Amino acid dipepetide frequency for Sinorhizobium phage phiM5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.498AlaAla: 17.498 ± 1.73
0.871AlaCys: 0.871 ± 0.302
8.132AlaAsp: 8.132 ± 0.857
7.987AlaGlu: 7.987 ± 0.935
3.122AlaPhe: 3.122 ± 0.616
10.6AlaGly: 10.6 ± 1.417
1.96AlaHis: 1.96 ± 0.406
5.591AlaIle: 5.591 ± 0.496
6.171AlaLys: 6.171 ± 0.646
12.125AlaLeu: 12.125 ± 1.005
3.848AlaMet: 3.848 ± 0.536
3.195AlaAsn: 3.195 ± 0.468
5.881AlaPro: 5.881 ± 0.51
4.211AlaGln: 4.211 ± 0.732
7.841AlaArg: 7.841 ± 0.637
7.188AlaSer: 7.188 ± 0.845
6.97AlaThr: 6.97 ± 0.577
7.914AlaVal: 7.914 ± 0.721
1.307AlaTrp: 1.307 ± 0.288
2.832AlaTyr: 2.832 ± 0.532
0.0AlaXaa: 0.0 ± 0.0
Cys
1.016CysAla: 1.016 ± 0.288
0.0CysCys: 0.0 ± 0.0
0.653CysAsp: 0.653 ± 0.251
0.29CysGlu: 0.29 ± 0.144
0.073CysPhe: 0.073 ± 0.083
0.436CysGly: 0.436 ± 0.237
0.29CysHis: 0.29 ± 0.15
0.218CysIle: 0.218 ± 0.13
0.29CysLys: 0.29 ± 0.178
0.581CysLeu: 0.581 ± 0.245
0.073CysMet: 0.073 ± 0.064
0.073CysAsn: 0.073 ± 0.083
0.363CysPro: 0.363 ± 0.152
0.218CysGln: 0.218 ± 0.126
0.581CysArg: 0.581 ± 0.332
0.436CysSer: 0.436 ± 0.18
0.363CysThr: 0.363 ± 0.147
0.363CysVal: 0.363 ± 0.156
0.0CysTrp: 0.0 ± 0.0
0.145CysTyr: 0.145 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
6.752AspAla: 6.752 ± 0.634
0.508AspCys: 0.508 ± 0.178
3.703AspAsp: 3.703 ± 0.599
3.485AspGlu: 3.485 ± 0.555
2.759AspPhe: 2.759 ± 0.541
3.993AspGly: 3.993 ± 0.671
1.162AspHis: 1.162 ± 0.387
2.614AspIle: 2.614 ± 0.443
3.267AspLys: 3.267 ± 0.662
5.736AspLeu: 5.736 ± 0.609
1.743AspMet: 1.743 ± 0.405
2.251AspAsn: 2.251 ± 0.421
4.139AspPro: 4.139 ± 0.581
1.597AspGln: 1.597 ± 0.403
4.356AspArg: 4.356 ± 0.541
3.703AspSer: 3.703 ± 0.51
4.574AspThr: 4.574 ± 0.583
5.228AspVal: 5.228 ± 0.599
1.089AspTrp: 1.089 ± 0.312
1.815AspTyr: 1.815 ± 0.359
0.0AspXaa: 0.0 ± 0.0
Glu
7.551GluAla: 7.551 ± 0.773
0.436GluCys: 0.436 ± 0.185
3.485GluAsp: 3.485 ± 0.555
4.211GluGlu: 4.211 ± 0.927
2.251GluPhe: 2.251 ± 0.407
3.049GluGly: 3.049 ± 0.507
1.162GluHis: 1.162 ± 0.279
2.977GluIle: 2.977 ± 0.36
3.122GluLys: 3.122 ± 0.438
6.535GluLeu: 6.535 ± 0.752
1.815GluMet: 1.815 ± 0.383
1.743GluAsn: 1.743 ± 0.347
2.251GluPro: 2.251 ± 0.43
2.469GluGln: 2.469 ± 0.592
3.267GluArg: 3.267 ± 0.439
1.815GluSer: 1.815 ± 0.437
3.34GluThr: 3.34 ± 0.453
4.647GluVal: 4.647 ± 0.453
1.67GluTrp: 1.67 ± 0.395
1.307GluTyr: 1.307 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
2.904PheAla: 2.904 ± 0.429
0.363PheCys: 0.363 ± 0.156
2.323PheAsp: 2.323 ± 0.409
1.525PheGlu: 1.525 ± 0.3
1.089PhePhe: 1.089 ± 0.333
3.412PheGly: 3.412 ± 0.438
0.581PheHis: 0.581 ± 0.198
0.944PheIle: 0.944 ± 0.241
1.743PheLys: 1.743 ± 0.387
2.686PheLeu: 2.686 ± 0.462
0.653PheMet: 0.653 ± 0.213
1.234PheAsn: 1.234 ± 0.316
1.38PhePro: 1.38 ± 0.396
1.016PheGln: 1.016 ± 0.23
1.452PheArg: 1.452 ± 0.334
1.597PheSer: 1.597 ± 0.237
2.323PheThr: 2.323 ± 0.43
2.106PheVal: 2.106 ± 0.389
0.581PheTrp: 0.581 ± 0.18
1.016PheTyr: 1.016 ± 0.22
0.0PheXaa: 0.0 ± 0.0
Gly
10.237GlyAla: 10.237 ± 1.311
0.363GlyCys: 0.363 ± 0.178
4.502GlyAsp: 4.502 ± 0.554
3.195GlyGlu: 3.195 ± 0.577
3.485GlyPhe: 3.485 ± 0.51
7.551GlyGly: 7.551 ± 1.185
1.234GlyHis: 1.234 ± 0.277
3.703GlyIle: 3.703 ± 0.495
3.993GlyLys: 3.993 ± 0.504
6.462GlyLeu: 6.462 ± 0.712
1.525GlyMet: 1.525 ± 0.311
3.267GlyAsn: 3.267 ± 0.694
2.541GlyPro: 2.541 ± 0.614
3.195GlyGln: 3.195 ± 0.562
3.703GlyArg: 3.703 ± 0.572
4.792GlySer: 4.792 ± 0.622
4.792GlyThr: 4.792 ± 0.915
6.026GlyVal: 6.026 ± 0.713
1.597GlyTrp: 1.597 ± 0.43
1.96GlyTyr: 1.96 ± 0.364
0.0GlyXaa: 0.0 ± 0.0
His
2.251HisAla: 2.251 ± 0.553
0.073HisCys: 0.073 ± 0.086
1.67HisAsp: 1.67 ± 0.433
0.871HisGlu: 0.871 ± 0.22
0.29HisPhe: 0.29 ± 0.129
1.67HisGly: 1.67 ± 0.323
0.436HisHis: 0.436 ± 0.148
0.581HisIle: 0.581 ± 0.198
0.871HisLys: 0.871 ± 0.301
1.452HisLeu: 1.452 ± 0.344
0.218HisMet: 0.218 ± 0.118
0.944HisAsn: 0.944 ± 0.273
0.871HisPro: 0.871 ± 0.263
0.363HisGln: 0.363 ± 0.168
0.944HisArg: 0.944 ± 0.221
0.653HisSer: 0.653 ± 0.225
1.162HisThr: 1.162 ± 0.285
1.162HisVal: 1.162 ± 0.314
0.145HisTrp: 0.145 ± 0.111
0.726HisTyr: 0.726 ± 0.264
0.0HisXaa: 0.0 ± 0.0
Ile
6.317IleAla: 6.317 ± 0.556
0.29IleCys: 0.29 ± 0.129
3.049IleAsp: 3.049 ± 0.452
3.485IleGlu: 3.485 ± 0.592
1.307IlePhe: 1.307 ± 0.271
4.284IleGly: 4.284 ± 0.447
0.436IleHis: 0.436 ± 0.181
1.162IleIle: 1.162 ± 0.308
2.323IleLys: 2.323 ± 0.338
3.122IleLeu: 3.122 ± 0.514
0.653IleMet: 0.653 ± 0.225
1.743IleAsn: 1.743 ± 0.295
2.106IlePro: 2.106 ± 0.398
0.944IleGln: 0.944 ± 0.221
2.541IleArg: 2.541 ± 0.439
2.106IleSer: 2.106 ± 0.312
2.977IleThr: 2.977 ± 0.422
3.703IleVal: 3.703 ± 0.589
0.581IleTrp: 0.581 ± 0.212
1.452IleTyr: 1.452 ± 0.338
0.0IleXaa: 0.0 ± 0.0
Lys
5.373LysAla: 5.373 ± 0.686
0.29LysCys: 0.29 ± 0.134
2.759LysAsp: 2.759 ± 0.433
2.686LysGlu: 2.686 ± 0.375
1.307LysPhe: 1.307 ± 0.299
2.614LysGly: 2.614 ± 0.368
0.944LysHis: 0.944 ± 0.264
2.759LysIle: 2.759 ± 0.409
3.049LysLys: 3.049 ± 0.464
4.865LysLeu: 4.865 ± 0.474
1.307LysMet: 1.307 ± 0.278
1.452LysAsn: 1.452 ± 0.371
3.63LysPro: 3.63 ± 0.536
2.106LysGln: 2.106 ± 0.353
3.703LysArg: 3.703 ± 0.706
2.614LysSer: 2.614 ± 0.522
3.34LysThr: 3.34 ± 0.56
2.977LysVal: 2.977 ± 0.629
0.871LysTrp: 0.871 ± 0.238
1.016LysTyr: 1.016 ± 0.298
0.0LysXaa: 0.0 ± 0.0
Leu
9.439LeuAla: 9.439 ± 0.698
0.508LeuCys: 0.508 ± 0.237
6.825LeuAsp: 6.825 ± 0.774
5.591LeuGlu: 5.591 ± 0.644
3.195LeuPhe: 3.195 ± 0.479
6.607LeuGly: 6.607 ± 0.919
1.307LeuHis: 1.307 ± 0.309
3.63LeuIle: 3.63 ± 0.482
4.502LeuLys: 4.502 ± 0.643
6.244LeuLeu: 6.244 ± 0.702
1.96LeuMet: 1.96 ± 0.327
2.832LeuAsn: 2.832 ± 0.515
4.429LeuPro: 4.429 ± 0.547
3.267LeuGln: 3.267 ± 0.735
6.099LeuArg: 6.099 ± 0.86
4.937LeuSer: 4.937 ± 0.567
6.535LeuThr: 6.535 ± 0.726
5.3LeuVal: 5.3 ± 0.67
1.162LeuTrp: 1.162 ± 0.321
1.452LeuTyr: 1.452 ± 0.305
0.0LeuXaa: 0.0 ± 0.0
Met
3.34MetAla: 3.34 ± 0.541
0.0MetCys: 0.0 ± 0.0
1.234MetAsp: 1.234 ± 0.365
1.234MetGlu: 1.234 ± 0.304
0.581MetPhe: 0.581 ± 0.168
1.234MetGly: 1.234 ± 0.487
0.363MetHis: 0.363 ± 0.15
0.581MetIle: 0.581 ± 0.196
0.726MetLys: 0.726 ± 0.208
2.469MetLeu: 2.469 ± 0.363
0.436MetMet: 0.436 ± 0.173
0.799MetAsn: 0.799 ± 0.2
1.307MetPro: 1.307 ± 0.355
1.234MetGln: 1.234 ± 0.331
1.525MetArg: 1.525 ± 0.315
2.759MetSer: 2.759 ± 0.486
1.743MetThr: 1.743 ± 0.31
1.597MetVal: 1.597 ± 0.316
0.218MetTrp: 0.218 ± 0.157
0.145MetTyr: 0.145 ± 0.117
0.0MetXaa: 0.0 ± 0.0
Asn
5.445AsnAla: 5.445 ± 0.628
0.218AsnCys: 0.218 ± 0.133
1.96AsnAsp: 1.96 ± 0.333
1.96AsnGlu: 1.96 ± 0.364
1.38AsnPhe: 1.38 ± 0.363
3.122AsnGly: 3.122 ± 0.446
0.581AsnHis: 0.581 ± 0.17
1.743AsnIle: 1.743 ± 0.343
0.871AsnLys: 0.871 ± 0.278
2.759AsnLeu: 2.759 ± 0.48
1.016AsnMet: 1.016 ± 0.287
1.089AsnAsn: 1.089 ± 0.273
2.106AsnPro: 2.106 ± 0.369
1.888AsnGln: 1.888 ± 0.489
1.597AsnArg: 1.597 ± 0.281
2.759AsnSer: 2.759 ± 0.507
2.178AsnThr: 2.178 ± 0.35
2.323AsnVal: 2.323 ± 0.33
0.581AsnTrp: 0.581 ± 0.214
0.871AsnTyr: 0.871 ± 0.231
0.0AsnXaa: 0.0 ± 0.0
Pro
4.865ProAla: 4.865 ± 0.635
0.073ProCys: 0.073 ± 0.08
4.066ProAsp: 4.066 ± 0.619
3.993ProGlu: 3.993 ± 0.53
1.525ProPhe: 1.525 ± 0.281
2.106ProGly: 2.106 ± 0.408
0.726ProHis: 0.726 ± 0.189
2.469ProIle: 2.469 ± 0.417
1.96ProLys: 1.96 ± 0.365
4.647ProLeu: 4.647 ± 0.539
1.089ProMet: 1.089 ± 0.32
1.67ProAsn: 1.67 ± 0.31
3.267ProPro: 3.267 ± 0.779
1.67ProGln: 1.67 ± 0.399
2.904ProArg: 2.904 ± 0.449
2.904ProSer: 2.904 ± 0.449
3.412ProThr: 3.412 ± 0.57
3.485ProVal: 3.485 ± 0.449
0.508ProTrp: 0.508 ± 0.183
1.597ProTyr: 1.597 ± 0.335
0.0ProXaa: 0.0 ± 0.0
Gln
5.591GlnAla: 5.591 ± 0.947
0.218GlnCys: 0.218 ± 0.133
1.307GlnAsp: 1.307 ± 0.296
1.888GlnGlu: 1.888 ± 0.424
0.653GlnPhe: 0.653 ± 0.213
2.977GlnGly: 2.977 ± 0.593
0.29GlnHis: 0.29 ± 0.117
2.178GlnIle: 2.178 ± 0.356
1.888GlnLys: 1.888 ± 0.451
3.267GlnLeu: 3.267 ± 0.526
0.799GlnMet: 0.799 ± 0.293
1.743GlnAsn: 1.743 ± 0.496
1.67GlnPro: 1.67 ± 0.29
2.686GlnGln: 2.686 ± 0.824
2.469GlnArg: 2.469 ± 0.515
1.815GlnSer: 1.815 ± 0.324
1.743GlnThr: 1.743 ± 0.48
2.106GlnVal: 2.106 ± 0.525
0.944GlnTrp: 0.944 ± 0.3
0.726GlnTyr: 0.726 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
8.931ArgAla: 8.931 ± 1.019
0.363ArgCys: 0.363 ± 0.166
3.776ArgAsp: 3.776 ± 0.515
3.848ArgGlu: 3.848 ± 0.506
1.96ArgPhe: 1.96 ± 0.312
4.211ArgGly: 4.211 ± 0.464
1.525ArgHis: 1.525 ± 0.361
2.323ArgIle: 2.323 ± 0.424
3.558ArgLys: 3.558 ± 0.562
5.663ArgLeu: 5.663 ± 0.644
1.452ArgMet: 1.452 ± 0.371
2.396ArgAsn: 2.396 ± 0.415
2.106ArgPro: 2.106 ± 0.42
2.251ArgGln: 2.251 ± 0.464
4.574ArgArg: 4.574 ± 0.818
2.106ArgSer: 2.106 ± 0.349
2.977ArgThr: 2.977 ± 0.49
4.429ArgVal: 4.429 ± 0.547
1.815ArgTrp: 1.815 ± 0.339
1.38ArgTyr: 1.38 ± 0.27
0.0ArgXaa: 0.0 ± 0.0
Ser
6.97SerAla: 6.97 ± 0.822
0.29SerCys: 0.29 ± 0.189
3.412SerAsp: 3.412 ± 0.461
2.759SerGlu: 2.759 ± 0.486
1.234SerPhe: 1.234 ± 0.262
6.68SerGly: 6.68 ± 0.81
0.726SerHis: 0.726 ± 0.215
2.106SerIle: 2.106 ± 0.381
2.614SerLys: 2.614 ± 0.432
4.356SerLeu: 4.356 ± 0.636
0.944SerMet: 0.944 ± 0.235
2.832SerAsn: 2.832 ± 0.543
2.759SerPro: 2.759 ± 0.49
1.96SerGln: 1.96 ± 0.364
2.759SerArg: 2.759 ± 0.44
4.356SerSer: 4.356 ± 0.71
3.63SerThr: 3.63 ± 0.457
4.284SerVal: 4.284 ± 0.463
0.726SerTrp: 0.726 ± 0.261
1.743SerTyr: 1.743 ± 0.467
0.0SerXaa: 0.0 ± 0.0
Thr
8.713ThrAla: 8.713 ± 0.845
0.436ThrCys: 0.436 ± 0.203
3.558ThrAsp: 3.558 ± 0.521
3.993ThrGlu: 3.993 ± 0.735
1.815ThrPhe: 1.815 ± 0.348
5.736ThrGly: 5.736 ± 0.925
1.525ThrHis: 1.525 ± 0.378
2.977ThrIle: 2.977 ± 0.53
2.977ThrLys: 2.977 ± 0.58
4.284ThrLeu: 4.284 ± 0.477
1.089ThrMet: 1.089 ± 0.223
2.323ThrAsn: 2.323 ± 0.573
3.848ThrPro: 3.848 ± 0.677
1.815ThrGln: 1.815 ± 0.629
3.703ThrArg: 3.703 ± 0.636
4.066ThrSer: 4.066 ± 0.516
3.848ThrThr: 3.848 ± 0.666
3.848ThrVal: 3.848 ± 0.535
0.799ThrTrp: 0.799 ± 0.229
1.743ThrTyr: 1.743 ± 0.316
0.0ThrXaa: 0.0 ± 0.0
Val
7.841ValAla: 7.841 ± 0.589
0.363ValCys: 0.363 ± 0.155
4.356ValAsp: 4.356 ± 0.517
4.356ValGlu: 4.356 ± 0.596
1.525ValPhe: 1.525 ± 0.368
4.284ValGly: 4.284 ± 0.614
1.016ValHis: 1.016 ± 0.261
4.139ValIle: 4.139 ± 0.674
3.921ValLys: 3.921 ± 0.554
5.228ValLeu: 5.228 ± 0.552
1.96ValMet: 1.96 ± 0.355
3.195ValAsn: 3.195 ± 0.412
2.614ValPro: 2.614 ± 0.426
2.541ValGln: 2.541 ± 0.4
4.792ValArg: 4.792 ± 0.635
4.792ValSer: 4.792 ± 0.518
4.719ValThr: 4.719 ± 0.635
5.155ValVal: 5.155 ± 0.888
0.871ValTrp: 0.871 ± 0.24
1.888ValTyr: 1.888 ± 0.435
0.0ValXaa: 0.0 ± 0.0
Trp
1.96TrpAla: 1.96 ± 0.381
0.218TrpCys: 0.218 ± 0.115
1.162TrpAsp: 1.162 ± 0.23
0.581TrpGlu: 0.581 ± 0.224
0.436TrpPhe: 0.436 ± 0.185
0.871TrpGly: 0.871 ± 0.252
0.581TrpHis: 0.581 ± 0.238
0.581TrpIle: 0.581 ± 0.211
0.871TrpLys: 0.871 ± 0.218
1.452TrpLeu: 1.452 ± 0.374
0.363TrpMet: 0.363 ± 0.138
0.799TrpAsn: 0.799 ± 0.208
0.653TrpPro: 0.653 ± 0.214
0.653TrpGln: 0.653 ± 0.185
1.162TrpArg: 1.162 ± 0.295
0.799TrpSer: 0.799 ± 0.249
1.234TrpThr: 1.234 ± 0.31
1.016TrpVal: 1.016 ± 0.236
0.436TrpTrp: 0.436 ± 0.221
0.508TrpTyr: 0.508 ± 0.228
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.389
0.581TyrCys: 0.581 ± 0.241
2.541TyrAsp: 2.541 ± 0.42
1.162TyrGlu: 1.162 ± 0.264
0.944TyrPhe: 0.944 ± 0.236
2.686TyrGly: 2.686 ± 0.478
0.508TyrHis: 0.508 ± 0.2
1.307TyrIle: 1.307 ± 0.291
0.944TyrLys: 0.944 ± 0.21
1.888TyrLeu: 1.888 ± 0.397
0.508TyrMet: 0.508 ± 0.191
0.871TyrAsn: 0.871 ± 0.265
1.016TyrPro: 1.016 ± 0.276
0.871TyrGln: 0.871 ± 0.26
1.67TyrArg: 1.67 ± 0.297
0.944TyrSer: 0.944 ± 0.281
1.234TyrThr: 1.234 ± 0.287
1.888TyrVal: 1.888 ± 0.392
0.436TyrTrp: 0.436 ± 0.182
0.29TyrTyr: 0.29 ± 0.166
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (13774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski