Amino acid dipepetide frequency for Thalassolituus sp. C2-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.911AlaAla: 11.911 ± 0.152	1.074AlaCys: 1.074 ± 0.035	6.637AlaAsp: 6.637 ± 0.087	7.346AlaGlu: 7.346 ± 0.093	3.567AlaPhe: 3.567 ± 0.059	8.365AlaGly: 8.365 ± 0.094	1.894AlaHis: 1.894 ± 0.042	5.208AlaIle: 5.208 ± 0.071	3.392AlaLys: 3.392 ± 0.067	12.069AlaLeu: 12.069 ± 0.133	2.756AlaMet: 2.756 ± 0.045	3.167AlaAsn: 3.167 ± 0.059	3.523AlaPro: 3.523 ± 0.06	4.861AlaGln: 4.861 ± 0.081	5.371AlaArg: 5.371 ± 0.072	5.892AlaSer: 5.892 ± 0.079	4.69AlaThr: 4.69 ± 0.069	6.934AlaVal: 6.934 ± 0.077	1.199AlaTrp: 1.199 ± 0.031	2.421AlaTyr: 2.421 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.029	0.157CysCys: 0.157 ± 0.012	0.571CysAsp: 0.571 ± 0.021	0.515CysGlu: 0.515 ± 0.022	0.377CysPhe: 0.377 ± 0.018	0.948CysGly: 0.948 ± 0.031	0.303CysHis: 0.303 ± 0.016	0.505CysIle: 0.505 ± 0.022	0.315CysLys: 0.315 ± 0.016	1.033CysLeu: 1.033 ± 0.031	0.221CysMet: 0.221 ± 0.012	0.36CysAsn: 0.36 ± 0.017	0.463CysPro: 0.463 ± 0.02	0.438CysGln: 0.438 ± 0.021	0.563CysArg: 0.563 ± 0.022	0.685CysSer: 0.685 ± 0.027	0.456CysThr: 0.456 ± 0.019	0.594CysVal: 0.594 ± 0.022	0.142CysTrp: 0.142 ± 0.009	0.296CysTyr: 0.296 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.38AspAla: 5.38 ± 0.075	0.564AspCys: 0.564 ± 0.021	3.688AspAsp: 3.688 ± 0.073	3.772AspGlu: 3.772 ± 0.055	2.364AspPhe: 2.364 ± 0.052	4.371AspGly: 4.371 ± 0.095	1.201AspHis: 1.201 ± 0.031	3.826AspIle: 3.826 ± 0.06	2.317AspLys: 2.317 ± 0.043	5.56AspLeu: 5.56 ± 0.076	1.453AspMet: 1.453 ± 0.037	2.429AspAsn: 2.429 ± 0.053	2.222AspPro: 2.222 ± 0.047	2.31AspGln: 2.31 ± 0.042	2.515AspArg: 2.515 ± 0.045	3.541AspSer: 3.541 ± 0.065	2.61AspThr: 2.61 ± 0.052	3.882AspVal: 3.882 ± 0.057	1.028AspTrp: 1.028 ± 0.03	2.009AspTyr: 2.009 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.705GluAla: 5.705 ± 0.081	0.471GluCys: 0.471 ± 0.021	2.702GluAsp: 2.702 ± 0.055	3.496GluGlu: 3.496 ± 0.06	2.326GluPhe: 2.326 ± 0.046	3.521GluGly: 3.521 ± 0.055	1.621GluHis: 1.621 ± 0.042	3.277GluIle: 3.277 ± 0.058	2.935GluLys: 2.935 ± 0.063	6.928GluLeu: 6.928 ± 0.086	1.481GluMet: 1.481 ± 0.036	2.109GluAsn: 2.109 ± 0.044	2.082GluPro: 2.082 ± 0.047	4.371GluGln: 4.371 ± 0.078	4.093GluArg: 4.093 ± 0.074	3.064GluSer: 3.064 ± 0.061	2.664GluThr: 2.664 ± 0.048	3.859GluVal: 3.859 ± 0.06	0.787GluTrp: 0.787 ± 0.026	1.689GluTyr: 1.689 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.713PheAla: 3.713 ± 0.058	0.466PheCys: 0.466 ± 0.019	2.4PheAsp: 2.4 ± 0.045	1.909PheGlu: 1.909 ± 0.046	1.635PhePhe: 1.635 ± 0.035	2.855PheGly: 2.855 ± 0.053	0.762PheHis: 0.762 ± 0.025	2.346PheIle: 2.346 ± 0.049	1.284PheLys: 1.284 ± 0.031	3.299PheLeu: 3.299 ± 0.059	1.043PheMet: 1.043 ± 0.028	1.752PheAsn: 1.752 ± 0.036	1.453PhePro: 1.453 ± 0.033	1.179PheGln: 1.179 ± 0.03	2.013PheArg: 2.013 ± 0.043	3.179PheSer: 3.179 ± 0.058	2.102PheThr: 2.102 ± 0.044	2.286PheVal: 2.286 ± 0.05	0.63PheTrp: 0.63 ± 0.025	1.246PheTyr: 1.246 ± 0.031	0.001PheXaa: 0.001 ± 0.001
Gly	6.025GlyAla: 6.025 ± 0.089	0.959GlyCys: 0.959 ± 0.031	4.08GlyAsp: 4.08 ± 0.064	4.44GlyGlu: 4.44 ± 0.072	3.271GlyPhe: 3.271 ± 0.059	5.071GlyGly: 5.071 ± 0.095	1.709GlyHis: 1.709 ± 0.041	4.52GlyIle: 4.52 ± 0.073	3.402GlyLys: 3.402 ± 0.054	7.722GlyLeu: 7.722 ± 0.078	2.139GlyMet: 2.139 ± 0.044	2.784GlyAsn: 2.784 ± 0.066	1.894GlyPro: 1.894 ± 0.04	3.309GlyGln: 3.309 ± 0.053	3.977GlyArg: 3.977 ± 0.058	4.573GlySer: 4.573 ± 0.072	3.369GlyThr: 3.369 ± 0.063	5.043GlyVal: 5.043 ± 0.065	1.194GlyTrp: 1.194 ± 0.029	2.49GlyTyr: 2.49 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.851HisAla: 1.851 ± 0.04	0.35HisCys: 0.35 ± 0.018	1.147HisAsp: 1.147 ± 0.033	1.211HisGlu: 1.211 ± 0.038	1.048HisPhe: 1.048 ± 0.03	1.628HisGly: 1.628 ± 0.037	0.68HisHis: 0.68 ± 0.023	1.279HisIle: 1.279 ± 0.031	0.892HisLys: 0.892 ± 0.025	2.36HisLeu: 2.36 ± 0.046	0.551HisMet: 0.551 ± 0.021	0.871HisAsn: 0.871 ± 0.026	1.273HisPro: 1.273 ± 0.04	1.129HisGln: 1.129 ± 0.034	1.173HisArg: 1.173 ± 0.034	1.575HisSer: 1.575 ± 0.043	1.007HisThr: 1.007 ± 0.028	1.098HisVal: 1.098 ± 0.031	0.51HisTrp: 0.51 ± 0.021	0.871HisTyr: 0.871 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.919IleAla: 5.919 ± 0.079	0.556IleCys: 0.556 ± 0.022	3.434IleAsp: 3.434 ± 0.056	3.407IleGlu: 3.407 ± 0.062	1.718IlePhe: 1.718 ± 0.043	4.03IleGly: 4.03 ± 0.066	1.157IleHis: 1.157 ± 0.031	2.763IleIle: 2.763 ± 0.059	2.063IleLys: 2.063 ± 0.044	4.712IleLeu: 4.712 ± 0.069	1.128IleMet: 1.128 ± 0.033	2.54IleAsn: 2.54 ± 0.051	2.54IlePro: 2.54 ± 0.045	2.124IleGln: 2.124 ± 0.043	3.453IleArg: 3.453 ± 0.06	4.024IleSer: 4.024 ± 0.062	3.02IleThr: 3.02 ± 0.063	3.242IleVal: 3.242 ± 0.061	0.606IleTrp: 0.606 ± 0.024	1.398IleTyr: 1.398 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.37LysAla: 4.37 ± 0.065	0.208LysCys: 0.208 ± 0.014	2.181LysAsp: 2.181 ± 0.052	2.345LysGlu: 2.345 ± 0.06	0.978LysPhe: 0.978 ± 0.029	2.547LysGly: 2.547 ± 0.056	0.837LysHis: 0.837 ± 0.029	1.976LysIle: 1.976 ± 0.043	1.911LysLys: 1.911 ± 0.051	3.785LysLeu: 3.785 ± 0.059	0.907LysMet: 0.907 ± 0.029	1.598LysAsn: 1.598 ± 0.039	1.987LysPro: 1.987 ± 0.043	1.933LysGln: 1.933 ± 0.042	2.3LysArg: 2.3 ± 0.055	2.122LysSer: 2.122 ± 0.043	2.294LysThr: 2.294 ± 0.045	2.728LysVal: 2.728 ± 0.05	0.35LysTrp: 0.35 ± 0.018	0.911LysTyr: 0.911 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.97LeuAla: 11.97 ± 0.116	1.151LeuCys: 1.151 ± 0.028	5.757LeuAsp: 5.757 ± 0.077	5.818LeuGlu: 5.818 ± 0.082	3.895LeuPhe: 3.895 ± 0.069	7.132LeuGly: 7.132 ± 0.082	2.375LeuHis: 2.375 ± 0.049	5.678LeuIle: 5.678 ± 0.078	4.388LeuLys: 4.388 ± 0.07	13.543LeuLeu: 13.543 ± 0.207	2.67LeuMet: 2.67 ± 0.049	4.729LeuAsn: 4.729 ± 0.062	5.707LeuPro: 5.707 ± 0.085	6.021LeuGln: 6.021 ± 0.109	6.067LeuArg: 6.067 ± 0.084	8.088LeuSer: 8.088 ± 0.094	6.204LeuThr: 6.204 ± 0.086	6.698LeuVal: 6.698 ± 0.1	1.429LeuTrp: 1.429 ± 0.043	2.71LeuTyr: 2.71 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.759MetAla: 2.759 ± 0.048	0.158MetCys: 0.158 ± 0.011	1.248MetAsp: 1.248 ± 0.034	1.265MetGlu: 1.265 ± 0.032	0.74MetPhe: 0.74 ± 0.027	1.624MetGly: 1.624 ± 0.042	0.52MetHis: 0.52 ± 0.018	1.279MetIle: 1.279 ± 0.036	1.129MetLys: 1.129 ± 0.029	2.721MetLeu: 2.721 ± 0.048	0.702MetMet: 0.702 ± 0.024	1.171MetAsn: 1.171 ± 0.03	1.366MetPro: 1.366 ± 0.035	1.216MetGln: 1.216 ± 0.03	1.372MetArg: 1.372 ± 0.03	1.787MetSer: 1.787 ± 0.039	1.56MetThr: 1.56 ± 0.033	1.602MetVal: 1.602 ± 0.033	0.188MetTrp: 0.188 ± 0.013	0.456MetTyr: 0.456 ± 0.019	0.001MetXaa: 0.001 ± 0.001
Asn	3.727AsnAla: 3.727 ± 0.072	0.329AsnCys: 0.329 ± 0.015	2.224AsnAsp: 2.224 ± 0.05	2.079AsnGlu: 2.079 ± 0.044	1.259AsnPhe: 1.259 ± 0.031	3.129AsnGly: 3.129 ± 0.069	0.829AsnHis: 0.829 ± 0.028	2.26AsnIle: 2.26 ± 0.054	1.531AsnLys: 1.531 ± 0.042	3.728AsnLeu: 3.728 ± 0.06	0.871AsnMet: 0.871 ± 0.027	1.802AsnAsn: 1.802 ± 0.061	2.108AsnPro: 2.108 ± 0.043	1.606AsnGln: 1.606 ± 0.04	2.144AsnArg: 2.144 ± 0.051	2.461AsnSer: 2.461 ± 0.054	2.134AsnThr: 2.134 ± 0.052	2.174AsnVal: 2.174 ± 0.048	0.562AsnTrp: 0.562 ± 0.019	1.13AsnTyr: 1.13 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.052ProAla: 5.052 ± 0.083	0.33ProCys: 0.33 ± 0.016	3.035ProAsp: 3.035 ± 0.053	3.198ProGlu: 3.198 ± 0.054	1.623ProPhe: 1.623 ± 0.035	3.308ProGly: 3.308 ± 0.044	0.877ProHis: 0.877 ± 0.026	1.61ProIle: 1.61 ± 0.036	1.359ProLys: 1.359 ± 0.035	5.165ProLeu: 5.165 ± 0.073	0.999ProMet: 0.999 ± 0.031	1.111ProAsn: 1.111 ± 0.034	1.488ProPro: 1.488 ± 0.041	2.513ProGln: 2.513 ± 0.048	1.757ProArg: 1.757 ± 0.041	1.99ProSer: 1.99 ± 0.045	1.725ProThr: 1.725 ± 0.043	3.74ProVal: 3.74 ± 0.051	0.623ProTrp: 0.623 ± 0.022	1.212ProTyr: 1.212 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.531GlnAla: 5.531 ± 0.09	0.41GlnCys: 0.41 ± 0.018	2.17GlnAsp: 2.17 ± 0.041	2.555GlnGlu: 2.555 ± 0.05	1.541GlnPhe: 1.541 ± 0.032	3.294GlnGly: 3.294 ± 0.054	1.392GlnHis: 1.392 ± 0.039	2.365GlnIle: 2.365 ± 0.045	1.793GlnLys: 1.793 ± 0.044	6.348GlnLeu: 6.348 ± 0.098	1.133GlnMet: 1.133 ± 0.032	1.676GlnAsn: 1.676 ± 0.039	2.538GlnPro: 2.538 ± 0.053	4.75GlnGln: 4.75 ± 0.113	3.583GlnArg: 3.583 ± 0.067	2.713GlnSer: 2.713 ± 0.057	2.321GlnThr: 2.321 ± 0.042	3.251GlnVal: 3.251 ± 0.059	0.928GlnTrp: 0.928 ± 0.03	1.298GlnTyr: 1.298 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.761ArgAla: 4.761 ± 0.069	0.545ArgCys: 0.545 ± 0.022	3.069ArgAsp: 3.069 ± 0.057	3.49ArgGlu: 3.49 ± 0.064	2.5ArgPhe: 2.5 ± 0.044	3.212ArgGly: 3.212 ± 0.054	1.475ArgHis: 1.475 ± 0.035	3.52ArgIle: 3.52 ± 0.061	2.212ArgLys: 2.212 ± 0.045	6.764ArgLeu: 6.764 ± 0.099	1.506ArgMet: 1.506 ± 0.036	2.133ArgAsn: 2.133 ± 0.042	2.151ArgPro: 2.151 ± 0.049	3.107ArgGln: 3.107 ± 0.06	3.429ArgArg: 3.429 ± 0.062	3.224ArgSer: 3.224 ± 0.055	2.576ArgThr: 2.576 ± 0.047	3.562ArgVal: 3.562 ± 0.063	1.094ArgTrp: 1.094 ± 0.032	2.102ArgTyr: 2.102 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.208SerAla: 7.208 ± 0.093	0.583SerCys: 0.583 ± 0.024	3.747SerAsp: 3.747 ± 0.06	3.677SerGlu: 3.677 ± 0.057	2.41SerPhe: 2.41 ± 0.045	5.937SerGly: 5.937 ± 0.101	1.446SerHis: 1.446 ± 0.035	3.014SerIle: 3.014 ± 0.052	2.06SerLys: 2.06 ± 0.046	6.766SerLeu: 6.766 ± 0.086	1.507SerMet: 1.507 ± 0.034	2.214SerAsn: 2.214 ± 0.051	2.44SerPro: 2.44 ± 0.051	2.754SerGln: 2.754 ± 0.051	3.472SerArg: 3.472 ± 0.052	4.183SerSer: 4.183 ± 0.07	2.867SerThr: 2.867 ± 0.051	4.443SerVal: 4.443 ± 0.069	0.907SerTrp: 0.907 ± 0.029	1.877SerTyr: 1.877 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.225ThrAla: 5.225 ± 0.083	0.404ThrCys: 0.404 ± 0.02	2.982ThrAsp: 2.982 ± 0.063	2.864ThrGlu: 2.864 ± 0.052	1.844ThrPhe: 1.844 ± 0.045	4.098ThrGly: 4.098 ± 0.075	1.069ThrHis: 1.069 ± 0.033	2.475ThrIle: 2.475 ± 0.052	1.272ThrLys: 1.272 ± 0.038	6.628ThrLeu: 6.628 ± 0.09	1.011ThrMet: 1.011 ± 0.027	1.538ThrAsn: 1.538 ± 0.04	2.715ThrPro: 2.715 ± 0.053	2.152ThrGln: 2.152 ± 0.044	2.561ThrArg: 2.561 ± 0.045	2.98ThrSer: 2.98 ± 0.061	2.734ThrThr: 2.734 ± 0.062	3.307ThrVal: 3.307 ± 0.067	0.522ThrTrp: 0.522 ± 0.019	1.312ThrTyr: 1.312 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.756ValAla: 6.756 ± 0.082	0.679ValCys: 0.679 ± 0.022	3.709ValAsp: 3.709 ± 0.057	3.739ValGlu: 3.739 ± 0.059	2.616ValPhe: 2.616 ± 0.042	4.032ValGly: 4.032 ± 0.055	1.303ValHis: 1.303 ± 0.035	3.885ValIle: 3.885 ± 0.061	2.675ValLys: 2.675 ± 0.06	7.261ValLeu: 7.261 ± 0.093	1.858ValMet: 1.858 ± 0.04	2.594ValAsn: 2.594 ± 0.051	2.682ValPro: 2.682 ± 0.045	2.74ValGln: 2.74 ± 0.047	3.684ValArg: 3.684 ± 0.055	4.645ValSer: 4.645 ± 0.069	3.564ValThr: 3.564 ± 0.064	4.876ValVal: 4.876 ± 0.072	0.818ValTrp: 0.818 ± 0.025	1.711ValTyr: 1.711 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.04TrpAla: 1.04 ± 0.031	0.15TrpCys: 0.15 ± 0.009	0.639TrpAsp: 0.639 ± 0.024	0.543TrpGlu: 0.543 ± 0.02	0.577TrpPhe: 0.577 ± 0.023	0.792TrpGly: 0.792 ± 0.025	0.39TrpHis: 0.39 ± 0.018	0.707TrpIle: 0.707 ± 0.024	0.395TrpLys: 0.395 ± 0.02	2.423TrpLeu: 2.423 ± 0.054	0.357TrpMet: 0.357 ± 0.018	0.545TrpAsn: 0.545 ± 0.021	0.673TrpPro: 0.673 ± 0.023	1.276TrpGln: 1.276 ± 0.037	0.883TrpArg: 0.883 ± 0.025	0.833TrpSer: 0.833 ± 0.025	0.519TrpThr: 0.519 ± 0.019	0.893TrpVal: 0.893 ± 0.029	0.25TrpTrp: 0.25 ± 0.013	0.382TrpTyr: 0.382 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.407TyrAla: 2.407 ± 0.048	0.365TyrCys: 0.365 ± 0.015	1.619TyrAsp: 1.619 ± 0.037	1.513TyrGlu: 1.513 ± 0.038	1.266TyrPhe: 1.266 ± 0.034	2.075TyrGly: 2.075 ± 0.043	0.666TyrHis: 0.666 ± 0.022	1.341TyrIle: 1.341 ± 0.029	0.944TyrLys: 0.944 ± 0.029	3.216TyrLeu: 3.216 ± 0.065	0.569TyrMet: 0.569 ± 0.023	0.965TyrAsn: 0.965 ± 0.029	1.412TyrPro: 1.412 ± 0.031	1.798TyrGln: 1.798 ± 0.043	2.023TyrArg: 2.023 ± 0.043	1.952TyrSer: 1.952 ± 0.044	1.276TyrThr: 1.276 ± 0.035	1.614TyrVal: 1.614 ± 0.037	0.499TyrTrp: 0.499 ± 0.02	0.917TyrTyr: 0.917 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3803 proteins (1278525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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