Amino acid dipepetide frequency for Klebsiella phage vB_KpnP_KpV767

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.087AlaAla: 8.087 ± 0.965
0.728AlaCys: 0.728 ± 0.269
5.984AlaAsp: 5.984 ± 0.781
5.822AlaGlu: 5.822 ± 0.845
2.83AlaPhe: 2.83 ± 0.456
6.793AlaGly: 6.793 ± 0.959
1.213AlaHis: 1.213 ± 0.267
4.852AlaIle: 4.852 ± 0.58
6.227AlaLys: 6.227 ± 0.8
8.168AlaLeu: 8.168 ± 1.023
2.992AlaMet: 2.992 ± 0.618
4.448AlaAsn: 4.448 ± 0.561
2.83AlaPro: 2.83 ± 0.493
3.882AlaGln: 3.882 ± 0.667
4.852AlaArg: 4.852 ± 0.649
5.337AlaSer: 5.337 ± 0.642
4.205AlaThr: 4.205 ± 0.522
5.337AlaVal: 5.337 ± 0.665
1.213AlaTrp: 1.213 ± 0.399
3.235AlaTyr: 3.235 ± 0.551
0.0AlaXaa: 0.0 ± 0.0
Cys
0.566CysAla: 0.566 ± 0.24
0.081CysCys: 0.081 ± 0.087
0.566CysAsp: 0.566 ± 0.267
0.728CysGlu: 0.728 ± 0.258
0.404CysPhe: 0.404 ± 0.214
0.566CysGly: 0.566 ± 0.188
0.323CysHis: 0.323 ± 0.144
0.728CysIle: 0.728 ± 0.233
0.404CysLys: 0.404 ± 0.224
0.89CysLeu: 0.89 ± 0.339
0.0CysMet: 0.0 ± 0.0
0.081CysAsn: 0.081 ± 0.086
0.566CysPro: 0.566 ± 0.254
0.485CysGln: 0.485 ± 0.212
0.566CysArg: 0.566 ± 0.278
0.647CysSer: 0.647 ± 0.268
0.404CysThr: 0.404 ± 0.199
0.97CysVal: 0.97 ± 0.264
0.162CysTrp: 0.162 ± 0.109
0.323CysTyr: 0.323 ± 0.181
0.0CysXaa: 0.0 ± 0.0
Asp
5.337AspAla: 5.337 ± 0.612
0.485AspCys: 0.485 ± 0.24
3.962AspAsp: 3.962 ± 0.486
3.882AspGlu: 3.882 ± 0.432
2.911AspPhe: 2.911 ± 0.486
6.388AspGly: 6.388 ± 0.573
0.89AspHis: 0.89 ± 0.25
3.235AspIle: 3.235 ± 0.524
4.448AspLys: 4.448 ± 0.644
3.962AspLeu: 3.962 ± 0.703
2.345AspMet: 2.345 ± 0.41
2.264AspAsn: 2.264 ± 0.414
3.073AspPro: 3.073 ± 0.462
2.426AspGln: 2.426 ± 0.481
3.235AspArg: 3.235 ± 0.565
3.154AspSer: 3.154 ± 0.418
4.205AspThr: 4.205 ± 0.499
4.205AspVal: 4.205 ± 0.437
0.89AspTrp: 0.89 ± 0.304
2.426AspTyr: 2.426 ± 0.524
0.0AspXaa: 0.0 ± 0.0
Glu
7.44GluAla: 7.44 ± 1.051
0.566GluCys: 0.566 ± 0.261
5.095GluAsp: 5.095 ± 0.824
5.418GluGlu: 5.418 ± 1.151
2.669GluPhe: 2.669 ± 0.491
5.418GluGly: 5.418 ± 0.824
1.779GluHis: 1.779 ± 0.533
2.749GluIle: 2.749 ± 0.353
3.073GluLys: 3.073 ± 0.563
6.712GluLeu: 6.712 ± 0.803
2.183GluMet: 2.183 ± 0.631
1.941GluAsn: 1.941 ± 0.331
2.588GluPro: 2.588 ± 0.642
3.316GluGln: 3.316 ± 0.717
3.801GluArg: 3.801 ± 0.654
4.043GluSer: 4.043 ± 0.622
3.073GluThr: 3.073 ± 0.54
5.418GluVal: 5.418 ± 0.743
0.566GluTrp: 0.566 ± 0.197
3.073GluTyr: 3.073 ± 0.404
0.0GluXaa: 0.0 ± 0.0
Phe
2.588PheAla: 2.588 ± 0.489
0.243PheCys: 0.243 ± 0.181
2.992PheAsp: 2.992 ± 0.57
1.779PheGlu: 1.779 ± 0.347
0.809PhePhe: 0.809 ± 0.266
3.073PheGly: 3.073 ± 0.59
0.566PheHis: 0.566 ± 0.281
1.779PheIle: 1.779 ± 0.429
2.507PheLys: 2.507 ± 0.402
2.992PheLeu: 2.992 ± 0.582
0.89PheMet: 0.89 ± 0.299
2.103PheAsn: 2.103 ± 0.369
1.617PhePro: 1.617 ± 0.367
1.375PheGln: 1.375 ± 0.312
1.86PheArg: 1.86 ± 0.439
1.941PheSer: 1.941 ± 0.382
2.426PheThr: 2.426 ± 0.335
2.992PheVal: 2.992 ± 0.566
0.323PheTrp: 0.323 ± 0.149
1.213PheTyr: 1.213 ± 0.257
0.0PheXaa: 0.0 ± 0.0
Gly
7.197GlyAla: 7.197 ± 1.061
0.566GlyCys: 0.566 ± 0.264
5.337GlyAsp: 5.337 ± 0.508
5.499GlyGlu: 5.499 ± 0.735
2.83GlyPhe: 2.83 ± 0.414
5.499GlyGly: 5.499 ± 0.771
1.294GlyHis: 1.294 ± 0.326
4.933GlyIle: 4.933 ± 0.876
5.822GlyLys: 5.822 ± 0.909
5.822GlyLeu: 5.822 ± 0.811
1.779GlyMet: 1.779 ± 0.402
2.911GlyAsn: 2.911 ± 0.408
1.051GlyPro: 1.051 ± 0.387
2.588GlyGln: 2.588 ± 0.434
4.529GlyArg: 4.529 ± 0.432
5.903GlySer: 5.903 ± 0.826
4.286GlyThr: 4.286 ± 0.697
4.852GlyVal: 4.852 ± 0.724
1.698GlyTrp: 1.698 ± 0.418
3.235GlyTyr: 3.235 ± 0.467
0.0GlyXaa: 0.0 ± 0.0
His
1.213HisAla: 1.213 ± 0.295
0.404HisCys: 0.404 ± 0.161
1.132HisAsp: 1.132 ± 0.275
1.051HisGlu: 1.051 ± 0.385
0.97HisPhe: 0.97 ± 0.242
1.86HisGly: 1.86 ± 0.409
0.647HisHis: 0.647 ± 0.232
1.132HisIle: 1.132 ± 0.308
1.456HisLys: 1.456 ± 0.357
1.213HisLeu: 1.213 ± 0.326
0.647HisMet: 0.647 ± 0.232
0.404HisAsn: 0.404 ± 0.164
0.809HisPro: 0.809 ± 0.229
0.485HisGln: 0.485 ± 0.195
0.566HisArg: 0.566 ± 0.188
0.566HisSer: 0.566 ± 0.219
0.809HisThr: 0.809 ± 0.237
1.779HisVal: 1.779 ± 0.341
0.404HisTrp: 0.404 ± 0.161
0.809HisTyr: 0.809 ± 0.205
0.0HisXaa: 0.0 ± 0.0
Ile
4.852IleAla: 4.852 ± 0.62
0.485IleCys: 0.485 ± 0.171
3.477IleAsp: 3.477 ± 0.494
3.396IleGlu: 3.396 ± 0.682
0.728IlePhe: 0.728 ± 0.212
3.962IleGly: 3.962 ± 0.616
0.89IleHis: 0.89 ± 0.282
2.183IleIle: 2.183 ± 0.499
3.882IleLys: 3.882 ± 0.44
4.043IleLeu: 4.043 ± 0.497
1.051IleMet: 1.051 ± 0.334
2.264IleAsn: 2.264 ± 0.579
2.507IlePro: 2.507 ± 0.49
1.536IleGln: 1.536 ± 0.4
3.316IleArg: 3.316 ± 0.479
2.83IleSer: 2.83 ± 0.486
2.588IleThr: 2.588 ± 0.478
3.316IleVal: 3.316 ± 0.452
0.647IleTrp: 0.647 ± 0.228
1.779IleTyr: 1.779 ± 0.442
0.0IleXaa: 0.0 ± 0.0
Lys
7.763LysAla: 7.763 ± 0.792
0.485LysCys: 0.485 ± 0.187
3.962LysAsp: 3.962 ± 0.589
5.903LysGlu: 5.903 ± 0.714
2.669LysPhe: 2.669 ± 0.443
6.469LysGly: 6.469 ± 0.957
1.941LysHis: 1.941 ± 0.442
2.507LysIle: 2.507 ± 0.471
2.992LysLys: 2.992 ± 0.764
5.903LysLeu: 5.903 ± 0.807
1.698LysMet: 1.698 ± 0.351
2.749LysAsn: 2.749 ± 0.386
2.426LysPro: 2.426 ± 0.53
2.345LysGln: 2.345 ± 0.399
3.316LysArg: 3.316 ± 0.652
3.396LysSer: 3.396 ± 0.561
3.558LysThr: 3.558 ± 0.514
5.58LysVal: 5.58 ± 0.73
0.97LysTrp: 0.97 ± 0.295
1.617LysTyr: 1.617 ± 0.451
0.0LysXaa: 0.0 ± 0.0
Leu
7.601LeuAla: 7.601 ± 1.044
0.323LeuCys: 0.323 ± 0.16
4.529LeuAsp: 4.529 ± 0.583
6.955LeuGlu: 6.955 ± 1.138
2.83LeuPhe: 2.83 ± 0.44
5.661LeuGly: 5.661 ± 0.635
1.213LeuHis: 1.213 ± 0.332
3.639LeuIle: 3.639 ± 0.577
6.874LeuLys: 6.874 ± 0.745
6.388LeuLeu: 6.388 ± 0.922
2.345LeuMet: 2.345 ± 0.381
3.882LeuAsn: 3.882 ± 0.558
3.073LeuPro: 3.073 ± 0.528
3.316LeuGln: 3.316 ± 0.524
5.095LeuArg: 5.095 ± 0.553
4.043LeuSer: 4.043 ± 0.563
5.014LeuThr: 5.014 ± 0.738
5.256LeuVal: 5.256 ± 0.614
1.294LeuTrp: 1.294 ± 0.382
2.426LeuTyr: 2.426 ± 0.468
0.0LeuXaa: 0.0 ± 0.0
Met
3.154MetAla: 3.154 ± 0.476
0.323MetCys: 0.323 ± 0.199
1.941MetAsp: 1.941 ± 0.324
1.132MetGlu: 1.132 ± 0.283
0.809MetPhe: 0.809 ± 0.245
1.698MetGly: 1.698 ± 0.368
0.404MetHis: 0.404 ± 0.225
1.051MetIle: 1.051 ± 0.286
1.456MetLys: 1.456 ± 0.353
3.154MetLeu: 3.154 ± 0.511
0.647MetMet: 0.647 ± 0.264
1.213MetAsn: 1.213 ± 0.304
0.89MetPro: 0.89 ± 0.219
2.022MetGln: 2.022 ± 0.376
1.132MetArg: 1.132 ± 0.301
1.456MetSer: 1.456 ± 0.332
2.022MetThr: 2.022 ± 0.436
1.536MetVal: 1.536 ± 0.397
0.081MetTrp: 0.081 ± 0.093
0.809MetTyr: 0.809 ± 0.157
0.0MetXaa: 0.0 ± 0.0
Asn
4.286AsnAla: 4.286 ± 0.676
0.647AsnCys: 0.647 ± 0.292
2.426AsnAsp: 2.426 ± 0.362
2.749AsnGlu: 2.749 ± 0.558
1.456AsnPhe: 1.456 ± 0.347
4.205AsnGly: 4.205 ± 0.678
0.243AsnHis: 0.243 ± 0.125
2.911AsnIle: 2.911 ± 0.556
2.588AsnLys: 2.588 ± 0.46
2.588AsnLeu: 2.588 ± 0.426
0.89AsnMet: 0.89 ± 0.278
1.213AsnAsn: 1.213 ± 0.282
2.183AsnPro: 2.183 ± 0.355
1.213AsnGln: 1.213 ± 0.255
1.779AsnArg: 1.779 ± 0.468
2.669AsnSer: 2.669 ± 0.476
1.536AsnThr: 1.536 ± 0.348
2.83AsnVal: 2.83 ± 0.578
0.566AsnTrp: 0.566 ± 0.249
1.617AsnTyr: 1.617 ± 0.354
0.0AsnXaa: 0.0 ± 0.0
Pro
2.749ProAla: 2.749 ± 0.389
0.404ProCys: 0.404 ± 0.212
2.103ProAsp: 2.103 ± 0.341
4.529ProGlu: 4.529 ± 0.762
1.456ProPhe: 1.456 ± 0.3
2.022ProGly: 2.022 ± 0.383
0.485ProHis: 0.485 ± 0.175
1.132ProIle: 1.132 ± 0.304
2.911ProLys: 2.911 ± 0.537
2.507ProLeu: 2.507 ± 0.366
0.728ProMet: 0.728 ± 0.295
2.264ProAsn: 2.264 ± 0.453
0.97ProPro: 0.97 ± 0.326
1.375ProGln: 1.375 ± 0.302
1.698ProArg: 1.698 ± 0.391
2.345ProSer: 2.345 ± 0.414
2.183ProThr: 2.183 ± 0.497
2.83ProVal: 2.83 ± 0.374
0.647ProTrp: 0.647 ± 0.219
1.536ProTyr: 1.536 ± 0.358
0.0ProXaa: 0.0 ± 0.0
Gln
3.882GlnAla: 3.882 ± 0.631
0.162GlnCys: 0.162 ± 0.121
2.507GlnAsp: 2.507 ± 0.314
3.073GlnGlu: 3.073 ± 0.509
1.617GlnPhe: 1.617 ± 0.324
2.507GlnGly: 2.507 ± 0.437
0.485GlnHis: 0.485 ± 0.227
1.536GlnIle: 1.536 ± 0.428
2.911GlnLys: 2.911 ± 0.46
4.286GlnLeu: 4.286 ± 0.47
1.213GlnMet: 1.213 ± 0.378
1.213GlnAsn: 1.213 ± 0.278
1.779GlnPro: 1.779 ± 0.241
3.477GlnGln: 3.477 ± 0.669
2.022GlnArg: 2.022 ± 0.521
2.911GlnSer: 2.911 ± 0.523
1.86GlnThr: 1.86 ± 0.452
2.992GlnVal: 2.992 ± 0.522
0.97GlnTrp: 0.97 ± 0.275
1.617GlnTyr: 1.617 ± 0.466
0.0GlnXaa: 0.0 ± 0.0
Arg
4.771ArgAla: 4.771 ± 0.739
0.728ArgCys: 0.728 ± 0.278
3.72ArgAsp: 3.72 ± 0.53
3.801ArgGlu: 3.801 ± 0.574
1.86ArgPhe: 1.86 ± 0.426
3.639ArgGly: 3.639 ± 0.463
1.213ArgHis: 1.213 ± 0.332
3.639ArgIle: 3.639 ± 0.562
4.124ArgLys: 4.124 ± 0.584
4.286ArgLeu: 4.286 ± 0.494
1.294ArgMet: 1.294 ± 0.257
2.345ArgAsn: 2.345 ± 0.371
1.86ArgPro: 1.86 ± 0.37
2.264ArgGln: 2.264 ± 0.485
3.073ArgArg: 3.073 ± 0.495
3.801ArgSer: 3.801 ± 0.55
2.83ArgThr: 2.83 ± 0.484
3.073ArgVal: 3.073 ± 0.513
0.89ArgTrp: 0.89 ± 0.286
1.213ArgTyr: 1.213 ± 0.241
0.0ArgXaa: 0.0 ± 0.0
Ser
4.205SerAla: 4.205 ± 0.491
0.97SerCys: 0.97 ± 0.281
4.043SerAsp: 4.043 ± 0.573
3.882SerGlu: 3.882 ± 0.488
3.235SerPhe: 3.235 ± 0.497
4.448SerGly: 4.448 ± 0.657
1.294SerHis: 1.294 ± 0.301
2.83SerIle: 2.83 ± 0.487
4.448SerLys: 4.448 ± 0.475
4.205SerLeu: 4.205 ± 0.607
1.617SerMet: 1.617 ± 0.373
1.456SerAsn: 1.456 ± 0.394
1.698SerPro: 1.698 ± 0.35
2.749SerGln: 2.749 ± 0.544
3.396SerArg: 3.396 ± 0.623
2.83SerSer: 2.83 ± 0.472
3.882SerThr: 3.882 ± 0.631
4.043SerVal: 4.043 ± 0.595
0.809SerTrp: 0.809 ± 0.184
2.183SerTyr: 2.183 ± 0.532
0.0SerXaa: 0.0 ± 0.0
Thr
4.286ThrAla: 4.286 ± 0.74
0.809ThrCys: 0.809 ± 0.248
3.154ThrAsp: 3.154 ± 0.403
3.477ThrGlu: 3.477 ± 0.637
2.103ThrPhe: 2.103 ± 0.437
4.933ThrGly: 4.933 ± 0.744
1.132ThrHis: 1.132 ± 0.25
3.235ThrIle: 3.235 ± 0.48
4.529ThrLys: 4.529 ± 0.669
5.175ThrLeu: 5.175 ± 0.651
1.375ThrMet: 1.375 ± 0.306
1.941ThrAsn: 1.941 ± 0.462
2.669ThrPro: 2.669 ± 0.401
2.669ThrGln: 2.669 ± 0.444
2.426ThrArg: 2.426 ± 0.37
3.396ThrSer: 3.396 ± 0.561
2.992ThrThr: 2.992 ± 0.667
3.72ThrVal: 3.72 ± 0.686
0.809ThrTrp: 0.809 ± 0.289
1.86ThrTyr: 1.86 ± 0.449
0.0ThrXaa: 0.0 ± 0.0
Val
5.661ValAla: 5.661 ± 0.69
0.404ValCys: 0.404 ± 0.186
3.396ValAsp: 3.396 ± 0.37
3.962ValGlu: 3.962 ± 0.488
2.183ValPhe: 2.183 ± 0.462
4.852ValGly: 4.852 ± 0.451
1.294ValHis: 1.294 ± 0.32
3.72ValIle: 3.72 ± 0.519
4.043ValLys: 4.043 ± 0.478
5.742ValLeu: 5.742 ± 0.746
1.294ValMet: 1.294 ± 0.355
3.477ValAsn: 3.477 ± 0.688
2.507ValPro: 2.507 ± 0.572
2.911ValGln: 2.911 ± 0.528
4.69ValArg: 4.69 ± 0.664
4.529ValSer: 4.529 ± 0.8
5.984ValThr: 5.984 ± 0.73
4.771ValVal: 4.771 ± 0.716
0.89ValTrp: 0.89 ± 0.276
2.669ValTyr: 2.669 ± 0.482
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.271
0.404TrpCys: 0.404 ± 0.17
0.647TrpAsp: 0.647 ± 0.213
1.213TrpGlu: 1.213 ± 0.262
0.485TrpPhe: 0.485 ± 0.194
0.647TrpGly: 0.647 ± 0.207
0.404TrpHis: 0.404 ± 0.254
0.566TrpIle: 0.566 ± 0.356
1.536TrpLys: 1.536 ± 0.376
1.375TrpLeu: 1.375 ± 0.348
0.566TrpMet: 0.566 ± 0.263
0.566TrpAsn: 0.566 ± 0.225
0.243TrpPro: 0.243 ± 0.126
0.647TrpGln: 0.647 ± 0.27
0.97TrpArg: 0.97 ± 0.219
1.051TrpSer: 1.051 ± 0.325
0.809TrpThr: 0.809 ± 0.248
1.213TrpVal: 1.213 ± 0.342
0.243TrpTrp: 0.243 ± 0.142
0.081TrpTyr: 0.081 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.507TyrAla: 2.507 ± 0.447
0.243TyrCys: 0.243 ± 0.217
2.83TyrAsp: 2.83 ± 0.61
2.669TyrGlu: 2.669 ± 0.458
1.213TyrPhe: 1.213 ± 0.284
2.992TyrGly: 2.992 ± 0.439
0.647TyrHis: 0.647 ± 0.23
1.375TyrIle: 1.375 ± 0.302
2.022TyrLys: 2.022 ± 0.379
2.345TyrLeu: 2.345 ± 0.455
1.294TyrMet: 1.294 ± 0.351
1.86TyrAsn: 1.86 ± 0.428
1.536TyrPro: 1.536 ± 0.388
1.941TyrGln: 1.941 ± 0.523
2.103TyrArg: 2.103 ± 0.398
1.375TyrSer: 1.375 ± 0.395
2.022TyrThr: 2.022 ± 0.432
2.264TyrVal: 2.264 ± 0.491
0.485TyrTrp: 0.485 ± 0.229
1.051TyrTyr: 1.051 ± 0.326
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (12367 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski