Amino acid dipepetide frequency for Planctomycetes bacterium SRT547

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.467AlaAla: 4.467 ± 0.055	0.786AlaCys: 0.786 ± 0.02	2.736AlaAsp: 2.736 ± 0.036	3.763AlaGlu: 3.763 ± 0.046	2.882AlaPhe: 2.882 ± 0.04	3.227AlaGly: 3.227 ± 0.046	1.585AlaHis: 1.585 ± 0.029	5.64AlaIle: 5.64 ± 0.062	5.71AlaLys: 5.71 ± 0.071	6.958AlaLeu: 6.958 ± 0.094	1.764AlaMet: 1.764 ± 0.029	3.13AlaAsn: 3.13 ± 0.049	1.929AlaPro: 1.929 ± 0.028	3.547AlaGln: 3.547 ± 0.04	2.676AlaArg: 2.676 ± 0.034	3.676AlaSer: 3.676 ± 0.049	3.572AlaThr: 3.572 ± 0.046	4.266AlaVal: 4.266 ± 0.055	0.672AlaTrp: 0.672 ± 0.017	2.304AlaTyr: 2.304 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.867CysAla: 0.867 ± 0.019	0.296CysCys: 0.296 ± 0.012	0.735CysAsp: 0.735 ± 0.018	0.842CysGlu: 0.842 ± 0.017	0.697CysPhe: 0.697 ± 0.015	0.927CysGly: 0.927 ± 0.022	0.389CysHis: 0.389 ± 0.019	0.97CysIle: 0.97 ± 0.019	0.782CysLys: 0.782 ± 0.018	1.315CysLeu: 1.315 ± 0.024	0.271CysMet: 0.271 ± 0.01	0.556CysAsn: 0.556 ± 0.016	0.409CysPro: 0.409 ± 0.013	0.468CysGln: 0.468 ± 0.012	0.557CysArg: 0.557 ± 0.015	0.91CysSer: 0.91 ± 0.019	0.561CysThr: 0.561 ± 0.016	0.842CysVal: 0.842 ± 0.019	0.147CysTrp: 0.147 ± 0.008	0.568CysTyr: 0.568 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.144AspAla: 3.144 ± 0.063	0.556AspCys: 0.556 ± 0.016	2.881AspAsp: 2.881 ± 0.055	3.63AspGlu: 3.63 ± 0.05	2.996AspPhe: 2.996 ± 0.035	2.988AspGly: 2.988 ± 0.053	1.158AspHis: 1.158 ± 0.024	4.531AspIle: 4.531 ± 0.044	3.89AspLys: 3.89 ± 0.042	5.094AspLeu: 5.094 ± 0.053	1.125AspMet: 1.125 ± 0.024	2.672AspAsn: 2.672 ± 0.043	1.778AspPro: 1.778 ± 0.034	1.533AspGln: 1.533 ± 0.024	1.997AspArg: 1.997 ± 0.028	2.961AspSer: 2.961 ± 0.043	2.537AspThr: 2.537 ± 0.043	3.579AspVal: 3.579 ± 0.051	0.618AspTrp: 0.618 ± 0.015	2.147AspTyr: 2.147 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	3.847GluAla: 3.847 ± 0.059	0.589GluCys: 0.589 ± 0.015	3.506GluAsp: 3.506 ± 0.041	5.163GluGlu: 5.163 ± 0.061	2.416GluPhe: 2.416 ± 0.033	2.937GluGly: 2.937 ± 0.036	1.323GluHis: 1.323 ± 0.024	5.533GluIle: 5.533 ± 0.06	7.274GluLys: 7.274 ± 0.088	5.737GluLeu: 5.737 ± 0.054	1.682GluMet: 1.682 ± 0.025	4.323GluAsn: 4.323 ± 0.043	1.418GluPro: 1.418 ± 0.029	3.257GluGln: 3.257 ± 0.036	2.715GluArg: 2.715 ± 0.032	3.182GluSer: 3.182 ± 0.04	2.894GluThr: 2.894 ± 0.036	4.052GluVal: 4.052 ± 0.044	0.718GluTrp: 0.718 ± 0.018	2.485GluTyr: 2.485 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.694PheAla: 3.694 ± 0.038	0.875PheCys: 0.875 ± 0.018	2.478PheAsp: 2.478 ± 0.041	2.375PheGlu: 2.375 ± 0.035	2.836PhePhe: 2.836 ± 0.041	2.601PheGly: 2.601 ± 0.037	1.173PheHis: 1.173 ± 0.023	3.307PheIle: 3.307 ± 0.038	1.981PheLys: 1.981 ± 0.03	4.799PheLeu: 4.799 ± 0.05	0.957PheMet: 0.957 ± 0.019	1.65PheAsn: 1.65 ± 0.025	1.784PhePro: 1.784 ± 0.029	1.481PheGln: 1.481 ± 0.026	2.073PheArg: 2.073 ± 0.033	4.147PheSer: 4.147 ± 0.05	2.575PheThr: 2.575 ± 0.035	3.457PheVal: 3.457 ± 0.036	0.555PheTrp: 0.555 ± 0.016	1.982PheTyr: 1.982 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	3.196GlyAla: 3.196 ± 0.041	0.788GlyCys: 0.788 ± 0.019	2.977GlyAsp: 2.977 ± 0.057	3.96GlyGlu: 3.96 ± 0.052	2.517GlyPhe: 2.517 ± 0.036	3.575GlyGly: 3.575 ± 0.062	1.324GlyHis: 1.324 ± 0.03	4.22GlyIle: 4.22 ± 0.049	5.156GlyLys: 5.156 ± 0.062	4.218GlyLeu: 4.218 ± 0.045	1.423GlyMet: 1.423 ± 0.034	2.963GlyAsn: 2.963 ± 0.045	1.139GlyPro: 1.139 ± 0.02	2.036GlyGln: 2.036 ± 0.03	2.329GlyArg: 2.329 ± 0.033	3.242GlySer: 3.242 ± 0.044	2.857GlyThr: 2.857 ± 0.034	3.645GlyVal: 3.645 ± 0.045	0.669GlyTrp: 0.669 ± 0.019	2.188GlyTyr: 2.188 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.253HisAla: 1.253 ± 0.02	0.409HisCys: 0.409 ± 0.013	1.164HisAsp: 1.164 ± 0.021	1.366HisGlu: 1.366 ± 0.024	1.287HisPhe: 1.287 ± 0.021	1.307HisGly: 1.307 ± 0.026	0.753HisHis: 0.753 ± 0.02	1.727HisIle: 1.727 ± 0.025	1.833HisLys: 1.833 ± 0.026	2.503HisLeu: 2.503 ± 0.034	0.466HisMet: 0.466 ± 0.013	1.292HisAsn: 1.292 ± 0.023	1.159HisPro: 1.159 ± 0.02	1.002HisGln: 1.002 ± 0.02	1.346HisArg: 1.346 ± 0.023	1.615HisSer: 1.615 ± 0.03	1.154HisThr: 1.154 ± 0.025	1.272HisVal: 1.272 ± 0.023	0.286HisTrp: 0.286 ± 0.009	1.012HisTyr: 1.012 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.148IleAla: 6.148 ± 0.05	1.251IleCys: 1.251 ± 0.021	4.372IleAsp: 4.372 ± 0.044	4.964IleGlu: 4.964 ± 0.046	3.683IlePhe: 3.683 ± 0.038	3.956IleGly: 3.956 ± 0.048	1.991IleHis: 1.991 ± 0.024	4.806IleIle: 4.806 ± 0.047	4.692IleLys: 4.692 ± 0.047	7.054IleLeu: 7.054 ± 0.063	1.33IleMet: 1.33 ± 0.025	3.101IleAsn: 3.101 ± 0.039	3.281IlePro: 3.281 ± 0.043	2.781IleGln: 2.781 ± 0.035	3.241IleArg: 3.241 ± 0.036	5.286IleSer: 5.286 ± 0.048	4.068IleThr: 4.068 ± 0.054	5.173IleVal: 5.173 ± 0.045	0.81IleTrp: 0.81 ± 0.023	2.796IleTyr: 2.796 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.896LysAla: 4.896 ± 0.085	0.752LysCys: 0.752 ± 0.019	4.148LysAsp: 4.148 ± 0.057	5.442LysGlu: 5.442 ± 0.056	2.714LysPhe: 2.714 ± 0.036	3.306LysGly: 3.306 ± 0.038	1.632LysHis: 1.632 ± 0.024	6.819LysIle: 6.819 ± 0.054	8.115LysLys: 8.115 ± 0.088	6.804LysLeu: 6.804 ± 0.054	2.191LysMet: 2.191 ± 0.027	5.274LysAsn: 5.274 ± 0.052	2.418LysPro: 2.418 ± 0.032	3.538LysGln: 3.538 ± 0.044	3.605LysArg: 3.605 ± 0.034	4.664LysSer: 4.664 ± 0.048	4.233LysThr: 4.233 ± 0.043	4.724LysVal: 4.724 ± 0.047	0.975LysTrp: 0.975 ± 0.019	3.094LysTyr: 3.094 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.634LeuAla: 6.634 ± 0.061	1.472LeuCys: 1.472 ± 0.025	4.679LeuAsp: 4.679 ± 0.051	6.299LeuGlu: 6.299 ± 0.064	4.364LeuPhe: 4.364 ± 0.054	5.525LeuGly: 5.525 ± 0.058	2.542LeuHis: 2.542 ± 0.035	5.46LeuIle: 5.46 ± 0.057	6.675LeuLys: 6.675 ± 0.061	9.377LeuLeu: 9.377 ± 0.082	1.757LeuMet: 1.757 ± 0.027	3.954LeuAsn: 3.954 ± 0.048	3.998LeuPro: 3.998 ± 0.048	6.192LeuGln: 6.192 ± 0.062	4.905LeuArg: 4.905 ± 0.047	6.58LeuSer: 6.58 ± 0.059	4.514LeuThr: 4.514 ± 0.06	5.374LeuVal: 5.374 ± 0.043	1.321LeuTrp: 1.321 ± 0.033	3.647LeuTyr: 3.647 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.648MetAla: 1.648 ± 0.026	0.271MetCys: 0.271 ± 0.011	1.232MetAsp: 1.232 ± 0.023	1.491MetGlu: 1.491 ± 0.023	0.874MetPhe: 0.874 ± 0.018	1.482MetGly: 1.482 ± 0.027	0.501MetHis: 0.501 ± 0.014	1.482MetIle: 1.482 ± 0.025	1.681MetLys: 1.681 ± 0.026	2.057MetLeu: 2.057 ± 0.031	0.567MetMet: 0.567 ± 0.017	1.029MetAsn: 1.029 ± 0.018	0.806MetPro: 0.806 ± 0.018	1.095MetGln: 1.095 ± 0.022	1.241MetArg: 1.241 ± 0.02	1.566MetSer: 1.566 ± 0.027	1.106MetThr: 1.106 ± 0.022	1.327MetVal: 1.327 ± 0.022	0.262MetTrp: 0.262 ± 0.01	0.78MetTyr: 0.78 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.132AsnAla: 3.132 ± 0.042	0.607AsnCys: 0.607 ± 0.018	2.646AsnAsp: 2.646 ± 0.038	3.011AsnGlu: 3.011 ± 0.035	2.488AsnPhe: 2.488 ± 0.036	2.627AsnGly: 2.627 ± 0.052	1.134AsnHis: 1.134 ± 0.02	4.564AsnIle: 4.564 ± 0.051	3.825AsnLys: 3.825 ± 0.043	4.724AsnLeu: 4.724 ± 0.05	1.025AsnMet: 1.025 ± 0.019	3.072AsnAsn: 3.072 ± 0.054	2.027AsnPro: 2.027 ± 0.026	1.589AsnGln: 1.589 ± 0.029	2.241AsnArg: 2.241 ± 0.033	3.173AsnSer: 3.173 ± 0.035	2.823AsnThr: 2.823 ± 0.039	3.233AsnVal: 3.233 ± 0.05	0.595AsnTrp: 0.595 ± 0.014	2.011AsnTyr: 2.011 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	1.933ProAla: 1.933 ± 0.037	0.344ProCys: 0.344 ± 0.012	1.731ProAsp: 1.731 ± 0.03	2.501ProGlu: 2.501 ± 0.034	1.746ProPhe: 1.746 ± 0.033	1.99ProGly: 1.99 ± 0.032	0.991ProHis: 0.991 ± 0.022	2.362ProIle: 2.362 ± 0.031	2.65ProLys: 2.65 ± 0.039	3.168ProLeu: 3.168 ± 0.042	0.644ProMet: 0.644 ± 0.016	1.724ProAsn: 1.724 ± 0.025	1.372ProPro: 1.372 ± 0.025	2.837ProGln: 2.837 ± 0.04	1.553ProArg: 1.553 ± 0.024	2.186ProSer: 2.186 ± 0.032	1.774ProThr: 1.774 ± 0.031	2.219ProVal: 2.219 ± 0.034	0.411ProTrp: 0.411 ± 0.014	1.257ProTyr: 1.257 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.687GlnAla: 2.687 ± 0.042	0.422GlnCys: 0.422 ± 0.012	2.248GlnAsp: 2.248 ± 0.034	3.214GlnGlu: 3.214 ± 0.04	1.525GlnPhe: 1.525 ± 0.024	2.25GlnGly: 2.25 ± 0.029	1.201GlnHis: 1.201 ± 0.022	3.558GlnIle: 3.558 ± 0.037	5.335GlnLys: 5.335 ± 0.055	4.26GlnLeu: 4.26 ± 0.058	1.073GlnMet: 1.073 ± 0.019	2.983GlnAsn: 2.983 ± 0.036	1.341GlnPro: 1.341 ± 0.024	3.948GlnGln: 3.948 ± 0.064	2.353GlnArg: 2.353 ± 0.035	2.483GlnSer: 2.483 ± 0.034	2.236GlnThr: 2.236 ± 0.031	2.732GlnVal: 2.732 ± 0.039	0.471GlnTrp: 0.471 ± 0.013	1.459GlnTyr: 1.459 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	2.54ArgAla: 2.54 ± 0.036	0.57ArgCys: 0.57 ± 0.014	2.641ArgAsp: 2.641 ± 0.033	3.488ArgGlu: 3.488 ± 0.037	2.196ArgPhe: 2.196 ± 0.029	2.599ArgGly: 2.599 ± 0.037	1.046ArgHis: 1.046 ± 0.022	3.227ArgIle: 3.227 ± 0.035	3.918ArgLys: 3.918 ± 0.041	4.028ArgLeu: 4.028 ± 0.04	0.983ArgMet: 0.983 ± 0.019	2.406ArgAsn: 2.406 ± 0.035	1.29ArgPro: 1.29 ± 0.024	1.962ArgGln: 1.962 ± 0.03	2.216ArgArg: 2.216 ± 0.034	2.699ArgSer: 2.699 ± 0.034	1.923ArgThr: 1.923 ± 0.032	2.644ArgVal: 2.644 ± 0.03	0.553ArgTrp: 0.553 ± 0.016	2.151ArgTyr: 2.151 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	3.786SerAla: 3.786 ± 0.048	0.863SerCys: 0.863 ± 0.021	3.223SerAsp: 3.223 ± 0.044	3.643SerGlu: 3.643 ± 0.044	3.385SerPhe: 3.385 ± 0.04	4.083SerGly: 4.083 ± 0.056	1.49SerHis: 1.49 ± 0.027	4.639SerIle: 4.639 ± 0.047	4.218SerLys: 4.218 ± 0.037	6.907SerLeu: 6.907 ± 0.049	1.375SerMet: 1.375 ± 0.025	2.696SerAsn: 2.696 ± 0.034	2.792SerPro: 2.792 ± 0.045	3.064SerGln: 3.064 ± 0.034	2.681SerArg: 2.681 ± 0.03	4.537SerSer: 4.537 ± 0.049	3.14SerThr: 3.14 ± 0.04	3.761SerVal: 3.761 ± 0.045	0.877SerTrp: 0.877 ± 0.018	2.365SerTyr: 2.365 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	3.425ThrAla: 3.425 ± 0.044	0.575ThrCys: 0.575 ± 0.017	2.116ThrAsp: 2.116 ± 0.043	2.58ThrGlu: 2.58 ± 0.034	2.497ThrPhe: 2.497 ± 0.034	2.909ThrGly: 2.909 ± 0.037	1.202ThrHis: 1.202 ± 0.022	4.077ThrIle: 4.077 ± 0.051	3.778ThrLys: 3.778 ± 0.045	5.27ThrLeu: 5.27 ± 0.052	1.196ThrMet: 1.196 ± 0.022	2.446ThrAsn: 2.446 ± 0.032	2.47ThrPro: 2.47 ± 0.031	2.452ThrGln: 2.452 ± 0.032	1.908ThrArg: 1.908 ± 0.03	3.354ThrSer: 3.354 ± 0.041	3.29ThrThr: 3.29 ± 0.042	3.201ThrVal: 3.201 ± 0.048	0.585ThrTrp: 0.585 ± 0.016	1.772ThrTyr: 1.772 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	4.851ValAla: 4.851 ± 0.048	0.948ValCys: 0.948 ± 0.02	3.551ValAsp: 3.551 ± 0.046	4.119ValGlu: 4.119 ± 0.041	3.15ValPhe: 3.15 ± 0.035	3.424ValGly: 3.424 ± 0.038	1.421ValHis: 1.421 ± 0.02	4.471ValIle: 4.471 ± 0.043	4.277ValLys: 4.277 ± 0.049	5.764ValLeu: 5.764 ± 0.051	1.496ValMet: 1.496 ± 0.024	2.778ValAsn: 2.778 ± 0.042	2.241ValPro: 2.241 ± 0.039	2.274ValGln: 2.274 ± 0.034	2.75ValArg: 2.75 ± 0.042	4.087ValSer: 4.087 ± 0.042	3.331ValThr: 3.331 ± 0.049	5.064ValVal: 5.064 ± 0.055	0.745ValTrp: 0.745 ± 0.02	2.573ValTyr: 2.573 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.608TrpAla: 0.608 ± 0.016	0.199TrpCys: 0.199 ± 0.009	0.737TrpAsp: 0.737 ± 0.03	0.834TrpGlu: 0.834 ± 0.018	0.457TrpPhe: 0.457 ± 0.015	0.779TrpGly: 0.779 ± 0.017	0.284TrpHis: 0.284 ± 0.01	0.722TrpIle: 0.722 ± 0.016	0.959TrpLys: 0.959 ± 0.022	1.219TrpLeu: 1.219 ± 0.022	0.282TrpMet: 0.282 ± 0.009	0.661TrpAsn: 0.661 ± 0.018	0.346TrpPro: 0.346 ± 0.013	0.864TrpGln: 0.864 ± 0.02	0.659TrpArg: 0.659 ± 0.017	0.724TrpSer: 0.724 ± 0.017	0.457TrpThr: 0.457 ± 0.014	0.579TrpVal: 0.579 ± 0.016	0.187TrpTrp: 0.187 ± 0.008	0.403TrpTyr: 0.403 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.534TyrAla: 2.534 ± 0.032	0.534TyrCys: 0.534 ± 0.014	2.014TyrAsp: 2.014 ± 0.029	2.368TyrGlu: 2.368 ± 0.035	2.071TyrPhe: 2.071 ± 0.03	1.929TyrGly: 1.929 ± 0.027	1.066TyrHis: 1.066 ± 0.02	2.665TyrIle: 2.665 ± 0.037	2.598TyrLys: 2.598 ± 0.035	4.015TyrLeu: 4.015 ± 0.044	0.888TyrMet: 0.888 ± 0.017	1.839TyrAsn: 1.839 ± 0.035	1.395TyrPro: 1.395 ± 0.026	1.858TyrGln: 1.858 ± 0.026	2.032TyrArg: 2.032 ± 0.026	2.454TyrSer: 2.454 ± 0.031	2.06TyrThr: 2.06 ± 0.03	2.171TyrVal: 2.171 ± 0.028	0.503TyrTrp: 0.503 ± 0.014	1.734TyrTyr: 1.734 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6642 proteins (2884994 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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