Amino acid dipepetide frequency for Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.376AlaAla: 20.376 ± 0.18	1.433AlaCys: 1.433 ± 0.039	6.868AlaAsp: 6.868 ± 0.073	7.16AlaGlu: 7.16 ± 0.087	3.96AlaPhe: 3.96 ± 0.056	11.381AlaGly: 11.381 ± 0.104	2.737AlaHis: 2.737 ± 0.045	4.954AlaIle: 4.954 ± 0.065	3.605AlaLys: 3.605 ± 0.066	16.124AlaLeu: 16.124 ± 0.158	3.291AlaMet: 3.291 ± 0.051	2.453AlaAsn: 2.453 ± 0.042	7.085AlaPro: 7.085 ± 0.09	5.438AlaGln: 5.438 ± 0.068	10.071AlaArg: 10.071 ± 0.121	6.689AlaSer: 6.689 ± 0.081	6.281AlaThr: 6.281 ± 0.063	9.713AlaVal: 9.713 ± 0.097	2.176AlaTrp: 2.176 ± 0.042	2.471AlaTyr: 2.471 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.245CysAla: 1.245 ± 0.032	0.161CysCys: 0.161 ± 0.01	0.55CysAsp: 0.55 ± 0.024	0.562CysGlu: 0.562 ± 0.023	0.318CysPhe: 0.318 ± 0.013	1.064CysGly: 1.064 ± 0.028	0.295CysHis: 0.295 ± 0.014	0.412CysIle: 0.412 ± 0.017	0.218CysLys: 0.218 ± 0.013	0.86CysLeu: 0.86 ± 0.025	0.184CysMet: 0.184 ± 0.012	0.23CysAsn: 0.23 ± 0.012	0.536CysPro: 0.536 ± 0.022	0.247CysGln: 0.247 ± 0.016	0.725CysArg: 0.725 ± 0.021	0.574CysSer: 0.574 ± 0.026	0.506CysThr: 0.506 ± 0.02	0.777CysVal: 0.777 ± 0.024	0.136CysTrp: 0.136 ± 0.01	0.192CysTyr: 0.192 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.866AspAla: 7.866 ± 0.097	0.474AspCys: 0.474 ± 0.019	3.052AspAsp: 3.052 ± 0.049	3.506AspGlu: 3.506 ± 0.052	1.96AspPhe: 1.96 ± 0.042	5.042AspGly: 5.042 ± 0.071	1.148AspHis: 1.148 ± 0.025	2.136AspIle: 2.136 ± 0.037	1.46AspLys: 1.46 ± 0.034	5.414AspLeu: 5.414 ± 0.079	1.031AspMet: 1.031 ± 0.034	0.991AspAsn: 0.991 ± 0.027	3.194AspPro: 3.194 ± 0.047	1.437AspGln: 1.437 ± 0.035	3.87AspArg: 3.87 ± 0.061	2.173AspSer: 2.173 ± 0.05	2.611AspThr: 2.611 ± 0.044	3.966AspVal: 3.966 ± 0.049	0.961AspTrp: 0.961 ± 0.024	1.313AspTyr: 1.313 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.437GluAla: 7.437 ± 0.087	0.414GluCys: 0.414 ± 0.02	2.189GluAsp: 2.189 ± 0.037	2.329GluGlu: 2.329 ± 0.038	1.786GluPhe: 1.786 ± 0.033	3.794GluGly: 3.794 ± 0.047	1.475GluHis: 1.475 ± 0.031	2.633GluIle: 2.633 ± 0.046	1.612GluLys: 1.612 ± 0.042	6.235GluLeu: 6.235 ± 0.075	1.15GluMet: 1.15 ± 0.03	1.072GluAsn: 1.072 ± 0.028	2.871GluPro: 2.871 ± 0.055	2.585GluGln: 2.585 ± 0.042	5.512GluArg: 5.512 ± 0.061	2.576GluSer: 2.576 ± 0.038	2.56GluThr: 2.56 ± 0.037	4.11GluVal: 4.11 ± 0.061	0.723GluTrp: 0.723 ± 0.028	0.937GluTyr: 0.937 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.051PheAla: 4.051 ± 0.062	0.357PheCys: 0.357 ± 0.016	2.534PheAsp: 2.534 ± 0.044	2.238PheGlu: 2.238 ± 0.04	1.296PhePhe: 1.296 ± 0.035	3.399PheGly: 3.399 ± 0.048	0.717PheHis: 0.717 ± 0.026	1.336PheIle: 1.336 ± 0.035	1.076PheLys: 1.076 ± 0.028	2.755PheLeu: 2.755 ± 0.046	0.704PheMet: 0.704 ± 0.023	0.937PheAsn: 0.937 ± 0.026	1.465PhePro: 1.465 ± 0.035	0.944PheGln: 0.944 ± 0.025	1.969PheArg: 1.969 ± 0.029	1.911PheSer: 1.911 ± 0.038	1.772PheThr: 1.772 ± 0.032	2.791PheVal: 2.791 ± 0.05	0.487PheTrp: 0.487 ± 0.019	0.78PheTyr: 0.78 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.875GlyAla: 9.875 ± 0.081	0.972GlyCys: 0.972 ± 0.025	4.306GlyAsp: 4.306 ± 0.053	4.651GlyGlu: 4.651 ± 0.057	3.188GlyPhe: 3.188 ± 0.058	7.284GlyGly: 7.284 ± 0.101	1.991GlyHis: 1.991 ± 0.03	3.529GlyIle: 3.529 ± 0.052	2.871GlyLys: 2.871 ± 0.059	9.282GlyLeu: 9.282 ± 0.095	1.975GlyMet: 1.975 ± 0.043	1.884GlyAsn: 1.884 ± 0.041	3.488GlyPro: 3.488 ± 0.047	3.083GlyGln: 3.083 ± 0.054	6.483GlyArg: 6.483 ± 0.065	4.779GlySer: 4.779 ± 0.062	4.304GlyThr: 4.304 ± 0.069	6.696GlyVal: 6.696 ± 0.057	1.528GlyTrp: 1.528 ± 0.035	2.234GlyTyr: 2.234 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	3.086HisAla: 3.086 ± 0.058	0.303HisCys: 0.303 ± 0.018	1.256HisAsp: 1.256 ± 0.033	1.258HisGlu: 1.258 ± 0.031	0.855HisPhe: 0.855 ± 0.028	2.321HisGly: 2.321 ± 0.047	0.702HisHis: 0.702 ± 0.029	0.753HisIle: 0.753 ± 0.025	0.507HisLys: 0.507 ± 0.021	2.304HisLeu: 2.304 ± 0.045	0.412HisMet: 0.412 ± 0.015	0.46HisAsn: 0.46 ± 0.02	1.533HisPro: 1.533 ± 0.037	0.687HisGln: 0.687 ± 0.021	1.809HisArg: 1.809 ± 0.036	0.952HisSer: 0.952 ± 0.027	0.991HisThr: 0.991 ± 0.027	1.611HisVal: 1.611 ± 0.036	0.408HisTrp: 0.408 ± 0.02	0.623HisTyr: 0.623 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.759IleAla: 5.759 ± 0.064	0.349IleCys: 0.349 ± 0.015	3.173IleAsp: 3.173 ± 0.048	3.211IleGlu: 3.211 ± 0.046	1.065IlePhe: 1.065 ± 0.029	4.05IleGly: 4.05 ± 0.066	0.738IleHis: 0.738 ± 0.021	1.117IleIle: 1.117 ± 0.035	1.227IleLys: 1.227 ± 0.033	2.715IleLeu: 2.715 ± 0.043	0.595IleMet: 0.595 ± 0.023	1.125IleAsn: 1.125 ± 0.033	1.787IlePro: 1.787 ± 0.037	1.097IleGln: 1.097 ± 0.029	2.428IleArg: 2.428 ± 0.047	1.987IleSer: 1.987 ± 0.046	2.127IleThr: 2.127 ± 0.046	3.409IleVal: 3.409 ± 0.052	0.394IleTrp: 0.394 ± 0.015	0.825IleTyr: 0.825 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.789LysAla: 3.789 ± 0.074	0.186LysCys: 0.186 ± 0.013	1.511LysAsp: 1.511 ± 0.038	1.346LysGlu: 1.346 ± 0.03	0.832LysPhe: 0.832 ± 0.03	2.134LysGly: 2.134 ± 0.04	0.637LysHis: 0.637 ± 0.018	1.242LysIle: 1.242 ± 0.035	1.211LysLys: 1.211 ± 0.041	3.317LysLeu: 3.317 ± 0.054	0.679LysMet: 0.679 ± 0.023	0.777LysAsn: 0.777 ± 0.031	1.878LysPro: 1.878 ± 0.039	1.146LysGln: 1.146 ± 0.031	2.212LysArg: 2.212 ± 0.043	1.583LysSer: 1.583 ± 0.039	1.738LysThr: 1.738 ± 0.036	2.177LysVal: 2.177 ± 0.059	0.34LysTrp: 0.34 ± 0.019	0.577LysTyr: 0.577 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.639LeuAla: 15.639 ± 0.14	1.052LeuCys: 1.052 ± 0.026	6.149LeuAsp: 6.149 ± 0.068	5.315LeuGlu: 5.315 ± 0.067	3.334LeuPhe: 3.334 ± 0.059	8.819LeuGly: 8.819 ± 0.084	2.483LeuHis: 2.483 ± 0.052	4.002LeuIle: 4.002 ± 0.049	3.449LeuLys: 3.449 ± 0.052	11.904LeuLeu: 11.904 ± 0.136	2.373LeuMet: 2.373 ± 0.059	2.484LeuAsn: 2.484 ± 0.052	6.528LeuPro: 6.528 ± 0.069	4.351LeuGln: 4.351 ± 0.059	8.76LeuArg: 8.76 ± 0.093	6.053LeuSer: 6.053 ± 0.069	5.312LeuThr: 5.312 ± 0.061	8.052LeuVal: 8.052 ± 0.087	1.434LeuTrp: 1.434 ± 0.036	2.01LeuTyr: 2.01 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.726MetAla: 2.726 ± 0.051	0.176MetCys: 0.176 ± 0.009	0.978MetAsp: 0.978 ± 0.024	0.921MetGlu: 0.921 ± 0.029	0.644MetPhe: 0.644 ± 0.021	1.556MetGly: 1.556 ± 0.034	0.497MetHis: 0.497 ± 0.016	0.861MetIle: 0.861 ± 0.026	0.966MetLys: 0.966 ± 0.027	2.487MetLeu: 2.487 ± 0.052	0.464MetMet: 0.464 ± 0.017	0.765MetAsn: 0.765 ± 0.025	1.373MetPro: 1.373 ± 0.028	0.903MetGln: 0.903 ± 0.026	1.636MetArg: 1.636 ± 0.03	1.672MetSer: 1.672 ± 0.037	1.407MetThr: 1.407 ± 0.036	1.46MetVal: 1.46 ± 0.029	0.185MetTrp: 0.185 ± 0.01	0.321MetTyr: 0.321 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.936AsnAla: 2.936 ± 0.046	0.259AsnCys: 0.259 ± 0.017	1.253AsnAsp: 1.253 ± 0.033	1.155AsnGlu: 1.155 ± 0.032	0.814AsnPhe: 0.814 ± 0.027	1.892AsnGly: 1.892 ± 0.043	0.437AsnHis: 0.437 ± 0.018	0.861AsnIle: 0.861 ± 0.025	0.659AsnLys: 0.659 ± 0.02	2.334AsnLeu: 2.334 ± 0.041	0.442AsnMet: 0.442 ± 0.02	0.609AsnAsn: 0.609 ± 0.025	1.602AsnPro: 1.602 ± 0.038	0.73AsnGln: 0.73 ± 0.027	1.585AsnArg: 1.585 ± 0.035	1.003AsnSer: 1.003 ± 0.026	1.188AsnThr: 1.188 ± 0.032	1.736AsnVal: 1.736 ± 0.05	0.373AsnTrp: 0.373 ± 0.017	0.568AsnTyr: 0.568 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	8.0ProAla: 8.0 ± 0.099	0.435ProCys: 0.435 ± 0.017	3.161ProAsp: 3.161 ± 0.052	3.248ProGlu: 3.248 ± 0.048	1.726ProPhe: 1.726 ± 0.031	5.009ProGly: 5.009 ± 0.067	1.088ProHis: 1.088 ± 0.026	1.818ProIle: 1.818 ± 0.036	1.533ProLys: 1.533 ± 0.031	5.582ProLeu: 5.582 ± 0.075	1.253ProMet: 1.253 ± 0.04	1.221ProAsn: 1.221 ± 0.035	3.229ProPro: 3.229 ± 0.07	2.11ProGln: 2.11 ± 0.038	3.623ProArg: 3.623 ± 0.061	2.988ProSer: 2.988 ± 0.046	2.819ProThr: 2.819 ± 0.046	4.413ProVal: 4.413 ± 0.055	0.835ProTrp: 0.835 ± 0.029	1.074ProTyr: 1.074 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.437GlnAla: 5.437 ± 0.079	0.315GlnCys: 0.315 ± 0.016	1.421GlnAsp: 1.421 ± 0.036	1.411GlnGlu: 1.411 ± 0.031	1.164GlnPhe: 1.164 ± 0.027	2.884GlnGly: 2.884 ± 0.041	0.937GlnHis: 0.937 ± 0.028	1.609GlnIle: 1.609 ± 0.04	0.919GlnLys: 0.919 ± 0.033	4.179GlnLeu: 4.179 ± 0.059	0.826GlnMet: 0.826 ± 0.018	0.633GlnAsn: 0.633 ± 0.022	2.202GlnPro: 2.202 ± 0.049	1.775GlnGln: 1.775 ± 0.042	3.837GlnArg: 3.837 ± 0.058	1.725GlnSer: 1.725 ± 0.043	1.717GlnThr: 1.717 ± 0.038	2.978GlnVal: 2.978 ± 0.049	0.59GlnTrp: 0.59 ± 0.023	0.658GlnTyr: 0.658 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.257ArgAla: 9.257 ± 0.106	0.776ArgCys: 0.776 ± 0.025	4.074ArgAsp: 4.074 ± 0.062	4.6ArgGlu: 4.6 ± 0.074	2.858ArgPhe: 2.858 ± 0.044	5.556ArgGly: 5.556 ± 0.077	2.177ArgHis: 2.177 ± 0.044	3.33ArgIle: 3.33 ± 0.048	2.004ArgLys: 2.004 ± 0.038	8.912ArgLeu: 8.912 ± 0.096	1.818ArgMet: 1.818 ± 0.037	1.717ArgAsn: 1.717 ± 0.037	4.014ArgPro: 4.014 ± 0.061	2.93ArgGln: 2.93 ± 0.049	6.622ArgArg: 6.622 ± 0.089	4.168ArgSer: 4.168 ± 0.05	3.406ArgThr: 3.406 ± 0.05	5.637ArgVal: 5.637 ± 0.058	1.417ArgTrp: 1.417 ± 0.037	1.951ArgTyr: 1.951 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.575SerAla: 6.575 ± 0.061	0.504SerCys: 0.504 ± 0.021	2.604SerAsp: 2.604 ± 0.052	2.57SerGlu: 2.57 ± 0.049	2.135SerPhe: 2.135 ± 0.047	5.043SerGly: 5.043 ± 0.074	1.115SerHis: 1.115 ± 0.023	2.181SerIle: 2.181 ± 0.04	1.449SerLys: 1.449 ± 0.03	5.655SerLeu: 5.655 ± 0.069	1.256SerMet: 1.256 ± 0.031	1.214SerAsn: 1.214 ± 0.028	2.874SerPro: 2.874 ± 0.045	1.719SerGln: 1.719 ± 0.036	3.763SerArg: 3.763 ± 0.054	2.952SerSer: 2.952 ± 0.056	2.843SerThr: 2.843 ± 0.051	4.067SerVal: 4.067 ± 0.05	0.731SerTrp: 0.731 ± 0.019	1.181SerTyr: 1.181 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.209ThrAla: 6.209 ± 0.074	0.438ThrCys: 0.438 ± 0.022	2.462ThrAsp: 2.462 ± 0.041	2.466ThrGlu: 2.466 ± 0.038	1.428ThrPhe: 1.428 ± 0.042	4.477ThrGly: 4.477 ± 0.062	1.161ThrHis: 1.161 ± 0.028	1.803ThrIle: 1.803 ± 0.037	1.164ThrLys: 1.164 ± 0.038	6.394ThrLeu: 6.394 ± 0.073	1.047ThrMet: 1.047 ± 0.025	1.094ThrAsn: 1.094 ± 0.033	3.604ThrPro: 3.604 ± 0.053	1.778ThrGln: 1.778 ± 0.033	3.475ThrArg: 3.475 ± 0.044	2.424ThrSer: 2.424 ± 0.056	2.674ThrThr: 2.674 ± 0.044	4.202ThrVal: 4.202 ± 0.07	0.734ThrTrp: 0.734 ± 0.022	0.998ThrTyr: 0.998 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.926ValAla: 9.926 ± 0.08	0.762ValCys: 0.762 ± 0.024	4.311ValAsp: 4.311 ± 0.059	4.304ValGlu: 4.304 ± 0.062	2.754ValPhe: 2.754 ± 0.051	5.812ValGly: 5.812 ± 0.066	1.662ValHis: 1.662 ± 0.043	3.242ValIle: 3.242 ± 0.048	2.354ValLys: 2.354 ± 0.051	8.61ValLeu: 8.61 ± 0.106	1.732ValMet: 1.732 ± 0.034	1.867ValAsn: 1.867 ± 0.038	4.077ValPro: 4.077 ± 0.058	2.751ValGln: 2.751 ± 0.043	5.589ValArg: 5.589 ± 0.072	4.226ValSer: 4.226 ± 0.046	3.906ValThr: 3.906 ± 0.056	6.384ValVal: 6.384 ± 0.077	1.064ValTrp: 1.064 ± 0.034	1.514ValTyr: 1.514 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.507TrpAla: 1.507 ± 0.038	0.192TrpCys: 0.192 ± 0.011	0.624TrpAsp: 0.624 ± 0.024	0.587TrpGlu: 0.587 ± 0.021	0.547TrpPhe: 0.547 ± 0.02	0.925TrpGly: 0.925 ± 0.025	0.416TrpHis: 0.416 ± 0.015	0.665TrpIle: 0.665 ± 0.025	0.449TrpLys: 0.449 ± 0.021	2.194TrpLeu: 2.194 ± 0.049	0.405TrpMet: 0.405 ± 0.018	0.375TrpAsn: 0.375 ± 0.013	0.789TrpPro: 0.789 ± 0.026	0.743TrpGln: 0.743 ± 0.02	1.413TrpArg: 1.413 ± 0.035	0.877TrpSer: 0.877 ± 0.021	0.743TrpThr: 0.743 ± 0.028	1.079TrpVal: 1.079 ± 0.029	0.312TrpTrp: 0.312 ± 0.018	0.332TrpTyr: 0.332 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.57TyrAla: 2.57 ± 0.047	0.237TyrCys: 0.237 ± 0.015	1.127TyrAsp: 1.127 ± 0.029	1.163TyrGlu: 1.163 ± 0.026	0.856TyrPhe: 0.856 ± 0.029	1.958TyrGly: 1.958 ± 0.04	0.418TyrHis: 0.418 ± 0.017	0.694TyrIle: 0.694 ± 0.024	0.579TyrLys: 0.579 ± 0.025	2.247TyrLeu: 2.247 ± 0.046	0.359TyrMet: 0.359 ± 0.015	0.53TyrAsn: 0.53 ± 0.019	1.036TyrPro: 1.036 ± 0.028	0.765TyrGln: 0.765 ± 0.022	1.844TyrArg: 1.844 ± 0.042	1.116TyrSer: 1.116 ± 0.033	1.126TyrThr: 1.126 ± 0.028	1.588TyrVal: 1.588 ± 0.036	0.346TyrTrp: 0.346 ± 0.016	0.516TyrTyr: 0.516 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4359 proteins (1382589 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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