Amino acid dipepetide frequency for Hylemonella gracilis ATCC 19624

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.257AlaAla: 17.257 ± 0.181
1.184AlaCys: 1.184 ± 0.038
6.087AlaAsp: 6.087 ± 0.079
6.738AlaGlu: 6.738 ± 0.084
3.773AlaPhe: 3.773 ± 0.067
10.228AlaGly: 10.228 ± 0.109
2.728AlaHis: 2.728 ± 0.056
4.956AlaIle: 4.956 ± 0.066
3.854AlaLys: 3.854 ± 0.072
15.857AlaLeu: 15.857 ± 0.137
3.304AlaMet: 3.304 ± 0.055
2.669AlaAsn: 2.669 ± 0.058
6.113AlaPro: 6.113 ± 0.099
6.859AlaGln: 6.859 ± 0.087
9.701AlaArg: 9.701 ± 0.122
6.964AlaSer: 6.964 ± 0.085
5.808AlaThr: 5.808 ± 0.078
8.937AlaVal: 8.937 ± 0.099
2.128AlaTrp: 2.128 ± 0.053
2.516AlaTyr: 2.516 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.109CysAla: 1.109 ± 0.031
0.095CysCys: 0.095 ± 0.01
0.44CysAsp: 0.44 ± 0.02
0.436CysGlu: 0.436 ± 0.02
0.281CysPhe: 0.281 ± 0.016
0.89CysGly: 0.89 ± 0.03
0.221CysHis: 0.221 ± 0.016
0.392CysIle: 0.392 ± 0.019
0.194CysLys: 0.194 ± 0.014
0.81CysLeu: 0.81 ± 0.028
0.166CysMet: 0.166 ± 0.013
0.202CysAsn: 0.202 ± 0.014
0.441CysPro: 0.441 ± 0.024
0.247CysGln: 0.247 ± 0.016
0.479CysArg: 0.479 ± 0.02
0.392CysSer: 0.392 ± 0.019
0.451CysThr: 0.451 ± 0.02
0.653CysVal: 0.653 ± 0.023
0.109CysTrp: 0.109 ± 0.01
0.173CysTyr: 0.173 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.837AspAla: 6.837 ± 0.082
0.423AspCys: 0.423 ± 0.022
2.387AspAsp: 2.387 ± 0.056
3.2AspGlu: 3.2 ± 0.054
1.981AspPhe: 1.981 ± 0.04
4.337AspGly: 4.337 ± 0.071
1.082AspHis: 1.082 ± 0.033
2.402AspIle: 2.402 ± 0.055
1.768AspLys: 1.768 ± 0.053
5.488AspLeu: 5.488 ± 0.079
1.188AspMet: 1.188 ± 0.032
1.171AspAsn: 1.171 ± 0.035
2.786AspPro: 2.786 ± 0.054
1.734AspGln: 1.734 ± 0.043
2.988AspArg: 2.988 ± 0.053
2.192AspSer: 2.192 ± 0.046
2.506AspThr: 2.506 ± 0.042
3.831AspVal: 3.831 ± 0.061
0.984AspTrp: 0.984 ± 0.028
1.463AspTyr: 1.463 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.06GluAla: 7.06 ± 0.088
0.312GluCys: 0.312 ± 0.016
2.338GluAsp: 2.338 ± 0.049
2.768GluGlu: 2.768 ± 0.06
1.821GluPhe: 1.821 ± 0.038
3.891GluGly: 3.891 ± 0.06
1.383GluHis: 1.383 ± 0.041
2.682GluIle: 2.682 ± 0.051
1.907GluLys: 1.907 ± 0.048
6.146GluLeu: 6.146 ± 0.082
1.239GluMet: 1.239 ± 0.032
1.183GluAsn: 1.183 ± 0.032
2.495GluPro: 2.495 ± 0.056
2.842GluGln: 2.842 ± 0.061
4.54GluArg: 4.54 ± 0.073
2.558GluSer: 2.558 ± 0.05
2.619GluThr: 2.619 ± 0.052
4.142GluVal: 4.142 ± 0.071
0.655GluTrp: 0.655 ± 0.028
1.004GluTyr: 1.004 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.786PheAla: 3.786 ± 0.058
0.329PheCys: 0.329 ± 0.017
2.202PheAsp: 2.202 ± 0.047
1.983PheGlu: 1.983 ± 0.046
1.356PhePhe: 1.356 ± 0.042
3.202PheGly: 3.202 ± 0.063
0.696PheHis: 0.696 ± 0.024
1.537PheIle: 1.537 ± 0.041
1.184PheLys: 1.184 ± 0.035
2.983PheLeu: 2.983 ± 0.061
0.814PheMet: 0.814 ± 0.026
1.052PheAsn: 1.052 ± 0.032
1.471PhePro: 1.471 ± 0.042
1.193PheGln: 1.193 ± 0.037
1.676PheArg: 1.676 ± 0.043
2.02PheSer: 2.02 ± 0.049
1.83PheThr: 1.83 ± 0.042
2.617PheVal: 2.617 ± 0.056
0.52PheTrp: 0.52 ± 0.021
0.867PheTyr: 0.867 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.289GlyAla: 9.289 ± 0.104
0.795GlyCys: 0.795 ± 0.027
3.711GlyAsp: 3.711 ± 0.065
4.517GlyGlu: 4.517 ± 0.068
3.044GlyPhe: 3.044 ± 0.052
6.943GlyGly: 6.943 ± 0.112
1.969GlyHis: 1.969 ± 0.045
3.735GlyIle: 3.735 ± 0.059
3.342GlyLys: 3.342 ± 0.065
9.857GlyLeu: 9.857 ± 0.112
2.239GlyMet: 2.239 ± 0.047
2.018GlyAsn: 2.018 ± 0.05
3.14GlyPro: 3.14 ± 0.057
3.836GlyGln: 3.836 ± 0.071
5.446GlyArg: 5.446 ± 0.076
4.417GlySer: 4.417 ± 0.075
4.046GlyThr: 4.046 ± 0.066
6.683GlyVal: 6.683 ± 0.071
1.482GlyTrp: 1.482 ± 0.044
2.281GlyTyr: 2.281 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
3.06HisAla: 3.06 ± 0.061
0.281HisCys: 0.281 ± 0.018
1.199HisAsp: 1.199 ± 0.037
1.181HisGlu: 1.181 ± 0.038
0.815HisPhe: 0.815 ± 0.03
2.201HisGly: 2.201 ± 0.054
0.634HisHis: 0.634 ± 0.025
0.951HisIle: 0.951 ± 0.031
0.613HisLys: 0.613 ± 0.025
2.43HisLeu: 2.43 ± 0.055
0.47HisMet: 0.47 ± 0.02
0.486HisAsn: 0.486 ± 0.023
1.508HisPro: 1.508 ± 0.041
0.794HisGln: 0.794 ± 0.028
1.432HisArg: 1.432 ± 0.042
1.012HisSer: 1.012 ± 0.034
1.0HisThr: 1.0 ± 0.031
1.641HisVal: 1.641 ± 0.038
0.402HisTrp: 0.402 ± 0.018
0.658HisTyr: 0.658 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.85IleAla: 5.85 ± 0.081
0.376IleCys: 0.376 ± 0.021
2.779IleAsp: 2.779 ± 0.051
2.949IleGlu: 2.949 ± 0.056
1.254IlePhe: 1.254 ± 0.037
3.907IleGly: 3.907 ± 0.062
0.858IleHis: 0.858 ± 0.026
1.516IleIle: 1.516 ± 0.039
1.511IleLys: 1.511 ± 0.046
3.379IleLeu: 3.379 ± 0.065
0.792IleMet: 0.792 ± 0.03
1.428IleAsn: 1.428 ± 0.043
1.984IlePro: 1.984 ± 0.046
1.42IleGln: 1.42 ± 0.037
2.406IleArg: 2.406 ± 0.049
2.432IleSer: 2.432 ± 0.048
2.56IleThr: 2.56 ± 0.054
3.476IleVal: 3.476 ± 0.059
0.458IleTrp: 0.458 ± 0.02
1.0IleTyr: 1.0 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.926LysAla: 3.926 ± 0.073
0.136LysCys: 0.136 ± 0.012
1.804LysAsp: 1.804 ± 0.05
1.631LysGlu: 1.631 ± 0.041
1.01LysPhe: 1.01 ± 0.031
2.399LysGly: 2.399 ± 0.053
0.687LysHis: 0.687 ± 0.028
1.491LysIle: 1.491 ± 0.044
1.53LysLys: 1.53 ± 0.046
3.623LysLeu: 3.623 ± 0.061
0.763LysMet: 0.763 ± 0.026
1.026LysAsn: 1.026 ± 0.035
1.966LysPro: 1.966 ± 0.044
1.31LysGln: 1.31 ± 0.04
2.099LysArg: 2.099 ± 0.048
1.892LysSer: 1.892 ± 0.047
2.055LysThr: 2.055 ± 0.047
2.562LysVal: 2.562 ± 0.061
0.333LysTrp: 0.333 ± 0.021
0.642LysTyr: 0.642 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
15.037LeuAla: 15.037 ± 0.144
0.987LeuCys: 0.987 ± 0.029
6.065LeuAsp: 6.065 ± 0.078
5.258LeuGlu: 5.258 ± 0.068
3.38LeuPhe: 3.38 ± 0.06
9.258LeuGly: 9.258 ± 0.107
2.606LeuHis: 2.606 ± 0.056
4.656LeuIle: 4.656 ± 0.065
3.813LeuLys: 3.813 ± 0.069
12.842LeuLeu: 12.842 ± 0.174
2.619LeuMet: 2.619 ± 0.062
3.068LeuAsn: 3.068 ± 0.053
6.459LeuPro: 6.459 ± 0.085
4.409LeuGln: 4.409 ± 0.069
8.705LeuArg: 8.705 ± 0.111
6.71LeuSer: 6.71 ± 0.079
5.727LeuThr: 5.727 ± 0.093
7.864LeuVal: 7.864 ± 0.097
1.431LeuTrp: 1.431 ± 0.041
2.12LeuTyr: 2.12 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.972MetAla: 2.972 ± 0.047
0.139MetCys: 0.139 ± 0.012
1.222MetAsp: 1.222 ± 0.036
1.087MetGlu: 1.087 ± 0.031
0.64MetPhe: 0.64 ± 0.027
1.897MetGly: 1.897 ± 0.046
0.535MetHis: 0.535 ± 0.023
0.905MetIle: 0.905 ± 0.031
1.039MetLys: 1.039 ± 0.033
2.591MetLeu: 2.591 ± 0.059
0.519MetMet: 0.519 ± 0.023
0.922MetAsn: 0.922 ± 0.025
1.423MetPro: 1.423 ± 0.038
1.126MetGln: 1.126 ± 0.031
1.653MetArg: 1.653 ± 0.039
1.614MetSer: 1.614 ± 0.037
1.457MetThr: 1.457 ± 0.033
1.647MetVal: 1.647 ± 0.043
0.177MetTrp: 0.177 ± 0.013
0.343MetTyr: 0.343 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.31AsnAla: 3.31 ± 0.059
0.214AsnCys: 0.214 ± 0.014
1.265AsnAsp: 1.265 ± 0.034
1.244AsnGlu: 1.244 ± 0.033
0.927AsnPhe: 0.927 ± 0.031
2.032AsnGly: 2.032 ± 0.048
0.514AsnHis: 0.514 ± 0.022
1.206AsnIle: 1.206 ± 0.039
0.832AsnLys: 0.832 ± 0.031
2.689AsnLeu: 2.689 ± 0.053
0.545AsnMet: 0.545 ± 0.024
0.691AsnAsn: 0.691 ± 0.032
1.821AsnPro: 1.821 ± 0.047
0.992AsnGln: 0.992 ± 0.038
1.519AsnArg: 1.519 ± 0.034
1.216AsnSer: 1.216 ± 0.042
1.43AsnThr: 1.43 ± 0.04
1.888AsnVal: 1.888 ± 0.047
0.381AsnTrp: 0.381 ± 0.02
0.695AsnTyr: 0.695 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
6.808ProAla: 6.808 ± 0.103
0.339ProCys: 0.339 ± 0.018
2.974ProAsp: 2.974 ± 0.059
3.347ProGlu: 3.347 ± 0.057
1.675ProPhe: 1.675 ± 0.038
4.6ProGly: 4.6 ± 0.069
1.174ProHis: 1.174 ± 0.034
1.847ProIle: 1.847 ± 0.041
1.535ProLys: 1.535 ± 0.041
5.479ProLeu: 5.479 ± 0.085
1.272ProMet: 1.272 ± 0.033
1.229ProAsn: 1.229 ± 0.031
2.643ProPro: 2.643 ± 0.061
2.389ProGln: 2.389 ± 0.051
3.117ProArg: 3.117 ± 0.06
2.973ProSer: 2.973 ± 0.051
2.616ProThr: 2.616 ± 0.049
4.226ProVal: 4.226 ± 0.061
0.837ProTrp: 0.837 ± 0.028
1.185ProTyr: 1.185 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
6.839GlnAla: 6.839 ± 0.111
0.241GlnCys: 0.241 ± 0.014
2.004GlnAsp: 2.004 ± 0.045
1.801GlnGlu: 1.801 ± 0.039
1.241GlnPhe: 1.241 ± 0.033
3.932GlnGly: 3.932 ± 0.061
0.986GlnHis: 0.986 ± 0.031
1.862GlnIle: 1.862 ± 0.042
1.196GlnLys: 1.196 ± 0.035
4.459GlnLeu: 4.459 ± 0.08
0.982GlnMet: 0.982 ± 0.03
0.964GlnAsn: 0.964 ± 0.033
2.337GlnPro: 2.337 ± 0.054
2.095GlnGln: 2.095 ± 0.054
3.599GlnArg: 3.599 ± 0.06
2.164GlnSer: 2.164 ± 0.044
2.388GlnThr: 2.388 ± 0.045
3.149GlnVal: 3.149 ± 0.062
0.589GlnTrp: 0.589 ± 0.022
0.793GlnTyr: 0.793 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.392ArgAla: 8.392 ± 0.12
0.526ArgCys: 0.526 ± 0.023
3.532ArgAsp: 3.532 ± 0.056
4.354ArgGlu: 4.354 ± 0.067
2.531ArgPhe: 2.531 ± 0.047
4.849ArgGly: 4.849 ± 0.074
1.875ArgHis: 1.875 ± 0.05
3.249ArgIle: 3.249 ± 0.057
2.131ArgLys: 2.131 ± 0.051
8.161ArgLeu: 8.161 ± 0.114
1.827ArgMet: 1.827 ± 0.043
1.665ArgAsn: 1.665 ± 0.036
3.232ArgPro: 3.232 ± 0.057
3.226ArgGln: 3.226 ± 0.061
5.01ArgArg: 5.01 ± 0.088
3.278ArgSer: 3.278 ± 0.057
2.989ArgThr: 2.989 ± 0.055
5.267ArgVal: 5.267 ± 0.071
1.262ArgTrp: 1.262 ± 0.041
1.881ArgTyr: 1.881 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.813SerAla: 6.813 ± 0.101
0.414SerCys: 0.414 ± 0.02
2.534SerAsp: 2.534 ± 0.045
2.746SerGlu: 2.746 ± 0.052
1.969SerPhe: 1.969 ± 0.043
5.204SerGly: 5.204 ± 0.086
1.117SerHis: 1.117 ± 0.033
2.275SerIle: 2.275 ± 0.046
1.558SerLys: 1.558 ± 0.041
5.846SerLeu: 5.846 ± 0.087
1.372SerMet: 1.372 ± 0.042
1.328SerAsn: 1.328 ± 0.041
2.948SerPro: 2.948 ± 0.055
1.972SerGln: 1.972 ± 0.045
3.366SerArg: 3.366 ± 0.059
3.323SerSer: 3.323 ± 0.078
3.089SerThr: 3.089 ± 0.064
3.907SerVal: 3.907 ± 0.06
0.769SerTrp: 0.769 ± 0.025
1.331SerTyr: 1.331 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
5.996ThrAla: 5.996 ± 0.081
0.327ThrCys: 0.327 ± 0.018
2.407ThrAsp: 2.407 ± 0.054
2.467ThrGlu: 2.467 ± 0.051
1.571ThrPhe: 1.571 ± 0.042
4.632ThrGly: 4.632 ± 0.063
1.191ThrHis: 1.191 ± 0.034
1.874ThrIle: 1.874 ± 0.041
1.189ThrLys: 1.189 ± 0.041
6.672ThrLeu: 6.672 ± 0.086
1.026ThrMet: 1.026 ± 0.033
1.163ThrAsn: 1.163 ± 0.041
3.753ThrPro: 3.753 ± 0.058
2.348ThrGln: 2.348 ± 0.048
3.404ThrArg: 3.404 ± 0.058
2.744ThrSer: 2.744 ± 0.056
2.726ThrThr: 2.726 ± 0.069
4.377ThrVal: 4.377 ± 0.063
0.661ThrTrp: 0.661 ± 0.024
0.997ThrTyr: 0.997 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.054ValAla: 9.054 ± 0.1
0.685ValCys: 0.685 ± 0.025
3.938ValAsp: 3.938 ± 0.062
4.084ValGlu: 4.084 ± 0.058
2.618ValPhe: 2.618 ± 0.052
5.438ValGly: 5.438 ± 0.08
1.718ValHis: 1.718 ± 0.037
3.357ValIle: 3.357 ± 0.06
2.463ValLys: 2.463 ± 0.054
9.018ValLeu: 9.018 ± 0.113
1.883ValMet: 1.883 ± 0.043
2.137ValAsn: 2.137 ± 0.051
3.78ValPro: 3.78 ± 0.056
3.14ValGln: 3.14 ± 0.052
5.242ValArg: 5.242 ± 0.068
4.097ValSer: 4.097 ± 0.06
4.206ValThr: 4.206 ± 0.07
6.013ValVal: 6.013 ± 0.08
1.074ValTrp: 1.074 ± 0.031
1.601ValTyr: 1.601 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.419TrpAla: 1.419 ± 0.037
0.152TrpCys: 0.152 ± 0.012
0.628TrpAsp: 0.628 ± 0.026
0.542TrpGlu: 0.542 ± 0.022
0.551TrpPhe: 0.551 ± 0.022
1.012TrpGly: 1.012 ± 0.031
0.375TrpHis: 0.375 ± 0.017
0.637TrpIle: 0.637 ± 0.026
0.477TrpLys: 0.477 ± 0.021
2.228TrpLeu: 2.228 ± 0.057
0.453TrpMet: 0.453 ± 0.021
0.432TrpAsn: 0.432 ± 0.02
0.813TrpPro: 0.813 ± 0.03
0.775TrpGln: 0.775 ± 0.031
1.295TrpArg: 1.295 ± 0.042
0.759TrpSer: 0.759 ± 0.027
0.744TrpThr: 0.744 ± 0.025
1.051TrpVal: 1.051 ± 0.031
0.279TrpTrp: 0.279 ± 0.018
0.278TrpTyr: 0.278 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.846TyrAla: 2.846 ± 0.054
0.228TyrCys: 0.228 ± 0.013
1.231TyrAsp: 1.231 ± 0.033
1.25TyrGlu: 1.25 ± 0.034
0.881TyrPhe: 0.881 ± 0.031
1.94TyrGly: 1.94 ± 0.045
0.42TyrHis: 0.42 ± 0.021
0.807TyrIle: 0.807 ± 0.027
0.748TyrLys: 0.748 ± 0.03
2.458TyrLeu: 2.458 ± 0.052
0.435TyrMet: 0.435 ± 0.022
0.577TyrAsn: 0.577 ± 0.023
1.152TyrPro: 1.152 ± 0.039
0.915TyrGln: 0.915 ± 0.028
1.559TyrArg: 1.559 ± 0.043
1.124TyrSer: 1.124 ± 0.035
1.278TyrThr: 1.278 ± 0.045
1.613TyrVal: 1.613 ± 0.038
0.367TyrTrp: 0.367 ± 0.019
0.59TyrTyr: 0.59 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3342 proteins (1084002 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski