Amino acid dipepetide frequency for Prevotella sp. CAG:924

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.774AlaAla: 6.774 ± 0.118
1.096AlaCys: 1.096 ± 0.042
5.001AlaAsp: 5.001 ± 0.079
4.273AlaGlu: 4.273 ± 0.092
3.12AlaPhe: 3.12 ± 0.066
5.423AlaGly: 5.423 ± 0.101
1.672AlaHis: 1.672 ± 0.049
4.711AlaIle: 4.711 ± 0.103
4.009AlaLys: 4.009 ± 0.078
7.253AlaLeu: 7.253 ± 0.133
2.19AlaMet: 2.19 ± 0.057
3.009AlaAsn: 3.009 ± 0.057
2.471AlaPro: 2.471 ± 0.057
3.213AlaGln: 3.213 ± 0.073
3.912AlaArg: 3.912 ± 0.087
4.402AlaSer: 4.402 ± 0.091
4.494AlaThr: 4.494 ± 0.079
5.495AlaVal: 5.495 ± 0.114
0.871AlaTrp: 0.871 ± 0.032
2.886AlaTyr: 2.886 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.888CysAla: 0.888 ± 0.037
0.216CysCys: 0.216 ± 0.019
0.772CysAsp: 0.772 ± 0.033
0.644CysGlu: 0.644 ± 0.029
0.502CysPhe: 0.502 ± 0.026
1.127CysGly: 1.127 ± 0.043
0.37CysHis: 0.37 ± 0.022
0.844CysIle: 0.844 ± 0.036
0.636CysLys: 0.636 ± 0.026
1.175CysLeu: 1.175 ± 0.045
0.378CysMet: 0.378 ± 0.022
0.555CysAsn: 0.555 ± 0.03
0.644CysPro: 0.644 ± 0.035
0.437CysGln: 0.437 ± 0.026
0.742CysArg: 0.742 ± 0.03
0.796CysSer: 0.796 ± 0.036
0.729CysThr: 0.729 ± 0.029
0.794CysVal: 0.794 ± 0.038
0.178CysTrp: 0.178 ± 0.018
0.566CysTyr: 0.566 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.583AspAla: 4.583 ± 0.084
0.721AspCys: 0.721 ± 0.036
3.687AspAsp: 3.687 ± 0.078
3.852AspGlu: 3.852 ± 0.087
2.812AspPhe: 2.812 ± 0.062
4.781AspGly: 4.781 ± 0.094
1.372AspHis: 1.372 ± 0.051
4.024AspIle: 4.024 ± 0.089
3.589AspLys: 3.589 ± 0.07
4.97AspLeu: 4.97 ± 0.086
1.674AspMet: 1.674 ± 0.05
3.063AspAsn: 3.063 ± 0.074
2.343AspPro: 2.343 ± 0.056
1.745AspGln: 1.745 ± 0.049
3.124AspArg: 3.124 ± 0.07
3.261AspSer: 3.261 ± 0.073
3.194AspThr: 3.194 ± 0.067
4.039AspVal: 4.039 ± 0.08
0.919AspTrp: 0.919 ± 0.036
3.135AspTyr: 3.135 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.75GluAla: 4.75 ± 0.098
0.574GluCys: 0.574 ± 0.031
3.287GluAsp: 3.287 ± 0.069
4.352GluGlu: 4.352 ± 0.1
1.877GluPhe: 1.877 ± 0.046
3.942GluGly: 3.942 ± 0.075
1.426GluHis: 1.426 ± 0.048
3.706GluIle: 3.706 ± 0.081
4.025GluLys: 4.025 ± 0.077
5.051GluLeu: 5.051 ± 0.095
2.022GluMet: 2.022 ± 0.054
2.693GluAsn: 2.693 ± 0.068
1.87GluPro: 1.87 ± 0.049
2.645GluGln: 2.645 ± 0.061
3.131GluArg: 3.131 ± 0.066
2.616GluSer: 2.616 ± 0.052
3.086GluThr: 3.086 ± 0.073
3.803GluVal: 3.803 ± 0.074
0.787GluTrp: 0.787 ± 0.03
2.303GluTyr: 2.303 ± 0.065
0.001GluXaa: 0.001 ± 0.001
Phe
2.918PheAla: 2.918 ± 0.066
0.736PheCys: 0.736 ± 0.03
2.746PheAsp: 2.746 ± 0.058
1.99PheGlu: 1.99 ± 0.05
1.96PhePhe: 1.96 ± 0.053
3.111PheGly: 3.111 ± 0.057
1.038PheHis: 1.038 ± 0.036
2.688PheIle: 2.688 ± 0.069
2.012PheLys: 2.012 ± 0.052
3.62PheLeu: 3.62 ± 0.079
1.19PheMet: 1.19 ± 0.04
2.036PheAsn: 2.036 ± 0.064
1.471PhePro: 1.471 ± 0.045
1.226PheGln: 1.226 ± 0.041
2.127PheArg: 2.127 ± 0.056
3.041PheSer: 3.041 ± 0.069
2.678PheThr: 2.678 ± 0.068
2.74PheVal: 2.74 ± 0.063
0.512PheTrp: 0.512 ± 0.028
1.762PheTyr: 1.762 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.687GlyAla: 4.687 ± 0.101
1.021GlyCys: 1.021 ± 0.037
4.06GlyAsp: 4.06 ± 0.076
3.874GlyGlu: 3.874 ± 0.068
2.975GlyPhe: 2.975 ± 0.072
5.036GlyGly: 5.036 ± 0.118
1.779GlyHis: 1.779 ± 0.05
4.909GlyIle: 4.909 ± 0.08
4.777GlyLys: 4.777 ± 0.094
6.273GlyLeu: 6.273 ± 0.115
2.304GlyMet: 2.304 ± 0.059
3.253GlyAsn: 3.253 ± 0.074
1.577GlyPro: 1.577 ± 0.051
2.702GlyGln: 2.702 ± 0.064
3.762GlyArg: 3.762 ± 0.073
4.112GlySer: 4.112 ± 0.082
4.462GlyThr: 4.462 ± 0.089
4.876GlyVal: 4.876 ± 0.094
1.076GlyTrp: 1.076 ± 0.041
3.257GlyTyr: 3.257 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.511HisAla: 1.511 ± 0.04
0.385HisCys: 0.385 ± 0.023
1.385HisAsp: 1.385 ± 0.046
1.248HisGlu: 1.248 ± 0.045
1.12HisPhe: 1.12 ± 0.037
1.654HisGly: 1.654 ± 0.05
0.752HisHis: 0.752 ± 0.033
1.603HisIle: 1.603 ± 0.047
1.082HisLys: 1.082 ± 0.039
2.193HisLeu: 2.193 ± 0.063
0.409HisMet: 0.409 ± 0.023
0.981HisAsn: 0.981 ± 0.038
1.321HisPro: 1.321 ± 0.042
0.827HisGln: 0.827 ± 0.032
1.323HisArg: 1.323 ± 0.047
1.29HisSer: 1.29 ± 0.041
1.267HisThr: 1.267 ± 0.037
1.462HisVal: 1.462 ± 0.045
0.363HisTrp: 0.363 ± 0.024
1.12HisTyr: 1.12 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.026IleAla: 5.026 ± 0.089
0.919IleCys: 0.919 ± 0.036
4.527IleAsp: 4.527 ± 0.083
3.622IleGlu: 3.622 ± 0.077
2.576IlePhe: 2.576 ± 0.071
4.671IleGly: 4.671 ± 0.085
1.345IleHis: 1.345 ± 0.048
4.181IleIle: 4.181 ± 0.091
3.329IleLys: 3.329 ± 0.074
5.368IleLeu: 5.368 ± 0.101
1.466IleMet: 1.466 ± 0.043
3.157IleAsn: 3.157 ± 0.07
2.773IlePro: 2.773 ± 0.064
2.018IleGln: 2.018 ± 0.051
3.46IleArg: 3.46 ± 0.076
3.995IleSer: 3.995 ± 0.078
3.778IleThr: 3.778 ± 0.075
4.404IleVal: 4.404 ± 0.081
0.615IleTrp: 0.615 ± 0.035
2.424IleTyr: 2.424 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.956LysAla: 4.956 ± 0.086
0.463LysCys: 0.463 ± 0.026
3.685LysAsp: 3.685 ± 0.08
4.285LysGlu: 4.285 ± 0.088
1.845LysPhe: 1.845 ± 0.048
4.03LysGly: 4.03 ± 0.069
1.174LysHis: 1.174 ± 0.041
3.689LysIle: 3.689 ± 0.064
4.22LysLys: 4.22 ± 0.095
4.484LysLeu: 4.484 ± 0.066
2.132LysMet: 2.132 ± 0.053
2.816LysAsn: 2.816 ± 0.068
2.0LysPro: 2.0 ± 0.055
2.186LysGln: 2.186 ± 0.057
2.784LysArg: 2.784 ± 0.054
2.886LysSer: 2.886 ± 0.068
3.496LysThr: 3.496 ± 0.077
3.805LysVal: 3.805 ± 0.079
0.689LysTrp: 0.689 ± 0.027
2.448LysTyr: 2.448 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
6.89LeuAla: 6.89 ± 0.132
1.452LeuCys: 1.452 ± 0.051
5.054LeuAsp: 5.054 ± 0.088
4.233LeuGlu: 4.233 ± 0.074
3.954LeuPhe: 3.954 ± 0.084
5.948LeuGly: 5.948 ± 0.111
2.246LeuHis: 2.246 ± 0.054
5.054LeuIle: 5.054 ± 0.097
5.213LeuLys: 5.213 ± 0.091
8.826LeuLeu: 8.826 ± 0.158
2.64LeuMet: 2.64 ± 0.067
4.048LeuAsn: 4.048 ± 0.087
4.276LeuPro: 4.276 ± 0.085
3.528LeuGln: 3.528 ± 0.081
5.213LeuArg: 5.213 ± 0.1
6.551LeuSer: 6.551 ± 0.122
5.646LeuThr: 5.646 ± 0.091
5.381LeuVal: 5.381 ± 0.094
1.012LeuTrp: 1.012 ± 0.039
3.558LeuTyr: 3.558 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.535MetAla: 2.535 ± 0.057
0.248MetCys: 0.248 ± 0.02
1.617MetAsp: 1.617 ± 0.05
1.775MetGlu: 1.775 ± 0.049
0.961MetPhe: 0.961 ± 0.038
1.972MetGly: 1.972 ± 0.056
0.579MetHis: 0.579 ± 0.03
1.652MetIle: 1.652 ± 0.053
2.252MetLys: 2.252 ± 0.057
2.616MetLeu: 2.616 ± 0.066
0.961MetMet: 0.961 ± 0.031
1.457MetAsn: 1.457 ± 0.04
1.321MetPro: 1.321 ± 0.042
1.149MetGln: 1.149 ± 0.042
1.548MetArg: 1.548 ± 0.051
1.752MetSer: 1.752 ± 0.053
1.844MetThr: 1.844 ± 0.051
1.766MetVal: 1.766 ± 0.051
0.229MetTrp: 0.229 ± 0.018
0.834MetTyr: 0.834 ± 0.032
0.001MetXaa: 0.001 ± 0.001
Asn
3.364AsnAla: 3.364 ± 0.073
0.494AsnCys: 0.494 ± 0.026
2.8AsnAsp: 2.8 ± 0.072
2.467AsnGlu: 2.467 ± 0.063
1.941AsnPhe: 1.941 ± 0.057
3.784AsnGly: 3.784 ± 0.086
0.999AsnHis: 0.999 ± 0.034
3.241AsnIle: 3.241 ± 0.071
2.56AsnLys: 2.56 ± 0.063
3.605AsnLeu: 3.605 ± 0.078
1.193AsnMet: 1.193 ± 0.04
2.299AsnAsn: 2.299 ± 0.075
2.12AsnPro: 2.12 ± 0.057
1.433AsnGln: 1.433 ± 0.049
2.273AsnArg: 2.273 ± 0.055
2.418AsnSer: 2.418 ± 0.072
2.548AsnThr: 2.548 ± 0.071
3.195AsnVal: 3.195 ± 0.069
0.613AsnTrp: 0.613 ± 0.031
2.095AsnTyr: 2.095 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
3.095ProAla: 3.095 ± 0.079
0.402ProCys: 0.402 ± 0.024
2.782ProAsp: 2.782 ± 0.069
3.045ProGlu: 3.045 ± 0.06
1.756ProPhe: 1.756 ± 0.045
2.59ProGly: 2.59 ± 0.066
0.88ProHis: 0.88 ± 0.034
2.215ProIle: 2.215 ± 0.047
1.933ProLys: 1.933 ± 0.054
3.386ProLeu: 3.386 ± 0.067
1.091ProMet: 1.091 ± 0.036
1.536ProAsn: 1.536 ± 0.052
0.734ProPro: 0.734 ± 0.033
1.545ProGln: 1.545 ± 0.045
1.523ProArg: 1.523 ± 0.048
2.422ProSer: 2.422 ± 0.055
2.23ProThr: 2.23 ± 0.062
3.015ProVal: 3.015 ± 0.061
0.538ProTrp: 0.538 ± 0.031
1.778ProTyr: 1.778 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
2.899GlnAla: 2.899 ± 0.072
0.347GlnCys: 0.347 ± 0.02
1.826GlnAsp: 1.826 ± 0.045
2.212GlnGlu: 2.212 ± 0.067
1.325GlnPhe: 1.325 ± 0.039
2.358GlnGly: 2.358 ± 0.057
0.852GlnHis: 0.852 ± 0.033
2.357GlnIle: 2.357 ± 0.066
2.33GlnLys: 2.33 ± 0.057
3.906GlnLeu: 3.906 ± 0.085
1.169GlnMet: 1.169 ± 0.036
1.567GlnAsn: 1.567 ± 0.047
1.598GlnPro: 1.598 ± 0.046
2.14GlnGln: 2.14 ± 0.068
2.151GlnArg: 2.151 ± 0.063
1.961GlnSer: 1.961 ± 0.052
2.182GlnThr: 2.182 ± 0.055
2.281GlnVal: 2.281 ± 0.065
0.591GlnTrp: 0.591 ± 0.023
1.623GlnTyr: 1.623 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
3.217ArgAla: 3.217 ± 0.071
0.6ArgCys: 0.6 ± 0.027
2.763ArgAsp: 2.763 ± 0.06
3.196ArgGlu: 3.196 ± 0.067
2.252ArgPhe: 2.252 ± 0.057
2.826ArgGly: 2.826 ± 0.068
1.589ArgHis: 1.589 ± 0.052
3.513ArgIle: 3.513 ± 0.07
3.186ArgLys: 3.186 ± 0.077
5.322ArgLeu: 5.322 ± 0.098
1.742ArgMet: 1.742 ± 0.048
2.332ArgAsn: 2.332 ± 0.062
2.078ArgPro: 2.078 ± 0.057
2.697ArgGln: 2.697 ± 0.068
3.209ArgArg: 3.209 ± 0.084
2.67ArgSer: 2.67 ± 0.058
2.746ArgThr: 2.746 ± 0.054
3.13ArgVal: 3.13 ± 0.062
0.767ArgTrp: 0.767 ± 0.033
2.482ArgTyr: 2.482 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
4.259SerAla: 4.259 ± 0.084
0.847SerCys: 0.847 ± 0.036
3.571SerAsp: 3.571 ± 0.084
3.023SerGlu: 3.023 ± 0.059
2.872SerPhe: 2.872 ± 0.063
4.331SerGly: 4.331 ± 0.087
1.339SerHis: 1.339 ± 0.046
3.79SerIle: 3.79 ± 0.077
2.949SerLys: 2.949 ± 0.071
5.86SerLeu: 5.86 ± 0.098
1.561SerMet: 1.561 ± 0.052
2.361SerAsn: 2.361 ± 0.064
2.212SerPro: 2.212 ± 0.056
2.071SerGln: 2.071 ± 0.05
2.997SerArg: 2.997 ± 0.065
3.663SerSer: 3.663 ± 0.081
3.495SerThr: 3.495 ± 0.085
4.264SerVal: 4.264 ± 0.092
0.78SerTrp: 0.78 ± 0.039
2.663SerTyr: 2.663 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.856ThrAla: 4.856 ± 0.089
0.649ThrCys: 0.649 ± 0.032
3.801ThrAsp: 3.801 ± 0.072
3.049ThrGlu: 3.049 ± 0.069
2.713ThrPhe: 2.713 ± 0.061
4.622ThrGly: 4.622 ± 0.077
1.276ThrHis: 1.276 ± 0.043
3.809ThrIle: 3.809 ± 0.064
2.638ThrLys: 2.638 ± 0.072
5.929ThrLeu: 5.929 ± 0.1
1.451ThrMet: 1.451 ± 0.043
2.153ThrAsn: 2.153 ± 0.066
2.922ThrPro: 2.922 ± 0.06
1.885ThrGln: 1.885 ± 0.051
2.477ThrArg: 2.477 ± 0.055
3.386ThrSer: 3.386 ± 0.064
3.735ThrThr: 3.735 ± 0.076
4.629ThrVal: 4.629 ± 0.091
0.689ThrTrp: 0.689 ± 0.032
2.387ThrTyr: 2.387 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.223ValAla: 5.223 ± 0.088
1.071ValCys: 1.071 ± 0.044
4.046ValAsp: 4.046 ± 0.091
4.009ValGlu: 4.009 ± 0.078
2.586ValPhe: 2.586 ± 0.056
4.52ValGly: 4.52 ± 0.101
1.224ValHis: 1.224 ± 0.044
4.286ValIle: 4.286 ± 0.087
4.206ValLys: 4.206 ± 0.072
5.867ValLeu: 5.867 ± 0.108
2.031ValMet: 2.031 ± 0.06
3.168ValAsn: 3.168 ± 0.072
2.636ValPro: 2.636 ± 0.059
1.934ValGln: 1.934 ± 0.049
3.585ValArg: 3.585 ± 0.072
4.532ValSer: 4.532 ± 0.086
4.073ValThr: 4.073 ± 0.075
4.993ValVal: 4.993 ± 0.097
0.778ValTrp: 0.778 ± 0.032
2.715ValTyr: 2.715 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.831TrpAla: 0.831 ± 0.037
0.176TrpCys: 0.176 ± 0.014
0.733TrpAsp: 0.733 ± 0.034
0.605TrpGlu: 0.605 ± 0.031
0.509TrpPhe: 0.509 ± 0.026
0.957TrpGly: 0.957 ± 0.039
0.34TrpHis: 0.34 ± 0.022
0.776TrpIle: 0.776 ± 0.034
0.808TrpLys: 0.808 ± 0.032
1.276TrpLeu: 1.276 ± 0.048
0.471TrpMet: 0.471 ± 0.027
0.698TrpAsn: 0.698 ± 0.032
0.362TrpPro: 0.362 ± 0.022
0.644TrpGln: 0.644 ± 0.027
0.645TrpArg: 0.645 ± 0.03
0.697TrpSer: 0.697 ± 0.032
0.78TrpThr: 0.78 ± 0.033
0.725TrpVal: 0.725 ± 0.033
0.222TrpTrp: 0.222 ± 0.017
0.515TrpTyr: 0.515 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.013TyrAla: 3.013 ± 0.068
0.577TyrCys: 0.577 ± 0.027
2.746TyrAsp: 2.746 ± 0.058
2.195TyrGlu: 2.195 ± 0.057
1.947TyrPhe: 1.947 ± 0.05
3.089TyrGly: 3.089 ± 0.065
1.043TyrHis: 1.043 ± 0.037
2.607TyrIle: 2.607 ± 0.062
2.317TyrLys: 2.317 ± 0.06
3.743TyrLeu: 3.743 ± 0.074
0.996TyrMet: 0.996 ± 0.038
2.26TyrAsn: 2.26 ± 0.074
1.766TyrPro: 1.766 ± 0.053
1.647TyrGln: 1.647 ± 0.055
2.33TyrArg: 2.33 ± 0.054
2.457TyrSer: 2.457 ± 0.07
2.592TyrThr: 2.592 ± 0.069
2.688TyrVal: 2.688 ± 0.065
0.539TyrTrp: 0.539 ± 0.028
1.989TyrTyr: 1.989 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.001XaaTyr: 0.001 ± 0.001
0.005XaaXaa: 0.005 ± 0.004
Statistics based on 2225 proteins (773435 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski