Amino acid dipepetide frequency for Tobacco bushy top virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.012AlaAla: 3.012 ± 1.197
0.602AlaCys: 0.602 ± 0.336
1.205AlaAsp: 1.205 ± 0.641
2.41AlaGlu: 2.41 ± 0.555
3.012AlaPhe: 3.012 ± 0.646
4.819AlaGly: 4.819 ± 1.11
1.807AlaHis: 1.807 ± 0.651
1.807AlaIle: 1.807 ± 0.679
3.614AlaLys: 3.614 ± 2.017
7.229AlaLeu: 7.229 ± 1.574
3.614AlaMet: 3.614 ± 1.303
1.807AlaAsn: 1.807 ± 0.696
4.819AlaPro: 4.819 ± 3.637
1.807AlaGln: 1.807 ± 2.358
9.639AlaArg: 9.639 ± 2.899
4.819AlaSer: 4.819 ± 1.11
6.024AlaThr: 6.024 ± 1.539
9.036AlaVal: 9.036 ± 3.396
1.807AlaTrp: 1.807 ± 1.009
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.602CysAla: 0.602 ± 0.336
0.602CysCys: 0.602 ± 0.336
1.205CysAsp: 1.205 ± 0.658
2.41CysGlu: 2.41 ± 1.128
1.205CysPhe: 1.205 ± 0.672
3.614CysGly: 3.614 ± 0.929
0.0CysHis: 0.0 ± 0.0
3.012CysIle: 3.012 ± 0.633
1.205CysLys: 1.205 ± 0.672
0.0CysLeu: 0.0 ± 0.0
0.602CysMet: 0.602 ± 0.501
1.205CysAsn: 1.205 ± 1.572
1.205CysPro: 1.205 ± 0.564
1.205CysGln: 1.205 ± 0.641
1.205CysArg: 1.205 ± 0.641
0.602CysSer: 0.602 ± 0.336
0.0CysThr: 0.0 ± 0.0
1.807CysVal: 1.807 ± 0.7
0.602CysTrp: 0.602 ± 0.786
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.217AspAla: 4.217 ± 1.147
1.205AspCys: 1.205 ± 0.672
1.205AspAsp: 1.205 ± 0.641
3.012AspGlu: 3.012 ± 1.197
2.41AspPhe: 2.41 ± 0.912
1.205AspGly: 1.205 ± 0.672
0.602AspHis: 0.602 ± 0.336
0.602AspIle: 0.602 ± 0.336
0.602AspLys: 0.602 ± 0.336
2.41AspLeu: 2.41 ± 0.912
2.41AspMet: 2.41 ± 0.555
0.602AspAsn: 0.602 ± 0.747
4.819AspPro: 4.819 ± 1.137
0.602AspGln: 0.602 ± 0.336
1.807AspArg: 1.807 ± 1.41
3.614AspSer: 3.614 ± 1.261
1.807AspThr: 1.807 ± 0.887
3.614AspVal: 3.614 ± 0.836
1.807AspTrp: 1.807 ± 0.679
2.41AspTyr: 2.41 ± 0.912
0.0AspXaa: 0.0 ± 0.0
Glu
4.819GluAla: 4.819 ± 1.425
1.205GluCys: 1.205 ± 0.641
4.217GluAsp: 4.217 ± 1.458
6.024GluGlu: 6.024 ± 1.407
1.807GluPhe: 1.807 ± 0.679
3.012GluGly: 3.012 ± 2.055
0.0GluHis: 0.0 ± 0.0
4.217GluIle: 4.217 ± 0.99
5.422GluLys: 5.422 ± 1.015
8.434GluLeu: 8.434 ± 1.119
0.602GluMet: 0.602 ± 0.336
0.602GluAsn: 0.602 ± 0.747
7.229GluPro: 7.229 ± 1.336
3.012GluGln: 3.012 ± 0.646
7.229GluArg: 7.229 ± 1.553
3.614GluSer: 3.614 ± 0.208
2.41GluThr: 2.41 ± 1.316
7.229GluVal: 7.229 ± 1.665
0.0GluTrp: 0.0 ± 0.0
0.602GluTyr: 0.602 ± 0.747
0.0GluXaa: 0.0 ± 0.0
Phe
0.602PheAla: 0.602 ± 0.336
1.205PheCys: 1.205 ± 0.564
3.012PheAsp: 3.012 ± 1.194
1.807PheGlu: 1.807 ± 0.679
0.0PhePhe: 0.0 ± 0.0
1.205PheGly: 1.205 ± 0.672
0.602PheHis: 0.602 ± 0.336
4.217PheIle: 4.217 ± 1.234
1.205PheLys: 1.205 ± 0.564
1.205PheLeu: 1.205 ± 0.672
0.0PheMet: 0.0 ± 0.0
1.807PheAsn: 1.807 ± 1.009
1.205PhePro: 1.205 ± 0.641
1.205PheGln: 1.205 ± 0.672
1.807PheArg: 1.807 ± 0.7
1.205PheSer: 1.205 ± 0.641
3.614PheThr: 3.614 ± 0.868
2.41PheVal: 2.41 ± 0.892
0.0PheTrp: 0.0 ± 0.0
1.205PheTyr: 1.205 ± 0.641
0.0PheXaa: 0.0 ± 0.0
Gly
6.627GlyAla: 6.627 ± 2.331
1.205GlyCys: 1.205 ± 0.658
1.807GlyAsp: 1.807 ± 1.009
7.229GlyGlu: 7.229 ± 1.098
1.807GlyPhe: 1.807 ± 1.009
7.831GlyGly: 7.831 ± 3.507
1.205GlyHis: 1.205 ± 0.564
3.012GlyIle: 3.012 ± 1.111
1.807GlyLys: 1.807 ± 1.009
6.024GlyLeu: 6.024 ± 1.407
1.205GlyMet: 1.205 ± 0.531
2.41GlyAsn: 2.41 ± 0.574
4.217GlyPro: 4.217 ± 1.234
1.205GlyGln: 1.205 ± 0.658
3.614GlyArg: 3.614 ± 3.054
4.217GlySer: 4.217 ± 1.106
3.012GlyThr: 3.012 ± 2.055
7.831GlyVal: 7.831 ± 0.559
0.0GlyTrp: 0.0 ± 0.0
1.205GlyTyr: 1.205 ± 0.564
0.0GlyXaa: 0.0 ± 0.0
His
1.807HisAla: 1.807 ± 1.41
0.602HisCys: 0.602 ± 0.786
0.602HisAsp: 0.602 ± 0.747
2.41HisGlu: 2.41 ± 0.861
0.602HisPhe: 0.602 ± 0.336
1.205HisGly: 1.205 ± 0.658
0.0HisHis: 0.0 ± 0.0
1.205HisIle: 1.205 ± 0.641
1.205HisLys: 1.205 ± 0.641
3.012HisLeu: 3.012 ± 1.127
0.0HisMet: 0.0 ± 0.0
2.41HisAsn: 2.41 ± 0.753
3.614HisPro: 3.614 ± 1.179
0.0HisGln: 0.0 ± 0.0
1.205HisArg: 1.205 ± 1.109
1.807HisSer: 1.807 ± 0.679
1.205HisThr: 1.205 ± 0.641
1.205HisVal: 1.205 ± 0.672
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
4.217IleAla: 4.217 ± 1.093
0.602IleCys: 0.602 ± 0.747
1.807IleAsp: 1.807 ± 1.009
1.807IleGlu: 1.807 ± 1.35
0.602IlePhe: 0.602 ± 0.336
4.819IleGly: 4.819 ± 1.137
2.41IleHis: 2.41 ± 0.753
0.602IleIle: 0.602 ± 0.786
2.41IleLys: 2.41 ± 0.574
3.012IleLeu: 3.012 ± 0.993
0.602IleMet: 0.602 ± 0.747
2.41IleAsn: 2.41 ± 0.574
6.024IlePro: 6.024 ± 1.407
0.602IleGln: 0.602 ± 0.336
1.205IleArg: 1.205 ± 0.658
1.807IleSer: 1.807 ± 0.688
2.41IleThr: 2.41 ± 1.128
3.012IleVal: 3.012 ± 0.646
1.807IleTrp: 1.807 ± 0.651
0.602IleTyr: 0.602 ± 0.336
0.0IleXaa: 0.0 ± 0.0
Lys
3.614LysAla: 3.614 ± 1.058
2.41LysCys: 2.41 ± 0.574
4.217LysAsp: 4.217 ± 0.99
1.205LysGlu: 1.205 ± 0.641
0.0LysPhe: 0.0 ± 0.0
3.012LysGly: 3.012 ± 0.633
1.205LysHis: 1.205 ± 0.641
4.819LysIle: 4.819 ± 0.587
1.205LysLys: 1.205 ± 0.672
1.807LysLeu: 1.807 ± 0.688
0.0LysMet: 0.0 ± 0.0
3.614LysAsn: 3.614 ± 0.836
3.614LysPro: 3.614 ± 0.836
4.217LysGln: 4.217 ± 1.231
2.41LysArg: 2.41 ± 0.892
2.41LysSer: 2.41 ± 0.804
1.205LysThr: 1.205 ± 0.672
3.614LysVal: 3.614 ± 1.058
1.807LysTrp: 1.807 ± 0.688
2.41LysTyr: 2.41 ± 0.912
0.0LysXaa: 0.0 ± 0.0
Leu
8.434LeuAla: 8.434 ± 3.502
0.602LeuCys: 0.602 ± 0.336
2.41LeuAsp: 2.41 ± 0.574
5.422LeuGlu: 5.422 ± 1.393
0.602LeuPhe: 0.602 ± 0.747
7.831LeuGly: 7.831 ± 1.37
0.602LeuHis: 0.602 ± 0.786
3.614LeuIle: 3.614 ± 1.303
2.41LeuLys: 2.41 ± 1.502
8.434LeuLeu: 8.434 ± 0.912
2.41LeuMet: 2.41 ± 0.892
1.807LeuAsn: 1.807 ± 1.35
10.241LeuPro: 10.241 ± 1.722
3.012LeuGln: 3.012 ± 0.993
7.831LeuArg: 7.831 ± 0.83
7.229LeuSer: 7.229 ± 1.447
3.012LeuThr: 3.012 ± 1.996
3.012LeuVal: 3.012 ± 0.646
1.807LeuTrp: 1.807 ± 0.679
2.41LeuTyr: 2.41 ± 1.282
0.0LeuXaa: 0.0 ± 0.0
Met
1.205MetAla: 1.205 ± 0.564
0.0MetCys: 0.0 ± 0.0
1.205MetAsp: 1.205 ± 0.672
3.012MetGlu: 3.012 ± 0.963
0.0MetPhe: 0.0 ± 0.0
1.807MetGly: 1.807 ± 0.679
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.602MetLys: 0.602 ± 0.336
0.602MetLeu: 0.602 ± 0.747
0.0MetMet: 0.0 ± 0.0
3.012MetAsn: 3.012 ± 1.202
0.602MetPro: 0.602 ± 0.747
0.602MetGln: 0.602 ± 0.336
0.602MetArg: 0.602 ± 0.747
5.422MetSer: 5.422 ± 1.6
1.205MetThr: 1.205 ± 0.641
4.217MetVal: 4.217 ± 1.572
0.602MetTrp: 0.602 ± 0.747
0.602MetTyr: 0.602 ± 0.336
0.0MetXaa: 0.0 ± 0.0
Asn
4.217AsnAla: 4.217 ± 0.284
1.205AsnCys: 1.205 ± 0.658
1.807AsnAsp: 1.807 ± 0.688
2.41AsnGlu: 2.41 ± 0.912
2.41AsnPhe: 2.41 ± 0.555
0.602AsnGly: 0.602 ± 0.336
0.602AsnHis: 0.602 ± 0.336
1.205AsnIle: 1.205 ± 0.564
3.012AsnLys: 3.012 ± 0.481
4.217AsnLeu: 4.217 ± 0.951
0.602AsnMet: 0.602 ± 0.747
2.41AsnAsn: 2.41 ± 0.861
1.807AsnPro: 1.807 ± 1.41
0.0AsnGln: 0.0 ± 0.0
2.41AsnArg: 2.41 ± 0.804
1.807AsnSer: 1.807 ± 0.7
0.602AsnThr: 0.602 ± 0.786
1.807AsnVal: 1.807 ± 2.358
1.205AsnTrp: 1.205 ± 0.564
0.602AsnTyr: 0.602 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
4.217ProAla: 4.217 ± 1.572
1.205ProCys: 1.205 ± 0.672
2.41ProAsp: 2.41 ± 0.753
4.819ProGlu: 4.819 ± 1.62
0.602ProPhe: 0.602 ± 0.747
3.012ProGly: 3.012 ± 0.758
3.614ProHis: 3.614 ± 2.561
2.41ProIle: 2.41 ± 0.555
6.024ProLys: 6.024 ± 1.07
7.229ProLeu: 7.229 ± 0.772
3.012ProMet: 3.012 ± 0.963
0.602ProAsn: 0.602 ± 0.786
12.651ProPro: 12.651 ± 3.337
2.41ProGln: 2.41 ± 1.373
10.241ProArg: 10.241 ± 1.712
4.217ProSer: 4.217 ± 0.982
9.036ProThr: 9.036 ± 1.73
4.819ProVal: 4.819 ± 1.197
1.205ProTrp: 1.205 ± 0.672
1.807ProTyr: 1.807 ± 0.651
0.0ProXaa: 0.0 ± 0.0
Gln
3.012GlnAla: 3.012 ± 1.202
4.217GlnCys: 4.217 ± 1.751
3.012GlnAsp: 3.012 ± 0.646
0.0GlnGlu: 0.0 ± 0.0
0.602GlnPhe: 0.602 ± 0.336
3.614GlnGly: 3.614 ± 1.854
1.205GlnHis: 1.205 ± 0.658
2.41GlnIle: 2.41 ± 0.912
0.602GlnLys: 0.602 ± 0.786
4.819GlnLeu: 4.819 ± 1.137
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
4.217GlnPro: 4.217 ± 0.982
0.0GlnGln: 0.0 ± 0.0
2.41GlnArg: 2.41 ± 2.186
1.205GlnSer: 1.205 ± 1.572
1.205GlnThr: 1.205 ± 0.658
3.012GlnVal: 3.012 ± 0.481
0.0GlnTrp: 0.0 ± 0.0
0.602GlnTyr: 0.602 ± 0.336
0.0GlnXaa: 0.0 ± 0.0
Arg
4.819ArgAla: 4.819 ± 0.802
0.602ArgCys: 0.602 ± 0.786
1.807ArgAsp: 1.807 ± 0.679
13.253ArgGlu: 13.253 ± 3.289
3.614ArgPhe: 3.614 ± 1.4
4.217ArgGly: 4.217 ± 2.866
2.41ArgHis: 2.41 ± 0.892
0.602ArgIle: 0.602 ± 0.747
2.41ArgLys: 2.41 ± 2.186
4.217ArgLeu: 4.217 ± 1.437
1.807ArgMet: 1.807 ± 1.009
1.205ArgAsn: 1.205 ± 0.658
4.819ArgPro: 4.819 ± 1.302
3.614ArgGln: 3.614 ± 1.098
6.627ArgArg: 6.627 ± 4.875
4.819ArgSer: 4.819 ± 2.217
1.205ArgThr: 1.205 ± 0.564
10.241ArgVal: 10.241 ± 2.518
1.205ArgTrp: 1.205 ± 0.658
4.217ArgTyr: 4.217 ± 0.56
0.0ArgXaa: 0.0 ± 0.0
Ser
2.41SerAla: 2.41 ± 0.753
1.205SerCys: 1.205 ± 0.641
3.614SerAsp: 3.614 ± 1.973
3.012SerGlu: 3.012 ± 0.481
1.807SerPhe: 1.807 ± 1.009
6.024SerGly: 6.024 ± 2.419
2.41SerHis: 2.41 ± 0.555
3.012SerIle: 3.012 ± 1.371
1.205SerLys: 1.205 ± 0.564
4.217SerLeu: 4.217 ± 1.926
0.602SerMet: 0.602 ± 0.336
4.217SerAsn: 4.217 ± 1.57
2.41SerPro: 2.41 ± 0.804
3.614SerGln: 3.614 ± 0.917
5.422SerArg: 5.422 ± 1.471
5.422SerSer: 5.422 ± 0.472
1.807SerThr: 1.807 ± 0.887
7.229SerVal: 7.229 ± 0.878
0.602SerTrp: 0.602 ± 0.336
1.807SerTyr: 1.807 ± 0.7
0.0SerXaa: 0.0 ± 0.0
Thr
4.217ThrAla: 4.217 ± 0.284
2.41ThrCys: 2.41 ± 1.128
0.602ThrAsp: 0.602 ± 0.336
1.205ThrGlu: 1.205 ± 1.572
1.807ThrPhe: 1.807 ± 0.688
3.614ThrGly: 3.614 ± 1.058
2.41ThrHis: 2.41 ± 1.316
1.205ThrIle: 1.205 ± 0.658
4.217ThrLys: 4.217 ± 1.093
6.024ThrLeu: 6.024 ± 1.372
1.807ThrMet: 1.807 ± 0.679
1.807ThrAsn: 1.807 ± 0.696
5.422ThrPro: 5.422 ± 1.6
3.012ThrGln: 3.012 ± 0.481
3.614ThrArg: 3.614 ± 1.359
1.205ThrSer: 1.205 ± 1.109
4.217ThrThr: 4.217 ± 1.305
0.602ThrVal: 0.602 ± 0.786
1.205ThrTrp: 1.205 ± 0.564
1.205ThrTyr: 1.205 ± 0.564
0.0ThrXaa: 0.0 ± 0.0
Val
9.639ValAla: 9.639 ± 2.45
1.807ValCys: 1.807 ± 0.688
3.614ValAsp: 3.614 ± 0.836
6.627ValGlu: 6.627 ± 1.579
2.41ValPhe: 2.41 ± 0.555
2.41ValGly: 2.41 ± 0.753
2.41ValHis: 2.41 ± 1.548
4.217ValIle: 4.217 ± 1.572
6.627ValLys: 6.627 ± 1.019
8.434ValLeu: 8.434 ± 0.28
3.012ValMet: 3.012 ± 0.963
2.41ValAsn: 2.41 ± 0.753
6.024ValPro: 6.024 ± 1.958
2.41ValGln: 2.41 ± 0.574
5.422ValArg: 5.422 ± 0.763
4.217ValSer: 4.217 ± 1.093
2.41ValThr: 2.41 ± 0.555
5.422ValVal: 5.422 ± 3.248
0.0ValTrp: 0.0 ± 0.0
1.807ValTyr: 1.807 ± 1.009
0.0ValXaa: 0.0 ± 0.0
Trp
0.602TrpAla: 0.602 ± 0.786
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.41TrpGlu: 2.41 ± 0.555
1.807TrpPhe: 1.807 ± 0.679
1.205TrpGly: 1.205 ± 0.564
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.205TrpLys: 1.205 ± 0.672
0.602TrpLeu: 0.602 ± 0.336
1.205TrpMet: 1.205 ± 0.57
0.602TrpAsn: 0.602 ± 0.336
0.0TrpPro: 0.0 ± 0.0
1.205TrpGln: 1.205 ± 0.564
1.205TrpArg: 1.205 ± 0.658
0.0TrpSer: 0.0 ± 0.0
1.205TrpThr: 1.205 ± 0.672
0.602TrpVal: 0.602 ± 0.747
0.602TrpTrp: 0.602 ± 0.336
1.807TrpTyr: 1.807 ± 0.679
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.602TyrAla: 0.602 ± 0.747
0.0TyrCys: 0.0 ± 0.0
1.205TyrAsp: 1.205 ± 0.672
1.205TyrGlu: 1.205 ± 0.658
2.41TyrPhe: 2.41 ± 0.555
2.41TyrGly: 2.41 ± 0.555
0.602TyrHis: 0.602 ± 0.336
0.602TyrIle: 0.602 ± 0.747
1.807TyrLys: 1.807 ± 1.009
1.205TyrLeu: 1.205 ± 0.641
1.205TyrMet: 1.205 ± 0.564
0.0TyrAsn: 0.0 ± 0.0
0.602TyrPro: 0.602 ± 0.747
2.41TyrGln: 2.41 ± 0.912
1.807TyrArg: 1.807 ± 0.679
2.41TyrSer: 2.41 ± 1.283
4.217TyrThr: 4.217 ± 1.572
0.602TyrVal: 0.602 ± 0.336
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski