Amino acid dipepetide frequency for Nasonia vitripennis (Parasitic wasp)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.49AlaAla: 7.49 ± 0.062	1.095AlaCys: 1.095 ± 0.013	3.423AlaAsp: 3.423 ± 0.029	4.621AlaGlu: 4.621 ± 0.029	2.04AlaPhe: 2.04 ± 0.013	4.103AlaGly: 4.103 ± 0.028	1.447AlaHis: 1.447 ± 0.011	3.277AlaIle: 3.277 ± 0.016	4.105AlaLys: 4.105 ± 0.05	5.862AlaLeu: 5.862 ± 0.029	1.563AlaMet: 1.563 ± 0.01	3.06AlaAsn: 3.06 ± 0.016	3.376AlaPro: 3.376 ± 0.027	2.983AlaGln: 2.983 ± 0.021	3.577AlaArg: 3.577 ± 0.018	5.944AlaSer: 5.944 ± 0.029	4.165AlaThr: 4.165 ± 0.019	4.376AlaVal: 4.376 ± 0.017	0.557AlaTrp: 0.557 ± 0.005	1.599AlaTyr: 1.599 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.032CysAla: 1.032 ± 0.009	0.466CysCys: 0.466 ± 0.008	0.998CysAsp: 0.998 ± 0.009	1.067CysGlu: 1.067 ± 0.011	0.629CysPhe: 0.629 ± 0.007	1.125CysGly: 1.125 ± 0.019	0.453CysHis: 0.453 ± 0.006	0.977CysIle: 0.977 ± 0.013	1.036CysLys: 1.036 ± 0.011	1.578CysLeu: 1.578 ± 0.013	0.361CysMet: 0.361 ± 0.005	0.848CysAsn: 0.848 ± 0.01	0.906CysPro: 0.906 ± 0.016	0.757CysGln: 0.757 ± 0.012	1.03CysArg: 1.03 ± 0.019	1.521CysSer: 1.521 ± 0.02	0.933CysThr: 0.933 ± 0.014	1.053CysVal: 1.053 ± 0.013	0.195CysTrp: 0.195 ± 0.004	0.515CysTyr: 0.515 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.532AspAla: 3.532 ± 0.042	0.963AspCys: 0.963 ± 0.01	4.097AspAsp: 4.097 ± 0.029	4.779AspGlu: 4.779 ± 0.032	2.05AspPhe: 2.05 ± 0.014	3.142AspGly: 3.142 ± 0.021	1.152AspHis: 1.152 ± 0.009	3.039AspIle: 3.039 ± 0.019	3.578AspLys: 3.578 ± 0.032	4.703AspLeu: 4.703 ± 0.023	1.175AspMet: 1.175 ± 0.01	2.585AspAsn: 2.585 ± 0.017	2.449AspPro: 2.449 ± 0.018	1.824AspGln: 1.824 ± 0.011	2.709AspArg: 2.709 ± 0.023	4.741AspSer: 4.741 ± 0.02	2.681AspThr: 2.681 ± 0.014	3.446AspVal: 3.446 ± 0.019	0.609AspTrp: 0.609 ± 0.007	1.798AspTyr: 1.798 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	4.663GluAla: 4.663 ± 0.029	1.081GluCys: 1.081 ± 0.02	4.404GluAsp: 4.404 ± 0.025	7.106GluGlu: 7.106 ± 0.076	2.136GluPhe: 2.136 ± 0.014	2.957GluGly: 2.957 ± 0.023	1.497GluHis: 1.497 ± 0.011	3.904GluIle: 3.904 ± 0.038	5.549GluLys: 5.549 ± 0.049	6.033GluLeu: 6.033 ± 0.034	1.604GluMet: 1.604 ± 0.01	3.701GluAsn: 3.701 ± 0.023	2.981GluPro: 2.981 ± 0.027	3.024GluGln: 3.024 ± 0.026	4.068GluArg: 4.068 ± 0.03	5.147GluSer: 5.147 ± 0.029	3.77GluThr: 3.77 ± 0.035	3.992GluVal: 3.992 ± 0.035	0.609GluTrp: 0.609 ± 0.008	1.792GluTyr: 1.792 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.102PheAla: 2.102 ± 0.015	0.69PheCys: 0.69 ± 0.007	1.969PheAsp: 1.969 ± 0.013	2.103PheGlu: 2.103 ± 0.015	1.367PhePhe: 1.367 ± 0.013	2.104PheGly: 2.104 ± 0.018	0.856PheHis: 0.856 ± 0.008	1.843PheIle: 1.843 ± 0.013	1.928PheLys: 1.928 ± 0.015	3.125PheLeu: 3.125 ± 0.022	0.737PheMet: 0.737 ± 0.007	1.627PheAsn: 1.627 ± 0.01	1.437PhePro: 1.437 ± 0.009	1.348PheGln: 1.348 ± 0.01	1.696PheArg: 1.696 ± 0.012	2.677PheSer: 2.677 ± 0.015	1.882PheThr: 1.882 ± 0.013	2.216PheVal: 2.216 ± 0.013	0.383PheTrp: 0.383 ± 0.006	1.132PheTyr: 1.132 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	3.674GlyAla: 3.674 ± 0.027	0.933GlyCys: 0.933 ± 0.011	2.788GlyAsp: 2.788 ± 0.016	3.276GlyGlu: 3.276 ± 0.019	2.039GlyPhe: 2.039 ± 0.015	5.048GlyGly: 5.048 ± 0.056	1.414GlyHis: 1.414 ± 0.011	2.85GlyIle: 2.85 ± 0.019	3.437GlyLys: 3.437 ± 0.029	4.442GlyLeu: 4.442 ± 0.024	1.22GlyMet: 1.22 ± 0.011	2.697GlyAsn: 2.697 ± 0.018	2.848GlyPro: 2.848 ± 0.033	2.339GlyGln: 2.339 ± 0.021	3.028GlyArg: 3.028 ± 0.019	5.31GlySer: 5.31 ± 0.034	3.021GlyThr: 3.021 ± 0.018	3.177GlyVal: 3.177 ± 0.016	0.568GlyTrp: 0.568 ± 0.007	1.864GlyTyr: 1.864 ± 0.013	0.0GlyXaa: 0.0 ± 0.0
His	1.503HisAla: 1.503 ± 0.015	0.527HisCys: 0.527 ± 0.007	1.099HisAsp: 1.099 ± 0.009	1.433HisGlu: 1.433 ± 0.011	0.873HisPhe: 0.873 ± 0.007	1.38HisGly: 1.38 ± 0.014	1.446HisHis: 1.446 ± 0.022	1.174HisIle: 1.174 ± 0.009	1.332HisLys: 1.332 ± 0.01	2.234HisLeu: 2.234 ± 0.014	0.551HisMet: 0.551 ± 0.007	1.136HisAsn: 1.136 ± 0.009	1.418HisPro: 1.418 ± 0.013	1.553HisGln: 1.553 ± 0.015	1.495HisArg: 1.495 ± 0.011	2.083HisSer: 2.083 ± 0.015	1.234HisThr: 1.234 ± 0.01	1.425HisVal: 1.425 ± 0.011	0.267HisTrp: 0.267 ± 0.004	0.807HisTyr: 0.807 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.352IleAla: 3.352 ± 0.016	0.997IleCys: 0.997 ± 0.012	2.993IleAsp: 2.993 ± 0.015	3.556IleGlu: 3.556 ± 0.027	2.023IlePhe: 2.023 ± 0.017	2.634IleGly: 2.634 ± 0.015	1.237IleHis: 1.237 ± 0.01	2.934IleIle: 2.934 ± 0.019	3.404IleLys: 3.404 ± 0.025	4.735IleLeu: 4.735 ± 0.025	1.086IleMet: 1.086 ± 0.009	2.653IleAsn: 2.653 ± 0.015	2.596IlePro: 2.596 ± 0.018	2.239IleGln: 2.239 ± 0.017	2.583IleArg: 2.583 ± 0.014	4.138IleSer: 4.138 ± 0.024	3.002IleThr: 3.002 ± 0.026	3.36IleVal: 3.36 ± 0.02	0.479IleTrp: 0.479 ± 0.005	1.475IleTyr: 1.475 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.805LysAla: 3.805 ± 0.033	1.104LysCys: 1.104 ± 0.014	3.812LysAsp: 3.812 ± 0.048	5.089LysGlu: 5.089 ± 0.046	2.013LysPhe: 2.013 ± 0.013	2.697LysGly: 2.697 ± 0.03	1.447LysHis: 1.447 ± 0.012	3.676LysIle: 3.676 ± 0.026	5.694LysLys: 5.694 ± 0.063	5.585LysLeu: 5.585 ± 0.028	1.437LysMet: 1.437 ± 0.01	3.234LysAsn: 3.234 ± 0.019	3.235LysPro: 3.235 ± 0.042	2.791LysGln: 2.791 ± 0.022	3.708LysArg: 3.708 ± 0.019	5.067LysSer: 5.067 ± 0.036	3.476LysThr: 3.476 ± 0.029	3.598LysVal: 3.598 ± 0.022	0.593LysTrp: 0.593 ± 0.007	1.844LysTyr: 1.844 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	6.016LeuAla: 6.016 ± 0.03	1.55LeuCys: 1.55 ± 0.013	4.776LeuAsp: 4.776 ± 0.023	6.413LeuGlu: 6.413 ± 0.038	2.789LeuPhe: 2.789 ± 0.021	4.428LeuGly: 4.428 ± 0.021	2.386LeuHis: 2.386 ± 0.016	4.005LeuIle: 4.005 ± 0.021	5.811LeuLys: 5.811 ± 0.027	8.443LeuLeu: 8.443 ± 0.047	1.893LeuMet: 1.893 ± 0.012	4.072LeuAsn: 4.072 ± 0.019	4.57LeuPro: 4.57 ± 0.024	4.688LeuGln: 4.688 ± 0.028	5.226LeuArg: 5.226 ± 0.028	7.055LeuSer: 7.055 ± 0.027	4.731LeuThr: 4.731 ± 0.018	4.914LeuVal: 4.914 ± 0.023	0.828LeuTrp: 0.828 ± 0.008	2.413LeuTyr: 2.413 ± 0.015	0.001LeuXaa: 0.001 ± 0.0
Met	1.554MetAla: 1.554 ± 0.011	0.363MetCys: 0.363 ± 0.005	1.277MetAsp: 1.277 ± 0.009	1.554MetGlu: 1.554 ± 0.012	0.768MetPhe: 0.768 ± 0.007	1.135MetGly: 1.135 ± 0.011	0.524MetHis: 0.524 ± 0.006	1.08MetIle: 1.08 ± 0.01	1.367MetLys: 1.367 ± 0.01	1.931MetLeu: 1.931 ± 0.013	0.653MetMet: 0.653 ± 0.007	1.049MetAsn: 1.049 ± 0.009	1.191MetPro: 1.191 ± 0.013	1.162MetGln: 1.162 ± 0.015	1.182MetArg: 1.182 ± 0.008	1.866MetSer: 1.866 ± 0.012	1.248MetThr: 1.248 ± 0.009	1.15MetVal: 1.15 ± 0.008	0.217MetTrp: 0.217 ± 0.004	0.652MetTyr: 0.652 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	3.185AsnAla: 3.185 ± 0.018	0.88AsnCys: 0.88 ± 0.01	2.682AsnAsp: 2.682 ± 0.018	3.181AsnGlu: 3.181 ± 0.016	1.736AsnPhe: 1.736 ± 0.014	3.082AsnGly: 3.082 ± 0.02	1.194AsnHis: 1.194 ± 0.01	2.792AsnIle: 2.792 ± 0.019	3.0AsnLys: 3.0 ± 0.017	4.318AsnLeu: 4.318 ± 0.022	1.054AsnMet: 1.054 ± 0.008	3.397AsnAsn: 3.397 ± 0.026	2.234AsnPro: 2.234 ± 0.017	2.136AsnGln: 2.136 ± 0.017	2.294AsnArg: 2.294 ± 0.014	4.288AsnSer: 4.288 ± 0.026	2.526AsnThr: 2.526 ± 0.015	3.109AsnVal: 3.109 ± 0.017	0.478AsnTrp: 0.478 ± 0.005	1.535AsnTyr: 1.535 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	3.881ProAla: 3.881 ± 0.024	0.731ProCys: 0.731 ± 0.024	2.596ProAsp: 2.596 ± 0.014	3.533ProGlu: 3.533 ± 0.037	1.477ProPhe: 1.477 ± 0.012	3.309ProGly: 3.309 ± 0.033	1.304ProHis: 1.304 ± 0.013	2.512ProIle: 2.512 ± 0.016	2.888ProLys: 2.888 ± 0.027	4.092ProLeu: 4.092 ± 0.017	1.148ProMet: 1.148 ± 0.011	2.345ProAsn: 2.345 ± 0.016	5.221ProPro: 5.221 ± 0.06	2.645ProGln: 2.645 ± 0.026	2.803ProArg: 2.803 ± 0.021	4.936ProSer: 4.936 ± 0.033	3.402ProThr: 3.402 ± 0.024	3.369ProVal: 3.369 ± 0.025	0.467ProTrp: 0.467 ± 0.006	1.416ProTyr: 1.416 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	3.102GlnAla: 3.102 ± 0.021	0.718GlnCys: 0.718 ± 0.01	2.122GlnAsp: 2.122 ± 0.013	3.266GlnGlu: 3.266 ± 0.027	1.278GlnPhe: 1.278 ± 0.01	2.066GlnGly: 2.066 ± 0.016	1.573GlnHis: 1.573 ± 0.017	2.195GlnIle: 2.195 ± 0.015	2.578GlnLys: 2.578 ± 0.02	4.191GlnLeu: 4.191 ± 0.023	1.098GlnMet: 1.098 ± 0.013	2.272GlnAsn: 2.272 ± 0.017	2.848GlnPro: 2.848 ± 0.026	7.088GlnGln: 7.088 ± 0.112	2.774GlnArg: 2.774 ± 0.017	3.598GlnSer: 3.598 ± 0.026	2.448GlnThr: 2.448 ± 0.018	2.545GlnVal: 2.545 ± 0.021	0.428GlnTrp: 0.428 ± 0.006	1.296GlnTyr: 1.296 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	3.393ArgAla: 3.393 ± 0.021	0.994ArgCys: 0.994 ± 0.011	3.042ArgAsp: 3.042 ± 0.02	3.85ArgGlu: 3.85 ± 0.023	1.844ArgPhe: 1.844 ± 0.013	2.914ArgGly: 2.914 ± 0.021	1.526ArgHis: 1.526 ± 0.012	2.728ArgIle: 2.728 ± 0.014	3.736ArgLys: 3.736 ± 0.018	5.004ArgLeu: 5.004 ± 0.027	1.175ArgMet: 1.175 ± 0.01	2.629ArgAsn: 2.629 ± 0.015	2.779ArgPro: 2.779 ± 0.023	2.555ArgGln: 2.555 ± 0.016	4.571ArgArg: 4.571 ± 0.033	4.809ArgSer: 4.809 ± 0.034	2.738ArgThr: 2.738 ± 0.015	2.98ArgVal: 2.98 ± 0.016	0.57ArgTrp: 0.57 ± 0.008	1.639ArgTyr: 1.639 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	5.705SerAla: 5.705 ± 0.03	1.393SerCys: 1.393 ± 0.019	4.525SerAsp: 4.525 ± 0.021	5.12SerGlu: 5.12 ± 0.029	2.659SerPhe: 2.659 ± 0.015	5.247SerGly: 5.247 ± 0.03	1.924SerHis: 1.924 ± 0.015	4.202SerIle: 4.202 ± 0.02	4.958SerLys: 4.958 ± 0.03	7.26SerLeu: 7.26 ± 0.032	1.792SerMet: 1.792 ± 0.012	4.315SerAsn: 4.315 ± 0.027	5.366SerPro: 5.366 ± 0.033	3.786SerGln: 3.786 ± 0.021	4.807SerArg: 4.807 ± 0.036	10.784SerSer: 10.784 ± 0.07	5.68SerThr: 5.68 ± 0.066	4.802SerVal: 4.802 ± 0.02	0.845SerTrp: 0.845 ± 0.007	2.134SerTyr: 2.134 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	4.148ThrAla: 4.148 ± 0.022	1.017ThrCys: 1.017 ± 0.013	2.876ThrAsp: 2.876 ± 0.017	3.576ThrGlu: 3.576 ± 0.03	1.869ThrPhe: 1.869 ± 0.012	3.353ThrGly: 3.353 ± 0.022	1.117ThrHis: 1.117 ± 0.009	3.112ThrIle: 3.112 ± 0.02	3.333ThrLys: 3.333 ± 0.026	4.895ThrLeu: 4.895 ± 0.022	1.202ThrMet: 1.202 ± 0.007	2.657ThrAsn: 2.657 ± 0.016	3.706ThrPro: 3.706 ± 0.025	2.125ThrGln: 2.125 ± 0.015	2.669ThrArg: 2.669 ± 0.017	5.471ThrSer: 5.471 ± 0.042	4.56ThrThr: 4.56 ± 0.055	3.56ThrVal: 3.56 ± 0.03	0.575ThrTrp: 0.575 ± 0.007	1.5ThrTyr: 1.5 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	4.241ValAla: 4.241 ± 0.017	1.166ValCys: 1.166 ± 0.013	3.392ValAsp: 3.392 ± 0.02	4.08ValGlu: 4.08 ± 0.038	2.036ValPhe: 2.036 ± 0.014	2.995ValGly: 2.995 ± 0.017	1.429ValHis: 1.429 ± 0.011	3.179ValIle: 3.179 ± 0.017	3.842ValLys: 3.842 ± 0.033	5.027ValLeu: 5.027 ± 0.022	1.275ValMet: 1.275 ± 0.01	2.856ValAsn: 2.856 ± 0.017	3.192ValPro: 3.192 ± 0.019	2.732ValGln: 2.732 ± 0.017	3.014ValArg: 3.014 ± 0.015	4.869ValSer: 4.869 ± 0.021	3.677ValThr: 3.677 ± 0.023	4.01ValVal: 4.01 ± 0.021	0.589ValTrp: 0.589 ± 0.006	1.683ValTyr: 1.683 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.542TrpAla: 0.542 ± 0.007	0.191TrpCys: 0.191 ± 0.004	0.513TrpAsp: 0.513 ± 0.006	0.582TrpGlu: 0.582 ± 0.006	0.4TrpPhe: 0.4 ± 0.006	0.484TrpGly: 0.484 ± 0.007	0.241TrpHis: 0.241 ± 0.004	0.564TrpIle: 0.564 ± 0.007	0.629TrpLys: 0.629 ± 0.007	1.002TrpLeu: 1.002 ± 0.011	0.261TrpMet: 0.261 ± 0.004	0.532TrpAsn: 0.532 ± 0.006	0.419TrpPro: 0.419 ± 0.006	0.445TrpGln: 0.445 ± 0.006	0.632TrpArg: 0.632 ± 0.006	0.776TrpSer: 0.776 ± 0.007	0.559TrpThr: 0.559 ± 0.006	0.485TrpVal: 0.485 ± 0.006	0.148TrpTrp: 0.148 ± 0.003	0.328TrpTyr: 0.328 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.745TyrAla: 1.745 ± 0.011	0.622TyrCys: 0.622 ± 0.007	1.668TyrAsp: 1.668 ± 0.012	1.833TyrGlu: 1.833 ± 0.011	1.194TyrPhe: 1.194 ± 0.012	1.769TyrGly: 1.769 ± 0.015	0.802TyrHis: 0.802 ± 0.008	1.433TyrIle: 1.433 ± 0.011	1.702TyrLys: 1.702 ± 0.012	2.547TyrLeu: 2.547 ± 0.017	0.638TyrMet: 0.638 ± 0.006	1.435TyrAsn: 1.435 ± 0.012	1.302TyrPro: 1.302 ± 0.012	1.265TyrGln: 1.265 ± 0.011	1.608TyrArg: 1.608 ± 0.009	2.223TyrSer: 2.223 ± 0.016	1.591TyrThr: 1.591 ± 0.01	1.717TyrVal: 1.717 ± 0.012	0.329TyrTrp: 0.329 ± 0.005	1.105TyrTyr: 1.105 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 24858 proteins (17866849 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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