Amino acid dipepetide frequency for Staphylococcus sp. CAG:324

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.604AlaAla: 2.604 ± 0.099
0.648AlaCys: 0.648 ± 0.042
2.128AlaAsp: 2.128 ± 0.075
2.501AlaGlu: 2.501 ± 0.072
2.428AlaPhe: 2.428 ± 0.097
2.878AlaGly: 2.878 ± 0.087
0.767AlaHis: 0.767 ± 0.044
5.703AlaIle: 5.703 ± 0.122
4.792AlaLys: 4.792 ± 0.112
5.322AlaLeu: 5.322 ± 0.132
1.426AlaMet: 1.426 ± 0.056
3.129AlaAsn: 3.129 ± 0.091
1.212AlaPro: 1.212 ± 0.042
1.428AlaGln: 1.428 ± 0.069
1.778AlaArg: 1.778 ± 0.071
3.687AlaSer: 3.687 ± 0.106
3.5AlaThr: 3.5 ± 0.099
2.92AlaVal: 2.92 ± 0.09
0.35AlaTrp: 0.35 ± 0.024
2.517AlaTyr: 2.517 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.654CysAla: 0.654 ± 0.038
0.199CysCys: 0.199 ± 0.026
0.691CysAsp: 0.691 ± 0.04
0.743CysGlu: 0.743 ± 0.04
0.622CysPhe: 0.622 ± 0.032
1.017CysGly: 1.017 ± 0.055
0.238CysHis: 0.238 ± 0.024
1.033CysIle: 1.033 ± 0.045
0.944CysLys: 0.944 ± 0.041
1.079CysLeu: 1.079 ± 0.047
0.266CysMet: 0.266 ± 0.024
0.729CysAsn: 0.729 ± 0.039
0.433CysPro: 0.433 ± 0.032
0.375CysGln: 0.375 ± 0.029
0.278CysArg: 0.278 ± 0.026
0.789CysSer: 0.789 ± 0.047
0.536CysThr: 0.536 ± 0.035
0.691CysVal: 0.691 ± 0.037
0.064CysTrp: 0.064 ± 0.011
0.685CysTyr: 0.685 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.182AspAla: 3.182 ± 0.099
0.66AspCys: 0.66 ± 0.047
3.554AspAsp: 3.554 ± 0.091
5.322AspGlu: 5.322 ± 0.121
2.857AspPhe: 2.857 ± 0.087
3.498AspGly: 3.498 ± 0.094
0.832AspHis: 0.832 ± 0.038
5.332AspIle: 5.332 ± 0.107
4.501AspLys: 4.501 ± 0.114
5.328AspLeu: 5.328 ± 0.108
1.248AspMet: 1.248 ± 0.051
3.443AspAsn: 3.443 ± 0.085
1.353AspPro: 1.353 ± 0.06
1.408AspGln: 1.408 ± 0.056
1.357AspArg: 1.357 ± 0.052
3.109AspSer: 3.109 ± 0.084
2.805AspThr: 2.805 ± 0.082
3.645AspVal: 3.645 ± 0.102
0.364AspTrp: 0.364 ± 0.028
3.278AspTyr: 3.278 ± 0.095
0.0AspXaa: 0.0 ± 0.0
Glu
3.691GluAla: 3.691 ± 0.107
0.62GluCys: 0.62 ± 0.037
3.623GluAsp: 3.623 ± 0.097
6.184GluGlu: 6.184 ± 0.16
2.861GluPhe: 2.861 ± 0.085
3.379GluGly: 3.379 ± 0.103
0.912GluHis: 0.912 ± 0.054
7.06GluIle: 7.06 ± 0.129
6.77GluLys: 6.77 ± 0.138
6.413GluLeu: 6.413 ± 0.112
1.919GluMet: 1.919 ± 0.059
5.209GluAsn: 5.209 ± 0.121
1.212GluPro: 1.212 ± 0.045
2.159GluGln: 2.159 ± 0.066
1.987GluArg: 1.987 ± 0.063
2.898GluSer: 2.898 ± 0.083
3.292GluThr: 3.292 ± 0.075
4.676GluVal: 4.676 ± 0.111
0.481GluTrp: 0.481 ± 0.037
3.842GluTyr: 3.842 ± 0.108
0.0GluXaa: 0.0 ± 0.0
Phe
2.507PheAla: 2.507 ± 0.08
0.606PheCys: 0.606 ± 0.034
3.238PheAsp: 3.238 ± 0.088
3.121PheGlu: 3.121 ± 0.085
2.094PhePhe: 2.094 ± 0.074
2.537PheGly: 2.537 ± 0.068
0.685PheHis: 0.685 ± 0.043
4.811PheIle: 4.811 ± 0.15
3.629PheLys: 3.629 ± 0.093
4.329PheLeu: 4.329 ± 0.118
1.021PheMet: 1.021 ± 0.052
2.799PheAsn: 2.799 ± 0.08
1.156PhePro: 1.156 ± 0.043
1.232PheGln: 1.232 ± 0.05
1.188PheArg: 1.188 ± 0.054
3.28PheSer: 3.28 ± 0.084
2.41PheThr: 2.41 ± 0.07
3.071PheVal: 3.071 ± 0.082
0.34PheTrp: 0.34 ± 0.031
2.209PheTyr: 2.209 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
3.107GlyAla: 3.107 ± 0.102
0.86GlyCys: 0.86 ± 0.045
2.761GlyAsp: 2.761 ± 0.087
3.341GlyGlu: 3.341 ± 0.097
2.698GlyPhe: 2.698 ± 0.075
3.584GlyGly: 3.584 ± 0.107
0.989GlyHis: 0.989 ± 0.047
5.815GlyIle: 5.815 ± 0.139
4.631GlyLys: 4.631 ± 0.097
5.012GlyLeu: 5.012 ± 0.108
1.563GlyMet: 1.563 ± 0.055
2.992GlyAsn: 2.992 ± 0.101
0.985GlyPro: 0.985 ± 0.047
1.444GlyGln: 1.444 ± 0.063
1.776GlyArg: 1.776 ± 0.074
3.474GlySer: 3.474 ± 0.094
3.421GlyThr: 3.421 ± 0.111
3.717GlyVal: 3.717 ± 0.088
0.608GlyTrp: 0.608 ± 0.049
3.194GlyTyr: 3.194 ± 0.093
0.0GlyXaa: 0.0 ± 0.0
His
0.888HisAla: 0.888 ± 0.051
0.242HisCys: 0.242 ± 0.023
0.757HisAsp: 0.757 ± 0.039
0.884HisGlu: 0.884 ± 0.043
1.045HisPhe: 1.045 ± 0.05
0.805HisGly: 0.805 ± 0.051
0.56HisHis: 0.56 ± 0.036
1.706HisIle: 1.706 ± 0.053
1.055HisLys: 1.055 ± 0.047
1.853HisLeu: 1.853 ± 0.063
0.397HisMet: 0.397 ± 0.027
1.003HisAsn: 1.003 ± 0.046
0.729HisPro: 0.729 ± 0.044
0.773HisGln: 0.773 ± 0.039
0.544HisArg: 0.544 ± 0.033
1.005HisSer: 1.005 ± 0.046
0.952HisThr: 0.952 ± 0.046
0.82HisVal: 0.82 ± 0.044
0.079HisTrp: 0.079 ± 0.014
0.894HisTyr: 0.894 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.534IleAla: 5.534 ± 0.113
1.438IleCys: 1.438 ± 0.061
6.488IleAsp: 6.488 ± 0.126
6.798IleGlu: 6.798 ± 0.125
4.559IlePhe: 4.559 ± 0.138
5.787IleGly: 5.787 ± 0.121
1.732IleHis: 1.732 ± 0.067
9.996IleIle: 9.996 ± 0.198
8.008IleLys: 8.008 ± 0.168
9.327IleLeu: 9.327 ± 0.211
2.171IleMet: 2.171 ± 0.081
5.872IleAsn: 5.872 ± 0.148
2.888IlePro: 2.888 ± 0.079
2.644IleGln: 2.644 ± 0.083
2.944IleArg: 2.944 ± 0.096
6.351IleSer: 6.351 ± 0.131
5.745IleThr: 5.745 ± 0.105
7.116IleVal: 7.116 ± 0.125
0.509IleTrp: 0.509 ± 0.033
4.684IleTyr: 4.684 ± 0.129
0.0IleXaa: 0.0 ± 0.0
Lys
4.112LysAla: 4.112 ± 0.108
0.717LysCys: 0.717 ± 0.042
5.135LysAsp: 5.135 ± 0.107
7.589LysGlu: 7.589 ± 0.138
2.789LysPhe: 2.789 ± 0.08
3.888LysGly: 3.888 ± 0.091
1.17LysHis: 1.17 ± 0.049
8.733LysIle: 8.733 ± 0.146
8.757LysLys: 8.757 ± 0.177
6.959LysLeu: 6.959 ± 0.121
2.811LysMet: 2.811 ± 0.08
6.047LysAsn: 6.047 ± 0.113
1.832LysPro: 1.832 ± 0.061
2.563LysGln: 2.563 ± 0.073
2.775LysArg: 2.775 ± 0.085
3.808LysSer: 3.808 ± 0.093
4.75LysThr: 4.75 ± 0.094
5.425LysVal: 5.425 ± 0.11
0.596LysTrp: 0.596 ± 0.04
4.734LysTyr: 4.734 ± 0.117
0.0LysXaa: 0.0 ± 0.0
Leu
5.07LeuAla: 5.07 ± 0.116
1.075LeuCys: 1.075 ± 0.046
5.733LeuAsp: 5.733 ± 0.113
6.895LeuGlu: 6.895 ± 0.138
4.619LeuPhe: 4.619 ± 0.129
5.199LeuGly: 5.199 ± 0.104
1.279LeuHis: 1.279 ± 0.052
8.635LeuIle: 8.635 ± 0.19
8.055LeuLys: 8.055 ± 0.143
8.065LeuLeu: 8.065 ± 0.174
2.165LeuMet: 2.165 ± 0.067
6.168LeuAsn: 6.168 ± 0.122
3.045LeuPro: 3.045 ± 0.088
2.491LeuGln: 2.491 ± 0.076
2.577LeuArg: 2.577 ± 0.071
6.585LeuSer: 6.585 ± 0.113
5.177LeuThr: 5.177 ± 0.111
5.662LeuVal: 5.662 ± 0.11
0.57LeuTrp: 0.57 ± 0.035
4.08LeuTyr: 4.08 ± 0.103
0.0LeuXaa: 0.0 ± 0.0
Met
1.498MetAla: 1.498 ± 0.06
0.228MetCys: 0.228 ± 0.02
1.196MetAsp: 1.196 ± 0.046
1.436MetGlu: 1.436 ± 0.058
0.888MetPhe: 0.888 ± 0.044
1.404MetGly: 1.404 ± 0.049
0.437MetHis: 0.437 ± 0.029
2.662MetIle: 2.662 ± 0.075
2.521MetLys: 2.521 ± 0.072
2.211MetLeu: 2.211 ± 0.067
0.755MetMet: 0.755 ± 0.039
1.808MetAsn: 1.808 ± 0.058
0.822MetPro: 0.822 ± 0.037
0.693MetGln: 0.693 ± 0.039
0.828MetArg: 0.828 ± 0.042
1.379MetSer: 1.379 ± 0.056
1.118MetThr: 1.118 ± 0.044
1.603MetVal: 1.603 ± 0.063
0.113MetTrp: 0.113 ± 0.013
0.993MetTyr: 0.993 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.085AsnAla: 3.085 ± 0.085
0.882AsnCys: 0.882 ± 0.054
3.884AsnAsp: 3.884 ± 0.098
4.412AsnGlu: 4.412 ± 0.099
2.773AsnPhe: 2.773 ± 0.089
3.687AsnGly: 3.687 ± 0.109
1.643AsnHis: 1.643 ± 0.064
6.15AsnIle: 6.15 ± 0.146
5.473AsnLys: 5.473 ± 0.117
5.987AsnLeu: 5.987 ± 0.127
1.46AsnMet: 1.46 ± 0.05
4.746AsnAsn: 4.746 ± 0.15
2.215AsnPro: 2.215 ± 0.071
2.602AsnGln: 2.602 ± 0.082
1.913AsnArg: 1.913 ± 0.065
3.391AsnSer: 3.391 ± 0.098
2.9AsnThr: 2.9 ± 0.09
3.508AsnVal: 3.508 ± 0.093
0.485AsnTrp: 0.485 ± 0.033
3.896AsnTyr: 3.896 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
1.178ProAla: 1.178 ± 0.051
0.254ProCys: 0.254 ± 0.024
1.224ProAsp: 1.224 ± 0.054
1.599ProGlu: 1.599 ± 0.067
1.468ProPhe: 1.468 ± 0.051
1.236ProGly: 1.236 ± 0.055
0.54ProHis: 0.54 ± 0.037
2.692ProIle: 2.692 ± 0.072
2.012ProLys: 2.012 ± 0.06
2.527ProLeu: 2.527 ± 0.078
0.54ProMet: 0.54 ± 0.035
1.849ProAsn: 1.849 ± 0.063
0.447ProPro: 0.447 ± 0.031
0.864ProGln: 0.864 ± 0.045
0.691ProArg: 0.691 ± 0.037
1.899ProSer: 1.899 ± 0.059
1.911ProThr: 1.911 ± 0.069
1.579ProVal: 1.579 ± 0.058
0.167ProTrp: 0.167 ± 0.017
1.351ProTyr: 1.351 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
1.544GlnAla: 1.544 ± 0.06
0.211GlnCys: 0.211 ± 0.022
1.54GlnAsp: 1.54 ± 0.058
2.149GlnGlu: 2.149 ± 0.073
1.301GlnPhe: 1.301 ± 0.052
1.255GlnGly: 1.255 ± 0.054
0.389GlnHis: 0.389 ± 0.028
3.186GlnIle: 3.186 ± 0.083
2.882GlnLys: 2.882 ± 0.081
2.857GlnLeu: 2.857 ± 0.083
1.025GlnMet: 1.025 ± 0.048
2.155GlnAsn: 2.155 ± 0.062
0.65GlnPro: 0.65 ± 0.037
0.779GlnGln: 0.779 ± 0.046
0.9GlnArg: 0.9 ± 0.047
1.593GlnSer: 1.593 ± 0.062
1.832GlnThr: 1.832 ± 0.065
1.687GlnVal: 1.687 ± 0.067
0.167GlnTrp: 0.167 ± 0.017
1.538GlnTyr: 1.538 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
1.45ArgAla: 1.45 ± 0.063
0.413ArgCys: 0.413 ± 0.036
1.347ArgAsp: 1.347 ± 0.055
1.893ArgGlu: 1.893 ± 0.066
1.416ArgPhe: 1.416 ± 0.052
1.663ArgGly: 1.663 ± 0.059
0.503ArgHis: 0.503 ± 0.037
3.059ArgIle: 3.059 ± 0.085
2.71ArgLys: 2.71 ± 0.086
2.928ArgLeu: 2.928 ± 0.082
0.807ArgMet: 0.807 ± 0.042
1.881ArgAsn: 1.881 ± 0.068
0.882ArgPro: 0.882 ± 0.046
0.906ArgGln: 0.906 ± 0.045
1.18ArgArg: 1.18 ± 0.056
1.512ArgSer: 1.512 ± 0.058
1.458ArgThr: 1.458 ± 0.056
1.863ArgVal: 1.863 ± 0.068
0.157ArgTrp: 0.157 ± 0.017
1.581ArgTyr: 1.581 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
2.579SerAla: 2.579 ± 0.077
0.854SerCys: 0.854 ± 0.046
3.276SerAsp: 3.276 ± 0.084
3.236SerGlu: 3.236 ± 0.08
3.27SerPhe: 3.27 ± 0.085
3.953SerGly: 3.953 ± 0.093
0.989SerHis: 0.989 ± 0.048
6.329SerIle: 6.329 ± 0.131
4.986SerLys: 4.986 ± 0.087
5.862SerLeu: 5.862 ± 0.122
1.444SerMet: 1.444 ± 0.053
4.055SerAsn: 4.055 ± 0.123
1.299SerPro: 1.299 ± 0.047
1.621SerGln: 1.621 ± 0.053
1.814SerArg: 1.814 ± 0.065
4.464SerSer: 4.464 ± 0.122
3.196SerThr: 3.196 ± 0.082
3.403SerVal: 3.403 ± 0.096
0.455SerTrp: 0.455 ± 0.033
3.375SerTyr: 3.375 ± 0.1
0.0SerXaa: 0.0 ± 0.0
Thr
2.495ThrAla: 2.495 ± 0.094
0.646ThrCys: 0.646 ± 0.044
2.765ThrAsp: 2.765 ± 0.073
2.698ThrGlu: 2.698 ± 0.093
2.751ThrPhe: 2.751 ± 0.076
3.238ThrGly: 3.238 ± 0.094
0.979ThrHis: 0.979 ± 0.043
6.764ThrIle: 6.764 ± 0.139
4.645ThrLys: 4.645 ± 0.087
5.264ThrLeu: 5.264 ± 0.119
1.085ThrMet: 1.085 ± 0.047
3.699ThrAsn: 3.699 ± 0.103
1.659ThrPro: 1.659 ± 0.064
1.319ThrGln: 1.319 ± 0.054
1.518ThrArg: 1.518 ± 0.056
3.812ThrSer: 3.812 ± 0.103
3.613ThrThr: 3.613 ± 0.083
2.867ThrVal: 2.867 ± 0.085
0.369ThrTrp: 0.369 ± 0.026
3.035ThrTyr: 3.035 ± 0.119
0.0ThrXaa: 0.0 ± 0.0
Val
3.522ValAla: 3.522 ± 0.101
0.854ValCys: 0.854 ± 0.042
3.78ValAsp: 3.78 ± 0.107
4.426ValGlu: 4.426 ± 0.111
2.823ValPhe: 2.823 ± 0.081
3.764ValGly: 3.764 ± 0.097
0.904ValHis: 0.904 ± 0.039
6.109ValIle: 6.109 ± 0.108
4.96ValLys: 4.96 ± 0.123
5.767ValLeu: 5.767 ± 0.117
1.383ValMet: 1.383 ± 0.052
3.617ValAsn: 3.617 ± 0.093
1.605ValPro: 1.605 ± 0.055
1.337ValGln: 1.337 ± 0.054
1.792ValArg: 1.792 ± 0.067
4.186ValSer: 4.186 ± 0.094
3.637ValThr: 3.637 ± 0.098
4.571ValVal: 4.571 ± 0.12
0.431ValTrp: 0.431 ± 0.029
2.785ValTyr: 2.785 ± 0.086
0.0ValXaa: 0.0 ± 0.0
Trp
0.35TrpAla: 0.35 ± 0.029
0.107TrpCys: 0.107 ± 0.014
0.391TrpAsp: 0.391 ± 0.03
0.455TrpGlu: 0.455 ± 0.034
0.379TrpPhe: 0.379 ± 0.03
0.366TrpGly: 0.366 ± 0.029
0.145TrpHis: 0.145 ± 0.019
0.568TrpIle: 0.568 ± 0.034
0.451TrpLys: 0.451 ± 0.03
0.61TrpLeu: 0.61 ± 0.039
0.177TrpMet: 0.177 ± 0.018
0.399TrpAsn: 0.399 ± 0.027
0.173TrpPro: 0.173 ± 0.017
0.298TrpGln: 0.298 ± 0.026
0.193TrpArg: 0.193 ± 0.02
0.425TrpSer: 0.425 ± 0.031
0.29TrpThr: 0.29 ± 0.023
0.352TrpVal: 0.352 ± 0.027
0.117TrpTrp: 0.117 ± 0.016
0.457TrpTyr: 0.457 ± 0.042
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.668TyrAla: 2.668 ± 0.087
0.552TyrCys: 0.552 ± 0.032
3.564TyrAsp: 3.564 ± 0.128
3.504TyrGlu: 3.504 ± 0.109
2.622TyrPhe: 2.622 ± 0.082
2.835TyrGly: 2.835 ± 0.096
1.297TyrHis: 1.297 ± 0.049
4.247TyrIle: 4.247 ± 0.107
3.407TyrLys: 3.407 ± 0.095
5.447TyrLeu: 5.447 ± 0.122
0.93TyrMet: 0.93 ± 0.045
3.494TyrAsn: 3.494 ± 0.124
1.432TyrPro: 1.432 ± 0.062
2.702TyrGln: 2.702 ± 0.097
1.577TyrArg: 1.577 ± 0.055
2.813TyrSer: 2.813 ± 0.086
2.678TyrThr: 2.678 ± 0.097
3.077TyrVal: 3.077 ± 0.079
0.282TyrTrp: 0.282 ± 0.022
3.069TyrTyr: 3.069 ± 0.141
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1476 proteins (503392 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski