Amino acid dipepetide frequency for Brucella suis bv. 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.998AlaAla: 13.998 ± 0.361
1.052AlaCys: 1.052 ± 0.074
5.718AlaAsp: 5.718 ± 0.162
7.264AlaGlu: 7.264 ± 0.212
4.213AlaPhe: 4.213 ± 0.151
9.707AlaGly: 9.707 ± 0.202
2.072AlaHis: 2.072 ± 0.109
6.994AlaIle: 6.994 ± 0.182
4.648AlaLys: 4.648 ± 0.171
12.054AlaLeu: 12.054 ± 0.276
3.408AlaMet: 3.408 ± 0.121
3.262AlaAsn: 3.262 ± 0.13
4.854AlaPro: 4.854 ± 0.181
3.559AlaGln: 3.559 ± 0.141
7.694AlaArg: 7.694 ± 0.179
6.45AlaSer: 6.45 ± 0.196
5.018AlaThr: 5.018 ± 0.149
7.635AlaVal: 7.635 ± 0.203
1.162AlaTrp: 1.162 ± 0.082
2.694AlaTyr: 2.694 ± 0.121
0.0AlaXaa: 0.0 ± 0.0
Cys
1.011CysAla: 1.011 ± 0.071
0.201CysCys: 0.201 ± 0.031
0.567CysAsp: 0.567 ± 0.05
0.586CysGlu: 0.586 ± 0.049
0.471CysPhe: 0.471 ± 0.045
1.016CysGly: 1.016 ± 0.065
0.334CysHis: 0.334 ± 0.039
0.576CysIle: 0.576 ± 0.05
0.311CysLys: 0.311 ± 0.038
0.769CysLeu: 0.769 ± 0.064
0.265CysMet: 0.265 ± 0.032
0.27CysAsn: 0.27 ± 0.035
0.535CysPro: 0.535 ± 0.046
0.229CysGln: 0.229 ± 0.029
0.709CysArg: 0.709 ± 0.066
0.686CysSer: 0.686 ± 0.06
0.531CysThr: 0.531 ± 0.04
0.613CysVal: 0.613 ± 0.053
0.119CysTrp: 0.119 ± 0.023
0.229CysTyr: 0.229 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
5.956AspAla: 5.956 ± 0.159
0.554AspCys: 0.554 ± 0.056
2.909AspAsp: 2.909 ± 0.137
3.628AspGlu: 3.628 ± 0.143
1.994AspPhe: 1.994 ± 0.11
4.456AspGly: 4.456 ± 0.155
1.134AspHis: 1.134 ± 0.076
3.463AspIle: 3.463 ± 0.144
2.15AspLys: 2.15 ± 0.098
5.055AspLeu: 5.055 ± 0.166
1.528AspMet: 1.528 ± 0.097
1.597AspAsn: 1.597 ± 0.101
2.854AspPro: 2.854 ± 0.124
1.67AspGln: 1.67 ± 0.093
3.705AspArg: 3.705 ± 0.132
1.981AspSer: 1.981 ± 0.095
2.612AspThr: 2.612 ± 0.106
3.843AspVal: 3.843 ± 0.151
0.846AspTrp: 0.846 ± 0.062
1.491AspTyr: 1.491 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
7.264GluAla: 7.264 ± 0.206
0.467GluCys: 0.467 ± 0.05
2.983GluAsp: 2.983 ± 0.144
3.701GluGlu: 3.701 ± 0.175
1.784GluPhe: 1.784 ± 0.093
4.346GluGly: 4.346 ± 0.14
1.153GluHis: 1.153 ± 0.072
3.646GluIle: 3.646 ± 0.17
3.152GluLys: 3.152 ± 0.127
5.082GluLeu: 5.082 ± 0.149
1.807GluMet: 1.807 ± 0.096
2.232GluAsn: 2.232 ± 0.097
2.511GluPro: 2.511 ± 0.112
2.264GluGln: 2.264 ± 0.093
4.959GluArg: 4.959 ± 0.146
2.232GluSer: 2.232 ± 0.114
3.632GluThr: 3.632 ± 0.127
3.815GluVal: 3.815 ± 0.136
0.65GluTrp: 0.65 ± 0.054
1.24GluTyr: 1.24 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
4.094PheAla: 4.094 ± 0.164
0.476PheCys: 0.476 ± 0.043
2.484PheAsp: 2.484 ± 0.116
2.008PheGlu: 2.008 ± 0.092
1.464PhePhe: 1.464 ± 0.108
3.385PheGly: 3.385 ± 0.141
0.906PheHis: 0.906 ± 0.061
2.301PheIle: 2.301 ± 0.135
1.441PheLys: 1.441 ± 0.075
3.477PheLeu: 3.477 ± 0.153
1.02PheMet: 1.02 ± 0.065
1.299PheAsn: 1.299 ± 0.083
1.601PhePro: 1.601 ± 0.087
1.148PheGln: 1.148 ± 0.066
2.356PheArg: 2.356 ± 0.116
2.681PheSer: 2.681 ± 0.136
1.958PheThr: 1.958 ± 0.088
2.868PheVal: 2.868 ± 0.118
0.554PheTrp: 0.554 ± 0.059
0.91PheTyr: 0.91 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
8.161GlyAla: 8.161 ± 0.196
0.993GlyCys: 0.993 ± 0.07
3.737GlyAsp: 3.737 ± 0.135
4.712GlyGlu: 4.712 ± 0.152
3.509GlyPhe: 3.509 ± 0.127
6.336GlyGly: 6.336 ± 0.188
1.834GlyHis: 1.834 ± 0.084
5.123GlyIle: 5.123 ± 0.158
4.236GlyLys: 4.236 ± 0.151
8.047GlyLeu: 8.047 ± 0.227
2.434GlyMet: 2.434 ± 0.12
2.264GlyAsn: 2.264 ± 0.109
2.704GlyPro: 2.704 ± 0.103
2.891GlyGln: 2.891 ± 0.104
5.558GlyArg: 5.558 ± 0.167
4.634GlySer: 4.634 ± 0.147
4.172GlyThr: 4.172 ± 0.14
5.736GlyVal: 5.736 ± 0.17
1.263GlyTrp: 1.263 ± 0.081
2.31GlyTyr: 2.31 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
2.059HisAla: 2.059 ± 0.102
0.21HisCys: 0.21 ± 0.032
1.199HisAsp: 1.199 ± 0.079
1.199HisGlu: 1.199 ± 0.066
1.043HisPhe: 1.043 ± 0.072
1.944HisGly: 1.944 ± 0.1
0.65HisHis: 0.65 ± 0.066
1.166HisIle: 1.166 ± 0.072
0.682HisLys: 0.682 ± 0.056
1.793HisLeu: 1.793 ± 0.1
0.718HisMet: 0.718 ± 0.061
0.727HisAsn: 0.727 ± 0.06
1.189HisPro: 1.189 ± 0.066
0.572HisGln: 0.572 ± 0.046
1.61HisArg: 1.61 ± 0.09
1.066HisSer: 1.066 ± 0.069
0.947HisThr: 0.947 ± 0.052
1.574HisVal: 1.574 ± 0.084
0.256HisTrp: 0.256 ± 0.033
0.787HisTyr: 0.787 ± 0.064
0.0HisXaa: 0.0 ± 0.0
Ile
7.681IleAla: 7.681 ± 0.194
0.627IleCys: 0.627 ± 0.056
3.714IleAsp: 3.714 ± 0.156
3.907IleGlu: 3.907 ± 0.146
2.191IlePhe: 2.191 ± 0.118
5.288IleGly: 5.288 ± 0.17
1.258IleHis: 1.258 ± 0.067
3.106IleIle: 3.106 ± 0.136
2.04IleLys: 2.04 ± 0.106
5.27IleLeu: 5.27 ± 0.179
1.327IleMet: 1.327 ± 0.074
2.036IleAsn: 2.036 ± 0.091
2.557IlePro: 2.557 ± 0.106
1.217IleGln: 1.217 ± 0.085
3.994IleArg: 3.994 ± 0.126
3.422IleSer: 3.422 ± 0.136
2.818IleThr: 2.818 ± 0.116
4.693IleVal: 4.693 ± 0.154
0.704IleTrp: 0.704 ± 0.059
1.491IleTyr: 1.491 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
5.654LysAla: 5.654 ± 0.183
0.297LysCys: 0.297 ± 0.04
2.306LysAsp: 2.306 ± 0.109
2.365LysGlu: 2.365 ± 0.115
1.295LysPhe: 1.295 ± 0.083
3.344LysGly: 3.344 ± 0.132
0.828LysHis: 0.828 ± 0.066
2.397LysIle: 2.397 ± 0.1
1.958LysLys: 1.958 ± 0.114
4.195LysLeu: 4.195 ± 0.146
1.208LysMet: 1.208 ± 0.081
1.194LysAsn: 1.194 ± 0.083
2.832LysPro: 2.832 ± 0.12
1.368LysGln: 1.368 ± 0.084
3.051LysArg: 3.051 ± 0.116
2.42LysSer: 2.42 ± 0.115
2.566LysThr: 2.566 ± 0.103
2.905LysVal: 2.905 ± 0.121
0.457LysTrp: 0.457 ± 0.049
0.956LysTyr: 0.956 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
11.551LeuAla: 11.551 ± 0.237
1.075LeuCys: 1.075 ± 0.075
5.572LeuAsp: 5.572 ± 0.176
5.389LeuGlu: 5.389 ± 0.152
3.71LeuPhe: 3.71 ± 0.158
7.392LeuGly: 7.392 ± 0.207
1.912LeuHis: 1.912 ± 0.102
5.604LeuIle: 5.604 ± 0.168
4.382LeuLys: 4.382 ± 0.138
8.815LeuLeu: 8.815 ± 0.259
2.429LeuMet: 2.429 ± 0.121
2.85LeuAsn: 2.85 ± 0.127
4.927LeuPro: 4.927 ± 0.157
3.037LeuGln: 3.037 ± 0.113
5.778LeuArg: 5.778 ± 0.184
6.221LeuSer: 6.221 ± 0.168
5.192LeuThr: 5.192 ± 0.181
6.702LeuVal: 6.702 ± 0.189
1.029LeuTrp: 1.029 ± 0.071
2.274LeuTyr: 2.274 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
3.321MetAla: 3.321 ± 0.137
0.183MetCys: 0.183 ± 0.026
1.29MetAsp: 1.29 ± 0.088
1.528MetGlu: 1.528 ± 0.092
0.823MetPhe: 0.823 ± 0.072
1.944MetGly: 1.944 ± 0.105
0.531MetHis: 0.531 ± 0.053
1.542MetIle: 1.542 ± 0.082
1.606MetLys: 1.606 ± 0.084
2.598MetLeu: 2.598 ± 0.122
0.919MetMet: 0.919 ± 0.081
1.107MetAsn: 1.107 ± 0.072
1.606MetPro: 1.606 ± 0.085
0.993MetGln: 0.993 ± 0.052
1.903MetArg: 1.903 ± 0.104
1.967MetSer: 1.967 ± 0.098
1.889MetThr: 1.889 ± 0.094
1.972MetVal: 1.972 ± 0.091
0.252MetTrp: 0.252 ± 0.034
0.334MetTyr: 0.334 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.499AsnAla: 3.499 ± 0.129
0.293AsnCys: 0.293 ± 0.04
1.624AsnAsp: 1.624 ± 0.087
1.491AsnGlu: 1.491 ± 0.076
1.189AsnPhe: 1.189 ± 0.088
2.649AsnGly: 2.649 ± 0.11
0.677AsnHis: 0.677 ± 0.057
2.022AsnIle: 2.022 ± 0.092
1.313AsnLys: 1.313 ± 0.073
2.79AsnLeu: 2.79 ± 0.134
0.947AsnMet: 0.947 ± 0.067
0.979AsnAsn: 0.979 ± 0.072
2.017AsnPro: 2.017 ± 0.1
1.029AsnGln: 1.029 ± 0.067
2.118AsnArg: 2.118 ± 0.107
1.702AsnSer: 1.702 ± 0.107
1.496AsnThr: 1.496 ± 0.082
2.095AsnVal: 2.095 ± 0.095
0.444AsnTrp: 0.444 ± 0.042
0.782AsnTyr: 0.782 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
5.252ProAla: 5.252 ± 0.157
0.448ProCys: 0.448 ± 0.042
3.188ProAsp: 3.188 ± 0.132
3.28ProGlu: 3.28 ± 0.122
2.031ProPhe: 2.031 ± 0.105
3.852ProGly: 3.852 ± 0.14
1.231ProHis: 1.231 ± 0.069
2.443ProIle: 2.443 ± 0.105
2.013ProLys: 2.013 ± 0.094
4.163ProLeu: 4.163 ± 0.14
1.267ProMet: 1.267 ± 0.083
1.354ProAsn: 1.354 ± 0.082
1.674ProPro: 1.674 ± 0.104
1.912ProGln: 1.912 ± 0.105
2.53ProArg: 2.53 ± 0.11
2.603ProSer: 2.603 ± 0.117
2.269ProThr: 2.269 ± 0.097
4.236ProVal: 4.236 ± 0.144
0.586ProTrp: 0.586 ± 0.05
1.185ProTyr: 1.185 ± 0.078
0.0ProXaa: 0.0 ± 0.0
Gln
3.847GlnAla: 3.847 ± 0.143
0.229GlnCys: 0.229 ± 0.033
1.441GlnAsp: 1.441 ± 0.082
1.67GlnGlu: 1.67 ± 0.097
1.212GlnPhe: 1.212 ± 0.079
2.214GlnGly: 2.214 ± 0.101
0.695GlnHis: 0.695 ± 0.05
1.958GlnIle: 1.958 ± 0.092
1.697GlnLys: 1.697 ± 0.095
2.786GlnLeu: 2.786 ± 0.101
1.112GlnMet: 1.112 ± 0.067
1.212GlnAsn: 1.212 ± 0.074
1.784GlnPro: 1.784 ± 0.086
1.166GlnGln: 1.166 ± 0.081
2.392GlnArg: 2.392 ± 0.099
1.944GlnSer: 1.944 ± 0.086
1.697GlnThr: 1.697 ± 0.082
2.155GlnVal: 2.155 ± 0.097
0.421GlnTrp: 0.421 ± 0.043
0.787GlnTyr: 0.787 ± 0.067
0.0GlnXaa: 0.0 ± 0.0
Arg
6.615ArgAla: 6.615 ± 0.217
0.686ArgCys: 0.686 ± 0.059
3.326ArgAsp: 3.326 ± 0.131
4.158ArgGlu: 4.158 ± 0.153
3.047ArgPhe: 3.047 ± 0.146
4.529ArgGly: 4.529 ± 0.146
1.77ArgHis: 1.77 ± 0.098
4.387ArgIle: 4.387 ± 0.145
3.367ArgLys: 3.367 ± 0.116
7.182ArgLeu: 7.182 ± 0.196
2.109ArgMet: 2.109 ± 0.093
2.246ArgAsn: 2.246 ± 0.097
3.312ArgPro: 3.312 ± 0.163
2.63ArgGln: 2.63 ± 0.114
5.165ArgArg: 5.165 ± 0.178
3.76ArgSer: 3.76 ± 0.149
3.179ArgThr: 3.179 ± 0.125
4.648ArgVal: 4.648 ± 0.141
0.819ArgTrp: 0.819 ± 0.059
1.729ArgTyr: 1.729 ± 0.089
0.0ArgXaa: 0.0 ± 0.0
Ser
5.983SerAla: 5.983 ± 0.183
0.599SerCys: 0.599 ± 0.064
2.822SerAsp: 2.822 ± 0.107
2.928SerGlu: 2.928 ± 0.131
2.319SerPhe: 2.319 ± 0.112
5.736SerGly: 5.736 ± 0.168
1.363SerHis: 1.363 ± 0.073
3.349SerIle: 3.349 ± 0.123
2.177SerLys: 2.177 ± 0.104
5.357SerLeu: 5.357 ± 0.162
1.496SerMet: 1.496 ± 0.078
1.615SerAsn: 1.615 ± 0.082
2.621SerPro: 2.621 ± 0.101
1.715SerGln: 1.715 ± 0.089
4.199SerArg: 4.199 ± 0.146
3.252SerSer: 3.252 ± 0.152
2.69SerThr: 2.69 ± 0.109
4.263SerVal: 4.263 ± 0.138
0.608SerTrp: 0.608 ± 0.053
1.455SerTyr: 1.455 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
5.773ThrAla: 5.773 ± 0.164
0.512ThrCys: 0.512 ± 0.051
2.749ThrAsp: 2.749 ± 0.128
2.589ThrGlu: 2.589 ± 0.108
2.054ThrPhe: 2.054 ± 0.113
4.529ThrGly: 4.529 ± 0.155
0.951ThrHis: 0.951 ± 0.061
3.252ThrIle: 3.252 ± 0.105
1.839ThrLys: 1.839 ± 0.1
5.357ThrLeu: 5.357 ± 0.147
1.345ThrMet: 1.345 ± 0.083
1.345ThrAsn: 1.345 ± 0.084
2.9ThrPro: 2.9 ± 0.12
1.395ThrGln: 1.395 ± 0.083
3.106ThrArg: 3.106 ± 0.115
2.731ThrSer: 2.731 ± 0.12
2.589ThrThr: 2.589 ± 0.122
4.552ThrVal: 4.552 ± 0.146
0.604ThrTrp: 0.604 ± 0.054
1.231ThrTyr: 1.231 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
8.262ValAla: 8.262 ± 0.236
0.686ValCys: 0.686 ± 0.066
3.747ValAsp: 3.747 ± 0.129
4.639ValGlu: 4.639 ± 0.147
2.63ValPhe: 2.63 ± 0.118
4.977ValGly: 4.977 ± 0.156
1.354ValHis: 1.354 ± 0.079
4.254ValIle: 4.254 ± 0.142
3.161ValLys: 3.161 ± 0.129
7.379ValLeu: 7.379 ± 0.218
2.031ValMet: 2.031 ± 0.103
2.26ValAsn: 2.26 ± 0.099
3.367ValPro: 3.367 ± 0.119
2.136ValGln: 2.136 ± 0.103
4.922ValArg: 4.922 ± 0.152
4.757ValSer: 4.757 ± 0.158
4.167ValThr: 4.167 ± 0.159
5.512ValVal: 5.512 ± 0.166
0.81ValTrp: 0.81 ± 0.062
1.34ValTyr: 1.34 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
1.18TrpAla: 1.18 ± 0.083
0.133TrpCys: 0.133 ± 0.025
0.489TrpAsp: 0.489 ± 0.049
0.476TrpGlu: 0.476 ± 0.049
0.467TrpPhe: 0.467 ± 0.049
0.778TrpGly: 0.778 ± 0.054
0.27TrpHis: 0.27 ± 0.032
0.604TrpIle: 0.604 ± 0.044
0.554TrpLys: 0.554 ± 0.048
1.441TrpLeu: 1.441 ± 0.079
0.38TrpMet: 0.38 ± 0.04
0.476TrpAsn: 0.476 ± 0.045
0.608TrpPro: 0.608 ± 0.057
0.567TrpGln: 0.567 ± 0.049
1.02TrpArg: 1.02 ± 0.078
0.732TrpSer: 0.732 ± 0.061
0.672TrpThr: 0.672 ± 0.059
0.791TrpVal: 0.791 ± 0.062
0.265TrpTrp: 0.265 ± 0.038
0.329TrpTyr: 0.329 ± 0.042
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.296TyrAla: 2.296 ± 0.105
0.306TyrCys: 0.306 ± 0.039
1.564TyrAsp: 1.564 ± 0.088
1.404TyrGlu: 1.404 ± 0.063
0.984TyrPhe: 0.984 ± 0.066
2.232TyrGly: 2.232 ± 0.105
0.467TyrHis: 0.467 ± 0.046
1.153TyrIle: 1.153 ± 0.07
0.869TyrLys: 0.869 ± 0.064
2.232TyrLeu: 2.232 ± 0.104
0.554TyrMet: 0.554 ± 0.049
0.833TyrAsn: 0.833 ± 0.06
1.061TyrPro: 1.061 ± 0.073
0.919TyrGln: 0.919 ± 0.065
1.894TyrArg: 1.894 ± 0.098
1.308TyrSer: 1.308 ± 0.075
1.308TyrThr: 1.308 ± 0.067
1.784TyrVal: 1.784 ± 0.089
0.384TyrTrp: 0.384 ± 0.044
0.727TyrTyr: 0.727 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1091 proteins (218604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski