Amino acid dipepetide frequency for Paraburkholderia ultramafica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.564AlaAla: 17.564 ± 0.138	1.328AlaCys: 1.328 ± 0.03	6.655AlaAsp: 6.655 ± 0.062	6.094AlaGlu: 6.094 ± 0.068	4.244AlaPhe: 4.244 ± 0.04	10.097AlaGly: 10.097 ± 0.095	2.888AlaHis: 2.888 ± 0.041	5.703AlaIle: 5.703 ± 0.051	3.688AlaLys: 3.688 ± 0.045	13.987AlaLeu: 13.987 ± 0.103	3.254AlaMet: 3.254 ± 0.043	3.372AlaAsn: 3.372 ± 0.04	5.81AlaPro: 5.81 ± 0.068	5.475AlaGln: 5.475 ± 0.053	8.866AlaArg: 8.866 ± 0.076	7.433AlaSer: 7.433 ± 0.066	6.373AlaThr: 6.373 ± 0.055	8.836AlaVal: 8.836 ± 0.073	1.641AlaTrp: 1.641 ± 0.031	2.696AlaTyr: 2.696 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.314CysAla: 1.314 ± 0.026	0.143CysCys: 0.143 ± 0.008	0.566CysAsp: 0.566 ± 0.018	0.527CysGlu: 0.527 ± 0.017	0.352CysPhe: 0.352 ± 0.012	1.026CysGly: 1.026 ± 0.026	0.267CysHis: 0.267 ± 0.012	0.439CysIle: 0.439 ± 0.013	0.245CysLys: 0.245 ± 0.011	0.841CysLeu: 0.841 ± 0.021	0.213CysMet: 0.213 ± 0.01	0.268CysAsn: 0.268 ± 0.011	0.474CysPro: 0.474 ± 0.016	0.23CysGln: 0.23 ± 0.011	0.679CysArg: 0.679 ± 0.02	0.555CysSer: 0.555 ± 0.017	0.497CysThr: 0.497 ± 0.017	0.837CysVal: 0.837 ± 0.02	0.136CysTrp: 0.136 ± 0.008	0.235CysTyr: 0.235 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.547AspAla: 7.547 ± 0.065	0.5AspCys: 0.5 ± 0.017	3.081AspAsp: 3.081 ± 0.04	3.372AspGlu: 3.372 ± 0.046	1.98AspPhe: 1.98 ± 0.033	4.447AspGly: 4.447 ± 0.052	1.227AspHis: 1.227 ± 0.027	2.449AspIle: 2.449 ± 0.032	1.598AspLys: 1.598 ± 0.03	5.152AspLeu: 5.152 ± 0.047	1.168AspMet: 1.168 ± 0.021	1.35AspAsn: 1.35 ± 0.026	2.895AspPro: 2.895 ± 0.039	1.674AspGln: 1.674 ± 0.03	3.304AspArg: 3.304 ± 0.043	2.6AspSer: 2.6 ± 0.036	2.814AspThr: 2.814 ± 0.034	4.261AspVal: 4.261 ± 0.048	0.905AspTrp: 0.905 ± 0.023	1.507AspTyr: 1.507 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.348GluAla: 6.348 ± 0.059	0.433GluCys: 0.433 ± 0.016	2.097GluAsp: 2.097 ± 0.034	2.344GluGlu: 2.344 ± 0.038	1.789GluPhe: 1.789 ± 0.032	3.242GluGly: 3.242 ± 0.043	1.52GluHis: 1.52 ± 0.028	2.789GluIle: 2.789 ± 0.042	1.81GluLys: 1.81 ± 0.034	5.524GluLeu: 5.524 ± 0.065	1.234GluMet: 1.234 ± 0.022	1.392GluAsn: 1.392 ± 0.026	2.541GluPro: 2.541 ± 0.038	2.5GluGln: 2.5 ± 0.034	4.847GluArg: 4.847 ± 0.052	2.651GluSer: 2.651 ± 0.039	2.828GluThr: 2.828 ± 0.039	3.618GluVal: 3.618 ± 0.048	0.753GluTrp: 0.753 ± 0.018	1.133GluTyr: 1.133 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.699PheAla: 4.699 ± 0.043	0.436PheCys: 0.436 ± 0.014	2.706PheAsp: 2.706 ± 0.034	2.087PheGlu: 2.087 ± 0.031	1.498PhePhe: 1.498 ± 0.032	3.655PheGly: 3.655 ± 0.045	0.767PheHis: 0.767 ± 0.017	1.668PheIle: 1.668 ± 0.029	1.038PheLys: 1.038 ± 0.026	2.976PheLeu: 2.976 ± 0.041	0.786PheMet: 0.786 ± 0.019	1.211PheAsn: 1.211 ± 0.022	1.599PhePro: 1.599 ± 0.026	1.012PheGln: 1.012 ± 0.02	2.056PheArg: 2.056 ± 0.029	2.333PheSer: 2.333 ± 0.036	1.985PheThr: 1.985 ± 0.028	3.15PheVal: 3.15 ± 0.044	0.508PheTrp: 0.508 ± 0.017	0.971PheTyr: 0.971 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.086GlyAla: 9.086 ± 0.073	0.897GlyCys: 0.897 ± 0.022	3.861GlyAsp: 3.861 ± 0.042	4.178GlyGlu: 4.178 ± 0.046	3.373GlyPhe: 3.373 ± 0.042	6.472GlyGly: 6.472 ± 0.076	1.966GlyHis: 1.966 ± 0.035	4.191GlyIle: 4.191 ± 0.05	3.199GlyLys: 3.199 ± 0.045	7.819GlyLeu: 7.819 ± 0.077	2.203GlyMet: 2.203 ± 0.036	2.357GlyAsn: 2.357 ± 0.036	2.865GlyPro: 2.865 ± 0.036	2.747GlyGln: 2.747 ± 0.037	5.061GlyArg: 5.061 ± 0.045	4.612GlySer: 4.612 ± 0.048	4.439GlyThr: 4.439 ± 0.046	6.581GlyVal: 6.581 ± 0.064	1.334GlyTrp: 1.334 ± 0.027	2.357GlyTyr: 2.357 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	3.125HisAla: 3.125 ± 0.044	0.29HisCys: 0.29 ± 0.014	1.401HisAsp: 1.401 ± 0.029	1.246HisGlu: 1.246 ± 0.024	0.972HisPhe: 0.972 ± 0.022	2.195HisGly: 2.195 ± 0.035	0.695HisHis: 0.695 ± 0.018	0.967HisIle: 0.967 ± 0.021	0.584HisLys: 0.584 ± 0.016	2.219HisLeu: 2.219 ± 0.034	0.51HisMet: 0.51 ± 0.015	0.575HisAsn: 0.575 ± 0.016	1.442HisPro: 1.442 ± 0.027	0.705HisGln: 0.705 ± 0.017	1.636HisArg: 1.636 ± 0.028	1.166HisSer: 1.166 ± 0.025	1.149HisThr: 1.149 ± 0.023	1.811HisVal: 1.811 ± 0.03	0.422HisTrp: 0.422 ± 0.015	0.683HisTyr: 0.683 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.874IleAla: 6.874 ± 0.058	0.505IleCys: 0.505 ± 0.015	3.449IleAsp: 3.449 ± 0.036	3.277IleGlu: 3.277 ± 0.043	1.519IlePhe: 1.519 ± 0.03	4.638IleGly: 4.638 ± 0.053	0.94IleHis: 0.94 ± 0.019	1.712IleIle: 1.712 ± 0.032	1.415IleLys: 1.415 ± 0.03	3.489IleLeu: 3.489 ± 0.042	0.813IleMet: 0.813 ± 0.024	1.413IleAsn: 1.413 ± 0.025	2.122IlePro: 2.122 ± 0.034	1.294IleGln: 1.294 ± 0.022	2.937IleArg: 2.937 ± 0.04	2.566IleSer: 2.566 ± 0.037	2.395IleThr: 2.395 ± 0.033	4.408IleVal: 4.408 ± 0.051	0.525IleTrp: 0.525 ± 0.018	1.082IleTyr: 1.082 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.634LysAla: 3.634 ± 0.052	0.195LysCys: 0.195 ± 0.011	1.504LysAsp: 1.504 ± 0.03	1.457LysGlu: 1.457 ± 0.031	0.927LysPhe: 0.927 ± 0.022	2.121LysGly: 2.121 ± 0.034	0.708LysHis: 0.708 ± 0.017	1.605LysIle: 1.605 ± 0.033	1.272LysLys: 1.272 ± 0.034	3.457LysLeu: 3.457 ± 0.045	0.807LysMet: 0.807 ± 0.022	0.912LysAsn: 0.912 ± 0.024	2.011LysPro: 2.011 ± 0.036	1.273LysGln: 1.273 ± 0.021	2.47LysArg: 2.47 ± 0.034	1.732LysSer: 1.732 ± 0.033	1.904LysThr: 1.904 ± 0.031	2.355LysVal: 2.355 ± 0.037	0.393LysTrp: 0.393 ± 0.013	0.691LysTyr: 0.691 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.729LeuAla: 13.729 ± 0.092	1.076LeuCys: 1.076 ± 0.021	5.864LeuAsp: 5.864 ± 0.053	5.029LeuGlu: 5.029 ± 0.053	3.696LeuPhe: 3.696 ± 0.044	7.943LeuGly: 7.943 ± 0.075	2.361LeuHis: 2.361 ± 0.039	4.811LeuIle: 4.811 ± 0.045	3.472LeuLys: 3.472 ± 0.045	10.176LeuLeu: 10.176 ± 0.099	2.251LeuMet: 2.251 ± 0.031	2.908LeuAsn: 2.908 ± 0.035	5.701LeuPro: 5.701 ± 0.057	3.499LeuGln: 3.499 ± 0.044	7.232LeuArg: 7.232 ± 0.063	6.39LeuSer: 6.39 ± 0.066	5.615LeuThr: 5.615 ± 0.052	7.388LeuVal: 7.388 ± 0.068	1.16LeuTrp: 1.16 ± 0.03	2.16LeuTyr: 2.16 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.515MetAla: 2.515 ± 0.035	0.18MetCys: 0.18 ± 0.009	0.973MetAsp: 0.973 ± 0.021	0.934MetGlu: 0.934 ± 0.021	0.78MetPhe: 0.78 ± 0.019	1.515MetGly: 1.515 ± 0.027	0.538MetHis: 0.538 ± 0.015	1.126MetIle: 1.126 ± 0.021	1.051MetLys: 1.051 ± 0.023	2.742MetLeu: 2.742 ± 0.043	0.607MetMet: 0.607 ± 0.016	0.939MetAsn: 0.939 ± 0.022	1.475MetPro: 1.475 ± 0.027	1.012MetGln: 1.012 ± 0.02	1.821MetArg: 1.821 ± 0.028	1.796MetSer: 1.796 ± 0.026	1.641MetThr: 1.641 ± 0.028	1.523MetVal: 1.523 ± 0.031	0.218MetTrp: 0.218 ± 0.008	0.413MetTyr: 0.413 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.61AsnAla: 3.61 ± 0.046	0.285AsnCys: 0.285 ± 0.012	1.502AsnAsp: 1.502 ± 0.029	1.39AsnGlu: 1.39 ± 0.025	1.046AsnPhe: 1.046 ± 0.024	2.613AsnGly: 2.613 ± 0.039	0.597AsnHis: 0.597 ± 0.018	1.244AsnIle: 1.244 ± 0.026	0.679AsnLys: 0.679 ± 0.016	2.878AsnLeu: 2.878 ± 0.035	0.6AsnMet: 0.6 ± 0.016	0.875AsnAsn: 0.875 ± 0.024	1.926AsnPro: 1.926 ± 0.027	0.978AsnGln: 0.978 ± 0.021	1.93AsnArg: 1.93 ± 0.028	1.465AsnSer: 1.465 ± 0.031	1.517AsnThr: 1.517 ± 0.034	2.251AsnVal: 2.251 ± 0.031	0.447AsnTrp: 0.447 ± 0.014	0.728AsnTyr: 0.728 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.648ProAla: 6.648 ± 0.059	0.385ProCys: 0.385 ± 0.013	3.201ProAsp: 3.201 ± 0.045	2.94ProGlu: 2.94 ± 0.041	1.949ProPhe: 1.949 ± 0.031	4.137ProGly: 4.137 ± 0.047	1.256ProHis: 1.256 ± 0.026	2.035ProIle: 2.035 ± 0.036	1.434ProLys: 1.434 ± 0.027	5.175ProLeu: 5.175 ± 0.058	1.115ProMet: 1.115 ± 0.021	1.478ProAsn: 1.478 ± 0.031	2.551ProPro: 2.551 ± 0.046	1.951ProGln: 1.951 ± 0.029	2.95ProArg: 2.95 ± 0.041	2.875ProSer: 2.875 ± 0.042	2.576ProThr: 2.576 ± 0.04	4.358ProVal: 4.358 ± 0.05	0.665ProTrp: 0.665 ± 0.017	1.238ProTyr: 1.238 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.593GlnAla: 4.593 ± 0.051	0.293GlnCys: 0.293 ± 0.012	1.386GlnAsp: 1.386 ± 0.028	1.384GlnGlu: 1.384 ± 0.026	1.35GlnPhe: 1.35 ± 0.027	2.459GlnGly: 2.459 ± 0.034	0.997GlnHis: 0.997 ± 0.021	2.048GlnIle: 2.048 ± 0.033	1.159GlnLys: 1.159 ± 0.022	3.982GlnLeu: 3.982 ± 0.043	1.066GlnMet: 1.066 ± 0.022	1.001GlnAsn: 1.001 ± 0.021	2.141GlnPro: 2.141 ± 0.035	2.039GlnGln: 2.039 ± 0.038	3.086GlnArg: 3.086 ± 0.04	2.063GlnSer: 2.063 ± 0.035	2.107GlnThr: 2.107 ± 0.033	2.556GlnVal: 2.556 ± 0.04	0.569GlnTrp: 0.569 ± 0.015	0.906GlnTyr: 0.906 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.176ArgAla: 8.176 ± 0.079	0.657ArgCys: 0.657 ± 0.019	3.854ArgAsp: 3.854 ± 0.042	4.197ArgGlu: 4.197 ± 0.047	2.998ArgPhe: 2.998 ± 0.034	4.546ArgGly: 4.546 ± 0.048	1.926ArgHis: 1.926 ± 0.032	3.694ArgIle: 3.694 ± 0.043	2.209ArgLys: 2.209 ± 0.038	7.258ArgLeu: 7.258 ± 0.063	1.841ArgMet: 1.841 ± 0.029	2.013ArgAsn: 2.013 ± 0.032	3.101ArgPro: 3.101 ± 0.044	2.617ArgGln: 2.617 ± 0.034	5.514ArgArg: 5.514 ± 0.057	3.711ArgSer: 3.711 ± 0.044	3.48ArgThr: 3.48 ± 0.04	5.251ArgVal: 5.251 ± 0.053	1.106ArgTrp: 1.106 ± 0.024	1.997ArgTyr: 1.997 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.081SerAla: 7.081 ± 0.067	0.513SerCys: 0.513 ± 0.016	2.807SerAsp: 2.807 ± 0.035	2.618SerGlu: 2.618 ± 0.04	2.239SerPhe: 2.239 ± 0.034	5.294SerGly: 5.294 ± 0.049	1.309SerHis: 1.309 ± 0.025	2.821SerIle: 2.821 ± 0.038	1.677SerLys: 1.677 ± 0.03	5.83SerLeu: 5.83 ± 0.061	1.439SerMet: 1.439 ± 0.026	1.779SerAsn: 1.779 ± 0.03	2.856SerPro: 2.856 ± 0.04	1.945SerGln: 1.945 ± 0.032	3.781SerArg: 3.781 ± 0.047	3.511SerSer: 3.511 ± 0.047	3.218SerThr: 3.218 ± 0.056	4.516SerVal: 4.516 ± 0.055	0.739SerTrp: 0.739 ± 0.021	1.325SerTyr: 1.325 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	6.037ThrAla: 6.037 ± 0.052	0.446ThrCys: 0.446 ± 0.014	2.673ThrAsp: 2.673 ± 0.039	2.364ThrGlu: 2.364 ± 0.035	1.974ThrPhe: 1.974 ± 0.031	4.702ThrGly: 4.702 ± 0.062	1.3ThrHis: 1.3 ± 0.025	2.636ThrIle: 2.636 ± 0.036	1.286ThrLys: 1.286 ± 0.026	6.522ThrLeu: 6.522 ± 0.064	1.205ThrMet: 1.205 ± 0.022	1.387ThrAsn: 1.387 ± 0.029	3.484ThrPro: 3.484 ± 0.044	2.036ThrGln: 2.036 ± 0.031	3.679ThrArg: 3.679 ± 0.04	3.015ThrSer: 3.015 ± 0.04	2.953ThrThr: 2.953 ± 0.042	4.361ThrVal: 4.361 ± 0.046	0.671ThrTrp: 0.671 ± 0.019	1.258ThrTyr: 1.258 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.486ValAla: 9.486 ± 0.071	0.843ValCys: 0.843 ± 0.021	4.277ValAsp: 4.277 ± 0.046	4.203ValGlu: 4.203 ± 0.048	2.889ValPhe: 2.889 ± 0.038	5.581ValGly: 5.581 ± 0.047	1.578ValHis: 1.578 ± 0.028	3.818ValIle: 3.818 ± 0.048	2.556ValLys: 2.556 ± 0.038	7.934ValLeu: 7.934 ± 0.077	1.863ValMet: 1.863 ± 0.031	2.215ValAsn: 2.215 ± 0.033	3.99ValPro: 3.99 ± 0.055	2.613ValGln: 2.613 ± 0.033	5.16ValArg: 5.16 ± 0.054	4.708ValSer: 4.708 ± 0.045	4.485ValThr: 4.485 ± 0.039	6.431ValVal: 6.431 ± 0.056	1.001ValTrp: 1.001 ± 0.022	1.694ValTyr: 1.694 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.169TrpAla: 1.169 ± 0.025	0.163TrpCys: 0.163 ± 0.009	0.63TrpAsp: 0.63 ± 0.019	0.53TrpGlu: 0.53 ± 0.015	0.552TrpPhe: 0.552 ± 0.016	0.856TrpGly: 0.856 ± 0.021	0.411TrpHis: 0.411 ± 0.013	0.718TrpIle: 0.718 ± 0.018	0.42TrpLys: 0.42 ± 0.014	1.945TrpLeu: 1.945 ± 0.034	0.374TrpMet: 0.374 ± 0.015	0.464TrpAsn: 0.464 ± 0.015	0.676TrpPro: 0.676 ± 0.019	0.684TrpGln: 0.684 ± 0.02	1.195TrpArg: 1.195 ± 0.029	0.788TrpSer: 0.788 ± 0.02	0.737TrpThr: 0.737 ± 0.017	0.941TrpVal: 0.941 ± 0.024	0.237TrpTrp: 0.237 ± 0.012	0.332TrpTyr: 0.332 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.767TyrAla: 2.767 ± 0.041	0.275TyrCys: 0.275 ± 0.011	1.345TyrAsp: 1.345 ± 0.025	1.221TyrGlu: 1.221 ± 0.023	1.014TyrPhe: 1.014 ± 0.024	2.058TyrGly: 2.058 ± 0.03	0.545TyrHis: 0.545 ± 0.018	0.898TyrIle: 0.898 ± 0.022	0.637TyrLys: 0.637 ± 0.017	2.555TyrLeu: 2.555 ± 0.034	0.45TyrMet: 0.45 ± 0.013	0.651TyrAsn: 0.651 ± 0.019	1.256TyrPro: 1.256 ± 0.026	0.9TyrGln: 0.9 ± 0.021	1.946TyrArg: 1.946 ± 0.031	1.329TyrSer: 1.329 ± 0.024	1.275TyrThr: 1.275 ± 0.026	1.893TyrVal: 1.893 ± 0.029	0.39TyrTrp: 0.39 ± 0.013	0.685TyrTyr: 0.685 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7265 proteins (2174488 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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