Amino acid dipepetide frequency for Clostridium nexile CAG:348

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.046AlaAla: 6.046 ± 0.122
0.945AlaCys: 0.945 ± 0.043
4.011AlaAsp: 4.011 ± 0.088
5.237AlaGlu: 5.237 ± 0.096
2.98AlaPhe: 2.98 ± 0.067
5.517AlaGly: 5.517 ± 0.105
1.064AlaHis: 1.064 ± 0.036
5.322AlaIle: 5.322 ± 0.086
5.584AlaLys: 5.584 ± 0.098
6.506AlaLeu: 6.506 ± 0.107
2.265AlaMet: 2.265 ± 0.06
2.727AlaAsn: 2.727 ± 0.067
1.88AlaPro: 1.88 ± 0.052
2.049AlaGln: 2.049 ± 0.05
2.515AlaArg: 2.515 ± 0.079
3.631AlaSer: 3.631 ± 0.069
3.348AlaThr: 3.348 ± 0.075
6.132AlaVal: 6.132 ± 0.101
0.543AlaTrp: 0.543 ± 0.026
2.796AlaTyr: 2.796 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.881CysAla: 0.881 ± 0.038
0.227CysCys: 0.227 ± 0.015
0.788CysAsp: 0.788 ± 0.033
0.987CysGlu: 0.987 ± 0.038
0.56CysPhe: 0.56 ± 0.029
1.29CysGly: 1.29 ± 0.052
0.265CysHis: 0.265 ± 0.018
1.077CysIle: 1.077 ± 0.043
0.88CysLys: 0.88 ± 0.031
1.058CysLeu: 1.058 ± 0.038
0.455CysMet: 0.455 ± 0.029
0.525CysAsn: 0.525 ± 0.029
0.54CysPro: 0.54 ± 0.03
0.342CysGln: 0.342 ± 0.023
0.521CysArg: 0.521 ± 0.025
0.746CysSer: 0.746 ± 0.031
0.67CysThr: 0.67 ± 0.031
0.994CysVal: 0.994 ± 0.042
0.098CysTrp: 0.098 ± 0.011
0.528CysTyr: 0.528 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.018AspAla: 4.018 ± 0.095
0.71AspCys: 0.71 ± 0.031
2.715AspAsp: 2.715 ± 0.076
4.638AspGlu: 4.638 ± 0.083
2.424AspPhe: 2.424 ± 0.061
4.34AspGly: 4.34 ± 0.111
0.774AspHis: 0.774 ± 0.032
4.363AspIle: 4.363 ± 0.08
3.745AspLys: 3.745 ± 0.089
4.415AspLeu: 4.415 ± 0.086
1.742AspMet: 1.742 ± 0.052
2.147AspAsn: 2.147 ± 0.074
1.446AspPro: 1.446 ± 0.05
1.33AspGln: 1.33 ± 0.044
2.017AspArg: 2.017 ± 0.057
2.86AspSer: 2.86 ± 0.07
3.112AspThr: 3.112 ± 0.073
4.09AspVal: 4.09 ± 0.079
0.544AspTrp: 0.544 ± 0.03
2.617AspTyr: 2.617 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
5.673GluAla: 5.673 ± 0.102
0.851GluCys: 0.851 ± 0.035
4.259GluAsp: 4.259 ± 0.083
9.06GluGlu: 9.06 ± 0.171
2.826GluPhe: 2.826 ± 0.059
4.716GluGly: 4.716 ± 0.097
1.584GluHis: 1.584 ± 0.047
6.392GluIle: 6.392 ± 0.097
8.262GluLys: 8.262 ± 0.117
7.284GluLeu: 7.284 ± 0.122
2.751GluMet: 2.751 ± 0.064
4.474GluAsn: 4.474 ± 0.088
1.821GluPro: 1.821 ± 0.051
3.435GluGln: 3.435 ± 0.092
3.603GluArg: 3.603 ± 0.078
3.645GluSer: 3.645 ± 0.077
4.129GluThr: 4.129 ± 0.08
5.415GluVal: 5.415 ± 0.089
0.67GluTrp: 0.67 ± 0.032
3.301GluTyr: 3.301 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.897PheAla: 2.897 ± 0.07
0.706PheCys: 0.706 ± 0.028
2.468PheAsp: 2.468 ± 0.061
3.13PheGlu: 3.13 ± 0.069
1.819PhePhe: 1.819 ± 0.056
3.106PheGly: 3.106 ± 0.071
0.849PheHis: 0.849 ± 0.032
2.722PheIle: 2.722 ± 0.069
1.98PheLys: 1.98 ± 0.059
3.896PheLeu: 3.896 ± 0.089
1.072PheMet: 1.072 ± 0.036
1.408PheAsn: 1.408 ± 0.047
1.357PhePro: 1.357 ± 0.039
1.444PheGln: 1.444 ± 0.045
1.588PheArg: 1.588 ± 0.045
2.731PheSer: 2.731 ± 0.068
2.24PheThr: 2.24 ± 0.055
3.044PheVal: 3.044 ± 0.076
0.357PheTrp: 0.357 ± 0.02
1.7PheTyr: 1.7 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
4.818GlyAla: 4.818 ± 0.091
1.108GlyCys: 1.108 ± 0.038
3.295GlyAsp: 3.295 ± 0.073
5.097GlyGlu: 5.097 ± 0.097
2.894GlyPhe: 2.894 ± 0.075
4.608GlyGly: 4.608 ± 0.09
1.2GlyHis: 1.2 ± 0.041
6.302GlyIle: 6.302 ± 0.121
6.03GlyLys: 6.03 ± 0.091
5.581GlyLeu: 5.581 ± 0.095
2.443GlyMet: 2.443 ± 0.063
3.299GlyAsn: 3.299 ± 0.075
1.172GlyPro: 1.172 ± 0.046
2.058GlyGln: 2.058 ± 0.057
2.598GlyArg: 2.598 ± 0.069
3.71GlySer: 3.71 ± 0.085
4.346GlyThr: 4.346 ± 0.079
5.268GlyVal: 5.268 ± 0.091
0.625GlyTrp: 0.625 ± 0.047
3.155GlyTyr: 3.155 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.136HisAla: 1.136 ± 0.042
0.252HisCys: 0.252 ± 0.018
0.877HisAsp: 0.877 ± 0.037
1.1HisGlu: 1.1 ± 0.04
0.825HisPhe: 0.825 ± 0.031
1.254HisGly: 1.254 ± 0.047
0.368HisHis: 0.368 ± 0.02
1.457HisIle: 1.457 ± 0.049
1.027HisLys: 1.027 ± 0.039
1.514HisLeu: 1.514 ± 0.043
0.596HisMet: 0.596 ± 0.029
0.722HisAsn: 0.722 ± 0.031
0.763HisPro: 0.763 ± 0.038
0.56HisGln: 0.56 ± 0.028
0.711HisArg: 0.711 ± 0.028
0.924HisSer: 0.924 ± 0.035
0.995HisThr: 0.995 ± 0.041
1.104HisVal: 1.104 ± 0.043
0.162HisTrp: 0.162 ± 0.016
0.709HisTyr: 0.709 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.87IleAla: 5.87 ± 0.112
1.299IleCys: 1.299 ± 0.045
4.289IleAsp: 4.289 ± 0.084
5.728IleGlu: 5.728 ± 0.102
3.078IlePhe: 3.078 ± 0.082
5.557IleGly: 5.557 ± 0.105
1.415IleHis: 1.415 ± 0.046
4.955IleIle: 4.955 ± 0.109
4.497IleLys: 4.497 ± 0.075
7.27IleLeu: 7.27 ± 0.123
2.001IleMet: 2.001 ± 0.061
2.755IleAsn: 2.755 ± 0.062
3.045IlePro: 3.045 ± 0.06
2.674IleGln: 2.674 ± 0.059
3.437IleArg: 3.437 ± 0.072
4.597IleSer: 4.597 ± 0.079
4.254IleThr: 4.254 ± 0.078
5.686IleVal: 5.686 ± 0.113
0.6IleTrp: 0.6 ± 0.027
2.8IleTyr: 2.8 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
5.289LysAla: 5.289 ± 0.114
0.747LysCys: 0.747 ± 0.036
4.379LysAsp: 4.379 ± 0.084
8.844LysGlu: 8.844 ± 0.121
2.112LysPhe: 2.112 ± 0.057
4.346LysGly: 4.346 ± 0.078
1.19LysHis: 1.19 ± 0.041
5.517LysIle: 5.517 ± 0.08
7.209LysLys: 7.209 ± 0.109
5.777LysLeu: 5.777 ± 0.097
2.57LysMet: 2.57 ± 0.07
3.81LysAsn: 3.81 ± 0.072
1.87LysPro: 1.87 ± 0.051
2.776LysGln: 2.776 ± 0.065
3.333LysArg: 3.333 ± 0.067
3.696LysSer: 3.696 ± 0.073
4.117LysThr: 4.117 ± 0.089
5.16LysVal: 5.16 ± 0.092
0.614LysTrp: 0.614 ± 0.026
3.187LysTyr: 3.187 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
6.282LeuAla: 6.282 ± 0.096
1.306LeuCys: 1.306 ± 0.052
4.804LeuAsp: 4.804 ± 0.088
7.055LeuGlu: 7.055 ± 0.111
3.787LeuPhe: 3.787 ± 0.086
5.991LeuGly: 5.991 ± 0.103
1.465LeuHis: 1.465 ± 0.043
6.112LeuIle: 6.112 ± 0.112
6.746LeuLys: 6.746 ± 0.112
8.097LeuLeu: 8.097 ± 0.138
2.416LeuMet: 2.416 ± 0.064
3.872LeuAsn: 3.872 ± 0.073
3.128LeuPro: 3.128 ± 0.065
3.069LeuGln: 3.069 ± 0.074
3.558LeuArg: 3.558 ± 0.066
5.845LeuSer: 5.845 ± 0.108
4.825LeuThr: 4.825 ± 0.082
5.574LeuVal: 5.574 ± 0.089
0.671LeuTrp: 0.671 ± 0.032
3.258LeuTyr: 3.258 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.208MetAla: 2.208 ± 0.058
0.358MetCys: 0.358 ± 0.022
1.661MetAsp: 1.661 ± 0.052
2.695MetGlu: 2.695 ± 0.057
1.022MetPhe: 1.022 ± 0.04
2.047MetGly: 2.047 ± 0.051
0.504MetHis: 0.504 ± 0.028
2.289MetIle: 2.289 ± 0.063
2.8MetLys: 2.8 ± 0.06
2.842MetLeu: 2.842 ± 0.071
1.024MetMet: 1.024 ± 0.041
1.556MetAsn: 1.556 ± 0.049
1.024MetPro: 1.024 ± 0.048
1.176MetGln: 1.176 ± 0.044
1.262MetArg: 1.262 ± 0.047
1.712MetSer: 1.712 ± 0.048
1.786MetThr: 1.786 ± 0.054
1.839MetVal: 1.839 ± 0.052
0.22MetTrp: 0.22 ± 0.018
0.979MetTyr: 0.979 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.157AsnAla: 3.157 ± 0.075
0.601AsnCys: 0.601 ± 0.029
2.075AsnAsp: 2.075 ± 0.055
3.149AsnGlu: 3.149 ± 0.071
1.56AsnPhe: 1.56 ± 0.045
3.523AsnGly: 3.523 ± 0.094
0.861AsnHis: 0.861 ± 0.037
3.489AsnIle: 3.489 ± 0.074
2.714AsnLys: 2.714 ± 0.071
3.803AsnLeu: 3.803 ± 0.074
1.426AsnMet: 1.426 ± 0.044
1.852AsnAsn: 1.852 ± 0.065
1.921AsnPro: 1.921 ± 0.055
1.626AsnGln: 1.626 ± 0.059
1.927AsnArg: 1.927 ± 0.054
2.193AsnSer: 2.193 ± 0.057
2.42AsnThr: 2.42 ± 0.065
3.142AsnVal: 3.142 ± 0.069
0.437AsnTrp: 0.437 ± 0.024
1.852AsnTyr: 1.852 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.036ProAla: 2.036 ± 0.05
0.406ProCys: 0.406 ± 0.024
1.949ProAsp: 1.949 ± 0.059
2.893ProGlu: 2.893 ± 0.066
1.445ProPhe: 1.445 ± 0.048
1.919ProGly: 1.919 ± 0.053
0.524ProHis: 0.524 ± 0.026
2.281ProIle: 2.281 ± 0.06
2.112ProLys: 2.112 ± 0.051
2.491ProLeu: 2.491 ± 0.054
0.852ProMet: 0.852 ± 0.032
1.387ProAsn: 1.387 ± 0.041
0.617ProPro: 0.617 ± 0.033
0.872ProGln: 0.872 ± 0.037
0.832ProArg: 0.832 ± 0.034
1.619ProSer: 1.619 ± 0.042
1.553ProThr: 1.553 ± 0.042
2.667ProVal: 2.667 ± 0.062
0.308ProTrp: 0.308 ± 0.022
1.377ProTyr: 1.377 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
2.205GlnAla: 2.205 ± 0.055
0.334GlnCys: 0.334 ± 0.024
1.583GlnAsp: 1.583 ± 0.062
2.976GlnGlu: 2.976 ± 0.057
1.242GlnPhe: 1.242 ± 0.04
1.943GlnGly: 1.943 ± 0.056
0.452GlnHis: 0.452 ± 0.023
2.87GlnIle: 2.87 ± 0.064
3.26GlnLys: 3.26 ± 0.066
2.871GlnLeu: 2.871 ± 0.071
1.32GlnMet: 1.32 ± 0.037
1.764GlnAsn: 1.764 ± 0.055
0.863GlnPro: 0.863 ± 0.032
1.188GlnGln: 1.188 ± 0.047
1.307GlnArg: 1.307 ± 0.037
1.669GlnSer: 1.669 ± 0.055
1.756GlnThr: 1.756 ± 0.049
2.159GlnVal: 2.159 ± 0.059
0.326GlnTrp: 0.326 ± 0.023
1.422GlnTyr: 1.422 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.373ArgAla: 2.373 ± 0.056
0.47ArgCys: 0.47 ± 0.026
1.903ArgAsp: 1.903 ± 0.059
3.603ArgGlu: 3.603 ± 0.078
1.733ArgPhe: 1.733 ± 0.052
2.233ArgGly: 2.233 ± 0.057
0.674ArgHis: 0.674 ± 0.029
3.313ArgIle: 3.313 ± 0.071
3.591ArgLys: 3.591 ± 0.075
3.42ArgLeu: 3.42 ± 0.08
1.4ArgMet: 1.4 ± 0.052
1.826ArgAsn: 1.826 ± 0.05
1.14ArgPro: 1.14 ± 0.042
1.587ArgGln: 1.587 ± 0.053
1.924ArgArg: 1.924 ± 0.056
1.745ArgSer: 1.745 ± 0.049
2.134ArgThr: 2.134 ± 0.058
2.58ArgVal: 2.58 ± 0.063
0.36ArgTrp: 0.36 ± 0.022
1.809ArgTyr: 1.809 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.899SerAla: 3.899 ± 0.073
0.685SerCys: 0.685 ± 0.029
3.007SerAsp: 3.007 ± 0.065
4.257SerGlu: 4.257 ± 0.076
2.473SerPhe: 2.473 ± 0.064
4.642SerGly: 4.642 ± 0.088
0.914SerHis: 0.914 ± 0.037
4.014SerIle: 4.014 ± 0.083
3.815SerLys: 3.815 ± 0.064
4.663SerLeu: 4.663 ± 0.087
1.72SerMet: 1.72 ± 0.051
2.233SerAsn: 2.233 ± 0.061
1.592SerPro: 1.592 ± 0.047
1.665SerGln: 1.665 ± 0.055
2.058SerArg: 2.058 ± 0.051
3.081SerSer: 3.081 ± 0.075
2.718SerThr: 2.718 ± 0.075
4.303SerVal: 4.303 ± 0.087
0.518SerTrp: 0.518 ± 0.031
2.412SerTyr: 2.412 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.121ThrAla: 4.121 ± 0.085
0.654ThrCys: 0.654 ± 0.031
3.002ThrAsp: 3.002 ± 0.076
4.184ThrGlu: 4.184 ± 0.094
2.42ThrPhe: 2.42 ± 0.061
4.436ThrGly: 4.436 ± 0.089
0.848ThrHis: 0.848 ± 0.035
4.298ThrIle: 4.298 ± 0.076
3.73ThrLys: 3.73 ± 0.066
4.85ThrLeu: 4.85 ± 0.081
1.46ThrMet: 1.46 ± 0.046
2.15ThrAsn: 2.15 ± 0.051
2.024ThrPro: 2.024 ± 0.06
1.554ThrGln: 1.554 ± 0.057
1.758ThrArg: 1.758 ± 0.046
2.968ThrSer: 2.968 ± 0.069
3.109ThrThr: 3.109 ± 0.078
4.516ThrVal: 4.516 ± 0.096
0.479ThrTrp: 0.479 ± 0.025
2.26ThrTyr: 2.26 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.979ValAla: 4.979 ± 0.096
1.088ValCys: 1.088 ± 0.041
4.031ValAsp: 4.031 ± 0.084
5.429ValGlu: 5.429 ± 0.101
3.071ValPhe: 3.071 ± 0.069
4.677ValGly: 4.677 ± 0.081
1.092ValHis: 1.092 ± 0.035
5.559ValIle: 5.559 ± 0.104
5.245ValLys: 5.245 ± 0.091
7.043ValLeu: 7.043 ± 0.102
2.098ValMet: 2.098 ± 0.06
2.881ValAsn: 2.881 ± 0.067
2.407ValPro: 2.407 ± 0.055
2.082ValGln: 2.082 ± 0.057
2.663ValArg: 2.663 ± 0.051
4.618ValSer: 4.618 ± 0.077
4.517ValThr: 4.517 ± 0.088
5.393ValVal: 5.393 ± 0.091
0.648ValTrp: 0.648 ± 0.028
2.809ValTyr: 2.809 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.507TrpAla: 0.507 ± 0.029
0.131TrpCys: 0.131 ± 0.015
0.464TrpAsp: 0.464 ± 0.028
0.683TrpGlu: 0.683 ± 0.034
0.385TrpPhe: 0.385 ± 0.024
0.63TrpGly: 0.63 ± 0.031
0.158TrpHis: 0.158 ± 0.016
0.679TrpIle: 0.679 ± 0.033
0.764TrpLys: 0.764 ± 0.029
0.767TrpLeu: 0.767 ± 0.038
0.273TrpMet: 0.273 ± 0.019
0.533TrpAsn: 0.533 ± 0.027
0.161TrpPro: 0.161 ± 0.015
0.308TrpGln: 0.308 ± 0.024
0.321TrpArg: 0.321 ± 0.022
0.486TrpSer: 0.486 ± 0.031
0.446TrpThr: 0.446 ± 0.028
0.458TrpVal: 0.458 ± 0.025
0.101TrpTrp: 0.101 ± 0.012
0.376TrpTyr: 0.376 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.704TyrAla: 2.704 ± 0.061
0.556TyrCys: 0.556 ± 0.027
2.484TyrAsp: 2.484 ± 0.068
3.406TyrGlu: 3.406 ± 0.068
1.856TyrPhe: 1.856 ± 0.054
2.829TyrGly: 2.829 ± 0.064
0.853TyrHis: 0.853 ± 0.03
2.796TyrIle: 2.796 ± 0.081
2.556TyrLys: 2.556 ± 0.059
3.713TyrLeu: 3.713 ± 0.079
1.12TyrMet: 1.12 ± 0.039
1.809TyrAsn: 1.809 ± 0.054
1.368TyrPro: 1.368 ± 0.041
1.718TyrGln: 1.718 ± 0.051
1.882TyrArg: 1.882 ± 0.049
2.195TyrSer: 2.195 ± 0.055
2.346TyrThr: 2.346 ± 0.068
2.805TyrVal: 2.805 ± 0.068
0.352TyrTrp: 0.352 ± 0.024
1.886TyrTyr: 1.886 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2321 proteins (753615 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski