Amino acid dipepetide frequency for Talaromyces amestolkiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.698AlaAla: 8.698 ± 0.062	0.991AlaCys: 0.991 ± 0.015	4.21AlaAsp: 4.21 ± 0.028	4.985AlaGlu: 4.985 ± 0.04	3.184AlaPhe: 3.184 ± 0.027	5.624AlaGly: 5.624 ± 0.038	1.704AlaHis: 1.704 ± 0.019	4.709AlaIle: 4.709 ± 0.031	3.892AlaLys: 3.892 ± 0.029	7.598AlaLeu: 7.598 ± 0.043	1.889AlaMet: 1.889 ± 0.02	3.09AlaAsn: 3.09 ± 0.02	4.091AlaPro: 4.091 ± 0.036	3.272AlaGln: 3.272 ± 0.026	4.39AlaArg: 4.39 ± 0.029	6.952AlaSer: 6.952 ± 0.042	5.381AlaThr: 5.381 ± 0.033	5.411AlaVal: 5.411 ± 0.037	1.153AlaTrp: 1.153 ± 0.016	2.276AlaTyr: 2.276 ± 0.02	0.026AlaXaa: 0.026 ± 0.002
Cys	0.888CysAla: 0.888 ± 0.014	0.193CysCys: 0.193 ± 0.006	0.623CysAsp: 0.623 ± 0.012	0.541CysGlu: 0.541 ± 0.011	0.52CysPhe: 0.52 ± 0.009	0.838CysGly: 0.838 ± 0.013	0.297CysHis: 0.297 ± 0.007	0.7CysIle: 0.7 ± 0.01	0.42CysLys: 0.42 ± 0.009	1.174CysLeu: 1.174 ± 0.015	0.242CysMet: 0.242 ± 0.006	0.407CysAsn: 0.407 ± 0.008	0.559CysPro: 0.559 ± 0.011	0.411CysGln: 0.411 ± 0.009	0.617CysArg: 0.617 ± 0.013	0.802CysSer: 0.802 ± 0.014	0.64CysThr: 0.64 ± 0.011	0.751CysVal: 0.751 ± 0.012	0.186CysTrp: 0.186 ± 0.006	0.346CysTyr: 0.346 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	4.517AspAla: 4.517 ± 0.031	0.581AspCys: 0.581 ± 0.012	4.192AspAsp: 4.192 ± 0.039	4.467AspGlu: 4.467 ± 0.034	2.346AspPhe: 2.346 ± 0.022	3.839AspGly: 3.839 ± 0.027	1.238AspHis: 1.238 ± 0.017	3.488AspIle: 3.488 ± 0.028	2.379AspLys: 2.379 ± 0.02	5.185AspLeu: 5.185 ± 0.03	1.276AspMet: 1.276 ± 0.015	2.08AspAsn: 2.08 ± 0.017	3.082AspPro: 3.082 ± 0.024	1.912AspGln: 1.912 ± 0.021	2.898AspArg: 2.898 ± 0.028	4.166AspSer: 4.166 ± 0.027	3.139AspThr: 3.139 ± 0.026	3.813AspVal: 3.813 ± 0.028	0.904AspTrp: 0.904 ± 0.013	1.782AspTyr: 1.782 ± 0.019	0.009AspXaa: 0.009 ± 0.001
Glu	5.104GluAla: 5.104 ± 0.035	0.546GluCys: 0.546 ± 0.011	4.224GluAsp: 4.224 ± 0.036	5.419GluGlu: 5.419 ± 0.053	2.048GluPhe: 2.048 ± 0.018	3.491GluGly: 3.491 ± 0.03	1.342GluHis: 1.342 ± 0.017	3.516GluIle: 3.516 ± 0.03	3.855GluLys: 3.855 ± 0.033	5.204GluLeu: 5.204 ± 0.036	1.418GluMet: 1.418 ± 0.015	2.58GluAsn: 2.58 ± 0.022	2.529GluPro: 2.529 ± 0.043	2.536GluGln: 2.536 ± 0.025	3.682GluArg: 3.682 ± 0.033	4.433GluSer: 4.433 ± 0.033	3.711GluThr: 3.711 ± 0.028	3.551GluVal: 3.551 ± 0.026	0.881GluTrp: 0.881 ± 0.013	1.824GluTyr: 1.824 ± 0.019	0.013GluXaa: 0.013 ± 0.002
Phe	3.139PheAla: 3.139 ± 0.028	0.519PheCys: 0.519 ± 0.01	2.391PheAsp: 2.391 ± 0.02	2.277PheGlu: 2.277 ± 0.022	1.73PhePhe: 1.73 ± 0.019	2.94PheGly: 2.94 ± 0.029	0.922PheHis: 0.922 ± 0.014	2.021PheIle: 2.021 ± 0.021	1.517PheLys: 1.517 ± 0.019	3.669PheLeu: 3.669 ± 0.031	0.824PheMet: 0.824 ± 0.013	1.545PheAsn: 1.545 ± 0.017	1.935PhePro: 1.935 ± 0.019	1.472PheGln: 1.472 ± 0.018	1.93PheArg: 1.93 ± 0.018	3.112PheSer: 3.112 ± 0.026	2.237PheThr: 2.237 ± 0.021	2.545PheVal: 2.545 ± 0.022	0.657PheTrp: 0.657 ± 0.011	1.224PheTyr: 1.224 ± 0.016	0.007PheXaa: 0.007 ± 0.001
Gly	5.114GlyAla: 5.114 ± 0.04	0.785GlyCys: 0.785 ± 0.013	3.473GlyAsp: 3.473 ± 0.027	3.348GlyGlu: 3.348 ± 0.027	2.878GlyPhe: 2.878 ± 0.026	5.376GlyGly: 5.376 ± 0.044	1.631GlyHis: 1.631 ± 0.02	3.817GlyIle: 3.817 ± 0.029	3.268GlyLys: 3.268 ± 0.031	6.134GlyLeu: 6.134 ± 0.032	1.47GlyMet: 1.47 ± 0.019	2.641GlyAsn: 2.641 ± 0.022	2.961GlyPro: 2.961 ± 0.025	2.516GlyGln: 2.516 ± 0.021	3.721GlyArg: 3.721 ± 0.028	5.511GlySer: 5.511 ± 0.038	4.019GlyThr: 4.019 ± 0.033	4.353GlyVal: 4.353 ± 0.039	1.161GlyTrp: 1.161 ± 0.016	2.304GlyTyr: 2.304 ± 0.026	0.035GlyXaa: 0.035 ± 0.003
His	1.732HisAla: 1.732 ± 0.019	0.281HisCys: 0.281 ± 0.007	1.328HisAsp: 1.328 ± 0.019	1.363HisGlu: 1.363 ± 0.019	0.94HisPhe: 0.94 ± 0.012	1.632HisGly: 1.632 ± 0.021	0.824HisHis: 0.824 ± 0.016	1.324HisIle: 1.324 ± 0.017	0.893HisLys: 0.893 ± 0.013	2.183HisLeu: 2.183 ± 0.022	0.474HisMet: 0.474 ± 0.01	0.906HisAsn: 0.906 ± 0.014	1.498HisPro: 1.498 ± 0.018	0.961HisGln: 0.961 ± 0.014	1.41HisArg: 1.41 ± 0.018	1.771HisSer: 1.771 ± 0.018	1.268HisThr: 1.268 ± 0.014	1.429HisVal: 1.429 ± 0.017	0.339HisTrp: 0.339 ± 0.008	0.722HisTyr: 0.722 ± 0.012	0.003HisXaa: 0.003 ± 0.001
Ile	4.595IleAla: 4.595 ± 0.03	0.78IleCys: 0.78 ± 0.012	3.299IleAsp: 3.299 ± 0.025	3.257IleGlu: 3.257 ± 0.027	2.259IlePhe: 2.259 ± 0.023	3.552IleGly: 3.552 ± 0.028	1.295IleHis: 1.295 ± 0.016	2.998IleIle: 2.998 ± 0.028	2.374IleLys: 2.374 ± 0.021	5.054IleLeu: 5.054 ± 0.033	1.091IleMet: 1.091 ± 0.015	2.142IleAsn: 2.142 ± 0.022	3.298IlePro: 3.298 ± 0.026	2.122IleGln: 2.122 ± 0.018	2.935IleArg: 2.935 ± 0.027	4.394IleSer: 4.394 ± 0.031	3.203IleThr: 3.203 ± 0.029	3.603IleVal: 3.603 ± 0.031	0.782IleTrp: 0.782 ± 0.013	1.643IleTyr: 1.643 ± 0.019	0.008IleXaa: 0.008 ± 0.001
Lys	4.032LysAla: 4.032 ± 0.031	0.451LysCys: 0.451 ± 0.008	2.783LysAsp: 2.783 ± 0.026	3.413LysGlu: 3.413 ± 0.032	1.535LysPhe: 1.535 ± 0.015	2.805LysGly: 2.805 ± 0.028	1.08LysHis: 1.08 ± 0.013	2.517LysIle: 2.517 ± 0.024	3.191LysLys: 3.191 ± 0.047	4.089LysLeu: 4.089 ± 0.034	0.967LysMet: 0.967 ± 0.013	1.892LysAsn: 1.892 ± 0.02	2.494LysPro: 2.494 ± 0.023	1.858LysGln: 1.858 ± 0.019	3.199LysArg: 3.199 ± 0.026	3.638LysSer: 3.638 ± 0.029	2.864LysThr: 2.864 ± 0.022	2.808LysVal: 2.808 ± 0.022	0.683LysTrp: 0.683 ± 0.012	1.509LysTyr: 1.509 ± 0.016	0.014LysXaa: 0.014 ± 0.001
Leu	7.62LeuAla: 7.62 ± 0.036	1.147LeuCys: 1.147 ± 0.016	5.265LeuAsp: 5.265 ± 0.034	5.593LeuGlu: 5.593 ± 0.041	3.424LeuPhe: 3.424 ± 0.026	5.862LeuGly: 5.862 ± 0.036	2.229LeuHis: 2.229 ± 0.024	4.467LeuIle: 4.467 ± 0.034	4.278LeuLys: 4.278 ± 0.029	8.557LeuLeu: 8.557 ± 0.05	1.792LeuMet: 1.792 ± 0.02	3.474LeuAsn: 3.474 ± 0.025	5.215LeuPro: 5.215 ± 0.037	3.992LeuGln: 3.992 ± 0.034	5.476LeuArg: 5.476 ± 0.039	7.575LeuSer: 7.575 ± 0.04	4.994LeuThr: 4.994 ± 0.035	5.477LeuVal: 5.477 ± 0.036	1.215LeuTrp: 1.215 ± 0.017	2.537LeuTyr: 2.537 ± 0.024	0.024LeuXaa: 0.024 ± 0.002
Met	2.088MetAla: 2.088 ± 0.022	0.224MetCys: 0.224 ± 0.006	1.169MetAsp: 1.169 ± 0.016	1.24MetGlu: 1.24 ± 0.017	0.765MetPhe: 0.765 ± 0.013	1.401MetGly: 1.401 ± 0.019	0.452MetHis: 0.452 ± 0.01	1.123MetIle: 1.123 ± 0.017	0.989MetLys: 0.989 ± 0.015	1.828MetLeu: 1.828 ± 0.018	0.565MetMet: 0.565 ± 0.011	0.827MetAsn: 0.827 ± 0.014	1.15MetPro: 1.15 ± 0.014	0.851MetGln: 0.851 ± 0.012	1.153MetArg: 1.153 ± 0.013	1.819MetSer: 1.819 ± 0.021	1.383MetThr: 1.383 ± 0.019	1.252MetVal: 1.252 ± 0.016	0.27MetTrp: 0.27 ± 0.008	0.516MetTyr: 0.516 ± 0.009	0.002MetXaa: 0.002 ± 0.001
Asn	3.312AsnAla: 3.312 ± 0.024	0.426AsnCys: 0.426 ± 0.01	2.247AsnAsp: 2.247 ± 0.021	2.291AsnGlu: 2.291 ± 0.023	1.504AsnPhe: 1.504 ± 0.017	3.187AsnGly: 3.187 ± 0.028	0.905AsnHis: 0.905 ± 0.014	2.403AsnIle: 2.403 ± 0.02	1.66AsnLys: 1.66 ± 0.018	3.49AsnLeu: 3.49 ± 0.026	0.887AsnMet: 0.887 ± 0.013	1.825AsnAsn: 1.825 ± 0.023	2.409AsnPro: 2.409 ± 0.018	1.44AsnGln: 1.44 ± 0.014	1.966AsnArg: 1.966 ± 0.019	3.012AsnSer: 3.012 ± 0.027	2.489AsnThr: 2.489 ± 0.022	2.585AsnVal: 2.585 ± 0.021	0.597AsnTrp: 0.597 ± 0.01	1.201AsnTyr: 1.201 ± 0.017	0.008AsnXaa: 0.008 ± 0.001
Pro	4.587ProAla: 4.587 ± 0.039	0.428ProCys: 0.428 ± 0.01	2.993ProAsp: 2.993 ± 0.025	3.689ProGlu: 3.689 ± 0.039	2.032ProPhe: 2.032 ± 0.021	3.493ProGly: 3.493 ± 0.032	1.184ProHis: 1.184 ± 0.013	2.666ProIle: 2.666 ± 0.023	2.412ProLys: 2.412 ± 0.025	4.549ProLeu: 4.549 ± 0.03	0.968ProMet: 0.968 ± 0.014	2.169ProAsn: 2.169 ± 0.02	4.092ProPro: 4.092 ± 0.051	2.28ProGln: 2.28 ± 0.023	2.941ProArg: 2.941 ± 0.029	5.492ProSer: 5.492 ± 0.04	3.697ProThr: 3.697 ± 0.032	3.439ProVal: 3.439 ± 0.032	0.741ProTrp: 0.741 ± 0.011	1.539ProTyr: 1.539 ± 0.017	0.013ProXaa: 0.013 ± 0.002
Gln	3.297GlnAla: 3.297 ± 0.026	0.419GlnCys: 0.419 ± 0.009	2.029GlnAsp: 2.029 ± 0.019	2.406GlnGlu: 2.406 ± 0.023	1.377GlnPhe: 1.377 ± 0.015	2.307GlnGly: 2.307 ± 0.02	1.05GlnHis: 1.05 ± 0.016	2.131GlnIle: 2.131 ± 0.021	2.072GlnLys: 2.072 ± 0.021	3.508GlnLeu: 3.508 ± 0.026	0.877GlnMet: 0.877 ± 0.015	1.752GlnAsn: 1.752 ± 0.022	2.336GlnPro: 2.336 ± 0.026	2.443GlnGln: 2.443 ± 0.044	2.542GlnArg: 2.542 ± 0.022	3.21GlnSer: 3.21 ± 0.027	2.427GlnThr: 2.427 ± 0.021	2.172GlnVal: 2.172 ± 0.02	0.6GlnTrp: 0.6 ± 0.01	1.288GlnTyr: 1.288 ± 0.015	0.012GlnXaa: 0.012 ± 0.001
Arg	4.194ArgAla: 4.194 ± 0.032	0.591ArgCys: 0.591 ± 0.011	3.213ArgAsp: 3.213 ± 0.028	3.595ArgGlu: 3.595 ± 0.031	2.113ArgPhe: 2.113 ± 0.02	3.315ArgGly: 3.315 ± 0.031	1.425ArgHis: 1.425 ± 0.017	3.029ArgIle: 3.029 ± 0.024	3.315ArgLys: 3.315 ± 0.028	5.292ArgLeu: 5.292 ± 0.037	1.175ArgMet: 1.175 ± 0.015	2.307ArgAsn: 2.307 ± 0.022	3.016ArgPro: 3.016 ± 0.03	2.465ArgGln: 2.465 ± 0.024	4.558ArgArg: 4.558 ± 0.039	4.408ArgSer: 4.408 ± 0.035	3.047ArgThr: 3.047 ± 0.027	3.184ArgVal: 3.184 ± 0.026	0.891ArgTrp: 0.891 ± 0.013	1.682ArgTyr: 1.682 ± 0.017	0.015ArgXaa: 0.015 ± 0.002
Ser	6.534SerAla: 6.534 ± 0.042	0.762SerCys: 0.762 ± 0.014	4.323SerAsp: 4.323 ± 0.03	4.229SerGlu: 4.229 ± 0.028	3.172SerPhe: 3.172 ± 0.024	5.404SerGly: 5.404 ± 0.036	1.885SerHis: 1.885 ± 0.02	4.439SerIle: 4.439 ± 0.03	3.715SerLys: 3.715 ± 0.032	7.47SerLeu: 7.47 ± 0.047	1.666SerMet: 1.666 ± 0.02	3.296SerAsn: 3.296 ± 0.027	5.014SerPro: 5.014 ± 0.047	3.307SerGln: 3.307 ± 0.026	4.669SerArg: 4.669 ± 0.034	8.903SerSer: 8.903 ± 0.072	5.937SerThr: 5.937 ± 0.037	4.766SerVal: 4.766 ± 0.031	1.17SerTrp: 1.17 ± 0.016	2.25SerTyr: 2.25 ± 0.02	0.015SerXaa: 0.015 ± 0.002
Thr	5.327ThrAla: 5.327 ± 0.031	0.672ThrCys: 0.672 ± 0.012	3.027ThrAsp: 3.027 ± 0.022	3.4ThrGlu: 3.4 ± 0.027	2.376ThrPhe: 2.376 ± 0.024	4.318ThrGly: 4.318 ± 0.034	1.284ThrHis: 1.284 ± 0.015	3.465ThrIle: 3.465 ± 0.028	2.707ThrLys: 2.707 ± 0.023	5.345ThrLeu: 5.345 ± 0.035	1.16ThrMet: 1.16 ± 0.013	2.432ThrAsn: 2.432 ± 0.022	4.033ThrPro: 4.033 ± 0.034	2.176ThrGln: 2.176 ± 0.021	2.898ThrArg: 2.898 ± 0.024	5.602ThrSer: 5.602 ± 0.04	4.753ThrThr: 4.753 ± 0.047	3.971ThrVal: 3.971 ± 0.033	0.909ThrTrp: 0.909 ± 0.015	1.812ThrTyr: 1.812 ± 0.018	0.011ThrXaa: 0.011 ± 0.001
Val	5.283ValAla: 5.283 ± 0.038	0.767ValCys: 0.767 ± 0.012	3.811ValAsp: 3.811 ± 0.03	3.86ValGlu: 3.86 ± 0.035	2.545ValPhe: 2.545 ± 0.021	3.969ValGly: 3.969 ± 0.029	1.382ValHis: 1.382 ± 0.016	3.362ValIle: 3.362 ± 0.026	2.887ValLys: 2.887 ± 0.023	5.65ValLeu: 5.65 ± 0.037	1.301ValMet: 1.301 ± 0.017	2.473ValAsn: 2.473 ± 0.02	3.476ValPro: 3.476 ± 0.026	2.422ValGln: 2.422 ± 0.02	3.268ValArg: 3.268 ± 0.028	4.843ValSer: 4.843 ± 0.03	3.749ValThr: 3.749 ± 0.028	4.394ValVal: 4.394 ± 0.039	0.865ValTrp: 0.865 ± 0.014	1.835ValTyr: 1.835 ± 0.021	0.008ValXaa: 0.008 ± 0.001
Trp	1.132TrpAla: 1.132 ± 0.016	0.181TrpCys: 0.181 ± 0.006	0.905TrpAsp: 0.905 ± 0.014	0.829TrpGlu: 0.829 ± 0.012	0.556TrpPhe: 0.556 ± 0.01	0.93TrpGly: 0.93 ± 0.015	0.352TrpHis: 0.352 ± 0.009	0.849TrpIle: 0.849 ± 0.014	0.827TrpLys: 0.827 ± 0.013	1.387TrpLeu: 1.387 ± 0.017	0.359TrpMet: 0.359 ± 0.009	0.703TrpAsn: 0.703 ± 0.013	0.6TrpPro: 0.6 ± 0.01	0.592TrpGln: 0.592 ± 0.011	0.926TrpArg: 0.926 ± 0.015	1.071TrpSer: 1.071 ± 0.014	0.927TrpThr: 0.927 ± 0.013	0.89TrpVal: 0.89 ± 0.013	0.273TrpTrp: 0.273 ± 0.007	0.465TrpTyr: 0.465 ± 0.009	0.006TrpXaa: 0.006 ± 0.001
Tyr	2.308TyrAla: 2.308 ± 0.024	0.41TyrCys: 0.41 ± 0.01	1.783TyrAsp: 1.783 ± 0.019	1.694TyrGlu: 1.694 ± 0.019	1.302TyrPhe: 1.302 ± 0.016	2.218TyrGly: 2.218 ± 0.024	0.797TyrHis: 0.797 ± 0.012	1.653TyrIle: 1.653 ± 0.02	1.165TyrLys: 1.165 ± 0.015	2.824TyrLeu: 2.824 ± 0.024	0.663TyrMet: 0.663 ± 0.01	1.297TyrAsn: 1.297 ± 0.016	1.562TyrPro: 1.562 ± 0.017	1.216TyrGln: 1.216 ± 0.015	1.634TyrArg: 1.634 ± 0.017	2.19TyrSer: 2.19 ± 0.019	1.811TyrThr: 1.811 ± 0.019	1.744TyrVal: 1.744 ± 0.018	0.482TyrTrp: 0.482 ± 0.009	1.064TyrTyr: 1.064 ± 0.014	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.027XaaAla: 0.027 ± 0.002	0.003XaaCys: 0.003 ± 0.001	0.006XaaAsp: 0.006 ± 0.001	0.013XaaGlu: 0.013 ± 0.002	0.006XaaPhe: 0.006 ± 0.001	0.013XaaGly: 0.013 ± 0.002	0.003XaaHis: 0.003 ± 0.001	0.005XaaIle: 0.005 ± 0.001	0.007XaaLys: 0.007 ± 0.001	0.025XaaLeu: 0.025 ± 0.002	0.004XaaMet: 0.004 ± 0.001	0.006XaaAsn: 0.006 ± 0.001	0.055XaaPro: 0.055 ± 0.003	0.01XaaGln: 0.01 ± 0.001	0.015XaaArg: 0.015 ± 0.002	0.02XaaSer: 0.02 ± 0.002	0.006XaaThr: 0.006 ± 0.001	0.008XaaVal: 0.008 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.003XaaTyr: 0.003 ± 0.001	0.02XaaXaa: 0.02 ± 0.006

Statistics based on 10407 proteins (5668149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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