Amino acid dipepetide frequency for Comamonas testosteroni (strain CNB-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.304AlaAla: 17.304 ± 0.183	1.324AlaCys: 1.324 ± 0.031	6.112AlaAsp: 6.112 ± 0.067	6.729AlaGlu: 6.729 ± 0.077	3.658AlaPhe: 3.658 ± 0.048	10.067AlaGly: 10.067 ± 0.088	2.575AlaHis: 2.575 ± 0.041	5.111AlaIle: 5.111 ± 0.061	4.248AlaLys: 4.248 ± 0.081	14.367AlaLeu: 14.367 ± 0.142	3.788AlaMet: 3.788 ± 0.057	2.958AlaAsn: 2.958 ± 0.054	5.479AlaPro: 5.479 ± 0.068	7.068AlaGln: 7.068 ± 0.094	7.887AlaArg: 7.887 ± 0.083	7.1AlaSer: 7.1 ± 0.088	5.552AlaThr: 5.552 ± 0.064	8.84AlaVal: 8.84 ± 0.082	1.842AlaTrp: 1.842 ± 0.041	2.49AlaTyr: 2.49 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.176CysAla: 1.176 ± 0.032	0.134CysCys: 0.134 ± 0.01	0.481CysAsp: 0.481 ± 0.017	0.527CysGlu: 0.527 ± 0.021	0.343CysPhe: 0.343 ± 0.015	0.992CysGly: 0.992 ± 0.027	0.269CysHis: 0.269 ± 0.016	0.446CysIle: 0.446 ± 0.02	0.286CysLys: 0.286 ± 0.012	0.928CysLeu: 0.928 ± 0.026	0.295CysMet: 0.295 ± 0.015	0.269CysAsn: 0.269 ± 0.014	0.464CysPro: 0.464 ± 0.019	0.319CysGln: 0.319 ± 0.014	0.534CysArg: 0.534 ± 0.019	0.59CysSer: 0.59 ± 0.022	0.52CysThr: 0.52 ± 0.019	0.718CysVal: 0.718 ± 0.021	0.143CysTrp: 0.143 ± 0.011	0.198CysTyr: 0.198 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.495AspAla: 6.495 ± 0.075	0.479AspCys: 0.479 ± 0.018	2.273AspAsp: 2.273 ± 0.044	3.071AspGlu: 3.071 ± 0.045	2.013AspPhe: 2.013 ± 0.039	4.212AspGly: 4.212 ± 0.058	1.017AspHis: 1.017 ± 0.029	2.43AspIle: 2.43 ± 0.04	1.952AspLys: 1.952 ± 0.037	5.032AspLeu: 5.032 ± 0.058	1.436AspMet: 1.436 ± 0.03	1.234AspAsn: 1.234 ± 0.029	2.36AspPro: 2.36 ± 0.039	1.778AspGln: 1.778 ± 0.036	2.717AspArg: 2.717 ± 0.048	2.564AspSer: 2.564 ± 0.041	2.182AspThr: 2.182 ± 0.041	3.691AspVal: 3.691 ± 0.054	1.014AspTrp: 1.014 ± 0.028	1.371AspTyr: 1.371 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.47GluAla: 6.47 ± 0.074	0.419GluCys: 0.419 ± 0.016	2.297GluAsp: 2.297 ± 0.039	2.775GluGlu: 2.775 ± 0.044	1.797GluPhe: 1.797 ± 0.037	3.714GluGly: 3.714 ± 0.054	1.416GluHis: 1.416 ± 0.033	2.601GluIle: 2.601 ± 0.049	2.214GluLys: 2.214 ± 0.047	6.166GluLeu: 6.166 ± 0.072	1.39GluMet: 1.39 ± 0.033	1.373GluAsn: 1.373 ± 0.029	2.334GluPro: 2.334 ± 0.039	3.433GluGln: 3.433 ± 0.056	4.293GluArg: 4.293 ± 0.059	2.779GluSer: 2.779 ± 0.042	2.363GluThr: 2.363 ± 0.038	4.019GluVal: 4.019 ± 0.051	0.73GluTrp: 0.73 ± 0.023	1.088GluTyr: 1.088 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.068PheAla: 4.068 ± 0.049	0.427PheCys: 0.427 ± 0.019	2.207PheAsp: 2.207 ± 0.037	1.967PheGlu: 1.967 ± 0.04	1.337PhePhe: 1.337 ± 0.037	3.22PheGly: 3.22 ± 0.046	0.657PheHis: 0.657 ± 0.021	1.492PheIle: 1.492 ± 0.036	1.337PheLys: 1.337 ± 0.031	2.837PheLeu: 2.837 ± 0.052	0.936PheMet: 0.936 ± 0.026	1.143PheAsn: 1.143 ± 0.033	1.41PhePro: 1.41 ± 0.029	1.054PheGln: 1.054 ± 0.027	1.623PheArg: 1.623 ± 0.032	2.228PheSer: 2.228 ± 0.042	1.804PheThr: 1.804 ± 0.036	2.71PheVal: 2.71 ± 0.042	0.562PheTrp: 0.562 ± 0.022	0.907PheTyr: 0.907 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.437GlyAla: 8.437 ± 0.087	0.891GlyCys: 0.891 ± 0.026	3.66GlyAsp: 3.66 ± 0.051	4.183GlyGlu: 4.183 ± 0.062	3.187GlyPhe: 3.187 ± 0.052	6.67GlyGly: 6.67 ± 0.093	1.857GlyHis: 1.857 ± 0.038	4.0GlyIle: 4.0 ± 0.053	3.714GlyLys: 3.714 ± 0.062	9.021GlyLeu: 9.021 ± 0.089	2.602GlyMet: 2.602 ± 0.043	2.417GlyAsn: 2.417 ± 0.047	2.723GlyPro: 2.723 ± 0.043	3.85GlyGln: 3.85 ± 0.055	4.933GlyArg: 4.933 ± 0.069	5.008GlySer: 5.008 ± 0.058	4.071GlyThr: 4.071 ± 0.062	6.248GlyVal: 6.248 ± 0.071	1.513GlyTrp: 1.513 ± 0.035	2.324GlyTyr: 2.324 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.712HisAla: 2.712 ± 0.047	0.313HisCys: 0.313 ± 0.015	1.144HisAsp: 1.144 ± 0.029	1.193HisGlu: 1.193 ± 0.03	0.896HisPhe: 0.896 ± 0.024	2.053HisGly: 2.053 ± 0.034	0.601HisHis: 0.601 ± 0.023	1.07HisIle: 1.07 ± 0.03	0.651HisLys: 0.651 ± 0.019	2.218HisLeu: 2.218 ± 0.043	0.624HisMet: 0.624 ± 0.022	0.544HisAsn: 0.544 ± 0.019	1.332HisPro: 1.332 ± 0.031	0.906HisGln: 0.906 ± 0.026	1.273HisArg: 1.273 ± 0.034	1.291HisSer: 1.291 ± 0.033	0.998HisThr: 0.998 ± 0.026	1.56HisVal: 1.56 ± 0.038	0.505HisTrp: 0.505 ± 0.019	0.646HisTyr: 0.646 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.364IleAla: 6.364 ± 0.072	0.479IleCys: 0.479 ± 0.018	2.742IleAsp: 2.742 ± 0.039	2.933IleGlu: 2.933 ± 0.052	1.397IlePhe: 1.397 ± 0.034	3.905IleGly: 3.905 ± 0.061	0.923IleHis: 0.923 ± 0.029	1.697IleIle: 1.697 ± 0.038	1.726IleLys: 1.726 ± 0.042	3.315IleLeu: 3.315 ± 0.049	0.889IleMet: 0.889 ± 0.028	1.623IleAsn: 1.623 ± 0.04	2.112IlePro: 2.112 ± 0.039	1.55IleGln: 1.55 ± 0.034	2.48IleArg: 2.48 ± 0.043	2.839IleSer: 2.839 ± 0.049	2.555IleThr: 2.555 ± 0.048	3.368IleVal: 3.368 ± 0.051	0.608IleTrp: 0.608 ± 0.02	1.079IleTyr: 1.079 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.771LysAla: 4.771 ± 0.079	0.17LysCys: 0.17 ± 0.01	1.898LysAsp: 1.898 ± 0.044	1.816LysGlu: 1.816 ± 0.043	0.945LysPhe: 0.945 ± 0.026	2.701LysGly: 2.701 ± 0.049	0.732LysHis: 0.732 ± 0.021	1.62LysIle: 1.62 ± 0.046	1.564LysLys: 1.564 ± 0.043	3.912LysLeu: 3.912 ± 0.059	0.87LysMet: 0.87 ± 0.027	1.152LysAsn: 1.152 ± 0.032	2.3LysPro: 2.3 ± 0.047	1.636LysGln: 1.636 ± 0.036	2.191LysArg: 2.191 ± 0.039	2.112LysSer: 2.112 ± 0.042	2.08LysThr: 2.08 ± 0.048	2.757LysVal: 2.757 ± 0.049	0.367LysTrp: 0.367 ± 0.016	0.7LysTyr: 0.7 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.922LeuAla: 13.922 ± 0.125	1.102LeuCys: 1.102 ± 0.031	5.404LeuAsp: 5.404 ± 0.062	5.372LeuGlu: 5.372 ± 0.066	3.192LeuPhe: 3.192 ± 0.05	8.79LeuGly: 8.79 ± 0.088	2.468LeuHis: 2.468 ± 0.052	4.635LeuIle: 4.635 ± 0.063	3.865LeuLys: 3.865 ± 0.051	11.644LeuLeu: 11.644 ± 0.137	2.922LeuMet: 2.922 ± 0.047	3.027LeuAsn: 3.027 ± 0.048	6.106LeuPro: 6.106 ± 0.064	5.608LeuGln: 5.608 ± 0.082	7.116LeuArg: 7.116 ± 0.087	6.758LeuSer: 6.758 ± 0.072	5.161LeuThr: 5.161 ± 0.064	7.281LeuVal: 7.281 ± 0.089	1.468LeuTrp: 1.468 ± 0.038	2.054LeuTyr: 2.054 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.48MetAla: 3.48 ± 0.051	0.197MetCys: 0.197 ± 0.014	1.329MetAsp: 1.329 ± 0.029	1.302MetGlu: 1.302 ± 0.032	0.79MetPhe: 0.79 ± 0.023	2.203MetGly: 2.203 ± 0.042	0.664MetHis: 0.664 ± 0.022	0.98MetIle: 0.98 ± 0.027	1.092MetLys: 1.092 ± 0.028	3.143MetLeu: 3.143 ± 0.052	0.581MetMet: 0.581 ± 0.021	0.874MetAsn: 0.874 ± 0.023	1.649MetPro: 1.649 ± 0.034	1.521MetGln: 1.521 ± 0.032	1.789MetArg: 1.789 ± 0.035	1.82MetSer: 1.82 ± 0.037	1.62MetThr: 1.62 ± 0.033	1.902MetVal: 1.902 ± 0.038	0.251MetTrp: 0.251 ± 0.013	0.438MetTyr: 0.438 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.476AsnAla: 3.476 ± 0.052	0.272AsnCys: 0.272 ± 0.013	1.322AsnAsp: 1.322 ± 0.028	1.292AsnGlu: 1.292 ± 0.028	1.034AsnPhe: 1.034 ± 0.025	2.348AsnGly: 2.348 ± 0.039	0.59AsnHis: 0.59 ± 0.02	1.342AsnIle: 1.342 ± 0.031	0.969AsnLys: 0.969 ± 0.025	2.811AsnLeu: 2.811 ± 0.046	0.721AsnMet: 0.721 ± 0.024	0.886AsnAsn: 0.886 ± 0.028	1.871AsnPro: 1.871 ± 0.036	1.173AsnGln: 1.173 ± 0.029	1.655AsnArg: 1.655 ± 0.034	1.433AsnSer: 1.433 ± 0.033	1.554AsnThr: 1.554 ± 0.032	2.001AsnVal: 2.001 ± 0.035	0.473AsnTrp: 0.473 ± 0.017	0.774AsnTyr: 0.774 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.452ProAla: 6.452 ± 0.088	0.356ProCys: 0.356 ± 0.016	2.753ProAsp: 2.753 ± 0.05	3.452ProGlu: 3.452 ± 0.044	1.698ProPhe: 1.698 ± 0.033	4.227ProGly: 4.227 ± 0.059	1.103ProHis: 1.103 ± 0.03	1.854ProIle: 1.854 ± 0.036	1.534ProLys: 1.534 ± 0.036	5.088ProLeu: 5.088 ± 0.065	1.399ProMet: 1.399 ± 0.027	1.224ProAsn: 1.224 ± 0.029	2.003ProPro: 2.003 ± 0.042	2.507ProGln: 2.507 ± 0.041	2.56ProArg: 2.56 ± 0.044	2.688ProSer: 2.688 ± 0.045	2.229ProThr: 2.229 ± 0.038	4.175ProVal: 4.175 ± 0.053	0.782ProTrp: 0.782 ± 0.023	1.109ProTyr: 1.109 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	6.932GlnAla: 6.932 ± 0.098	0.387GlnCys: 0.387 ± 0.017	1.957GlnAsp: 1.957 ± 0.04	2.159GlnGlu: 2.159 ± 0.044	1.402GlnPhe: 1.402 ± 0.029	3.812GlnGly: 3.812 ± 0.057	1.136GlnHis: 1.136 ± 0.027	2.194GlnIle: 2.194 ± 0.036	1.553GlnLys: 1.553 ± 0.033	5.456GlnLeu: 5.456 ± 0.075	1.25GlnMet: 1.25 ± 0.032	1.111GlnAsn: 1.111 ± 0.03	2.605GlnPro: 2.605 ± 0.043	3.051GlnGln: 3.051 ± 0.072	3.638GlnArg: 3.638 ± 0.052	2.773GlnSer: 2.773 ± 0.05	2.324GlnThr: 2.324 ± 0.045	3.247GlnVal: 3.247 ± 0.046	0.965GlnTrp: 0.965 ± 0.027	0.926GlnTyr: 0.926 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.552ArgAla: 6.552 ± 0.068	0.598ArgCys: 0.598 ± 0.02	3.144ArgAsp: 3.144 ± 0.051	3.806ArgGlu: 3.806 ± 0.057	2.495ArgPhe: 2.495 ± 0.038	3.932ArgGly: 3.932 ± 0.053	1.703ArgHis: 1.703 ± 0.037	3.322ArgIle: 3.322 ± 0.048	2.33ArgLys: 2.33 ± 0.047	6.959ArgLeu: 6.959 ± 0.086	1.934ArgMet: 1.934 ± 0.033	1.98ArgAsn: 1.98 ± 0.038	2.728ArgPro: 2.728 ± 0.046	3.206ArgGln: 3.206 ± 0.057	4.085ArgArg: 4.085 ± 0.062	3.824ArgSer: 3.824 ± 0.057	2.867ArgThr: 2.867 ± 0.044	4.211ArgVal: 4.211 ± 0.051	1.221ArgTrp: 1.221 ± 0.03	1.685ArgTyr: 1.685 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.883SerAla: 6.883 ± 0.065	0.547SerCys: 0.547 ± 0.021	2.676SerAsp: 2.676 ± 0.046	2.896SerGlu: 2.896 ± 0.047	2.204SerPhe: 2.204 ± 0.043	5.35SerGly: 5.35 ± 0.062	1.333SerHis: 1.333 ± 0.036	2.828SerIle: 2.828 ± 0.044	1.97SerLys: 1.97 ± 0.04	6.217SerLeu: 6.217 ± 0.067	1.768SerMet: 1.768 ± 0.032	1.693SerAsn: 1.693 ± 0.038	2.829SerPro: 2.829 ± 0.049	2.495SerGln: 2.495 ± 0.043	3.581SerArg: 3.581 ± 0.053	3.919SerSer: 3.919 ± 0.062	3.053SerThr: 3.053 ± 0.045	4.219SerVal: 4.219 ± 0.057	0.952SerTrp: 0.952 ± 0.025	1.551SerTyr: 1.551 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.016ThrAla: 6.016 ± 0.078	0.393ThrCys: 0.393 ± 0.017	2.348ThrAsp: 2.348 ± 0.038	2.48ThrGlu: 2.48 ± 0.042	1.495ThrPhe: 1.495 ± 0.035	4.635ThrGly: 4.635 ± 0.06	1.044ThrHis: 1.044 ± 0.027	2.023ThrIle: 2.023 ± 0.04	1.345ThrLys: 1.345 ± 0.037	5.675ThrLeu: 5.675 ± 0.069	1.195ThrMet: 1.195 ± 0.03	1.187ThrAsn: 1.187 ± 0.029	3.305ThrPro: 3.305 ± 0.048	2.164ThrGln: 2.164 ± 0.041	2.902ThrArg: 2.902 ± 0.054	2.809ThrSer: 2.809 ± 0.047	2.648ThrThr: 2.648 ± 0.047	3.885ThrVal: 3.885 ± 0.054	0.653ThrTrp: 0.653 ± 0.022	1.036ThrTyr: 1.036 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.872ValAla: 8.872 ± 0.086	0.728ValCys: 0.728 ± 0.023	3.759ValAsp: 3.759 ± 0.046	3.854ValGlu: 3.854 ± 0.052	2.558ValPhe: 2.558 ± 0.042	5.32ValGly: 5.32 ± 0.064	1.605ValHis: 1.605 ± 0.034	3.471ValIle: 3.471 ± 0.052	2.627ValLys: 2.627 ± 0.048	8.31ValLeu: 8.31 ± 0.086	2.045ValMet: 2.045 ± 0.04	2.192ValAsn: 2.192 ± 0.044	3.72ValPro: 3.72 ± 0.044	3.593ValGln: 3.593 ± 0.051	4.531ValArg: 4.531 ± 0.059	4.157ValSer: 4.157 ± 0.052	3.748ValThr: 3.748 ± 0.057	5.833ValVal: 5.833 ± 0.084	0.972ValTrp: 0.972 ± 0.026	1.496ValTyr: 1.496 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.444TrpAla: 1.444 ± 0.029	0.181TrpCys: 0.181 ± 0.01	0.616TrpAsp: 0.616 ± 0.02	0.618TrpGlu: 0.618 ± 0.023	0.577TrpPhe: 0.577 ± 0.02	1.105TrpGly: 1.105 ± 0.027	0.404TrpHis: 0.404 ± 0.016	0.668TrpIle: 0.668 ± 0.021	0.54TrpLys: 0.54 ± 0.021	2.34TrpLeu: 2.34 ± 0.051	0.473TrpMet: 0.473 ± 0.019	0.482TrpAsn: 0.482 ± 0.017	0.769TrpPro: 0.769 ± 0.023	0.975TrpGln: 0.975 ± 0.031	1.181TrpArg: 1.181 ± 0.031	0.952TrpSer: 0.952 ± 0.026	0.726TrpThr: 0.726 ± 0.025	1.075TrpVal: 1.075 ± 0.027	0.314TrpTrp: 0.314 ± 0.017	0.289TrpTyr: 0.289 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.674TyrAla: 2.674 ± 0.04	0.237TyrCys: 0.237 ± 0.012	1.198TyrAsp: 1.198 ± 0.031	1.248TyrGlu: 1.248 ± 0.031	0.909TyrPhe: 0.909 ± 0.025	2.053TyrGly: 2.053 ± 0.04	0.432TyrHis: 0.432 ± 0.018	0.798TyrIle: 0.798 ± 0.027	0.778TyrLys: 0.778 ± 0.025	2.46TyrLeu: 2.46 ± 0.042	0.505TyrMet: 0.505 ± 0.018	0.625TyrAsn: 0.625 ± 0.025	1.096TyrPro: 1.096 ± 0.027	0.989TyrGln: 0.989 ± 0.025	1.612TyrArg: 1.612 ± 0.037	1.32TyrSer: 1.32 ± 0.028	1.183TyrThr: 1.183 ± 0.033	1.65TyrVal: 1.65 ± 0.035	0.393TyrTrp: 0.393 ± 0.016	0.59TyrTyr: 0.59 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4780 proteins (1538069 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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