlyIle: 4.551 ± 0.099	3.767GlyLys: 3.767 ± 0.096	7.1GlyLeu: 7.1 ± 0.117	2.02GlyMet: 2.02 ± 0.053	2.785GlyAsn: 2.785 ± 0.08	1.766GlyPro: 1.766 ± 0.051	2.687GlyGln: 2.687 ± 0.061	5.54GlyArg: 5.54 ± 0.114	4.074GlySer: 4.074 ± 0.084	4.474GlyThr: 4.474 ± 0.091	5.75GlyVal: 5.75 ± 0.108	1.071GlyTrp: 1.071 ± 0.039	3.115GlyTyr: 3.115 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.844HisAla: 1.844 ± 0.054	0.386HisCys: 0.386 ± 0.022	1.305HisAsp: 1.305 ± 0.05	1.233HisGlu: 1.233 ± 0.044	1.184HisPhe: 1.184 ± 0.037	1.726HisGly: 1.726 ± 0.062	0.673HisHis: 0.673 ± 0.036	1.562HisIle: 1.562 ± 0.047	0.903HisLys: 0.903 ± 0.038	2.021HisLeu: 2.021 ± 0.066	0.447HisMet: 0.447 ± 0.024	0.791HisAsn: 0.791 ± 0.038	1.308HisPro: 1.308 ± 0.055	0.561HisGln: 0.561 ± 0.032	1.52HisArg: 1.52 ± 0.051	1.151HisSer: 1.151 ± 0.04	1.336HisThr: 1.336 ± 0.044	1.634HisVal: 1.634 ± 0.05	0.263HisTrp: 0.263 ± 0.021	0.984HisTyr: 0.984 ± 0.046	0.0HisXaa: 0.0 ± 0.0
Ile	4.783IleAla: 4.783 ± 0.107	0.772IleCys: 0.772 ± 0.038	3.837IleAsp: 3.837 ± 0.08	3.367IleGlu: 3.367 ± 0.077	1.923IlePhe: 1.923 ± 0.06	3.901IleGly: 3.901 ± 0.084	1.142IleHis: 1.142 ± 0.048	2.867IleIle: 2.867 ± 0.085	2.507IleLys: 2.507 ± 0.077	4.278IleLeu: 4.278 ± 0.081	1.057IleMet: 1.057 ± 0.042	2.104IleAsn: 2.104 ± 0.068	2.623IlePro: 2.623 ± 0.069	1.469IleGln: 1.469 ± 0.046	3.334IleArg: 3.334 ± 0.077	3.04IleSer: 3.04 ± 0.077	3.073IleThr: 3.073 ± 0.075	3.964IleVal: 3.964 ± 0.091	0.48IleTrp: 0.48 ± 0.026	1.902IleTyr: 1.902 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	4.37LysAla: 4.37 ± 0.09	0.455LysCys: 0.455 ± 0.028	2.504LysAsp: 2.504 ± 0.073	3.255LysGlu: 3.255 ± 0.076	1.54LysPhe: 1.54 ± 0.053	3.144LysGly: 3.144 ± 0.073	0.897LysHis: 0.897 ± 0.042	2.333LysIle: 2.333 ± 0.067	2.847LysLys: 2.847 ± 0.066	3.699LysLeu: 3.699 ± 0.08	1.416LysMet: 1.416 ± 0.046	1.933LysAsn: 1.933 ± 0.058	1.749LysPro: 1.749 ± 0.059	1.612LysGln: 1.612 ± 0.048	2.828LysArg: 2.828 ± 0.077	2.219LysSer: 2.219 ± 0.06	2.75LysThr: 2.75 ± 0.07	3.038LysVal: 3.038 ± 0.076	0.467LysTrp: 0.467 ± 0.03	1.671LysTyr: 1.671 ± 0.061	0.002LysXaa: 0.002 ± 0.002
Leu	8.606LeuAla: 8.606 ± 0.13	1.584LeuCys: 1.584 ± 0.056	5.465LeuAsp: 5.465 ± 0.093	4.221LeuGlu: 4.221 ± 0.089	4.186LeuPhe: 4.186 ± 0.092	6.23LeuGly: 6.23 ± 0.096	2.398LeuHis: 2.398 ± 0.061	4.544LeuIle: 4.544 ± 0.088	3.819LeuLys: 3.819 ± 0.084	9.408LeuLeu: 9.408 ± 0.17	2.42LeuMet: 2.42 ± 0.061	3.608LeuAsn: 3.608 ± 0.063	4.848LeuPro: 4.848 ± 0.091	2.671LeuGln: 2.671 ± 0.07	6.888LeuArg: 6.888 ± 0.119	6.452LeuSer: 6.452 ± 0.099	6.485LeuThr: 6.485 ± 0.126	6.237LeuVal: 6.237 ± 0.111	1.096LeuTrp: 1.096 ± 0.043	3.292LeuTyr: 3.292 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	2.752MetAla: 2.752 ± 0.074	0.287MetCys: 0.287 ± 0.021	1.445MetAsp: 1.445 ± 0.047	1.571MetGlu: 1.571 ± 0.045	0.903MetPhe: 0.903 ± 0.039	1.799MetGly: 1.799 ± 0.055	0.458MetHis: 0.458 ± 0.029	1.026MetIle: 1.026 ± 0.044	1.852MetLys: 1.852 ± 0.05	2.363MetLeu: 2.363 ± 0.071	0.743MetMet: 0.743 ± 0.035	1.202MetAsn: 1.202 ± 0.043	1.305MetPro: 1.305 ± 0.044	0.955MetGln: 0.955 ± 0.036	1.567MetArg: 1.567 ± 0.047	1.427MetSer: 1.427 ± 0.053	1.635MetThr: 1.635 ± 0.052	1.517MetVal: 1.517 ± 0.057	0.255MetTrp: 0.255 ± 0.018	0.568MetTyr: 0.568 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.246AsnAla: 3.246 ± 0.075	0.453AsnCys: 0.453 ± 0.026	2.101AsnAsp: 2.101 ± 0.067	2.088AsnGlu: 2.088 ± 0.051	1.637AsnPhe: 1.637 ± 0.058	3.081AsnGly: 3.081 ± 0.092	0.793AsnHis: 0.793 ± 0.034	2.093AsnIle: 2.093 ± 0.058	1.656AsnLys: 1.656 ± 0.052	3.426AsnLeu: 3.426 ± 0.082	0.92AsnMet: 0.92 ± 0.037	1.501AsnAsn: 1.501 ± 0.057	2.099AsnPro: 2.099 ± 0.054	1.081AsnGln: 1.081 ± 0.042	2.324AsnArg: 2.324 ± 0.054	1.875AsnSer: 1.875 ± 0.058	2.0AsnThr: 2.0 ± 0.058	2.834AsnVal: 2.834 ± 0.081	0.461AsnTrp: 0.461 ± 0.029	1.627AsnTyr: 1.627 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	4.406ProAla: 4.406 ± 0.092	0.515ProCys: 0.515 ± 0.033	3.352ProAsp: 3.352 ± 0.077	3.236ProGlu: 3.236 ± 0.081	1.841ProPhe: 1.841 ± 0.051	3.347ProGly: 3.347 ± 0.067	0.989ProHis: 0.989 ± 0.04	1.951ProIle: 1.951 ± 0.058	1.61ProLys: 1.61 ± 0.051	3.777ProLeu: 3.777 ± 0.077	1.034ProMet: 1.034 ± 0.042	1.4ProAsn: 1.4 ± 0.051	1.363ProPro: 1.363 ± 0.046	1.462ProGln: 1.462 ± 0.043	2.029ProArg: 2.029 ± 0.067	2.49ProSer: 2.49 ± 0.067	2.535ProThr: 2.535 ± 0.073	3.454ProVal: 3.454 ± 0.074	0.491ProTrp: 0.491 ± 0.029	1.724ProTyr: 1.724 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.096GlnAla: 3.096 ± 0.078	0.377GlnCys: 0.377 ± 0.022	1.356GlnAsp: 1.356 ± 0.044	1.8GlnGlu: 1.8 ± 0.064	1.251GlnPhe: 1.251 ± 0.04	2.131GlnGly: 2.131 ± 0.067	0.741GlnHis: 0.741 ± 0.033	1.719GlnIle: 1.719 ± 0.057	1.526GlnLys: 1.526 ± 0.051	3.487GlnLeu: 3.487 ± 0.075	0.924GlnMet: 0.924 ± 0.038	1.162GlnAsn: 1.162 ± 0.045	1.495GlnPro: 1.495 ± 0.047	1.459GlnGln: 1.459 ± 0.06	2.208GlnArg: 2.208 ± 0.065	1.707GlnSer: 1.707 ± 0.052	2.112GlnThr: 2.112 ± 0.058	2.168GlnVal: 2.168 ± 0.06	0.442GlnTrp: 0.442 ± 0.029	1.163GlnTyr: 1.163 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	4.984ArgAla: 4.984 ± 0.099	0.81ArgCys: 0.81 ± 0.04	3.096ArgAsp: 3.096 ± 0.066	3.95ArgGlu: 3.95 ± 0.083	3.119ArgPhe: 3.119 ± 0.072	3.797ArgGly: 3.797 ± 0.093	2.039ArgHis: 2.039 ± 0.061	3.686ArgIle: 3.686 ± 0.068	3.024ArgLys: 3.024 ± 0.073	7.289ArgLeu: 7.289 ± 0.132	1.841ArgMet: 1.841 ± 0.051	2.294ArgAsn: 2.294 ± 0.062	3.222ArgPro: 3.222 ± 0.084	2.816ArgGln: 2.816 ± 0.072	5.765ArgArg: 5.765 ± 0.144	3.235ArgSer: 3.235 ± 0.074	3.602ArgThr: 3.602 ± 0.084	4.235ArgVal: 4.235 ± 0.079	0.838ArgTrp: 0.838 ± 0.041	2.648ArgTyr: 2.648 ± 0.064	0.002ArgXaa: 0.002 ± 0.001
Ser	4.778SerAla: 4.778 ± 0.084	0.744SerCys: 0.744 ± 0.033	3.149SerAsp: 3.149 ± 0.078	2.954SerGlu: 2.954 ± 0.074	2.498SerPhe: 2.498 ± 0.062	4.526SerGly: 4.526 ± 0.086	1.257SerHis: 1.257 ± 0.045	3.051SerIle: 3.051 ± 0.081	2.106SerLys: 2.106 ± 0.061	5.968SerLeu: 5.968 ± 0.131	1.33SerMet: 1.33 ± 0.05	1.816SerAsn: 1.816 ± 0.058	2.481SerPro: 2.481 ± 0.061	1.752SerGln: 1.752 ± 0.06	3.51SerArg: 3.51 ± 0.086	3.082SerSer: 3.082 ± 0.087	3.107SerThr: 3.107 ± 0.075	4.303SerVal: 4.303 ± 0.074	0.673SerTrp: 0.673 ± 0.033	2.162SerTyr: 2.162 ± 0.066	0.002SerXaa: 0.002 ± 0.001
Thr	5.954ThrAla: 5.954 ± 0.122	0.705ThrCys: 0.705 ± 0.037	3.789ThrAsp: 3.789 ± 0.078	3.082ThrGlu: 3.082 ± 0.066	2.705ThrPhe: 2.705 ± 0.074	4.812ThrGly: 4.812 ± 0.092	1.297ThrHis: 1.297 ± 0.047	2.898ThrIle: 2.898 ± 0.086	1.973ThrLys: 1.973 ± 0.057	6.312ThrLeu: 6.312 ± 0.107	1.279ThrMet: 1.279 ± 0.043	1.922ThrAsn: 1.922 ± 0.065	3.429ThrPro: 3.429 ± 0.076	1.751ThrGln: 1.751 ± 0.055	2.875ThrArg: 2.875 ± 0.069	3.252ThrSer: 3.252 ± 0.085	3.638ThrThr: 3.638 ± 0.098	4.889ThrVal: 4.889 ± 0.099	0.702ThrTrp: 0.702 ± 0.036	2.274ThrTyr: 2.274 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	7.198ValAla: 7.198 ± 0.133	1.276ValCys: 1.276 ± 0.051	4.478ValAsp: 4.478 ± 0.093	4.529ValGlu: 4.529 ± 0.097	2.864ValPhe: 2.864 ± 0.069	5.508ValGly: 5.508 ± 0.111	1.441ValHis: 1.441 ± 0.049	3.576ValIle: 3.576 ± 0.087	3.429ValLys: 3.429 ± 0.081	6.23ValLeu: 6.23 ± 0.095	1.869ValMet: 1.869 ± 0.062	2.869ValAsn: 2.869 ± 0.072	3.316ValPro: 3.316 ± 0.079	1.933ValGln: 1.933 ± 0.06	4.856ValArg: 4.856 ± 0.094	4.546ValSer: 4.546 ± 0.073	4.462ValThr: 4.462 ± 0.093	6.035ValVal: 6.035 ± 0.131	0.766ValTrp: 0.766 ± 0.036	2.342ValTyr: 2.342 ± 0.058	0.002ValXaa: 0.002 ± 0.002
Trp	0.941TrpAla: 0.941 ± 0.037	0.176TrpCys: 0.176 ± 0.016	0.62TrpAsp: 0.62 ± 0.031	0.6TrpGlu: 0.6 ± 0.032	0.534TrpPhe: 0.534 ± 0.031	0.897TrpGly: 0.897 ± 0.042	0.297TrpHis: 0.297 ± 0.023	0.568TrpIle: 0.568 ± 0.033	0.554TrpLys: 0.554 ± 0.029	1.294TrpLeu: 1.294 ± 0.055	0.406TrpMet: 0.406 ± 0.027	0.643TrpAsn: 0.643 ± 0.04	0.438TrpPro: 0.438 ± 0.026	0.522TrpGln: 0.522 ± 0.027	0.889TrpArg: 0.889 ± 0.04	0.604TrpSer: 0.604 ± 0.038	0.746TrpThr: 0.746 ± 0.039	0.704TrpVal: 0.704 ± 0.032	0.192TrpTrp: 0.192 ± 0.019	0.388TrpTyr: 0.388 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.594TyrAla: 3.594 ± 0.078	0.533TyrCys: 0.533 ± 0.034	2.602TyrAsp: 2.602 ± 0.067	2.19TyrGlu: 2.19 ± 0.048	1.71TyrPhe: 1.71 ± 0.051	2.917TyrGly: 2.917 ± 0.076	0.779TyrHis: 0.779 ± 0.04	1.866TyrIle: 1.866 ± 0.056	1.584TyrLys: 1.584 ± 0.054	3.358TyrLeu: 3.358 ± 0.08	0.852TyrMet: 0.852 ± 0.037	1.504TyrAsn: 1.504 ± 0.058	1.626TyrPro: 1.626 ± 0.045	1.029TyrGln: 1.029 ± 0.041	2.378TyrArg: 2.378 ± 0.063	1.964TyrSer: 1.964 ± 0.06	2.143TyrThr: 2.143 ± 0.058	2.886TyrVal: 2.886 ± 0.07	0.435TyrTrp: 0.435 ± 0.027	1.674TyrTyr: 1.674 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.006

Statistics based on 1936 proteins (642100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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