Amino acid dipepetide frequency for Microviridae Bog5275_51

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.551AlaAla: 15.551 ± 6.818
0.676AlaCys: 0.676 ± 0.636
12.17AlaAsp: 12.17 ± 1.336
6.085AlaGlu: 6.085 ± 2.797
3.381AlaPhe: 3.381 ± 1.233
8.79AlaGly: 8.79 ± 1.644
3.381AlaHis: 3.381 ± 1.65
2.028AlaIle: 2.028 ± 2.256
5.409AlaLys: 5.409 ± 2.98
6.085AlaLeu: 6.085 ± 2.272
5.409AlaMet: 5.409 ± 2.149
6.761AlaAsn: 6.761 ± 4.27
10.142AlaPro: 10.142 ± 2.478
6.085AlaGln: 6.085 ± 2.398
4.057AlaArg: 4.057 ± 2.762
8.114AlaSer: 8.114 ± 5.627
4.733AlaThr: 4.733 ± 3.457
4.057AlaVal: 4.057 ± 0.789
1.352AlaTrp: 1.352 ± 1.108
3.381AlaTyr: 3.381 ± 1.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.676CysAla: 0.676 ± 0.636
0.0CysCys: 0.0 ± 0.0
0.676CysAsp: 0.676 ± 0.636
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.352CysGly: 1.352 ± 0.68
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.352CysLeu: 1.352 ± 1.002
0.0CysMet: 0.0 ± 0.0
1.352CysAsn: 1.352 ± 0.68
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.676CysThr: 0.676 ± 0.636
1.352CysVal: 1.352 ± 0.68
0.676CysTrp: 0.676 ± 0.636
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
10.142AspAla: 10.142 ± 1.609
0.0AspCys: 0.0 ± 0.0
2.705AspAsp: 2.705 ± 1.221
0.676AspGlu: 0.676 ± 0.501
2.028AspPhe: 2.028 ± 1.012
4.057AspGly: 4.057 ± 1.277
2.028AspHis: 2.028 ± 1.069
1.352AspIle: 1.352 ± 0.732
2.705AspLys: 2.705 ± 1.472
3.381AspLeu: 3.381 ± 1.781
0.676AspMet: 0.676 ± 0.501
1.352AspAsn: 1.352 ± 0.493
5.409AspPro: 5.409 ± 1.941
2.028AspGln: 2.028 ± 0.909
5.409AspArg: 5.409 ± 1.673
4.057AspSer: 4.057 ± 2.023
2.028AspThr: 2.028 ± 0.919
4.733AspVal: 4.733 ± 0.986
2.705AspTrp: 2.705 ± 1.361
4.057AspTyr: 4.057 ± 0.789
0.0AspXaa: 0.0 ± 0.0
Glu
2.028GluAla: 2.028 ± 1.069
0.676GluCys: 0.676 ± 0.501
0.676GluAsp: 0.676 ± 0.501
1.352GluGlu: 1.352 ± 1.478
2.705GluPhe: 2.705 ± 0.73
2.028GluGly: 2.028 ± 0.749
1.352GluHis: 1.352 ± 1.002
2.705GluIle: 2.705 ± 2.205
1.352GluLys: 1.352 ± 1.108
6.085GluLeu: 6.085 ± 3.025
0.0GluMet: 0.0 ± 0.0
0.676GluAsn: 0.676 ± 0.551
0.676GluPro: 0.676 ± 0.882
3.381GluGln: 3.381 ± 0.965
2.705GluArg: 2.705 ± 1.965
1.352GluSer: 1.352 ± 1.002
2.028GluThr: 2.028 ± 0.998
3.381GluVal: 3.381 ± 1.875
0.0GluTrp: 0.0 ± 0.0
2.705GluTyr: 2.705 ± 1.444
0.0GluXaa: 0.0 ± 0.0
Phe
8.114PheAla: 8.114 ± 0.857
0.0PheCys: 0.0 ± 0.0
1.352PheAsp: 1.352 ± 1.108
1.352PheGlu: 1.352 ± 0.982
2.028PhePhe: 2.028 ± 1.069
4.057PheGly: 4.057 ± 0.869
0.676PheHis: 0.676 ± 0.636
1.352PheIle: 1.352 ± 1.232
0.676PheLys: 0.676 ± 0.501
3.381PheLeu: 3.381 ± 1.91
1.352PheMet: 1.352 ± 1.166
6.085PheAsn: 6.085 ± 1.623
1.352PhePro: 1.352 ± 0.842
2.028PheGln: 2.028 ± 0.919
1.352PheArg: 1.352 ± 0.68
1.352PheSer: 1.352 ± 1.272
2.028PheThr: 2.028 ± 0.998
1.352PheVal: 1.352 ± 1.002
1.352PheTrp: 1.352 ± 0.68
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
8.79GlyAla: 8.79 ± 3.222
0.676GlyCys: 0.676 ± 0.636
5.409GlyAsp: 5.409 ± 1.79
4.057GlyGlu: 4.057 ± 2.023
1.352GlyPhe: 1.352 ± 1.002
6.761GlyGly: 6.761 ± 1.308
2.705GlyHis: 2.705 ± 1.105
2.705GlyIle: 2.705 ± 0.987
2.705GlyLys: 2.705 ± 1.465
8.114GlyLeu: 8.114 ± 3.072
2.028GlyMet: 2.028 ± 0.533
1.352GlyAsn: 1.352 ± 0.68
0.0GlyPro: 0.0 ± 0.0
3.381GlyGln: 3.381 ± 0.684
4.733GlyArg: 4.733 ± 2.143
4.057GlySer: 4.057 ± 3.005
4.057GlyThr: 4.057 ± 1.655
3.381GlyVal: 3.381 ± 2.504
0.0GlyTrp: 0.0 ± 0.0
3.381GlyTyr: 3.381 ± 1.65
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.676HisCys: 0.676 ± 0.501
1.352HisAsp: 1.352 ± 0.68
0.676HisGlu: 0.676 ± 0.501
2.028HisPhe: 2.028 ± 0.907
2.028HisGly: 2.028 ± 1.502
0.676HisHis: 0.676 ± 0.636
1.352HisIle: 1.352 ± 0.68
2.028HisLys: 2.028 ± 1.65
2.028HisLeu: 2.028 ± 1.218
1.352HisMet: 1.352 ± 1.296
0.676HisAsn: 0.676 ± 0.501
0.0HisPro: 0.0 ± 0.0
0.676HisGln: 0.676 ± 0.551
0.0HisArg: 0.0 ± 0.0
2.028HisSer: 2.028 ± 0.749
0.0HisThr: 0.0 ± 0.0
1.352HisVal: 1.352 ± 0.906
0.676HisTrp: 0.676 ± 0.501
0.676HisTyr: 0.676 ± 0.636
0.0HisXaa: 0.0 ± 0.0
Ile
3.381IleAla: 3.381 ± 1.967
0.676IleCys: 0.676 ± 0.636
5.409IleAsp: 5.409 ± 1.706
3.381IleGlu: 3.381 ± 2.047
2.705IlePhe: 2.705 ± 0.987
1.352IleGly: 1.352 ± 1.103
0.0IleHis: 0.0 ± 0.0
0.676IleIle: 0.676 ± 0.501
2.028IleLys: 2.028 ± 1.038
2.705IleLeu: 2.705 ± 0.844
0.0IleMet: 0.0 ± 0.0
4.733IleAsn: 4.733 ± 1.735
2.705IlePro: 2.705 ± 0.844
1.352IleGln: 1.352 ± 0.493
0.676IleArg: 0.676 ± 1.085
4.057IleSer: 4.057 ± 1.294
0.676IleThr: 0.676 ± 0.636
2.028IleVal: 2.028 ± 1.038
0.0IleTrp: 0.0 ± 0.0
1.352IleTyr: 1.352 ± 0.493
0.0IleXaa: 0.0 ± 0.0
Lys
4.733LysAla: 4.733 ± 2.305
0.0LysCys: 0.0 ± 0.0
1.352LysAsp: 1.352 ± 2.17
1.352LysGlu: 1.352 ± 0.842
0.676LysPhe: 0.676 ± 0.501
3.381LysGly: 3.381 ± 1.65
0.0LysHis: 0.0 ± 0.0
2.028LysIle: 2.028 ± 1.286
0.676LysLys: 0.676 ± 0.636
2.028LysLeu: 2.028 ± 0.998
1.352LysMet: 1.352 ± 1.098
1.352LysAsn: 1.352 ± 0.68
1.352LysPro: 1.352 ± 0.68
2.028LysGln: 2.028 ± 0.998
5.409LysArg: 5.409 ± 3.081
6.085LysSer: 6.085 ± 2.184
2.705LysThr: 2.705 ± 0.844
2.705LysVal: 2.705 ± 1.105
0.0LysTrp: 0.0 ± 0.0
0.676LysTyr: 0.676 ± 0.636
0.0LysXaa: 0.0 ± 0.0
Leu
8.79LeuAla: 8.79 ± 2.474
0.0LeuCys: 0.0 ± 0.0
6.085LeuAsp: 6.085 ± 1.933
2.028LeuGlu: 2.028 ± 0.749
2.705LeuPhe: 2.705 ± 1.826
6.085LeuGly: 6.085 ± 1.436
0.0LeuHis: 0.0 ± 0.0
4.057LeuIle: 4.057 ± 1.495
2.705LeuLys: 2.705 ± 1.465
4.733LeuLeu: 4.733 ± 1.738
2.028LeuMet: 2.028 ± 0.957
8.114LeuAsn: 8.114 ± 0.579
5.409LeuPro: 5.409 ± 1.309
4.733LeuGln: 4.733 ± 1.646
4.057LeuArg: 4.057 ± 1.847
6.761LeuSer: 6.761 ± 4.033
4.057LeuThr: 4.057 ± 1.322
2.705LeuVal: 2.705 ± 1.245
1.352LeuTrp: 1.352 ± 1.002
3.381LeuTyr: 3.381 ± 1.868
0.0LeuXaa: 0.0 ± 0.0
Met
2.705MetAla: 2.705 ± 0.987
0.0MetCys: 0.0 ± 0.0
2.705MetAsp: 2.705 ± 0.711
0.676MetGlu: 0.676 ± 0.636
0.676MetPhe: 0.676 ± 0.882
0.676MetGly: 0.676 ± 0.501
0.0MetHis: 0.0 ± 0.0
3.381MetIle: 3.381 ± 1.072
0.676MetLys: 0.676 ± 0.636
2.028MetLeu: 2.028 ± 1.218
0.0MetMet: 0.0 ± 0.0
2.705MetAsn: 2.705 ± 0.987
5.409MetPro: 5.409 ± 2.19
2.705MetGln: 2.705 ± 0.987
0.0MetArg: 0.0 ± 0.0
2.028MetSer: 2.028 ± 1.012
0.676MetThr: 0.676 ± 1.085
1.352MetVal: 1.352 ± 0.842
0.676MetTrp: 0.676 ± 0.551
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
10.818AsnAla: 10.818 ± 5.545
0.0AsnCys: 0.0 ± 0.0
1.352AsnAsp: 1.352 ± 0.68
1.352AsnGlu: 1.352 ± 0.493
1.352AsnPhe: 1.352 ± 0.493
3.381AsnGly: 3.381 ± 0.806
0.676AsnHis: 0.676 ± 1.085
1.352AsnIle: 1.352 ± 0.493
2.705AsnLys: 2.705 ± 1.221
5.409AsnLeu: 5.409 ± 1.566
0.0AsnMet: 0.0 ± 0.0
0.676AsnAsn: 0.676 ± 0.551
4.057AsnPro: 4.057 ± 1.173
1.352AsnGln: 1.352 ± 0.493
3.381AsnArg: 3.381 ± 1.167
4.057AsnSer: 4.057 ± 1.502
5.409AsnThr: 5.409 ± 1.038
3.381AsnVal: 3.381 ± 1.072
0.676AsnTrp: 0.676 ± 0.551
4.733AsnTyr: 4.733 ± 1.701
0.0AsnXaa: 0.0 ± 0.0
Pro
4.057ProAla: 4.057 ± 2.24
0.0ProCys: 0.0 ± 0.0
4.057ProAsp: 4.057 ± 0.932
2.705ProGlu: 2.705 ± 1.685
3.381ProPhe: 3.381 ± 1.892
4.057ProGly: 4.057 ± 1.022
2.705ProHis: 2.705 ± 0.711
2.028ProIle: 2.028 ± 0.827
1.352ProLys: 1.352 ± 1.002
4.057ProLeu: 4.057 ± 0.878
3.381ProMet: 3.381 ± 1.091
4.057ProAsn: 4.057 ± 0.869
2.028ProPro: 2.028 ± 1.12
2.705ProGln: 2.705 ± 0.896
4.057ProArg: 4.057 ± 2.293
3.381ProSer: 3.381 ± 0.806
4.057ProThr: 4.057 ± 1.48
6.085ProVal: 6.085 ± 1.48
0.676ProTrp: 0.676 ± 0.501
2.028ProTyr: 2.028 ± 0.827
0.0ProXaa: 0.0 ± 0.0
Gln
7.437GlnAla: 7.437 ± 3.607
0.0GlnCys: 0.0 ± 0.0
2.028GlnAsp: 2.028 ± 1.012
2.028GlnGlu: 2.028 ± 0.907
2.028GlnPhe: 2.028 ± 1.13
2.705GlnGly: 2.705 ± 1.361
1.352GlnHis: 1.352 ± 0.906
2.705GlnIle: 2.705 ± 0.73
2.028GlnLys: 2.028 ± 1.012
5.409GlnLeu: 5.409 ± 2.155
2.028GlnMet: 2.028 ± 1.13
2.028GlnAsn: 2.028 ± 0.919
2.705GlnPro: 2.705 ± 1.276
6.085GlnGln: 6.085 ± 1.573
4.733GlnArg: 4.733 ± 2.878
2.028GlnSer: 2.028 ± 1.913
3.381GlnThr: 3.381 ± 1.967
1.352GlnVal: 1.352 ± 0.493
0.0GlnTrp: 0.0 ± 0.0
2.028GlnTyr: 2.028 ± 1.012
0.0GlnXaa: 0.0 ± 0.0
Arg
6.761ArgAla: 6.761 ± 4.738
2.028ArgCys: 2.028 ± 1.218
1.352ArgAsp: 1.352 ± 0.493
1.352ArgGlu: 1.352 ± 0.906
5.409ArgPhe: 5.409 ± 2.45
2.028ArgGly: 2.028 ± 1.218
0.0ArgHis: 0.0 ± 0.0
2.705ArgIle: 2.705 ± 0.896
3.381ArgLys: 3.381 ± 1.208
6.761ArgLeu: 6.761 ± 2.1
0.676ArgMet: 0.676 ± 0.551
3.381ArgAsn: 3.381 ± 2.495
2.028ArgPro: 2.028 ± 1.218
3.381ArgGln: 3.381 ± 1.579
3.381ArgArg: 3.381 ± 1.918
2.028ArgSer: 2.028 ± 1.218
1.352ArgThr: 1.352 ± 0.842
4.733ArgVal: 4.733 ± 1.514
0.0ArgTrp: 0.0 ± 0.0
2.028ArgTyr: 2.028 ± 1.012
0.0ArgXaa: 0.0 ± 0.0
Ser
6.085SerAla: 6.085 ± 2.548
0.676SerCys: 0.676 ± 0.636
3.381SerAsp: 3.381 ± 1.244
4.057SerGlu: 4.057 ± 1.643
2.705SerPhe: 2.705 ± 2.003
4.733SerGly: 4.733 ± 1.997
0.676SerHis: 0.676 ± 0.501
2.028SerIle: 2.028 ± 0.909
3.381SerLys: 3.381 ± 0.684
6.761SerLeu: 6.761 ± 1.527
2.028SerMet: 2.028 ± 0.907
1.352SerAsn: 1.352 ± 0.732
2.705SerPro: 2.705 ± 2.148
1.352SerGln: 1.352 ± 0.68
2.028SerArg: 2.028 ± 1.286
2.028SerSer: 2.028 ± 1.218
4.733SerThr: 4.733 ± 1.342
8.79SerVal: 8.79 ± 1.778
1.352SerTrp: 1.352 ± 1.272
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
6.085ThrAla: 6.085 ± 3.397
1.352ThrCys: 1.352 ± 0.68
2.705ThrAsp: 2.705 ± 2.205
2.028ThrGlu: 2.028 ± 1.12
2.028ThrPhe: 2.028 ± 1.571
2.705ThrGly: 2.705 ± 1.444
0.0ThrHis: 0.0 ± 0.0
2.705ThrIle: 2.705 ± 0.987
0.676ThrLys: 0.676 ± 0.882
2.705ThrLeu: 2.705 ± 1.064
2.028ThrMet: 2.028 ± 1.555
5.409ThrAsn: 5.409 ± 2.917
2.028ThrPro: 2.028 ± 1.218
4.733ThrGln: 4.733 ± 1.176
3.381ThrArg: 3.381 ± 1.208
2.028ThrSer: 2.028 ± 1.502
3.381ThrThr: 3.381 ± 1.698
6.085ThrVal: 6.085 ± 1.426
0.0ThrTrp: 0.0 ± 0.0
2.028ThrTyr: 2.028 ± 1.012
0.0ThrXaa: 0.0 ± 0.0
Val
6.761ValAla: 6.761 ± 2.058
0.676ValCys: 0.676 ± 0.501
3.381ValAsp: 3.381 ± 1.462
2.028ValGlu: 2.028 ± 0.909
2.028ValPhe: 2.028 ± 0.907
4.733ValGly: 4.733 ± 1.559
1.352ValHis: 1.352 ± 0.493
2.705ValIle: 2.705 ± 2.003
4.733ValLys: 4.733 ± 1.514
3.381ValLeu: 3.381 ± 1.244
2.705ValMet: 2.705 ± 1.444
1.352ValAsn: 1.352 ± 0.493
9.466ValPro: 9.466 ± 1.933
2.028ValGln: 2.028 ± 0.919
2.705ValArg: 2.705 ± 1.105
4.057ValSer: 4.057 ± 1.56
5.409ValThr: 5.409 ± 1.423
3.381ValVal: 3.381 ± 0.661
0.676ValTrp: 0.676 ± 0.636
1.352ValTyr: 1.352 ± 1.002
0.0ValXaa: 0.0 ± 0.0
Trp
1.352TrpAla: 1.352 ± 0.68
0.0TrpCys: 0.0 ± 0.0
1.352TrpAsp: 1.352 ± 0.493
0.0TrpGlu: 0.0 ± 0.0
0.676TrpPhe: 0.676 ± 0.636
0.676TrpGly: 0.676 ± 0.636
1.352TrpHis: 1.352 ± 0.68
2.028TrpIle: 2.028 ± 1.256
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.676TrpMet: 0.676 ± 1.085
0.676TrpAsn: 0.676 ± 0.636
2.028TrpPro: 2.028 ± 1.502
0.676TrpGln: 0.676 ± 0.501
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.676TrpTrp: 0.676 ± 0.501
1.352TrpTyr: 1.352 ± 0.68
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.381TyrAla: 3.381 ± 1.827
0.0TyrCys: 0.0 ± 0.0
2.028TyrAsp: 2.028 ± 0.907
0.676TyrGlu: 0.676 ± 0.636
1.352TyrPhe: 1.352 ± 0.68
4.057TyrGly: 4.057 ± 1.322
2.028TyrHis: 2.028 ± 1.218
0.0TyrIle: 0.0 ± 0.0
0.676TyrLys: 0.676 ± 1.085
3.381TyrLeu: 3.381 ± 1.65
0.676TyrMet: 0.676 ± 0.551
2.028TyrAsn: 2.028 ± 0.919
1.352TyrPro: 1.352 ± 1.002
3.381TyrGln: 3.381 ± 1.91
2.705TyrArg: 2.705 ± 0.73
1.352TyrSer: 1.352 ± 0.68
2.705TyrThr: 2.705 ± 2.544
2.705TyrVal: 2.705 ± 0.73
0.676TyrTrp: 0.676 ± 0.501
0.676TyrTyr: 0.676 ± 0.501
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski