Amino acid dipepetide frequency for Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.725AlaAla: 3.725 ± 1.189
1.096AlaCys: 1.096 ± 0.476
2.629AlaAsp: 2.629 ± 0.547
3.067AlaGlu: 3.067 ± 0.757
1.534AlaPhe: 1.534 ± 0.641
4.163AlaGly: 4.163 ± 1.1
0.657AlaHis: 0.657 ± 0.434
4.601AlaIle: 4.601 ± 1.092
2.191AlaLys: 2.191 ± 0.575
4.601AlaLeu: 4.601 ± 0.851
2.41AlaMet: 2.41 ± 0.856
3.725AlaAsn: 3.725 ± 0.501
2.191AlaPro: 2.191 ± 0.478
1.753AlaGln: 1.753 ± 0.487
2.848AlaArg: 2.848 ± 0.63
3.506AlaSer: 3.506 ± 0.929
5.039AlaThr: 5.039 ± 0.906
3.944AlaVal: 3.944 ± 0.969
0.657AlaTrp: 0.657 ± 0.422
1.315AlaTyr: 1.315 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
0.657CysAla: 0.657 ± 0.346
0.219CysCys: 0.219 ± 0.188
0.876CysAsp: 0.876 ± 0.669
0.657CysGlu: 0.657 ± 0.307
1.096CysPhe: 1.096 ± 0.472
0.219CysGly: 0.219 ± 0.217
0.876CysHis: 0.876 ± 0.304
1.096CysIle: 1.096 ± 0.554
0.657CysLys: 0.657 ± 0.401
1.534CysLeu: 1.534 ± 0.581
0.876CysMet: 0.876 ± 0.318
1.315CysAsn: 1.315 ± 0.326
0.438CysPro: 0.438 ± 0.437
0.219CysGln: 0.219 ± 0.218
1.753CysArg: 1.753 ± 0.815
1.753CysSer: 1.753 ± 0.503
0.876CysThr: 0.876 ± 0.475
0.876CysVal: 0.876 ± 0.292
0.438CysTrp: 0.438 ± 0.268
0.657CysTyr: 0.657 ± 0.466
0.0CysXaa: 0.0 ± 0.0
Asp
2.629AspAla: 2.629 ± 0.543
1.315AspCys: 1.315 ± 0.354
0.876AspAsp: 0.876 ± 0.342
3.067AspGlu: 3.067 ± 0.699
2.191AspPhe: 2.191 ± 0.774
3.287AspGly: 3.287 ± 0.857
0.438AspHis: 0.438 ± 0.268
1.972AspIle: 1.972 ± 0.591
2.629AspLys: 2.629 ± 0.553
3.506AspLeu: 3.506 ± 0.427
1.972AspMet: 1.972 ± 0.606
2.848AspAsn: 2.848 ± 0.584
2.848AspPro: 2.848 ± 0.854
1.753AspGln: 1.753 ± 0.695
2.191AspArg: 2.191 ± 0.586
3.506AspSer: 3.506 ± 0.845
2.191AspThr: 2.191 ± 0.579
3.944AspVal: 3.944 ± 0.658
0.657AspTrp: 0.657 ± 0.323
1.753AspTyr: 1.753 ± 0.444
0.0AspXaa: 0.0 ± 0.0
Glu
2.848GluAla: 2.848 ± 0.57
1.534GluCys: 1.534 ± 0.718
4.382GluAsp: 4.382 ± 0.589
6.792GluGlu: 6.792 ± 0.956
2.191GluPhe: 2.191 ± 0.665
4.163GluGly: 4.163 ± 1.051
0.876GluHis: 0.876 ± 0.365
5.478GluIle: 5.478 ± 0.729
5.039GluLys: 5.039 ± 1.143
5.039GluLeu: 5.039 ± 0.799
2.848GluMet: 2.848 ± 0.562
3.725GluAsn: 3.725 ± 1.021
2.41GluPro: 2.41 ± 1.091
4.382GluGln: 4.382 ± 1.141
5.039GluArg: 5.039 ± 1.195
6.573GluSer: 6.573 ± 1.218
3.506GluThr: 3.506 ± 0.739
4.163GluVal: 4.163 ± 1.162
1.315GluTrp: 1.315 ± 0.591
2.191GluTyr: 2.191 ± 0.417
0.0GluXaa: 0.0 ± 0.0
Phe
1.534PheAla: 1.534 ± 0.423
0.0PheCys: 0.0 ± 0.0
1.315PheAsp: 1.315 ± 0.467
5.478PheGlu: 5.478 ± 1.012
1.972PhePhe: 1.972 ± 0.463
1.753PheGly: 1.753 ± 0.263
0.876PheHis: 0.876 ± 0.5
1.753PheIle: 1.753 ± 0.708
0.876PheLys: 0.876 ± 0.388
3.506PheLeu: 3.506 ± 0.699
0.876PheMet: 0.876 ± 0.529
2.191PheAsn: 2.191 ± 0.702
0.657PhePro: 0.657 ± 0.4
2.41PheGln: 2.41 ± 0.827
2.191PheArg: 2.191 ± 0.484
3.287PheSer: 3.287 ± 0.698
2.629PheThr: 2.629 ± 0.558
3.067PheVal: 3.067 ± 0.859
0.657PheTrp: 0.657 ± 0.339
0.876PheTyr: 0.876 ± 0.37
0.0PheXaa: 0.0 ± 0.0
Gly
2.629GlyAla: 2.629 ± 0.777
0.657GlyCys: 0.657 ± 0.308
2.848GlyAsp: 2.848 ± 0.321
3.506GlyGlu: 3.506 ± 1.358
3.287GlyPhe: 3.287 ± 0.734
3.287GlyGly: 3.287 ± 0.826
1.315GlyHis: 1.315 ± 0.496
3.944GlyIle: 3.944 ± 0.821
4.601GlyLys: 4.601 ± 0.633
4.82GlyLeu: 4.82 ± 1.139
1.972GlyMet: 1.972 ± 0.476
3.067GlyAsn: 3.067 ± 0.788
3.067GlyPro: 3.067 ± 0.815
2.191GlyGln: 2.191 ± 0.525
5.259GlyArg: 5.259 ± 1.002
3.944GlySer: 3.944 ± 1.224
6.135GlyThr: 6.135 ± 0.936
5.478GlyVal: 5.478 ± 0.487
1.096GlyTrp: 1.096 ± 0.651
2.629GlyTyr: 2.629 ± 0.774
0.0GlyXaa: 0.0 ± 0.0
His
1.096HisAla: 1.096 ± 0.413
0.438HisCys: 0.438 ± 0.264
0.657HisAsp: 0.657 ± 0.466
1.096HisGlu: 1.096 ± 0.289
1.534HisPhe: 1.534 ± 0.45
0.876HisGly: 0.876 ± 0.44
0.438HisHis: 0.438 ± 0.437
1.315HisIle: 1.315 ± 0.654
1.315HisLys: 1.315 ± 0.482
1.315HisLeu: 1.315 ± 0.422
0.219HisMet: 0.219 ± 0.189
0.438HisAsn: 0.438 ± 0.437
1.096HisPro: 1.096 ± 0.426
0.438HisGln: 0.438 ± 0.25
1.096HisArg: 1.096 ± 0.55
1.972HisSer: 1.972 ± 0.557
0.438HisThr: 0.438 ± 0.302
0.657HisVal: 0.657 ± 0.371
0.219HisTrp: 0.219 ± 0.217
0.657HisTyr: 0.657 ± 0.315
0.0HisXaa: 0.0 ± 0.0
Ile
3.506IleAla: 3.506 ± 0.688
1.972IleCys: 1.972 ± 0.485
2.629IleAsp: 2.629 ± 0.728
6.354IleGlu: 6.354 ± 1.924
1.315IlePhe: 1.315 ± 0.38
5.259IleGly: 5.259 ± 0.903
0.876IleHis: 0.876 ± 0.646
4.163IleIle: 4.163 ± 0.878
3.944IleLys: 3.944 ± 0.803
7.23IleLeu: 7.23 ± 1.424
2.191IleMet: 2.191 ± 0.525
3.725IleAsn: 3.725 ± 0.731
1.753IlePro: 1.753 ± 0.518
1.972IleGln: 1.972 ± 0.591
5.697IleArg: 5.697 ± 1.527
2.41IleSer: 2.41 ± 0.524
3.287IleThr: 3.287 ± 0.932
4.382IleVal: 4.382 ± 0.661
0.657IleTrp: 0.657 ± 0.487
1.096IleTyr: 1.096 ± 0.483
0.0IleXaa: 0.0 ± 0.0
Lys
4.163LysAla: 4.163 ± 0.907
1.315LysCys: 1.315 ± 0.525
2.41LysAsp: 2.41 ± 0.587
4.601LysGlu: 4.601 ± 1.105
1.315LysPhe: 1.315 ± 0.608
2.848LysGly: 2.848 ± 0.567
0.876LysHis: 0.876 ± 0.272
4.382LysIle: 4.382 ± 0.733
4.163LysLys: 4.163 ± 1.58
4.601LysLeu: 4.601 ± 1.051
3.067LysMet: 3.067 ± 0.989
2.191LysAsn: 2.191 ± 0.767
1.315LysPro: 1.315 ± 0.646
2.191LysGln: 2.191 ± 0.987
4.163LysArg: 4.163 ± 1.086
3.287LysSer: 3.287 ± 0.78
4.163LysThr: 4.163 ± 1.29
2.848LysVal: 2.848 ± 0.731
2.191LysTrp: 2.191 ± 0.606
1.753LysTyr: 1.753 ± 0.42
0.0LysXaa: 0.0 ± 0.0
Leu
5.039LeuAla: 5.039 ± 0.675
1.096LeuCys: 1.096 ± 0.487
1.534LeuAsp: 1.534 ± 0.737
6.354LeuGlu: 6.354 ± 1.379
1.972LeuPhe: 1.972 ± 0.615
4.601LeuGly: 4.601 ± 0.892
1.096LeuHis: 1.096 ± 0.412
6.573LeuIle: 6.573 ± 0.991
6.573LeuLys: 6.573 ± 1.371
7.011LeuLeu: 7.011 ± 1.505
2.629LeuMet: 2.629 ± 0.439
4.163LeuAsn: 4.163 ± 1.015
3.944LeuPro: 3.944 ± 0.8
3.506LeuGln: 3.506 ± 0.834
5.697LeuArg: 5.697 ± 1.274
5.697LeuSer: 5.697 ± 0.66
5.259LeuThr: 5.259 ± 1.329
3.944LeuVal: 3.944 ± 0.982
1.534LeuTrp: 1.534 ± 0.46
2.848LeuTyr: 2.848 ± 0.998
0.0LeuXaa: 0.0 ± 0.0
Met
3.725MetAla: 3.725 ± 0.751
1.534MetCys: 1.534 ± 0.727
3.506MetAsp: 3.506 ± 0.949
5.478MetGlu: 5.478 ± 1.124
0.876MetPhe: 0.876 ± 0.56
1.972MetGly: 1.972 ± 0.881
0.438MetHis: 0.438 ± 0.268
2.629MetIle: 2.629 ± 0.634
2.629MetLys: 2.629 ± 1.071
1.315MetLeu: 1.315 ± 0.468
1.753MetMet: 1.753 ± 0.632
0.657MetAsn: 0.657 ± 0.363
0.657MetPro: 0.657 ± 0.33
1.096MetGln: 1.096 ± 0.374
2.629MetArg: 2.629 ± 0.974
2.41MetSer: 2.41 ± 0.476
1.534MetThr: 1.534 ± 0.523
3.287MetVal: 3.287 ± 1.17
0.219MetTrp: 0.219 ± 0.189
0.657MetTyr: 0.657 ± 0.261
0.0MetXaa: 0.0 ± 0.0
Asn
2.629AsnAla: 2.629 ± 0.684
0.219AsnCys: 0.219 ± 0.217
3.067AsnAsp: 3.067 ± 0.672
4.163AsnGlu: 4.163 ± 0.801
1.753AsnPhe: 1.753 ± 0.486
5.039AsnGly: 5.039 ± 1.597
0.657AsnHis: 0.657 ± 0.433
1.753AsnIle: 1.753 ± 0.544
3.067AsnLys: 3.067 ± 0.682
3.506AsnLeu: 3.506 ± 0.762
2.41AsnMet: 2.41 ± 0.723
2.41AsnAsn: 2.41 ± 0.906
4.163AsnPro: 4.163 ± 0.532
2.41AsnGln: 2.41 ± 0.672
3.287AsnArg: 3.287 ± 0.822
4.163AsnSer: 4.163 ± 0.721
4.382AsnThr: 4.382 ± 0.709
2.41AsnVal: 2.41 ± 0.806
0.876AsnTrp: 0.876 ± 0.512
0.876AsnTyr: 0.876 ± 0.389
0.0AsnXaa: 0.0 ± 0.0
Pro
2.629ProAla: 2.629 ± 0.982
0.438ProCys: 0.438 ± 0.271
1.534ProAsp: 1.534 ± 0.496
3.067ProGlu: 3.067 ± 0.562
2.629ProPhe: 2.629 ± 0.743
1.972ProGly: 1.972 ± 0.456
0.657ProHis: 0.657 ± 0.422
2.41ProIle: 2.41 ± 0.288
2.629ProLys: 2.629 ± 0.72
3.287ProLeu: 3.287 ± 0.928
1.096ProMet: 1.096 ± 0.377
3.725ProAsn: 3.725 ± 0.836
0.876ProPro: 0.876 ± 0.389
0.438ProGln: 0.438 ± 0.245
2.191ProArg: 2.191 ± 0.755
3.067ProSer: 3.067 ± 0.926
2.191ProThr: 2.191 ± 0.528
1.753ProVal: 1.753 ± 0.771
0.438ProTrp: 0.438 ± 0.303
0.657ProTyr: 0.657 ± 0.388
0.0ProXaa: 0.0 ± 0.0
Gln
2.848GlnAla: 2.848 ± 1.1
0.438GlnCys: 0.438 ± 0.264
1.753GlnAsp: 1.753 ± 0.503
1.972GlnGlu: 1.972 ± 0.649
0.876GlnPhe: 0.876 ± 0.381
3.944GlnGly: 3.944 ± 1.124
0.219GlnHis: 0.219 ± 0.267
3.287GlnIle: 3.287 ± 0.401
2.41GlnLys: 2.41 ± 0.813
3.506GlnLeu: 3.506 ± 1.046
2.629GlnMet: 2.629 ± 1.017
2.191GlnAsn: 2.191 ± 0.781
0.657GlnPro: 0.657 ± 0.377
1.534GlnGln: 1.534 ± 0.498
3.287GlnArg: 3.287 ± 0.986
3.067GlnSer: 3.067 ± 0.765
2.848GlnThr: 2.848 ± 0.863
1.753GlnVal: 1.753 ± 0.604
1.096GlnTrp: 1.096 ± 0.543
0.876GlnTyr: 0.876 ± 0.267
0.0GlnXaa: 0.0 ± 0.0
Arg
3.725ArgAla: 3.725 ± 0.949
0.657ArgCys: 0.657 ± 0.343
3.506ArgAsp: 3.506 ± 0.731
3.725ArgGlu: 3.725 ± 1.031
2.629ArgPhe: 2.629 ± 0.687
6.135ArgGly: 6.135 ± 1.256
0.657ArgHis: 0.657 ± 0.366
5.259ArgIle: 5.259 ± 0.86
2.848ArgLys: 2.848 ± 0.685
5.039ArgLeu: 5.039 ± 0.801
3.506ArgMet: 3.506 ± 1.577
4.601ArgAsn: 4.601 ± 1.088
1.753ArgPro: 1.753 ± 0.514
3.506ArgGln: 3.506 ± 0.742
6.573ArgArg: 6.573 ± 0.913
4.382ArgSer: 4.382 ± 0.953
6.573ArgThr: 6.573 ± 1.227
3.067ArgVal: 3.067 ± 0.99
0.219ArgTrp: 0.219 ± 0.251
1.315ArgTyr: 1.315 ± 0.539
0.0ArgXaa: 0.0 ± 0.0
Ser
3.506SerAla: 3.506 ± 1.445
1.753SerCys: 1.753 ± 0.844
3.067SerAsp: 3.067 ± 0.706
3.506SerGlu: 3.506 ± 0.981
4.163SerPhe: 4.163 ± 0.838
5.259SerGly: 5.259 ± 1.003
1.534SerHis: 1.534 ± 0.707
4.382SerIle: 4.382 ± 0.637
3.067SerLys: 3.067 ± 0.847
7.888SerLeu: 7.888 ± 1.298
2.629SerMet: 2.629 ± 1.011
3.725SerAsn: 3.725 ± 1.266
3.287SerPro: 3.287 ± 0.936
3.725SerGln: 3.725 ± 0.811
3.067SerArg: 3.067 ± 0.635
8.107SerSer: 8.107 ± 0.987
4.82SerThr: 4.82 ± 1.186
3.725SerVal: 3.725 ± 0.782
1.534SerTrp: 1.534 ± 0.622
1.753SerTyr: 1.753 ± 0.561
0.0SerXaa: 0.0 ± 0.0
Thr
3.506ThrAla: 3.506 ± 0.692
0.876ThrCys: 0.876 ± 0.351
2.41ThrAsp: 2.41 ± 0.803
4.601ThrGlu: 4.601 ± 1.299
2.629ThrPhe: 2.629 ± 0.572
4.163ThrGly: 4.163 ± 0.849
2.41ThrHis: 2.41 ± 0.656
5.259ThrIle: 5.259 ± 0.827
3.506ThrLys: 3.506 ± 0.73
4.82ThrLeu: 4.82 ± 0.928
2.191ThrMet: 2.191 ± 0.681
2.848ThrAsn: 2.848 ± 0.501
1.972ThrPro: 1.972 ± 0.534
3.944ThrGln: 3.944 ± 1.359
4.382ThrArg: 4.382 ± 1.035
3.944ThrSer: 3.944 ± 0.839
2.41ThrThr: 2.41 ± 0.941
4.163ThrVal: 4.163 ± 0.939
0.657ThrTrp: 0.657 ± 0.301
3.287ThrTyr: 3.287 ± 0.745
0.0ThrXaa: 0.0 ± 0.0
Val
3.725ValAla: 3.725 ± 0.85
1.315ValCys: 1.315 ± 0.486
3.944ValAsp: 3.944 ± 0.871
3.944ValGlu: 3.944 ± 0.915
2.191ValPhe: 2.191 ± 0.641
3.944ValGly: 3.944 ± 1.264
1.096ValHis: 1.096 ± 0.534
1.315ValIle: 1.315 ± 0.372
3.506ValLys: 3.506 ± 1.268
5.916ValLeu: 5.916 ± 1.29
1.972ValMet: 1.972 ± 0.645
3.067ValAsn: 3.067 ± 0.688
2.848ValPro: 2.848 ± 0.696
1.753ValGln: 1.753 ± 0.895
5.039ValArg: 5.039 ± 1.48
5.697ValSer: 5.697 ± 0.685
2.41ValThr: 2.41 ± 0.733
4.163ValVal: 4.163 ± 1.288
0.876ValTrp: 0.876 ± 0.483
1.315ValTyr: 1.315 ± 0.358
0.0ValXaa: 0.0 ± 0.0
Trp
0.657TrpAla: 0.657 ± 0.321
0.0TrpCys: 0.0 ± 0.0
0.438TrpAsp: 0.438 ± 0.245
1.534TrpGlu: 1.534 ± 0.63
0.657TrpPhe: 0.657 ± 0.319
0.657TrpGly: 0.657 ± 0.257
0.657TrpHis: 0.657 ± 0.35
1.096TrpIle: 1.096 ± 0.503
0.876TrpLys: 0.876 ± 0.606
1.096TrpLeu: 1.096 ± 0.605
1.096TrpMet: 1.096 ± 0.483
0.876TrpAsn: 0.876 ± 0.311
0.438TrpPro: 0.438 ± 0.264
0.219TrpGln: 0.219 ± 0.218
0.876TrpArg: 0.876 ± 0.555
1.315TrpSer: 1.315 ± 0.664
1.972TrpThr: 1.972 ± 0.714
1.096TrpVal: 1.096 ± 0.635
0.438TrpTrp: 0.438 ± 0.25
0.438TrpTyr: 0.438 ± 0.292
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.876TyrAla: 0.876 ± 0.423
0.219TyrCys: 0.219 ± 0.197
2.191TyrAsp: 2.191 ± 0.713
1.534TyrGlu: 1.534 ± 0.638
1.096TyrPhe: 1.096 ± 0.364
2.191TyrGly: 2.191 ± 0.417
0.657TyrHis: 0.657 ± 0.655
1.972TyrIle: 1.972 ± 0.438
1.315TyrLys: 1.315 ± 0.458
1.534TyrLeu: 1.534 ± 0.483
0.438TyrMet: 0.438 ± 0.25
1.753TyrAsn: 1.753 ± 0.568
1.315TyrPro: 1.315 ± 0.658
1.753TyrGln: 1.753 ± 0.45
2.41TyrArg: 2.41 ± 1.037
2.41TyrSer: 2.41 ± 0.407
1.315TyrThr: 1.315 ± 0.8
1.315TyrVal: 1.315 ± 0.558
0.657TyrTrp: 0.657 ± 0.296
0.219TyrTyr: 0.219 ± 0.197
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4565 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski