Amino acid dipepetide frequency for Oricola thermophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.497AlaAla: 16.497 ± 0.173	1.073AlaCys: 1.073 ± 0.034	7.02AlaAsp: 7.02 ± 0.083	8.244AlaGlu: 8.244 ± 0.098	4.657AlaPhe: 4.657 ± 0.065	11.211AlaGly: 11.211 ± 0.122	2.094AlaHis: 2.094 ± 0.042	6.995AlaIle: 6.995 ± 0.081	3.74AlaLys: 3.74 ± 0.064	12.419AlaLeu: 12.419 ± 0.136	3.768AlaMet: 3.768 ± 0.055	2.993AlaAsn: 2.993 ± 0.049	5.028AlaPro: 5.028 ± 0.069	3.077AlaGln: 3.077 ± 0.053	8.926AlaArg: 8.926 ± 0.108	5.99AlaSer: 5.99 ± 0.075	5.685AlaThr: 5.685 ± 0.071	9.206AlaVal: 9.206 ± 0.099	1.501AlaTrp: 1.501 ± 0.04	2.45AlaTyr: 2.45 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.971CysAla: 0.971 ± 0.032	0.096CysCys: 0.096 ± 0.01	0.568CysAsp: 0.568 ± 0.023	0.494CysGlu: 0.494 ± 0.019	0.324CysPhe: 0.324 ± 0.018	0.957CysGly: 0.957 ± 0.027	0.277CysHis: 0.277 ± 0.017	0.419CysIle: 0.419 ± 0.018	0.169CysLys: 0.169 ± 0.012	0.735CysLeu: 0.735 ± 0.026	0.171CysMet: 0.171 ± 0.011	0.222CysAsn: 0.222 ± 0.014	0.435CysPro: 0.435 ± 0.021	0.201CysGln: 0.201 ± 0.014	0.644CysArg: 0.644 ± 0.022	0.451CysSer: 0.451 ± 0.021	0.416CysThr: 0.416 ± 0.021	0.59CysVal: 0.59 ± 0.021	0.118CysTrp: 0.118 ± 0.009	0.192CysTyr: 0.192 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.015AspAla: 7.015 ± 0.089	0.538AspCys: 0.538 ± 0.021	3.489AspAsp: 3.489 ± 0.07	4.023AspGlu: 4.023 ± 0.061	2.345AspPhe: 2.345 ± 0.046	5.708AspGly: 5.708 ± 0.102	1.323AspHis: 1.323 ± 0.031	3.605AspIle: 3.605 ± 0.062	1.622AspLys: 1.622 ± 0.04	5.49AspLeu: 5.49 ± 0.068	1.614AspMet: 1.614 ± 0.04	1.443AspAsn: 1.443 ± 0.039	3.486AspPro: 3.486 ± 0.063	1.323AspGln: 1.323 ± 0.033	4.681AspArg: 4.681 ± 0.07	2.29AspSer: 2.29 ± 0.044	2.788AspThr: 2.788 ± 0.055	4.058AspVal: 4.058 ± 0.057	0.997AspTrp: 0.997 ± 0.027	1.522AspTyr: 1.522 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.052GluAla: 8.052 ± 0.088	0.447GluCys: 0.447 ± 0.018	3.301GluAsp: 3.301 ± 0.054	4.203GluGlu: 4.203 ± 0.069	2.13GluPhe: 2.13 ± 0.041	4.679GluGly: 4.679 ± 0.062	1.247GluHis: 1.247 ± 0.031	4.205GluIle: 4.205 ± 0.069	2.736GluLys: 2.736 ± 0.044	5.633GluLeu: 5.633 ± 0.065	1.835GluMet: 1.835 ± 0.035	2.017GluAsn: 2.017 ± 0.047	2.984GluPro: 2.984 ± 0.054	2.085GluGln: 2.085 ± 0.047	5.378GluArg: 5.378 ± 0.077	2.712GluSer: 2.712 ± 0.051	4.171GluThr: 4.171 ± 0.064	3.988GluVal: 3.988 ± 0.061	0.789GluTrp: 0.789 ± 0.025	1.233GluTyr: 1.233 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.792PheAla: 4.792 ± 0.07	0.4PheCys: 0.4 ± 0.02	2.823PheAsp: 2.823 ± 0.05	2.379PheGlu: 2.379 ± 0.043	1.556PhePhe: 1.556 ± 0.037	3.844PheGly: 3.844 ± 0.057	0.791PheHis: 0.791 ± 0.025	1.781PheIle: 1.781 ± 0.041	0.894PheLys: 0.894 ± 0.028	3.697PheLeu: 3.697 ± 0.066	0.95PheMet: 0.95 ± 0.027	1.079PheAsn: 1.079 ± 0.029	1.732PhePro: 1.732 ± 0.04	0.9PheGln: 0.9 ± 0.029	2.615PheArg: 2.615 ± 0.049	2.29PheSer: 2.29 ± 0.05	1.926PheThr: 1.926 ± 0.046	2.963PheVal: 2.963 ± 0.055	0.538PheTrp: 0.538 ± 0.02	0.915PheTyr: 0.915 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.085GlyAla: 9.085 ± 0.104	0.826GlyCys: 0.826 ± 0.026	4.745GlyAsp: 4.745 ± 0.076	5.513GlyGlu: 5.513 ± 0.068	3.749GlyPhe: 3.749 ± 0.058	7.51GlyGly: 7.51 ± 0.102	1.996GlyHis: 1.996 ± 0.042	5.35GlyIle: 5.35 ± 0.07	3.286GlyLys: 3.286 ± 0.064	8.426GlyLeu: 8.426 ± 0.098	2.605GlyMet: 2.605 ± 0.055	2.393GlyAsn: 2.393 ± 0.047	3.418GlyPro: 3.418 ± 0.06	2.43GlyGln: 2.43 ± 0.042	6.305GlyArg: 6.305 ± 0.08	4.627GlySer: 4.627 ± 0.077	4.867GlyThr: 4.867 ± 0.072	6.097GlyVal: 6.097 ± 0.073	1.292GlyTrp: 1.292 ± 0.033	2.384GlyTyr: 2.384 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.296HisAla: 2.296 ± 0.049	0.245HisCys: 0.245 ± 0.016	1.287HisAsp: 1.287 ± 0.036	1.222HisGlu: 1.222 ± 0.032	0.916HisPhe: 0.916 ± 0.031	1.946HisGly: 1.946 ± 0.048	0.531HisHis: 0.531 ± 0.028	0.929HisIle: 0.929 ± 0.029	0.464HisLys: 0.464 ± 0.02	1.815HisLeu: 1.815 ± 0.045	0.499HisMet: 0.499 ± 0.02	0.473HisAsn: 0.473 ± 0.019	1.285HisPro: 1.285 ± 0.039	0.457HisGln: 0.457 ± 0.017	1.373HisArg: 1.373 ± 0.037	0.947HisSer: 0.947 ± 0.032	0.755HisThr: 0.755 ± 0.025	1.71HisVal: 1.71 ± 0.042	0.275HisTrp: 0.275 ± 0.017	0.54HisTyr: 0.54 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.92IleAla: 7.92 ± 0.092	0.548IleCys: 0.548 ± 0.022	3.861IleAsp: 3.861 ± 0.06	3.929IleGlu: 3.929 ± 0.064	1.864IlePhe: 1.864 ± 0.039	5.19IleGly: 5.19 ± 0.077	0.979IleHis: 0.979 ± 0.026	2.436IleIle: 2.436 ± 0.05	1.275IleLys: 1.275 ± 0.037	4.843IleLeu: 4.843 ± 0.08	1.11IleMet: 1.11 ± 0.029	1.458IleAsn: 1.458 ± 0.039	2.499IlePro: 2.499 ± 0.053	1.097IleGln: 1.097 ± 0.029	3.814IleArg: 3.814 ± 0.064	3.096IleSer: 3.096 ± 0.058	2.571IleThr: 2.571 ± 0.049	4.842IleVal: 4.842 ± 0.063	0.585IleTrp: 0.585 ± 0.023	1.141IleTyr: 1.141 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.19LysAla: 4.19 ± 0.071	0.186LysCys: 0.186 ± 0.012	1.592LysAsp: 1.592 ± 0.041	1.719LysGlu: 1.719 ± 0.048	0.892LysPhe: 0.892 ± 0.028	2.579LysGly: 2.579 ± 0.053	0.592LysHis: 0.592 ± 0.022	1.684LysIle: 1.684 ± 0.043	1.345LysLys: 1.345 ± 0.048	3.054LysLeu: 3.054 ± 0.057	0.809LysMet: 0.809 ± 0.031	0.85LysAsn: 0.85 ± 0.03	2.077LysPro: 2.077 ± 0.047	0.869LysGln: 0.869 ± 0.033	2.622LysArg: 2.622 ± 0.049	1.797LysSer: 1.797 ± 0.046	1.88LysThr: 1.88 ± 0.044	2.358LysVal: 2.358 ± 0.046	0.378LysTrp: 0.378 ± 0.02	0.675LysTyr: 0.675 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.078LeuAla: 13.078 ± 0.13	0.783LeuCys: 0.783 ± 0.025	5.922LeuAsp: 5.922 ± 0.072	5.715LeuGlu: 5.715 ± 0.068	3.797LeuPhe: 3.797 ± 0.067	7.87LeuGly: 7.87 ± 0.099	1.7LeuHis: 1.7 ± 0.043	4.481LeuIle: 4.481 ± 0.075	3.378LeuLys: 3.378 ± 0.063	8.505LeuLeu: 8.505 ± 0.109	2.236LeuMet: 2.236 ± 0.045	2.402LeuAsn: 2.402 ± 0.046	5.175LeuPro: 5.175 ± 0.08	2.414LeuGln: 2.414 ± 0.048	6.412LeuArg: 6.412 ± 0.075	6.035LeuSer: 6.035 ± 0.085	4.916LeuThr: 4.916 ± 0.074	7.646LeuVal: 7.646 ± 0.092	0.979LeuTrp: 0.979 ± 0.03	1.946LeuTyr: 1.946 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.404MetAla: 3.404 ± 0.055	0.172MetCys: 0.172 ± 0.012	1.271MetAsp: 1.271 ± 0.032	1.412MetGlu: 1.412 ± 0.031	0.828MetPhe: 0.828 ± 0.025	1.873MetGly: 1.873 ± 0.045	0.482MetHis: 0.482 ± 0.023	1.547MetIle: 1.547 ± 0.038	1.131MetLys: 1.131 ± 0.03	2.56MetLeu: 2.56 ± 0.046	0.668MetMet: 0.668 ± 0.026	0.888MetAsn: 0.888 ± 0.026	1.567MetPro: 1.567 ± 0.034	0.875MetGln: 0.875 ± 0.027	1.99MetArg: 1.99 ± 0.039	1.66MetSer: 1.66 ± 0.044	1.976MetThr: 1.976 ± 0.038	1.852MetVal: 1.852 ± 0.041	0.217MetTrp: 0.217 ± 0.016	0.316MetTyr: 0.316 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.312AsnAla: 3.312 ± 0.059	0.242AsnCys: 0.242 ± 0.014	1.495AsnAsp: 1.495 ± 0.044	1.447AsnGlu: 1.447 ± 0.037	0.932AsnPhe: 0.932 ± 0.028	2.561AsnGly: 2.561 ± 0.054	0.513AsnHis: 0.513 ± 0.019	1.468AsnIle: 1.468 ± 0.039	0.712AsnLys: 0.712 ± 0.031	2.419AsnLeu: 2.419 ± 0.046	0.673AsnMet: 0.673 ± 0.025	0.68AsnAsn: 0.68 ± 0.026	1.825AsnPro: 1.825 ± 0.041	0.673AsnGln: 0.673 ± 0.021	2.049AsnArg: 2.049 ± 0.042	1.293AsnSer: 1.293 ± 0.039	1.277AsnThr: 1.277 ± 0.031	2.04AsnVal: 2.04 ± 0.043	0.431AsnTrp: 0.431 ± 0.02	0.701AsnTyr: 0.701 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.905ProAla: 5.905 ± 0.081	0.318ProCys: 0.318 ± 0.017	3.969ProAsp: 3.969 ± 0.063	4.132ProGlu: 4.132 ± 0.064	1.997ProPhe: 1.997 ± 0.042	4.536ProGly: 4.536 ± 0.058	0.992ProHis: 0.992 ± 0.03	2.082ProIle: 2.082 ± 0.043	1.55ProLys: 1.55 ± 0.038	4.395ProLeu: 4.395 ± 0.065	1.126ProMet: 1.126 ± 0.028	1.263ProAsn: 1.263 ± 0.035	2.225ProPro: 2.225 ± 0.059	1.442ProGln: 1.442 ± 0.038	2.849ProArg: 2.849 ± 0.051	2.513ProSer: 2.513 ± 0.047	2.098ProThr: 2.098 ± 0.046	4.65ProVal: 4.65 ± 0.064	0.673ProTrp: 0.673 ± 0.025	1.076ProTyr: 1.076 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.408GlnAla: 3.408 ± 0.059	0.169GlnCys: 0.169 ± 0.011	1.309GlnAsp: 1.309 ± 0.031	1.46GlnGlu: 1.46 ± 0.036	1.044GlnPhe: 1.044 ± 0.033	1.929GlnGly: 1.929 ± 0.04	0.482GlnHis: 0.482 ± 0.019	1.652GlnIle: 1.652 ± 0.036	0.967GlnLys: 0.967 ± 0.03	2.346GlnLeu: 2.346 ± 0.044	0.834GlnMet: 0.834 ± 0.027	0.754GlnAsn: 0.754 ± 0.023	1.38GlnPro: 1.38 ± 0.038	0.907GlnGln: 0.907 ± 0.031	1.956GlnArg: 1.956 ± 0.046	1.522GlnSer: 1.522 ± 0.038	1.437GlnThr: 1.437 ± 0.034	2.024GlnVal: 2.024 ± 0.037	0.311GlnTrp: 0.311 ± 0.015	0.562GlnTyr: 0.562 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.885ArgAla: 7.885 ± 0.111	0.498ArgCys: 0.498 ± 0.024	4.427ArgAsp: 4.427 ± 0.061	4.974ArgGlu: 4.974 ± 0.08	3.057ArgPhe: 3.057 ± 0.055	4.774ArgGly: 4.774 ± 0.076	1.797ArgHis: 1.797 ± 0.043	4.528ArgIle: 4.528 ± 0.061	2.729ArgLys: 2.729 ± 0.052	7.59ArgLeu: 7.59 ± 0.092	2.16ArgMet: 2.16 ± 0.039	2.093ArgAsn: 2.093 ± 0.041	3.475ArgPro: 3.475 ± 0.059	2.283ArgGln: 2.283 ± 0.044	5.957ArgArg: 5.957 ± 0.081	3.605ArgSer: 3.605 ± 0.057	3.491ArgThr: 3.491 ± 0.054	4.671ArgVal: 4.671 ± 0.061	0.845ArgTrp: 0.845 ± 0.026	1.705ArgTyr: 1.705 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.008SerAla: 6.008 ± 0.077	0.408SerCys: 0.408 ± 0.02	3.036SerAsp: 3.036 ± 0.05	3.059SerGlu: 3.059 ± 0.049	2.2SerPhe: 2.2 ± 0.046	5.898SerGly: 5.898 ± 0.089	1.021SerHis: 1.021 ± 0.032	2.762SerIle: 2.762 ± 0.057	1.522SerLys: 1.522 ± 0.041	5.09SerLeu: 5.09 ± 0.068	1.44SerMet: 1.44 ± 0.035	1.37SerAsn: 1.37 ± 0.034	2.551SerPro: 2.551 ± 0.045	1.343SerGln: 1.343 ± 0.038	3.74SerArg: 3.74 ± 0.066	2.688SerSer: 2.688 ± 0.055	2.479SerThr: 2.479 ± 0.045	4.153SerVal: 4.153 ± 0.069	0.685SerTrp: 0.685 ± 0.025	1.254SerTyr: 1.254 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.02ThrAla: 6.02 ± 0.088	0.432ThrCys: 0.432 ± 0.021	2.887ThrAsp: 2.887 ± 0.055	2.991ThrGlu: 2.991 ± 0.053	1.943ThrPhe: 1.943 ± 0.035	5.477ThrGly: 5.477 ± 0.07	0.931ThrHis: 0.931 ± 0.031	3.081ThrIle: 3.081 ± 0.056	1.276ThrLys: 1.276 ± 0.038	5.238ThrLeu: 5.238 ± 0.061	1.293ThrMet: 1.293 ± 0.03	1.258ThrAsn: 1.258 ± 0.034	2.971ThrPro: 2.971 ± 0.053	1.165ThrGln: 1.165 ± 0.033	3.283ThrArg: 3.283 ± 0.063	2.565ThrSer: 2.565 ± 0.05	2.572ThrThr: 2.572 ± 0.046	4.691ThrVal: 4.691 ± 0.073	0.626ThrTrp: 0.626 ± 0.024	1.094ThrTyr: 1.094 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.316ValAla: 9.316 ± 0.099	0.69ValCys: 0.69 ± 0.022	4.267ValAsp: 4.267 ± 0.058	4.915ValGlu: 4.915 ± 0.066	3.171ValPhe: 3.171 ± 0.059	5.435ValGly: 5.435 ± 0.078	1.423ValHis: 1.423 ± 0.039	4.432ValIle: 4.432 ± 0.058	2.265ValLys: 2.265 ± 0.051	7.446ValLeu: 7.446 ± 0.096	2.01ValMet: 2.01 ± 0.045	2.065ValAsn: 2.065 ± 0.045	3.89ValPro: 3.89 ± 0.057	1.806ValGln: 1.806 ± 0.036	5.076ValArg: 5.076 ± 0.062	4.611ValSer: 4.611 ± 0.075	4.661ValThr: 4.661 ± 0.068	6.013ValVal: 6.013 ± 0.084	0.885ValTrp: 0.885 ± 0.027	1.569ValTyr: 1.569 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.144TrpAla: 1.144 ± 0.035	0.116TrpCys: 0.116 ± 0.009	0.626TrpAsp: 0.626 ± 0.024	0.576TrpGlu: 0.576 ± 0.021	0.561TrpPhe: 0.561 ± 0.023	0.801TrpGly: 0.801 ± 0.026	0.3TrpHis: 0.3 ± 0.017	0.69TrpIle: 0.69 ± 0.026	0.534TrpLys: 0.534 ± 0.023	1.473TrpLeu: 1.473 ± 0.043	0.4TrpMet: 0.4 ± 0.017	0.444TrpAsn: 0.444 ± 0.018	0.704TrpPro: 0.704 ± 0.024	0.506TrpGln: 0.506 ± 0.023	1.091TrpArg: 1.091 ± 0.039	0.779TrpSer: 0.779 ± 0.025	0.725TrpThr: 0.725 ± 0.027	0.707TrpVal: 0.707 ± 0.025	0.213TrpTrp: 0.213 ± 0.014	0.282TrpTyr: 0.282 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.046	0.265TyrCys: 0.265 ± 0.014	1.466TyrAsp: 1.466 ± 0.037	1.418TyrGlu: 1.418 ± 0.036	0.904TyrPhe: 0.904 ± 0.023	2.126TyrGly: 2.126 ± 0.043	0.493TyrHis: 0.493 ± 0.019	0.931TyrIle: 0.931 ± 0.032	0.554TyrLys: 0.554 ± 0.021	2.215TyrLeu: 2.215 ± 0.045	0.49TyrMet: 0.49 ± 0.021	0.596TyrAsn: 0.596 ± 0.023	1.084TyrPro: 1.084 ± 0.032	0.602TyrGln: 0.602 ± 0.023	1.785TyrArg: 1.785 ± 0.037	1.237TyrSer: 1.237 ± 0.033	1.1TyrThr: 1.1 ± 0.03	1.688TyrVal: 1.688 ± 0.038	0.331TyrTrp: 0.331 ± 0.016	0.553TyrTyr: 0.553 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3798 proteins (1200695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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