Amino acid dipepetide frequency for Paracoccus sp. DMF

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.736AlaAla: 14.736 ± 0.154	1.004AlaCys: 1.004 ± 0.031	6.13AlaAsp: 6.13 ± 0.09	8.065AlaGlu: 8.065 ± 0.107	4.069AlaPhe: 4.069 ± 0.077	10.065AlaGly: 10.065 ± 0.134	2.096AlaHis: 2.096 ± 0.048	6.035AlaIle: 6.035 ± 0.089	3.792AlaLys: 3.792 ± 0.066	12.09AlaLeu: 12.09 ± 0.145	3.58AlaMet: 3.58 ± 0.07	2.643AlaAsn: 2.643 ± 0.06	4.842AlaPro: 4.842 ± 0.084	3.86AlaGln: 3.86 ± 0.07	7.913AlaArg: 7.913 ± 0.123	5.387AlaSer: 5.387 ± 0.068	5.251AlaThr: 5.251 ± 0.081	7.824AlaVal: 7.824 ± 0.1	1.47AlaTrp: 1.47 ± 0.04	2.505AlaTyr: 2.505 ± 0.054	0.001AlaXaa: 0.001 ± 0.001
Cys	0.954CysAla: 0.954 ± 0.033	0.144CysCys: 0.144 ± 0.013	0.549CysAsp: 0.549 ± 0.025	0.48CysGlu: 0.48 ± 0.023	0.345CysPhe: 0.345 ± 0.023	0.889CysGly: 0.889 ± 0.035	0.264CysHis: 0.264 ± 0.018	0.484CysIle: 0.484 ± 0.024	0.237CysLys: 0.237 ± 0.018	0.78CysLeu: 0.78 ± 0.033	0.209CysMet: 0.209 ± 0.014	0.187CysAsn: 0.187 ± 0.012	0.504CysPro: 0.504 ± 0.025	0.245CysGln: 0.245 ± 0.015	0.567CysArg: 0.567 ± 0.03	0.494CysSer: 0.494 ± 0.024	0.415CysThr: 0.415 ± 0.018	0.519CysVal: 0.519 ± 0.025	0.115CysTrp: 0.115 ± 0.012	0.212CysTyr: 0.212 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.197AspAla: 6.197 ± 0.093	0.459AspCys: 0.459 ± 0.025	2.963AspAsp: 2.963 ± 0.079	3.67AspGlu: 3.67 ± 0.073	2.412AspPhe: 2.412 ± 0.054	4.904AspGly: 4.904 ± 0.1	1.269AspHis: 1.269 ± 0.033	3.137AspIle: 3.137 ± 0.062	2.021AspLys: 2.021 ± 0.052	5.997AspLeu: 5.997 ± 0.084	1.442AspMet: 1.442 ± 0.042	1.368AspAsn: 1.368 ± 0.039	3.39AspPro: 3.39 ± 0.067	2.012AspGln: 2.012 ± 0.052	4.162AspArg: 4.162 ± 0.089	2.523AspSer: 2.523 ± 0.047	2.472AspThr: 2.472 ± 0.061	3.474AspVal: 3.474 ± 0.07	1.151AspTrp: 1.151 ± 0.035	1.768AspTyr: 1.768 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.114GluAla: 7.114 ± 0.092	0.413GluCys: 0.413 ± 0.022	3.283GluAsp: 3.283 ± 0.067	4.027GluGlu: 4.027 ± 0.089	2.053GluPhe: 2.053 ± 0.047	4.614GluGly: 4.614 ± 0.067	1.285GluHis: 1.285 ± 0.035	4.099GluIle: 4.099 ± 0.067	3.153GluLys: 3.153 ± 0.073	5.647GluLeu: 5.647 ± 0.082	1.893GluMet: 1.893 ± 0.037	2.078GluAsn: 2.078 ± 0.054	2.528GluPro: 2.528 ± 0.055	2.255GluGln: 2.255 ± 0.058	4.292GluArg: 4.292 ± 0.074	2.66GluSer: 2.66 ± 0.056	3.603GluThr: 3.603 ± 0.066	4.227GluVal: 4.227 ± 0.066	0.843GluTrp: 0.843 ± 0.04	1.433GluTyr: 1.433 ± 0.041	0.001GluXaa: 0.001 ± 0.001
Phe	4.283PheAla: 4.283 ± 0.08	0.384PheCys: 0.384 ± 0.021	2.664PheAsp: 2.664 ± 0.054	2.129PheGlu: 2.129 ± 0.051	1.641PhePhe: 1.641 ± 0.046	3.589PheGly: 3.589 ± 0.078	0.79PheHis: 0.79 ± 0.03	2.233PheIle: 2.233 ± 0.056	1.243PheLys: 1.243 ± 0.043	3.77PheLeu: 3.77 ± 0.074	0.986PheMet: 0.986 ± 0.035	1.282PheAsn: 1.282 ± 0.04	1.706PhePro: 1.706 ± 0.044	1.216PheGln: 1.216 ± 0.037	2.262PheArg: 2.262 ± 0.05	2.359PheSer: 2.359 ± 0.048	2.026PheThr: 2.026 ± 0.045	2.659PheVal: 2.659 ± 0.058	0.556PheTrp: 0.556 ± 0.027	1.137PheTyr: 1.137 ± 0.033	0.004PheXaa: 0.004 ± 0.003
Gly	8.817GlyAla: 8.817 ± 0.111	0.823GlyCys: 0.823 ± 0.029	4.379GlyAsp: 4.379 ± 0.078	4.676GlyGlu: 4.676 ± 0.077	3.777GlyPhe: 3.777 ± 0.069	6.753GlyGly: 6.753 ± 0.127	1.786GlyHis: 1.786 ± 0.051	5.132GlyIle: 5.132 ± 0.087	3.766GlyLys: 3.766 ± 0.077	8.769GlyLeu: 8.769 ± 0.126	2.577GlyMet: 2.577 ± 0.055	2.471GlyAsn: 2.471 ± 0.074	3.221GlyPro: 3.221 ± 0.064	3.105GlyGln: 3.105 ± 0.07	5.537GlyArg: 5.537 ± 0.096	4.426GlySer: 4.426 ± 0.073	4.678GlyThr: 4.678 ± 0.077	5.907GlyVal: 5.907 ± 0.082	1.502GlyTrp: 1.502 ± 0.046	2.459GlyTyr: 2.459 ± 0.056	0.003GlyXaa: 0.003 ± 0.002
His	2.118HisAla: 2.118 ± 0.058	0.266HisCys: 0.266 ± 0.021	1.272HisAsp: 1.272 ± 0.04	1.169HisGlu: 1.169 ± 0.037	0.91HisPhe: 0.91 ± 0.035	1.883HisGly: 1.883 ± 0.048	0.622HisHis: 0.622 ± 0.03	1.057HisIle: 1.057 ± 0.034	0.623HisLys: 0.623 ± 0.024	2.051HisLeu: 2.051 ± 0.047	0.524HisMet: 0.524 ± 0.023	0.459HisAsn: 0.459 ± 0.023	1.336HisPro: 1.336 ± 0.041	0.619HisGln: 0.619 ± 0.026	1.383HisArg: 1.383 ± 0.036	1.01HisSer: 1.01 ± 0.035	0.765HisThr: 0.765 ± 0.028	1.544HisVal: 1.544 ± 0.041	0.317HisTrp: 0.317 ± 0.019	0.669HisTyr: 0.669 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.889IleAla: 6.889 ± 0.103	0.567IleCys: 0.567 ± 0.02	3.486IleAsp: 3.486 ± 0.063	3.951IleGlu: 3.951 ± 0.081	2.136IlePhe: 2.136 ± 0.054	5.238IleGly: 5.238 ± 0.095	1.151IleHis: 1.151 ± 0.037	3.034IleIle: 3.034 ± 0.075	2.094IleLys: 2.094 ± 0.054	5.412IleLeu: 5.412 ± 0.09	1.336IleMet: 1.336 ± 0.037	1.725IleAsn: 1.725 ± 0.047	2.623IlePro: 2.623 ± 0.053	1.595IleGln: 1.595 ± 0.042	3.678IleArg: 3.678 ± 0.066	3.391IleSer: 3.391 ± 0.062	3.079IleThr: 3.079 ± 0.061	4.005IleVal: 4.005 ± 0.073	0.701IleTrp: 0.701 ± 0.029	1.481IleTyr: 1.481 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.111LysAla: 4.111 ± 0.084	0.226LysCys: 0.226 ± 0.016	2.167LysAsp: 2.167 ± 0.054	2.635LysGlu: 2.635 ± 0.067	1.141LysPhe: 1.141 ± 0.037	3.269LysGly: 3.269 ± 0.063	0.772LysHis: 0.772 ± 0.031	2.241LysIle: 2.241 ± 0.057	2.167LysLys: 2.167 ± 0.064	3.675LysLeu: 3.675 ± 0.059	1.058LysMet: 1.058 ± 0.035	1.375LysAsn: 1.375 ± 0.046	1.978LysPro: 1.978 ± 0.048	1.361LysGln: 1.361 ± 0.041	2.479LysArg: 2.479 ± 0.054	2.106LysSer: 2.106 ± 0.054	2.231LysThr: 2.231 ± 0.047	2.779LysVal: 2.779 ± 0.054	0.526LysTrp: 0.526 ± 0.022	1.001LysTyr: 1.001 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	12.262LeuAla: 12.262 ± 0.151	0.838LeuCys: 0.838 ± 0.03	5.766LeuAsp: 5.766 ± 0.094	5.169LeuGlu: 5.169 ± 0.088	3.733LeuPhe: 3.733 ± 0.083	8.192LeuGly: 8.192 ± 0.114	1.937LeuHis: 1.937 ± 0.045	5.648LeuIle: 5.648 ± 0.096	3.942LeuLys: 3.942 ± 0.078	9.038LeuLeu: 9.038 ± 0.144	2.687LeuMet: 2.687 ± 0.06	3.156LeuAsn: 3.156 ± 0.06	5.182LeuPro: 5.182 ± 0.076	2.861LeuGln: 2.861 ± 0.051	6.774LeuArg: 6.774 ± 0.106	6.111LeuSer: 6.111 ± 0.086	5.79LeuThr: 5.79 ± 0.095	6.861LeuVal: 6.861 ± 0.107	1.229LeuTrp: 1.229 ± 0.043	2.203LeuTyr: 2.203 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.394MetAla: 3.394 ± 0.071	0.165MetCys: 0.165 ± 0.014	1.383MetAsp: 1.383 ± 0.037	1.509MetGlu: 1.509 ± 0.038	0.917MetPhe: 0.917 ± 0.032	2.126MetGly: 2.126 ± 0.05	0.462MetHis: 0.462 ± 0.025	1.614MetIle: 1.614 ± 0.047	1.347MetLys: 1.347 ± 0.042	2.72MetLeu: 2.72 ± 0.056	0.806MetMet: 0.806 ± 0.031	1.079MetAsn: 1.079 ± 0.029	1.488MetPro: 1.488 ± 0.037	1.07MetGln: 1.07 ± 0.033	1.786MetArg: 1.786 ± 0.048	1.715MetSer: 1.715 ± 0.038	1.949MetThr: 1.949 ± 0.049	1.832MetVal: 1.832 ± 0.053	0.22MetTrp: 0.22 ± 0.015	0.436MetTyr: 0.436 ± 0.024	0.002MetXaa: 0.002 ± 0.002
Asn	3.052AsnAla: 3.052 ± 0.059	0.266AsnCys: 0.266 ± 0.018	1.605AsnAsp: 1.605 ± 0.064	1.617AsnGlu: 1.617 ± 0.049	1.114AsnPhe: 1.114 ± 0.034	2.559AsnGly: 2.559 ± 0.053	0.609AsnHis: 0.609 ± 0.029	1.763AsnIle: 1.763 ± 0.046	1.164AsnLys: 1.164 ± 0.039	2.818AsnLeu: 2.818 ± 0.057	0.786AsnMet: 0.786 ± 0.031	0.922AsnAsn: 0.922 ± 0.037	2.029AsnPro: 2.029 ± 0.051	0.98AsnGln: 0.98 ± 0.031	1.946AsnArg: 1.946 ± 0.047	1.493AsnSer: 1.493 ± 0.041	1.424AsnThr: 1.424 ± 0.04	2.026AsnVal: 2.026 ± 0.051	0.493AsnTrp: 0.493 ± 0.022	0.822AsnTyr: 0.822 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.694ProAla: 5.694 ± 0.085	0.362ProCys: 0.362 ± 0.02	3.401ProAsp: 3.401 ± 0.066	4.061ProGlu: 4.061 ± 0.072	1.994ProPhe: 1.994 ± 0.05	4.45ProGly: 4.45 ± 0.074	0.985ProHis: 0.985 ± 0.034	2.342ProIle: 2.342 ± 0.057	1.669ProLys: 1.669 ± 0.047	4.283ProLeu: 4.283 ± 0.074	1.256ProMet: 1.256 ± 0.041	1.363ProAsn: 1.363 ± 0.039	2.082ProPro: 2.082 ± 0.057	1.71ProGln: 1.71 ± 0.049	2.759ProArg: 2.759 ± 0.067	2.372ProSer: 2.372 ± 0.058	2.109ProThr: 2.109 ± 0.054	3.877ProVal: 3.877 ± 0.067	0.68ProTrp: 0.68 ± 0.028	1.138ProTyr: 1.138 ± 0.033	0.001ProXaa: 0.001 ± 0.001
Gln	4.004GlnAla: 4.004 ± 0.07	0.23GlnCys: 0.23 ± 0.016	1.731GlnAsp: 1.731 ± 0.04	1.845GlnGlu: 1.845 ± 0.056	1.188GlnPhe: 1.188 ± 0.033	2.863GlnGly: 2.863 ± 0.054	0.675GlnHis: 0.675 ± 0.027	2.155GlnIle: 2.155 ± 0.044	1.504GlnLys: 1.504 ± 0.041	3.022GlnLeu: 3.022 ± 0.06	1.116GlnMet: 1.116 ± 0.035	1.068GlnAsn: 1.068 ± 0.038	1.709GlnPro: 1.709 ± 0.048	1.249GlnGln: 1.249 ± 0.031	2.217GlnArg: 2.217 ± 0.058	1.742GlnSer: 1.742 ± 0.037	1.768GlnThr: 1.768 ± 0.049	2.295GlnVal: 2.295 ± 0.051	0.403GlnTrp: 0.403 ± 0.022	0.776GlnTyr: 0.776 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.157ArgAla: 7.157 ± 0.112	0.532ArgCys: 0.532 ± 0.028	4.029ArgAsp: 4.029 ± 0.077	4.144ArgGlu: 4.144 ± 0.074	2.581ArgPhe: 2.581 ± 0.062	4.653ArgGly: 4.653 ± 0.081	1.5ArgHis: 1.5 ± 0.046	4.234ArgIle: 4.234 ± 0.069	2.671ArgLys: 2.671 ± 0.058	7.211ArgLeu: 7.211 ± 0.106	2.029ArgMet: 2.029 ± 0.047	1.882ArgAsn: 1.882 ± 0.047	3.232ArgPro: 3.232 ± 0.063	2.419ArgGln: 2.419 ± 0.054	5.122ArgArg: 5.122 ± 0.092	3.189ArgSer: 3.189 ± 0.065	2.777ArgThr: 2.777 ± 0.055	4.237ArgVal: 4.237 ± 0.079	1.087ArgTrp: 1.087 ± 0.033	1.632ArgTyr: 1.632 ± 0.047	0.003ArgXaa: 0.003 ± 0.002
Ser	5.362SerAla: 5.362 ± 0.079	0.503SerCys: 0.503 ± 0.021	2.976SerAsp: 2.976 ± 0.059	2.865SerGlu: 2.865 ± 0.061	2.431SerPhe: 2.431 ± 0.055	5.277SerGly: 5.277 ± 0.068	1.099SerHis: 1.099 ± 0.034	3.032SerIle: 3.032 ± 0.063	1.86SerLys: 1.86 ± 0.043	5.103SerLeu: 5.103 ± 0.081	1.436SerMet: 1.436 ± 0.039	1.48SerAsn: 1.48 ± 0.046	2.455SerPro: 2.455 ± 0.051	1.748SerGln: 1.748 ± 0.036	3.433SerArg: 3.433 ± 0.066	2.874SerSer: 2.874 ± 0.068	2.533SerThr: 2.533 ± 0.053	3.688SerVal: 3.688 ± 0.066	0.79SerTrp: 0.79 ± 0.03	1.518SerTyr: 1.518 ± 0.038	0.001SerXaa: 0.001 ± 0.001
Thr	5.627ThrAla: 5.627 ± 0.089	0.432ThrCys: 0.432 ± 0.019	2.885ThrAsp: 2.885 ± 0.058	3.009ThrGlu: 3.009 ± 0.059	1.943ThrPhe: 1.943 ± 0.052	5.126ThrGly: 5.126 ± 0.077	1.043ThrHis: 1.043 ± 0.032	2.895ThrIle: 2.895 ± 0.059	1.624ThrLys: 1.624 ± 0.045	5.452ThrLeu: 5.452 ± 0.087	1.307ThrMet: 1.307 ± 0.037	1.418ThrAsn: 1.418 ± 0.043	3.057ThrPro: 3.057 ± 0.066	1.481ThrGln: 1.481 ± 0.046	3.14ThrArg: 3.14 ± 0.068	2.529ThrSer: 2.529 ± 0.056	2.663ThrThr: 2.663 ± 0.06	4.154ThrVal: 4.154 ± 0.067	0.653ThrTrp: 0.653 ± 0.028	1.278ThrTyr: 1.278 ± 0.044	0.001ThrXaa: 0.001 ± 0.001
Val	7.672ValAla: 7.672 ± 0.117	0.591ValCys: 0.591 ± 0.029	3.654ValAsp: 3.654 ± 0.065	4.309ValGlu: 4.309 ± 0.07	2.893ValPhe: 2.893 ± 0.053	4.906ValGly: 4.906 ± 0.08	1.342ValHis: 1.342 ± 0.039	4.392ValIle: 4.392 ± 0.075	2.92ValLys: 2.92 ± 0.067	7.269ValLeu: 7.269 ± 0.105	2.037ValMet: 2.037 ± 0.042	2.253ValAsn: 2.253 ± 0.057	3.435ValPro: 3.435 ± 0.065	2.158ValGln: 2.158 ± 0.052	3.918ValArg: 3.918 ± 0.065	3.922ValSer: 3.922 ± 0.066	4.199ValThr: 4.199 ± 0.065	5.201ValVal: 5.201 ± 0.093	0.985ValTrp: 0.985 ± 0.032	1.652ValTyr: 1.652 ± 0.045	0.001ValXaa: 0.001 ± 0.001
Trp	1.327TrpAla: 1.327 ± 0.044	0.139TrpCys: 0.139 ± 0.011	0.761TrpAsp: 0.761 ± 0.031	0.637TrpGlu: 0.637 ± 0.03	0.583TrpPhe: 0.583 ± 0.024	1.034TrpGly: 1.034 ± 0.038	0.318TrpHis: 0.318 ± 0.019	0.782TrpIle: 0.782 ± 0.03	0.566TrpLys: 0.566 ± 0.028	1.754TrpLeu: 1.754 ± 0.048	0.402TrpMet: 0.402 ± 0.026	0.482TrpAsn: 0.482 ± 0.021	0.631TrpPro: 0.631 ± 0.029	0.722TrpGln: 0.722 ± 0.03	1.18TrpArg: 1.18 ± 0.041	0.799TrpSer: 0.799 ± 0.026	0.79TrpThr: 0.79 ± 0.035	0.846TrpVal: 0.846 ± 0.031	0.256TrpTrp: 0.256 ± 0.018	0.326TrpTyr: 0.326 ± 0.022	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.585TyrAla: 2.585 ± 0.054	0.247TyrCys: 0.247 ± 0.017	1.711TyrAsp: 1.711 ± 0.048	1.532TyrGlu: 1.532 ± 0.044	1.055TyrPhe: 1.055 ± 0.043	2.171TyrGly: 2.171 ± 0.053	0.594TyrHis: 0.594 ± 0.024	1.266TyrIle: 1.266 ± 0.044	0.934TyrLys: 0.934 ± 0.034	2.516TyrLeu: 2.516 ± 0.054	0.552TyrMet: 0.552 ± 0.022	0.792TyrAsn: 0.792 ± 0.033	1.158TyrPro: 1.158 ± 0.035	0.89TyrGln: 0.89 ± 0.03	1.773TyrArg: 1.773 ± 0.047	1.361TyrSer: 1.361 ± 0.039	1.195TyrThr: 1.195 ± 0.038	1.754TyrVal: 1.754 ± 0.045	0.358TyrTrp: 0.358 ± 0.023	0.752TyrTyr: 0.752 ± 0.034	0.003TyrXaa: 0.003 ± 0.002
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.002	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.004XaaLeu: 0.004 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.002	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.002	0.003XaaArg: 0.003 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3948 proteins (905382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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