Amino acid dipepetide frequency for Prevotella copri CAG:164

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.285AlaAla: 6.285 ± 0.101	1.048AlaCys: 1.048 ± 0.035	4.429AlaAsp: 4.429 ± 0.074	5.122AlaGlu: 5.122 ± 0.094	3.261AlaPhe: 3.261 ± 0.067	5.13AlaGly: 5.13 ± 0.084	1.506AlaHis: 1.506 ± 0.043	4.963AlaIle: 4.963 ± 0.088	5.207AlaLys: 5.207 ± 0.084	6.748AlaLeu: 6.748 ± 0.09	2.287AlaMet: 2.287 ± 0.055	3.435AlaAsn: 3.435 ± 0.057	2.298AlaPro: 2.298 ± 0.055	3.155AlaGln: 3.155 ± 0.063	2.988AlaArg: 2.988 ± 0.066	4.47AlaSer: 4.47 ± 0.074	3.846AlaThr: 3.846 ± 0.066	4.671AlaVal: 4.671 ± 0.089	0.917AlaTrp: 0.917 ± 0.038	2.903AlaTyr: 2.903 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.037	0.235CysCys: 0.235 ± 0.019	0.747CysAsp: 0.747 ± 0.03	0.753CysGlu: 0.753 ± 0.033	0.664CysPhe: 0.664 ± 0.03	1.077CysGly: 1.077 ± 0.041	0.346CysHis: 0.346 ± 0.025	0.946CysIle: 0.946 ± 0.038	0.793CysLys: 0.793 ± 0.033	1.14CysLeu: 1.14 ± 0.044	0.379CysMet: 0.379 ± 0.024	0.65CysAsn: 0.65 ± 0.031	0.519CysPro: 0.519 ± 0.028	0.448CysGln: 0.448 ± 0.026	0.602CysArg: 0.602 ± 0.027	0.793CysSer: 0.793 ± 0.032	0.632CysThr: 0.632 ± 0.034	0.802CysVal: 0.802 ± 0.034	0.159CysTrp: 0.159 ± 0.014	0.575CysTyr: 0.575 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.541AspAla: 4.541 ± 0.081	0.741AspCys: 0.741 ± 0.034	3.194AspAsp: 3.194 ± 0.076	4.304AspGlu: 4.304 ± 0.077	3.08AspPhe: 3.08 ± 0.071	4.396AspGly: 4.396 ± 0.096	1.1AspHis: 1.1 ± 0.039	4.036AspIle: 4.036 ± 0.08	4.315AspLys: 4.315 ± 0.089	4.388AspLeu: 4.388 ± 0.08	1.753AspMet: 1.753 ± 0.056	2.87AspAsn: 2.87 ± 0.064	1.769AspPro: 1.769 ± 0.046	1.504AspGln: 1.504 ± 0.049	2.326AspArg: 2.326 ± 0.058	3.081AspSer: 3.081 ± 0.069	2.647AspThr: 2.647 ± 0.064	3.793AspVal: 3.793 ± 0.071	0.886AspTrp: 0.886 ± 0.033	2.897AspTyr: 2.897 ± 0.078	0.0AspXaa: 0.0 ± 0.0
Glu	4.897GluAla: 4.897 ± 0.088	0.659GluCys: 0.659 ± 0.031	3.584GluAsp: 3.584 ± 0.07	5.117GluGlu: 5.117 ± 0.093	2.476GluPhe: 2.476 ± 0.059	4.347GluGly: 4.347 ± 0.075	1.48GluHis: 1.48 ± 0.038	4.261GluIle: 4.261 ± 0.086	5.381GluLys: 5.381 ± 0.086	5.402GluLeu: 5.402 ± 0.093	2.248GluMet: 2.248 ± 0.06	3.409GluAsn: 3.409 ± 0.075	1.727GluPro: 1.727 ± 0.051	2.748GluGln: 2.748 ± 0.065	2.877GluArg: 2.877 ± 0.063	2.887GluSer: 2.887 ± 0.07	3.252GluThr: 3.252 ± 0.064	4.108GluVal: 4.108 ± 0.073	0.844GluTrp: 0.844 ± 0.033	2.611GluTyr: 2.611 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.19PheAla: 3.19 ± 0.071	0.797PheCys: 0.797 ± 0.033	2.93PheAsp: 2.93 ± 0.066	2.462PheGlu: 2.462 ± 0.061	2.09PhePhe: 2.09 ± 0.053	3.422PheGly: 3.422 ± 0.073	0.937PheHis: 0.937 ± 0.034	2.798PheIle: 2.798 ± 0.062	2.553PheLys: 2.553 ± 0.063	3.797PheLeu: 3.797 ± 0.084	1.324PheMet: 1.324 ± 0.049	2.155PheAsn: 2.155 ± 0.044	1.501PhePro: 1.501 ± 0.043	1.321PheGln: 1.321 ± 0.043	1.896PheArg: 1.896 ± 0.044	3.15PheSer: 3.15 ± 0.068	2.709PheThr: 2.709 ± 0.066	2.875PheVal: 2.875 ± 0.063	0.508PheTrp: 0.508 ± 0.024	1.869PheTyr: 1.869 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.681GlyAla: 4.681 ± 0.089	1.086GlyCys: 1.086 ± 0.035	3.698GlyAsp: 3.698 ± 0.077	4.216GlyGlu: 4.216 ± 0.076	3.245GlyPhe: 3.245 ± 0.071	4.835GlyGly: 4.835 ± 0.103	1.267GlyHis: 1.267 ± 0.038	5.397GlyIle: 5.397 ± 0.09	5.967GlyLys: 5.967 ± 0.105	5.629GlyLeu: 5.629 ± 0.09	2.263GlyMet: 2.263 ± 0.05	3.597GlyAsn: 3.597 ± 0.077	1.312GlyPro: 1.312 ± 0.044	1.982GlyGln: 1.982 ± 0.058	2.768GlyArg: 2.768 ± 0.069	4.021GlySer: 4.021 ± 0.088	4.023GlyThr: 4.023 ± 0.087	4.811GlyVal: 4.811 ± 0.089	1.024GlyTrp: 1.024 ± 0.038	3.229GlyTyr: 3.229 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.368HisAla: 1.368 ± 0.046	0.324HisCys: 0.324 ± 0.021	1.209HisAsp: 1.209 ± 0.041	1.176HisGlu: 1.176 ± 0.038	1.109HisPhe: 1.109 ± 0.041	1.425HisGly: 1.425 ± 0.053	0.721HisHis: 0.721 ± 0.034	1.61HisIle: 1.61 ± 0.045	1.12HisLys: 1.12 ± 0.038	2.047HisLeu: 2.047 ± 0.061	0.408HisMet: 0.408 ± 0.021	1.02HisAsn: 1.02 ± 0.035	1.1HisPro: 1.1 ± 0.041	0.897HisGln: 0.897 ± 0.033	0.952HisArg: 0.952 ± 0.036	1.152HisSer: 1.152 ± 0.042	0.983HisThr: 0.983 ± 0.041	1.323HisVal: 1.323 ± 0.044	0.272HisTrp: 0.272 ± 0.021	0.996HisTyr: 0.996 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.511IleAla: 5.511 ± 0.1	1.054IleCys: 1.054 ± 0.036	4.328IleAsp: 4.328 ± 0.078	4.187IleGlu: 4.187 ± 0.074	2.829IlePhe: 2.829 ± 0.076	4.585IleGly: 4.585 ± 0.083	1.389IleHis: 1.389 ± 0.042	4.68IleIle: 4.68 ± 0.087	4.286IleLys: 4.286 ± 0.078	5.637IleLeu: 5.637 ± 0.093	1.632IleMet: 1.632 ± 0.046	3.262IleAsn: 3.262 ± 0.071	2.89IlePro: 2.89 ± 0.066	2.219IleGln: 2.219 ± 0.047	3.122IleArg: 3.122 ± 0.067	4.456IleSer: 4.456 ± 0.082	3.908IleThr: 3.908 ± 0.068	4.254IleVal: 4.254 ± 0.076	0.694IleTrp: 0.694 ± 0.033	2.506IleTyr: 2.506 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.52LysAla: 5.52 ± 0.094	0.555LysCys: 0.555 ± 0.028	4.351LysAsp: 4.351 ± 0.084	5.536LysGlu: 5.536 ± 0.1	2.463LysPhe: 2.463 ± 0.061	4.841LysGly: 4.841 ± 0.085	1.416LysHis: 1.416 ± 0.043	4.27LysIle: 4.27 ± 0.071	5.958LysLys: 5.958 ± 0.095	5.683LysLeu: 5.683 ± 0.089	2.74LysMet: 2.74 ± 0.058	3.944LysAsn: 3.944 ± 0.072	2.339LysPro: 2.339 ± 0.055	2.894LysGln: 2.894 ± 0.065	3.069LysArg: 3.069 ± 0.075	3.606LysSer: 3.606 ± 0.073	3.931LysThr: 3.931 ± 0.077	4.798LysVal: 4.798 ± 0.088	0.901LysTrp: 0.901 ± 0.03	3.132LysTyr: 3.132 ± 0.075	0.001LysXaa: 0.001 ± 0.001
Leu	6.855LeuAla: 6.855 ± 0.095	1.31LeuCys: 1.31 ± 0.039	4.832LeuAsp: 4.832 ± 0.085	4.646LeuGlu: 4.646 ± 0.086	3.897LeuPhe: 3.897 ± 0.089	5.869LeuGly: 5.869 ± 0.099	1.924LeuHis: 1.924 ± 0.047	5.179LeuIle: 5.179 ± 0.101	6.512LeuLys: 6.512 ± 0.093	7.964LeuLeu: 7.964 ± 0.138	2.779LeuMet: 2.779 ± 0.062	4.435LeuAsn: 4.435 ± 0.074	3.607LeuPro: 3.607 ± 0.067	3.409LeuGln: 3.409 ± 0.067	3.942LeuArg: 3.942 ± 0.071	5.942LeuSer: 5.942 ± 0.092	4.845LeuThr: 4.845 ± 0.076	5.359LeuVal: 5.359 ± 0.085	1.009LeuTrp: 1.009 ± 0.036	3.476LeuTyr: 3.476 ± 0.079	0.001LeuXaa: 0.001 ± 0.001
Met	2.526MetAla: 2.526 ± 0.053	0.267MetCys: 0.267 ± 0.019	1.657MetAsp: 1.657 ± 0.045	1.889MetGlu: 1.889 ± 0.05	1.045MetPhe: 1.045 ± 0.04	2.155MetGly: 2.155 ± 0.054	0.529MetHis: 0.529 ± 0.027	1.893MetIle: 1.893 ± 0.043	2.927MetLys: 2.927 ± 0.061	2.859MetLeu: 2.859 ± 0.07	1.204MetMet: 1.204 ± 0.044	1.709MetAsn: 1.709 ± 0.044	1.257MetPro: 1.257 ± 0.042	1.219MetGln: 1.219 ± 0.039	1.3MetArg: 1.3 ± 0.045	1.776MetSer: 1.776 ± 0.051	1.667MetThr: 1.667 ± 0.043	1.964MetVal: 1.964 ± 0.043	0.25MetTrp: 0.25 ± 0.018	0.793MetTyr: 0.793 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.609AsnAla: 3.609 ± 0.073	0.549AsnCys: 0.549 ± 0.025	2.642AsnAsp: 2.642 ± 0.063	2.966AsnGlu: 2.966 ± 0.059	2.224AsnPhe: 2.224 ± 0.054	3.843AsnGly: 3.843 ± 0.085	1.166AsnHis: 1.166 ± 0.038	3.764AsnIle: 3.764 ± 0.073	3.373AsnLys: 3.373 ± 0.07	4.41AsnLeu: 4.41 ± 0.083	1.372AsnMet: 1.372 ± 0.043	2.531AsnAsn: 2.531 ± 0.061	2.403AsnPro: 2.403 ± 0.06	1.892AsnGln: 1.892 ± 0.05	2.264AsnArg: 2.264 ± 0.056	2.705AsnSer: 2.705 ± 0.069	2.611AsnThr: 2.611 ± 0.057	3.249AsnVal: 3.249 ± 0.07	0.668AsnTrp: 0.668 ± 0.035	2.342AsnTyr: 2.342 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.658ProAla: 2.658 ± 0.062	0.405ProCys: 0.405 ± 0.027	2.215ProAsp: 2.215 ± 0.055	3.011ProGlu: 3.011 ± 0.071	1.703ProPhe: 1.703 ± 0.047	2.29ProGly: 2.29 ± 0.049	0.716ProHis: 0.716 ± 0.035	2.241ProIle: 2.241 ± 0.054	2.151ProLys: 2.151 ± 0.055	2.959ProLeu: 2.959 ± 0.072	1.009ProMet: 1.009 ± 0.031	1.65ProAsn: 1.65 ± 0.047	0.623ProPro: 0.623 ± 0.029	1.424ProGln: 1.424 ± 0.046	1.213ProArg: 1.213 ± 0.042	1.951ProSer: 1.951 ± 0.047	1.956ProThr: 1.956 ± 0.048	2.719ProVal: 2.719 ± 0.061	0.474ProTrp: 0.474 ± 0.027	1.64ProTyr: 1.64 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.702GlnAla: 2.702 ± 0.066	0.343GlnCys: 0.343 ± 0.022	1.769GlnAsp: 1.769 ± 0.043	2.542GlnGlu: 2.542 ± 0.067	1.462GlnPhe: 1.462 ± 0.046	2.233GlnGly: 2.233 ± 0.058	0.875GlnHis: 0.875 ± 0.032	2.485GlnIle: 2.485 ± 0.059	2.841GlnLys: 2.841 ± 0.066	3.678GlnLeu: 3.678 ± 0.071	1.267GlnMet: 1.267 ± 0.043	1.954GlnAsn: 1.954 ± 0.059	1.301GlnPro: 1.301 ± 0.043	1.902GlnGln: 1.902 ± 0.058	1.631GlnArg: 1.631 ± 0.051	1.84GlnSer: 1.84 ± 0.045	1.981GlnThr: 1.981 ± 0.05	2.377GlnVal: 2.377 ± 0.054	0.474GlnTrp: 0.474 ± 0.027	1.575GlnTyr: 1.575 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.546ArgAla: 2.546 ± 0.062	0.456ArgCys: 0.456 ± 0.023	2.151ArgAsp: 2.151 ± 0.055	2.793ArgGlu: 2.793 ± 0.069	2.113ArgPhe: 2.113 ± 0.056	2.465ArgGly: 2.465 ± 0.059	0.983ArgHis: 0.983 ± 0.036	3.224ArgIle: 3.224 ± 0.077	3.492ArgLys: 3.492 ± 0.072	4.055ArgLeu: 4.055 ± 0.078	1.575ArgMet: 1.575 ± 0.044	2.37ArgAsn: 2.37 ± 0.058	1.485ArgPro: 1.485 ± 0.045	1.917ArgGln: 1.917 ± 0.052	2.136ArgArg: 2.136 ± 0.059	2.139ArgSer: 2.139 ± 0.05	2.131ArgThr: 2.131 ± 0.055	2.423ArgVal: 2.423 ± 0.048	0.565ArgTrp: 0.565 ± 0.023	1.967ArgTyr: 1.967 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.245SerAla: 4.245 ± 0.075	0.878SerCys: 0.878 ± 0.035	3.304SerAsp: 3.304 ± 0.068	3.371SerGlu: 3.371 ± 0.071	2.859SerPhe: 2.859 ± 0.061	4.003SerGly: 4.003 ± 0.075	1.288SerHis: 1.288 ± 0.037	4.023SerIle: 4.023 ± 0.074	3.805SerLys: 3.805 ± 0.075	5.598SerLeu: 5.598 ± 0.082	1.615SerMet: 1.615 ± 0.049	2.731SerAsn: 2.731 ± 0.056	2.068SerPro: 2.068 ± 0.052	2.074SerGln: 2.074 ± 0.053	2.501SerArg: 2.501 ± 0.068	3.632SerSer: 3.632 ± 0.084	3.06SerThr: 3.06 ± 0.071	3.903SerVal: 3.903 ± 0.071	0.763SerTrp: 0.763 ± 0.035	2.622SerTyr: 2.622 ± 0.079	0.0SerXaa: 0.0 ± 0.0
Thr	3.946ThrAla: 3.946 ± 0.076	0.629ThrCys: 0.629 ± 0.03	3.287ThrAsp: 3.287 ± 0.065	3.138ThrGlu: 3.138 ± 0.065	2.537ThrPhe: 2.537 ± 0.054	3.966ThrGly: 3.966 ± 0.076	1.104ThrHis: 1.104 ± 0.04	3.888ThrIle: 3.888 ± 0.073	2.861ThrLys: 2.861 ± 0.07	5.22ThrLeu: 5.22 ± 0.083	1.408ThrMet: 1.408 ± 0.04	2.34ThrAsn: 2.34 ± 0.063	2.514ThrPro: 2.514 ± 0.056	1.846ThrGln: 1.846 ± 0.045	2.075ThrArg: 2.075 ± 0.052	3.242ThrSer: 3.242 ± 0.069	3.085ThrThr: 3.085 ± 0.071	3.523ThrVal: 3.523 ± 0.069	0.685ThrTrp: 0.685 ± 0.028	2.38ThrTyr: 2.38 ± 0.05	0.001ThrXaa: 0.001 ± 0.001
Val	4.994ValAla: 4.994 ± 0.09	1.015ValCys: 1.015 ± 0.037	3.988ValAsp: 3.988 ± 0.067	4.14ValGlu: 4.14 ± 0.079	2.674ValPhe: 2.674 ± 0.066	4.33ValGly: 4.33 ± 0.072	1.132ValHis: 1.132 ± 0.037	4.297ValIle: 4.297 ± 0.079	4.845ValLys: 4.845 ± 0.095	5.561ValLeu: 5.561 ± 0.086	1.943ValMet: 1.943 ± 0.049	3.393ValAsn: 3.393 ± 0.064	2.334ValPro: 2.334 ± 0.059	1.965ValGln: 1.965 ± 0.047	2.685ValArg: 2.685 ± 0.063	4.33ValSer: 4.33 ± 0.083	3.484ValThr: 3.484 ± 0.075	4.684ValVal: 4.684 ± 0.086	0.713ValTrp: 0.713 ± 0.029	2.352ValTyr: 2.352 ± 0.048	0.001ValXaa: 0.001 ± 0.001
Trp	0.845TrpAla: 0.845 ± 0.034	0.186TrpCys: 0.186 ± 0.017	0.663TrpAsp: 0.663 ± 0.031	0.663TrpGlu: 0.663 ± 0.029	0.597TrpPhe: 0.597 ± 0.026	0.972TrpGly: 0.972 ± 0.034	0.313TrpHis: 0.313 ± 0.019	0.725TrpIle: 0.725 ± 0.033	0.979TrpLys: 0.979 ± 0.037	1.228TrpLeu: 1.228 ± 0.036	0.499TrpMet: 0.499 ± 0.029	0.816TrpAsn: 0.816 ± 0.033	0.269TrpPro: 0.269 ± 0.018	0.564TrpGln: 0.564 ± 0.027	0.551TrpArg: 0.551 ± 0.028	0.664TrpSer: 0.664 ± 0.03	0.624TrpThr: 0.624 ± 0.03	0.719TrpVal: 0.719 ± 0.032	0.197TrpTrp: 0.197 ± 0.016	0.497TrpTyr: 0.497 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.911TyrAla: 2.911 ± 0.066	0.564TyrCys: 0.564 ± 0.024	2.642TyrAsp: 2.642 ± 0.063	2.284TyrGlu: 2.284 ± 0.057	1.955TyrPhe: 1.955 ± 0.047	2.866TyrGly: 2.866 ± 0.068	1.019TyrHis: 1.019 ± 0.037	2.752TyrIle: 2.752 ± 0.059	2.581TyrLys: 2.581 ± 0.058	3.789TyrLeu: 3.789 ± 0.075	1.179TyrMet: 1.179 ± 0.036	2.309TyrAsn: 2.309 ± 0.058	1.693TyrPro: 1.693 ± 0.044	1.853TyrGln: 1.853 ± 0.052	2.087TyrArg: 2.087 ± 0.056	2.505TyrSer: 2.505 ± 0.064	2.3TyrThr: 2.3 ± 0.057	2.506TyrVal: 2.506 ± 0.059	0.567TyrTrp: 0.567 ± 0.025	2.061TyrTyr: 2.061 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.005

Statistics based on 2331 proteins (805592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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