Amino acid dipepetide frequency for Streptococcus satellite phage Javan327

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.012AlaAla: 2.012 ± 0.962
0.402AlaCys: 0.402 ± 0.453
5.231AlaAsp: 5.231 ± 1.806
6.841AlaGlu: 6.841 ± 1.877
2.817AlaPhe: 2.817 ± 1.353
1.207AlaGly: 1.207 ± 0.684
0.402AlaHis: 0.402 ± 0.406
4.829AlaIle: 4.829 ± 1.481
7.243AlaLys: 7.243 ± 1.419
6.439AlaLeu: 6.439 ± 1.768
1.61AlaMet: 1.61 ± 1.174
2.414AlaAsn: 2.414 ± 0.783
1.207AlaPro: 1.207 ± 0.635
2.817AlaGln: 2.817 ± 1.489
1.61AlaArg: 1.61 ± 0.55
3.622AlaSer: 3.622 ± 1.226
4.024AlaThr: 4.024 ± 1.311
1.61AlaVal: 1.61 ± 0.809
0.805AlaTrp: 0.805 ± 0.466
2.817AlaTyr: 2.817 ± 1.15
0.0AlaXaa: 0.0 ± 0.0
Cys
0.402CysAla: 0.402 ± 0.406
0.0CysCys: 0.0 ± 0.0
0.402CysAsp: 0.402 ± 0.435
0.402CysGlu: 0.402 ± 0.453
0.402CysPhe: 0.402 ± 0.453
0.402CysGly: 0.402 ± 0.369
0.0CysHis: 0.0 ± 0.0
0.402CysIle: 0.402 ± 0.369
0.0CysLys: 0.0 ± 0.0
0.805CysLeu: 0.805 ± 0.603
0.805CysMet: 0.805 ± 0.528
0.0CysAsn: 0.0 ± 0.0
0.805CysPro: 0.805 ± 0.479
0.0CysGln: 0.0 ± 0.0
0.402CysArg: 0.402 ± 0.375
0.0CysSer: 0.0 ± 0.0
0.402CysThr: 0.402 ± 0.34
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.805CysTyr: 0.805 ± 0.549
0.0CysXaa: 0.0 ± 0.0
Asp
1.61AspAla: 1.61 ± 0.901
0.805AspCys: 0.805 ± 0.554
3.622AspAsp: 3.622 ± 1.322
2.414AspGlu: 2.414 ± 1.095
4.024AspPhe: 4.024 ± 1.625
3.219AspGly: 3.219 ± 1.063
0.805AspHis: 0.805 ± 0.705
7.646AspIle: 7.646 ± 1.879
6.036AspLys: 6.036 ± 1.086
4.024AspLeu: 4.024 ± 1.256
1.61AspMet: 1.61 ± 0.672
4.829AspAsn: 4.829 ± 1.462
0.805AspPro: 0.805 ± 0.524
1.61AspGln: 1.61 ± 0.869
2.817AspArg: 2.817 ± 1.075
3.219AspSer: 3.219 ± 0.826
2.817AspThr: 2.817 ± 1.005
4.024AspVal: 4.024 ± 1.05
0.402AspTrp: 0.402 ± 0.435
4.024AspTyr: 4.024 ± 1.534
0.0AspXaa: 0.0 ± 0.0
Glu
4.024GluAla: 4.024 ± 1.712
0.805GluCys: 0.805 ± 0.524
4.829GluAsp: 4.829 ± 1.314
7.243GluGlu: 7.243 ± 1.965
1.207GluPhe: 1.207 ± 0.629
4.024GluGly: 4.024 ± 1.16
1.207GluHis: 1.207 ± 0.691
7.243GluIle: 7.243 ± 1.8
8.451GluLys: 8.451 ± 1.657
12.877GluLeu: 12.877 ± 1.614
2.012GluMet: 2.012 ± 0.847
4.024GluAsn: 4.024 ± 0.976
2.414GluPro: 2.414 ± 1.052
3.622GluGln: 3.622 ± 1.346
4.829GluArg: 4.829 ± 1.876
5.634GluSer: 5.634 ± 1.23
4.427GluThr: 4.427 ± 1.375
3.622GluVal: 3.622 ± 1.2
0.0GluTrp: 0.0 ± 0.0
2.817GluTyr: 2.817 ± 0.919
0.0GluXaa: 0.0 ± 0.0
Phe
2.414PheAla: 2.414 ± 0.868
0.402PheCys: 0.402 ± 0.453
2.817PheAsp: 2.817 ± 1.172
4.024PheGlu: 4.024 ± 1.327
1.207PhePhe: 1.207 ± 0.674
1.61PheGly: 1.61 ± 0.697
0.805PheHis: 0.805 ± 0.426
2.012PheIle: 2.012 ± 0.919
2.817PheLys: 2.817 ± 1.263
6.036PheLeu: 6.036 ± 1.448
1.207PheMet: 1.207 ± 0.725
0.402PheAsn: 0.402 ± 0.352
0.805PhePro: 0.805 ± 0.674
1.61PheGln: 1.61 ± 0.598
2.414PheArg: 2.414 ± 0.881
2.817PheSer: 2.817 ± 0.979
1.61PheThr: 1.61 ± 0.687
1.61PheVal: 1.61 ± 0.842
0.402PheTrp: 0.402 ± 0.484
2.414PheTyr: 2.414 ± 0.809
0.0PheXaa: 0.0 ± 0.0
Gly
2.817GlyAla: 2.817 ± 1.511
0.402GlyCys: 0.402 ± 0.375
0.805GlyAsp: 0.805 ± 0.677
3.219GlyGlu: 3.219 ± 1.251
2.414GlyPhe: 2.414 ± 0.913
1.61GlyGly: 1.61 ± 0.798
0.805GlyHis: 0.805 ± 0.485
3.219GlyIle: 3.219 ± 0.685
4.427GlyLys: 4.427 ± 1.048
3.622GlyLeu: 3.622 ± 0.908
1.61GlyMet: 1.61 ± 0.697
2.414GlyAsn: 2.414 ± 1.124
0.0GlyPro: 0.0 ± 0.0
2.817GlyGln: 2.817 ± 0.912
1.207GlyArg: 1.207 ± 0.608
1.207GlySer: 1.207 ± 0.746
2.414GlyThr: 2.414 ± 1.0
3.219GlyVal: 3.219 ± 1.152
0.402GlyTrp: 0.402 ± 0.34
3.622GlyTyr: 3.622 ± 1.138
0.0GlyXaa: 0.0 ± 0.0
His
1.207HisAla: 1.207 ± 0.775
0.0HisCys: 0.0 ± 0.0
1.207HisAsp: 1.207 ± 0.629
0.805HisGlu: 0.805 ± 0.485
1.207HisPhe: 1.207 ± 0.853
1.61HisGly: 1.61 ± 0.716
0.0HisHis: 0.0 ± 0.0
0.805HisIle: 0.805 ± 0.749
0.805HisLys: 0.805 ± 0.674
2.012HisLeu: 2.012 ± 0.559
0.0HisMet: 0.0 ± 0.0
0.402HisAsn: 0.402 ± 0.34
0.805HisPro: 0.805 ± 0.644
0.805HisGln: 0.805 ± 0.525
1.207HisArg: 1.207 ± 0.892
1.61HisSer: 1.61 ± 0.661
1.207HisThr: 1.207 ± 0.544
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.61HisTyr: 1.61 ± 0.68
0.0HisXaa: 0.0 ± 0.0
Ile
4.024IleAla: 4.024 ± 1.302
0.402IleCys: 0.402 ± 0.435
7.243IleAsp: 7.243 ± 1.814
6.841IleGlu: 6.841 ± 1.982
3.219IlePhe: 3.219 ± 1.101
3.622IleGly: 3.622 ± 0.927
1.61IleHis: 1.61 ± 0.869
5.634IleIle: 5.634 ± 1.019
8.048IleLys: 8.048 ± 1.163
7.646IleLeu: 7.646 ± 2.35
1.61IleMet: 1.61 ± 0.65
4.427IleAsn: 4.427 ± 1.528
1.61IlePro: 1.61 ± 0.885
2.817IleGln: 2.817 ± 0.978
2.012IleArg: 2.012 ± 1.173
5.634IleSer: 5.634 ± 1.88
6.439IleThr: 6.439 ± 1.469
1.61IleVal: 1.61 ± 0.953
1.207IleTrp: 1.207 ± 0.798
3.622IleTyr: 3.622 ± 0.897
0.0IleXaa: 0.0 ± 0.0
Lys
9.658LysAla: 9.658 ± 2.216
0.402LysCys: 0.402 ± 0.369
4.829LysAsp: 4.829 ± 1.782
9.658LysGlu: 9.658 ± 1.645
2.012LysPhe: 2.012 ± 0.713
2.817LysGly: 2.817 ± 1.005
2.817LysHis: 2.817 ± 1.253
8.048LysIle: 8.048 ± 2.144
9.658LysLys: 9.658 ± 1.88
8.451LysLeu: 8.451 ± 2.207
1.61LysMet: 1.61 ± 0.918
4.427LysAsn: 4.427 ± 1.009
2.012LysPro: 2.012 ± 0.654
4.427LysGln: 4.427 ± 1.109
7.243LysArg: 7.243 ± 2.101
4.024LysSer: 4.024 ± 1.111
5.634LysThr: 5.634 ± 1.45
5.634LysVal: 5.634 ± 1.261
0.402LysTrp: 0.402 ± 0.388
1.61LysTyr: 1.61 ± 0.891
0.0LysXaa: 0.0 ± 0.0
Leu
6.841LeuAla: 6.841 ± 1.541
1.207LeuCys: 1.207 ± 0.745
7.243LeuAsp: 7.243 ± 1.69
13.682LeuGlu: 13.682 ± 2.987
3.219LeuPhe: 3.219 ± 1.04
2.817LeuGly: 2.817 ± 1.332
1.207LeuHis: 1.207 ± 0.649
7.243LeuIle: 7.243 ± 2.159
9.658LeuLys: 9.658 ± 1.608
8.853LeuLeu: 8.853 ± 2.113
2.012LeuMet: 2.012 ± 0.672
8.048LeuAsn: 8.048 ± 1.754
2.414LeuPro: 2.414 ± 0.844
4.427LeuGln: 4.427 ± 1.238
2.414LeuArg: 2.414 ± 0.717
5.634LeuSer: 5.634 ± 1.342
6.841LeuThr: 6.841 ± 1.56
2.414LeuVal: 2.414 ± 0.945
0.805LeuTrp: 0.805 ± 0.541
2.414LeuTyr: 2.414 ± 0.849
0.0LeuXaa: 0.0 ± 0.0
Met
2.414MetAla: 2.414 ± 0.867
0.0MetCys: 0.0 ± 0.0
2.414MetAsp: 2.414 ± 0.764
2.414MetGlu: 2.414 ± 0.859
0.805MetPhe: 0.805 ± 0.605
1.61MetGly: 1.61 ± 0.671
0.0MetHis: 0.0 ± 0.0
2.012MetIle: 2.012 ± 0.997
1.61MetLys: 1.61 ± 0.693
0.805MetLeu: 0.805 ± 0.484
0.0MetMet: 0.0 ± 0.0
3.219MetAsn: 3.219 ± 1.211
0.0MetPro: 0.0 ± 0.0
1.207MetGln: 1.207 ± 0.472
0.402MetArg: 0.402 ± 0.406
1.207MetSer: 1.207 ± 0.765
2.414MetThr: 2.414 ± 0.805
1.207MetVal: 1.207 ± 0.634
0.0MetTrp: 0.0 ± 0.0
0.402MetTyr: 0.402 ± 0.443
0.0MetXaa: 0.0 ± 0.0
Asn
2.817AsnAla: 2.817 ± 0.87
0.0AsnCys: 0.0 ± 0.0
2.414AsnAsp: 2.414 ± 0.754
6.036AsnGlu: 6.036 ± 2.003
2.012AsnPhe: 2.012 ± 1.231
2.817AsnGly: 2.817 ± 1.096
1.207AsnHis: 1.207 ± 0.648
2.414AsnIle: 2.414 ± 0.964
3.622AsnLys: 3.622 ± 1.066
4.829AsnLeu: 4.829 ± 0.857
1.207AsnMet: 1.207 ± 0.591
3.219AsnAsn: 3.219 ± 1.35
1.61AsnPro: 1.61 ± 0.735
2.414AsnGln: 2.414 ± 0.941
1.61AsnArg: 1.61 ± 0.801
4.024AsnSer: 4.024 ± 1.271
4.024AsnThr: 4.024 ± 1.398
2.012AsnVal: 2.012 ± 0.894
2.012AsnTrp: 2.012 ± 0.874
2.414AsnTyr: 2.414 ± 0.957
0.0AsnXaa: 0.0 ± 0.0
Pro
2.012ProAla: 2.012 ± 0.588
0.0ProCys: 0.0 ± 0.0
1.207ProAsp: 1.207 ± 0.7
1.207ProGlu: 1.207 ± 0.792
0.402ProPhe: 0.402 ± 0.369
0.805ProGly: 0.805 ± 0.531
0.402ProHis: 0.402 ± 0.443
1.207ProIle: 1.207 ± 0.644
2.817ProLys: 2.817 ± 1.136
0.805ProLeu: 0.805 ± 0.511
0.402ProMet: 0.402 ± 0.435
1.61ProAsn: 1.61 ± 0.627
0.402ProPro: 0.402 ± 0.443
0.805ProGln: 0.805 ± 0.524
0.805ProArg: 0.805 ± 0.505
2.414ProSer: 2.414 ± 1.154
1.61ProThr: 1.61 ± 0.802
1.61ProVal: 1.61 ± 1.383
0.0ProTrp: 0.0 ± 0.0
2.817ProTyr: 2.817 ± 0.935
0.0ProXaa: 0.0 ± 0.0
Gln
5.634GlnAla: 5.634 ± 1.395
0.0GlnCys: 0.0 ± 0.0
0.805GlnAsp: 0.805 ± 0.58
2.414GlnGlu: 2.414 ± 0.789
2.817GlnPhe: 2.817 ± 1.016
2.012GlnGly: 2.012 ± 0.825
0.402GlnHis: 0.402 ± 0.435
4.024GlnIle: 4.024 ± 1.393
6.036GlnLys: 6.036 ± 1.727
2.817GlnLeu: 2.817 ± 1.037
0.0GlnMet: 0.0 ± 0.0
2.817GlnAsn: 2.817 ± 0.963
0.805GlnPro: 0.805 ± 0.517
2.414GlnGln: 2.414 ± 0.942
3.219GlnArg: 3.219 ± 0.93
2.817GlnSer: 2.817 ± 0.772
4.427GlnThr: 4.427 ± 1.151
2.414GlnVal: 2.414 ± 0.775
0.402GlnTrp: 0.402 ± 0.352
2.817GlnTyr: 2.817 ± 1.003
0.0GlnXaa: 0.0 ± 0.0
Arg
2.414ArgAla: 2.414 ± 0.814
0.0ArgCys: 0.0 ± 0.0
3.622ArgAsp: 3.622 ± 1.36
4.829ArgGlu: 4.829 ± 1.037
2.012ArgPhe: 2.012 ± 1.012
2.012ArgGly: 2.012 ± 0.607
2.012ArgHis: 2.012 ± 1.003
4.024ArgIle: 4.024 ± 1.04
2.414ArgLys: 2.414 ± 0.655
5.634ArgLeu: 5.634 ± 1.583
1.207ArgMet: 1.207 ± 0.611
2.414ArgAsn: 2.414 ± 1.099
0.402ArgPro: 0.402 ± 0.484
2.817ArgGln: 2.817 ± 0.776
0.805ArgArg: 0.805 ± 0.426
2.414ArgSer: 2.414 ± 0.818
1.61ArgThr: 1.61 ± 0.708
2.012ArgVal: 2.012 ± 0.961
0.0ArgTrp: 0.0 ± 0.0
2.414ArgTyr: 2.414 ± 1.089
0.0ArgXaa: 0.0 ± 0.0
Ser
2.012SerAla: 2.012 ± 0.785
0.402SerCys: 0.402 ± 0.435
2.817SerAsp: 2.817 ± 1.18
4.829SerGlu: 4.829 ± 1.598
2.414SerPhe: 2.414 ± 0.851
2.012SerGly: 2.012 ± 0.736
1.207SerHis: 1.207 ± 0.578
8.853SerIle: 8.853 ± 1.528
5.634SerLys: 5.634 ± 1.457
4.829SerLeu: 4.829 ± 1.308
1.207SerMet: 1.207 ± 0.797
2.012SerAsn: 2.012 ± 0.761
2.012SerPro: 2.012 ± 0.552
2.012SerGln: 2.012 ± 0.944
3.219SerArg: 3.219 ± 1.373
4.024SerSer: 4.024 ± 0.763
3.219SerThr: 3.219 ± 1.015
4.024SerVal: 4.024 ± 1.075
0.402SerTrp: 0.402 ± 0.375
3.219SerTyr: 3.219 ± 0.911
0.0SerXaa: 0.0 ± 0.0
Thr
3.622ThrAla: 3.622 ± 1.14
0.402ThrCys: 0.402 ± 0.488
4.024ThrAsp: 4.024 ± 1.187
4.427ThrGlu: 4.427 ± 1.532
2.012ThrPhe: 2.012 ± 0.888
3.219ThrGly: 3.219 ± 1.051
0.805ThrHis: 0.805 ± 0.749
2.414ThrIle: 2.414 ± 0.844
7.243ThrLys: 7.243 ± 2.186
6.841ThrLeu: 6.841 ± 1.241
3.219ThrMet: 3.219 ± 0.956
1.61ThrAsn: 1.61 ± 0.587
2.817ThrPro: 2.817 ± 1.227
4.427ThrGln: 4.427 ± 1.442
2.817ThrArg: 2.817 ± 1.078
3.219ThrSer: 3.219 ± 0.866
2.817ThrThr: 2.817 ± 1.094
3.622ThrVal: 3.622 ± 1.132
0.402ThrTrp: 0.402 ± 0.352
0.805ThrTyr: 0.805 ± 0.524
0.0ThrXaa: 0.0 ± 0.0
Val
1.207ValAla: 1.207 ± 0.592
0.402ValCys: 0.402 ± 0.453
0.805ValAsp: 0.805 ± 0.485
1.61ValGlu: 1.61 ± 0.794
1.61ValPhe: 1.61 ± 0.943
2.414ValGly: 2.414 ± 1.391
0.805ValHis: 0.805 ± 0.567
2.414ValIle: 2.414 ± 0.9
4.024ValLys: 4.024 ± 1.456
4.427ValLeu: 4.427 ± 1.347
0.805ValMet: 0.805 ± 0.554
2.414ValAsn: 2.414 ± 1.413
1.61ValPro: 1.61 ± 0.64
4.024ValGln: 4.024 ± 1.258
2.414ValArg: 2.414 ± 0.876
5.634ValSer: 5.634 ± 1.457
2.414ValThr: 2.414 ± 1.088
4.024ValVal: 4.024 ± 1.437
0.402ValTrp: 0.402 ± 0.388
2.012ValTyr: 2.012 ± 1.156
0.0ValXaa: 0.0 ± 0.0
Trp
1.207TrpAla: 1.207 ± 0.813
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.402TrpGlu: 0.402 ± 0.406
0.402TrpPhe: 0.402 ± 0.435
0.402TrpGly: 0.402 ± 0.388
0.0TrpHis: 0.0 ± 0.0
0.805TrpIle: 0.805 ± 0.571
0.805TrpLys: 0.805 ± 0.426
2.012TrpLeu: 2.012 ± 0.718
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.402TrpGln: 0.402 ± 0.34
0.402TrpArg: 0.402 ± 0.369
0.402TrpSer: 0.402 ± 0.375
0.0TrpThr: 0.0 ± 0.0
0.402TrpVal: 0.402 ± 0.34
0.402TrpTrp: 0.402 ± 0.435
0.402TrpTyr: 0.402 ± 0.435
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.61TyrAla: 1.61 ± 0.835
0.402TyrCys: 0.402 ± 0.34
4.024TyrAsp: 4.024 ± 1.704
2.012TyrGlu: 2.012 ± 0.761
3.622TyrPhe: 3.622 ± 1.292
2.012TyrGly: 2.012 ± 1.142
0.805TyrHis: 0.805 ± 0.605
4.024TyrIle: 4.024 ± 1.663
4.024TyrLys: 4.024 ± 1.608
5.634TyrLeu: 5.634 ± 0.981
1.61TyrMet: 1.61 ± 0.745
2.012TyrAsn: 2.012 ± 0.683
0.805TyrPro: 0.805 ± 0.549
3.622TyrGln: 3.622 ± 1.15
3.219TyrArg: 3.219 ± 1.435
0.805TyrSer: 0.805 ± 0.485
2.414TyrThr: 2.414 ± 0.849
0.402TyrVal: 0.402 ± 0.426
0.0TyrTrp: 0.0 ± 0.0
2.414TyrTyr: 2.414 ± 1.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2486 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski