Amino acid dipepetide frequency for Clostridium sp. CAG:269

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.104AlaAla: 2.104 ± 0.094
0.491AlaCys: 0.491 ± 0.034
2.575AlaAsp: 2.575 ± 0.077
3.916AlaGlu: 3.916 ± 0.111
2.0AlaPhe: 2.0 ± 0.088
3.374AlaGly: 3.374 ± 0.089
0.695AlaHis: 0.695 ± 0.041
5.792AlaIle: 5.792 ± 0.114
5.217AlaLys: 5.217 ± 0.12
4.157AlaLeu: 4.157 ± 0.103
1.383AlaMet: 1.383 ± 0.063
3.002AlaAsn: 3.002 ± 0.094
1.113AlaPro: 1.113 ± 0.056
1.805AlaGln: 1.805 ± 0.077
2.033AlaArg: 2.033 ± 0.077
2.766AlaSer: 2.766 ± 0.082
2.965AlaThr: 2.965 ± 0.089
3.283AlaVal: 3.283 ± 0.101
0.29AlaTrp: 0.29 ± 0.025
1.996AlaTyr: 1.996 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.553CysAla: 0.553 ± 0.033
0.212CysCys: 0.212 ± 0.024
0.589CysAsp: 0.589 ± 0.037
0.763CysGlu: 0.763 ± 0.042
0.496CysPhe: 0.496 ± 0.032
0.861CysGly: 0.861 ± 0.042
0.164CysHis: 0.164 ± 0.019
1.073CysIle: 1.073 ± 0.047
1.115CysLys: 1.115 ± 0.048
0.847CysLeu: 0.847 ± 0.048
0.268CysMet: 0.268 ± 0.023
0.695CysAsn: 0.695 ± 0.04
0.365CysPro: 0.365 ± 0.031
0.261CysGln: 0.261 ± 0.024
0.29CysArg: 0.29 ± 0.028
0.662CysSer: 0.662 ± 0.038
0.538CysThr: 0.538 ± 0.036
0.655CysVal: 0.655 ± 0.04
0.082CysTrp: 0.082 ± 0.013
0.451CysTyr: 0.451 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.365AspAla: 2.365 ± 0.083
0.546AspCys: 0.546 ± 0.034
2.874AspAsp: 2.874 ± 0.095
5.399AspGlu: 5.399 ± 0.124
2.507AspPhe: 2.507 ± 0.074
3.602AspGly: 3.602 ± 0.105
0.478AspHis: 0.478 ± 0.037
6.111AspIle: 6.111 ± 0.127
5.379AspLys: 5.379 ± 0.118
4.494AspLeu: 4.494 ± 0.102
1.451AspMet: 1.451 ± 0.061
3.412AspAsn: 3.412 ± 0.101
1.117AspPro: 1.117 ± 0.052
0.943AspGln: 0.943 ± 0.046
1.566AspArg: 1.566 ± 0.064
3.053AspSer: 3.053 ± 0.093
2.726AspThr: 2.726 ± 0.074
3.5AspVal: 3.5 ± 0.086
0.389AspTrp: 0.389 ± 0.037
2.571AspTyr: 2.571 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
3.916GluAla: 3.916 ± 0.107
0.732GluCys: 0.732 ± 0.036
4.179GluAsp: 4.179 ± 0.099
8.755GluGlu: 8.755 ± 0.19
3.142GluPhe: 3.142 ± 0.084
3.401GluGly: 3.401 ± 0.097
0.885GluHis: 0.885 ± 0.043
9.001GluIle: 9.001 ± 0.193
10.58GluLys: 10.58 ± 0.211
7.443GluLeu: 7.443 ± 0.135
2.305GluMet: 2.305 ± 0.077
7.793GluAsn: 7.793 ± 0.14
1.487GluPro: 1.487 ± 0.058
2.998GluGln: 2.998 ± 0.105
2.81GluArg: 2.81 ± 0.084
3.394GluSer: 3.394 ± 0.1
3.828GluThr: 3.828 ± 0.097
4.62GluVal: 4.62 ± 0.108
0.491GluTrp: 0.491 ± 0.032
3.859GluTyr: 3.859 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
2.325PheAla: 2.325 ± 0.066
0.571PheCys: 0.571 ± 0.034
2.527PheAsp: 2.527 ± 0.071
3.372PheGlu: 3.372 ± 0.093
1.595PhePhe: 1.595 ± 0.072
2.436PheGly: 2.436 ± 0.083
0.443PheHis: 0.443 ± 0.03
4.0PheIle: 4.0 ± 0.124
3.372PheLys: 3.372 ± 0.092
3.319PheLeu: 3.319 ± 0.109
0.94PheMet: 0.94 ± 0.051
2.558PheAsn: 2.558 ± 0.085
0.923PhePro: 0.923 ± 0.047
0.912PheGln: 0.912 ± 0.053
1.23PheArg: 1.23 ± 0.054
2.69PheSer: 2.69 ± 0.091
1.947PheThr: 1.947 ± 0.064
2.443PheVal: 2.443 ± 0.078
0.308PheTrp: 0.308 ± 0.021
1.679PheTyr: 1.679 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
3.093GlyAla: 3.093 ± 0.106
0.615GlyCys: 0.615 ± 0.038
2.637GlyAsp: 2.637 ± 0.08
4.095GlyGlu: 4.095 ± 0.096
2.494GlyPhe: 2.494 ± 0.071
3.325GlyGly: 3.325 ± 0.113
0.918GlyHis: 0.918 ± 0.042
6.503GlyIle: 6.503 ± 0.137
5.981GlyLys: 5.981 ± 0.116
4.319GlyLeu: 4.319 ± 0.104
1.527GlyMet: 1.527 ± 0.069
3.41GlyAsn: 3.41 ± 0.11
0.887GlyPro: 0.887 ± 0.041
1.52GlyGln: 1.52 ± 0.061
1.954GlyArg: 1.954 ± 0.084
2.662GlySer: 2.662 ± 0.079
3.58GlyThr: 3.58 ± 0.098
3.578GlyVal: 3.578 ± 0.092
0.403GlyTrp: 0.403 ± 0.034
2.812GlyTyr: 2.812 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.562HisAla: 0.562 ± 0.039
0.226HisCys: 0.226 ± 0.024
0.558HisAsp: 0.558 ± 0.036
0.728HisGlu: 0.728 ± 0.038
0.522HisPhe: 0.522 ± 0.038
0.794HisGly: 0.794 ± 0.045
0.25HisHis: 0.25 ± 0.026
1.221HisIle: 1.221 ± 0.048
0.978HisLys: 0.978 ± 0.05
1.009HisLeu: 1.009 ± 0.044
0.243HisMet: 0.243 ± 0.023
0.695HisAsn: 0.695 ± 0.039
0.516HisPro: 0.516 ± 0.037
0.378HisGln: 0.378 ± 0.029
0.445HisArg: 0.445 ± 0.029
0.77HisSer: 0.77 ± 0.038
0.622HisThr: 0.622 ± 0.035
0.593HisVal: 0.593 ± 0.037
0.066HisTrp: 0.066 ± 0.013
0.546HisTyr: 0.546 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.95IleAla: 5.95 ± 0.126
1.394IleCys: 1.394 ± 0.058
6.122IleAsp: 6.122 ± 0.107
8.642IleGlu: 8.642 ± 0.147
4.275IlePhe: 4.275 ± 0.121
5.854IleGly: 5.854 ± 0.112
1.073IleHis: 1.073 ± 0.052
10.724IleIle: 10.724 ± 0.268
9.622IleLys: 9.622 ± 0.143
9.242IleLeu: 9.242 ± 0.186
2.272IleMet: 2.272 ± 0.063
6.485IleAsn: 6.485 ± 0.132
3.171IlePro: 3.171 ± 0.091
2.925IleGln: 2.925 ± 0.077
3.084IleArg: 3.084 ± 0.087
7.014IleSer: 7.014 ± 0.152
5.724IleThr: 5.724 ± 0.124
6.476IleVal: 6.476 ± 0.131
0.549IleTrp: 0.549 ± 0.038
4.253IleTyr: 4.253 ± 0.106
0.0IleXaa: 0.0 ± 0.0
Lys
4.755LysAla: 4.755 ± 0.108
0.965LysCys: 0.965 ± 0.053
5.89LysAsp: 5.89 ± 0.124
10.423LysGlu: 10.423 ± 0.176
3.414LysPhe: 3.414 ± 0.093
4.303LysGly: 4.303 ± 0.096
0.991LysHis: 0.991 ± 0.046
11.032LysIle: 11.032 ± 0.188
9.795LysLys: 9.795 ± 0.184
7.866LysLeu: 7.866 ± 0.14
3.011LysMet: 3.011 ± 0.084
7.414LysAsn: 7.414 ± 0.159
1.898LysPro: 1.898 ± 0.057
3.489LysGln: 3.489 ± 0.093
3.421LysArg: 3.421 ± 0.091
4.841LysSer: 4.841 ± 0.101
5.452LysThr: 5.452 ± 0.115
5.826LysVal: 5.826 ± 0.124
0.62LysTrp: 0.62 ± 0.032
5.343LysTyr: 5.343 ± 0.103
0.0LysXaa: 0.0 ± 0.0
Leu
4.704LeuAla: 4.704 ± 0.104
0.887LeuCys: 0.887 ± 0.047
4.52LeuAsp: 4.52 ± 0.094
7.109LeuGlu: 7.109 ± 0.139
3.062LeuPhe: 3.062 ± 0.106
4.861LeuGly: 4.861 ± 0.114
0.976LeuHis: 0.976 ± 0.046
7.804LeuIle: 7.804 ± 0.152
8.704LeuLys: 8.704 ± 0.147
6.691LeuLeu: 6.691 ± 0.17
1.783LeuMet: 1.783 ± 0.063
5.392LeuAsn: 5.392 ± 0.127
2.363LeuPro: 2.363 ± 0.077
2.56LeuGln: 2.56 ± 0.062
2.673LeuArg: 2.673 ± 0.073
5.071LeuSer: 5.071 ± 0.111
4.29LeuThr: 4.29 ± 0.097
4.819LeuVal: 4.819 ± 0.107
0.496LeuTrp: 0.496 ± 0.036
3.264LeuTyr: 3.264 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
1.622MetAla: 1.622 ± 0.055
0.321MetCys: 0.321 ± 0.026
1.212MetAsp: 1.212 ± 0.052
1.814MetGlu: 1.814 ± 0.071
1.06MetPhe: 1.06 ± 0.059
1.215MetGly: 1.215 ± 0.058
0.272MetHis: 0.272 ± 0.023
2.235MetIle: 2.235 ± 0.077
2.859MetLys: 2.859 ± 0.084
2.317MetLeu: 2.317 ± 0.071
0.555MetMet: 0.555 ± 0.039
1.752MetAsn: 1.752 ± 0.06
0.934MetPro: 0.934 ± 0.047
0.974MetGln: 0.974 ± 0.052
0.739MetArg: 0.739 ± 0.038
1.5MetSer: 1.5 ± 0.06
1.21MetThr: 1.21 ± 0.054
1.288MetVal: 1.288 ± 0.057
0.215MetTrp: 0.215 ± 0.024
0.982MetTyr: 0.982 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.031AsnAla: 3.031 ± 0.082
0.81AsnCys: 0.81 ± 0.043
3.321AsnAsp: 3.321 ± 0.089
5.419AsnGlu: 5.419 ± 0.11
2.569AsnPhe: 2.569 ± 0.079
4.226AsnGly: 4.226 ± 0.133
0.668AsnHis: 0.668 ± 0.041
7.804AsnIle: 7.804 ± 0.16
6.981AsnLys: 6.981 ± 0.141
5.531AsnLeu: 5.531 ± 0.135
1.89AsnMet: 1.89 ± 0.063
5.056AsnAsn: 5.056 ± 0.156
1.881AsnPro: 1.881 ± 0.067
1.989AsnGln: 1.989 ± 0.076
2.009AsnArg: 2.009 ± 0.078
4.106AsnSer: 4.106 ± 0.108
3.631AsnThr: 3.631 ± 0.105
4.1AsnVal: 4.1 ± 0.095
0.48AsnTrp: 0.48 ± 0.035
2.938AsnTyr: 2.938 ± 0.091
0.0AsnXaa: 0.0 ± 0.0
Pro
1.25ProAla: 1.25 ± 0.053
0.241ProCys: 0.241 ± 0.023
1.48ProAsp: 1.48 ± 0.061
2.474ProGlu: 2.474 ± 0.081
1.047ProPhe: 1.047 ± 0.058
1.279ProGly: 1.279 ± 0.063
0.35ProHis: 0.35 ± 0.03
2.513ProIle: 2.513 ± 0.066
2.095ProLys: 2.095 ± 0.067
1.799ProLeu: 1.799 ± 0.067
0.569ProMet: 0.569 ± 0.039
1.566ProAsn: 1.566 ± 0.065
0.447ProPro: 0.447 ± 0.045
0.883ProGln: 0.883 ± 0.049
0.693ProArg: 0.693 ± 0.04
1.35ProSer: 1.35 ± 0.051
1.443ProThr: 1.443 ± 0.056
1.684ProVal: 1.684 ± 0.058
0.173ProTrp: 0.173 ± 0.021
0.987ProTyr: 0.987 ± 0.053
0.002ProXaa: 0.002 ± 0.002
Gln
1.531GlnAla: 1.531 ± 0.064
0.219GlnCys: 0.219 ± 0.021
1.679GlnAsp: 1.679 ± 0.067
2.772GlnGlu: 2.772 ± 0.092
1.024GlnPhe: 1.024 ± 0.057
1.502GlnGly: 1.502 ± 0.065
0.31GlnHis: 0.31 ± 0.027
3.414GlnIle: 3.414 ± 0.09
3.48GlnLys: 3.48 ± 0.099
2.297GlnLeu: 2.297 ± 0.076
0.836GlnMet: 0.836 ± 0.037
2.494GlnAsn: 2.494 ± 0.073
0.529GlnPro: 0.529 ± 0.035
0.929GlnGln: 0.929 ± 0.058
1.053GlnArg: 1.053 ± 0.047
1.467GlnSer: 1.467 ± 0.054
1.682GlnThr: 1.682 ± 0.058
1.786GlnVal: 1.786 ± 0.066
0.201GlnTrp: 0.201 ± 0.022
1.403GlnTyr: 1.403 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
1.604ArgAla: 1.604 ± 0.062
0.35ArgCys: 0.35 ± 0.029
1.662ArgAsp: 1.662 ± 0.062
2.735ArgGlu: 2.735 ± 0.084
1.294ArgPhe: 1.294 ± 0.056
1.611ArgGly: 1.611 ± 0.06
0.423ArgHis: 0.423 ± 0.033
3.235ArgIle: 3.235 ± 0.084
3.788ArgLys: 3.788 ± 0.09
2.617ArgLeu: 2.617 ± 0.083
0.865ArgMet: 0.865 ± 0.049
2.155ArgAsn: 2.155 ± 0.079
0.872ArgPro: 0.872 ± 0.046
1.051ArgGln: 1.051 ± 0.043
1.321ArgArg: 1.321 ± 0.067
1.356ArgSer: 1.356 ± 0.054
1.823ArgThr: 1.823 ± 0.055
1.894ArgVal: 1.894 ± 0.063
0.235ArgTrp: 0.235 ± 0.024
1.513ArgTyr: 1.513 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
2.768SerAla: 2.768 ± 0.092
0.535SerCys: 0.535 ± 0.034
3.04SerAsp: 3.04 ± 0.094
4.222SerGlu: 4.222 ± 0.097
2.37SerPhe: 2.37 ± 0.068
3.602SerGly: 3.602 ± 0.112
0.724SerHis: 0.724 ± 0.036
5.719SerIle: 5.719 ± 0.133
5.737SerLys: 5.737 ± 0.111
4.374SerLeu: 4.374 ± 0.114
1.365SerMet: 1.365 ± 0.055
4.129SerAsn: 4.129 ± 0.123
1.257SerPro: 1.257 ± 0.056
1.967SerGln: 1.967 ± 0.071
1.834SerArg: 1.834 ± 0.066
4.146SerSer: 4.146 ± 0.136
3.343SerThr: 3.343 ± 0.122
3.279SerVal: 3.279 ± 0.091
0.358SerTrp: 0.358 ± 0.029
2.35SerTyr: 2.35 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
2.945ThrAla: 2.945 ± 0.094
0.498ThrCys: 0.498 ± 0.035
3.142ThrAsp: 3.142 ± 0.091
4.224ThrGlu: 4.224 ± 0.103
2.049ThrPhe: 2.049 ± 0.071
3.713ThrGly: 3.713 ± 0.109
0.77ThrHis: 0.77 ± 0.036
5.815ThrIle: 5.815 ± 0.127
4.815ThrLys: 4.815 ± 0.103
4.339ThrLeu: 4.339 ± 0.101
1.148ThrMet: 1.148 ± 0.054
3.416ThrAsn: 3.416 ± 0.099
1.609ThrPro: 1.609 ± 0.06
1.646ThrGln: 1.646 ± 0.062
1.732ThrArg: 1.732 ± 0.063
3.401ThrSer: 3.401 ± 0.117
3.334ThrThr: 3.334 ± 0.108
2.976ThrVal: 2.976 ± 0.109
0.389ThrTrp: 0.389 ± 0.034
2.482ThrTyr: 2.482 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
3.529ValAla: 3.529 ± 0.101
0.717ValCys: 0.717 ± 0.042
3.489ValAsp: 3.489 ± 0.09
4.98ValGlu: 4.98 ± 0.128
2.378ValPhe: 2.378 ± 0.083
3.509ValGly: 3.509 ± 0.112
0.699ValHis: 0.699 ± 0.041
5.804ValIle: 5.804 ± 0.123
5.629ValLys: 5.629 ± 0.096
4.985ValLeu: 4.985 ± 0.111
1.416ValMet: 1.416 ± 0.053
3.208ValAsn: 3.208 ± 0.093
1.668ValPro: 1.668 ± 0.065
1.759ValGln: 1.759 ± 0.063
1.874ValArg: 1.874 ± 0.068
3.671ValSer: 3.671 ± 0.093
3.525ValThr: 3.525 ± 0.115
4.014ValVal: 4.014 ± 0.111
0.409ValTrp: 0.409 ± 0.032
2.339ValTyr: 2.339 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.279TrpAla: 0.279 ± 0.025
0.097TrpCys: 0.097 ± 0.016
0.381TrpAsp: 0.381 ± 0.03
0.431TrpGlu: 0.431 ± 0.027
0.296TrpPhe: 0.296 ± 0.029
0.383TrpGly: 0.383 ± 0.029
0.115TrpHis: 0.115 ± 0.016
0.622TrpIle: 0.622 ± 0.039
0.608TrpLys: 0.608 ± 0.038
0.584TrpLeu: 0.584 ± 0.045
0.17TrpMet: 0.17 ± 0.02
0.524TrpAsn: 0.524 ± 0.041
0.124TrpPro: 0.124 ± 0.017
0.285TrpGln: 0.285 ± 0.034
0.237TrpArg: 0.237 ± 0.026
0.345TrpSer: 0.345 ± 0.028
0.343TrpThr: 0.343 ± 0.026
0.305TrpVal: 0.305 ± 0.025
0.082TrpTrp: 0.082 ± 0.014
0.33TrpTyr: 0.33 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.071TyrAla: 2.071 ± 0.077
0.511TyrCys: 0.511 ± 0.034
2.606TyrAsp: 2.606 ± 0.079
3.345TyrGlu: 3.345 ± 0.091
1.996TyrPhe: 1.996 ± 0.08
2.46TyrGly: 2.46 ± 0.087
0.52TyrHis: 0.52 ± 0.033
4.43TyrIle: 4.43 ± 0.109
4.016TyrLys: 4.016 ± 0.105
3.799TyrLeu: 3.799 ± 0.109
1.073TyrMet: 1.073 ± 0.046
3.283TyrAsn: 3.283 ± 0.087
1.164TyrPro: 1.164 ± 0.055
1.334TyrGln: 1.334 ± 0.054
1.405TyrArg: 1.405 ± 0.062
2.854TyrSer: 2.854 ± 0.083
2.438TyrThr: 2.438 ± 0.073
2.485TyrVal: 2.485 ± 0.076
0.308TyrTrp: 0.308 ± 0.026
2.093TyrTyr: 2.093 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.005
Statistics based on 1540 proteins (451969 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski