Amino acid dipepetide frequency for Escherichia phage 186 (Bacteriophage 186)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.316AlaAla: 9.316 ± 1.85
1.114AlaCys: 1.114 ± 0.358
6.075AlaAsp: 6.075 ± 0.886
6.177AlaGlu: 6.177 ± 1.094
3.443AlaPhe: 3.443 ± 0.523
7.999AlaGly: 7.999 ± 1.047
1.721AlaHis: 1.721 ± 0.35
3.848AlaIle: 3.848 ± 0.765
5.569AlaLys: 5.569 ± 0.625
9.316AlaLeu: 9.316 ± 0.896
2.835AlaMet: 2.835 ± 0.534
2.025AlaAsn: 2.025 ± 0.556
5.67AlaPro: 5.67 ± 0.921
4.05AlaGln: 4.05 ± 0.744
6.278AlaArg: 6.278 ± 0.616
7.797AlaSer: 7.797 ± 0.873
5.468AlaThr: 5.468 ± 0.792
6.379AlaVal: 6.379 ± 0.792
1.519AlaTrp: 1.519 ± 0.345
2.531AlaTyr: 2.531 ± 0.521
0.0AlaXaa: 0.0 ± 0.0
Cys
0.709CysAla: 0.709 ± 0.288
0.203CysCys: 0.203 ± 0.157
0.608CysAsp: 0.608 ± 0.226
1.215CysGlu: 1.215 ± 0.335
0.304CysPhe: 0.304 ± 0.187
0.405CysGly: 0.405 ± 0.235
0.304CysHis: 0.304 ± 0.164
0.506CysIle: 0.506 ± 0.201
0.506CysLys: 0.506 ± 0.193
0.709CysLeu: 0.709 ± 0.269
0.608CysMet: 0.608 ± 0.3
0.405CysAsn: 0.405 ± 0.181
0.506CysPro: 0.506 ± 0.279
0.608CysGln: 0.608 ± 0.253
0.81CysArg: 0.81 ± 0.319
0.709CysSer: 0.709 ± 0.474
0.81CysThr: 0.81 ± 0.256
0.81CysVal: 0.81 ± 0.276
0.101CysTrp: 0.101 ± 0.093
0.405CysTyr: 0.405 ± 0.214
0.0CysXaa: 0.0 ± 0.0
Asp
5.772AspAla: 5.772 ± 0.661
0.405AspCys: 0.405 ± 0.203
4.658AspAsp: 4.658 ± 0.671
3.949AspGlu: 3.949 ± 0.512
3.038AspPhe: 3.038 ± 0.607
6.379AspGly: 6.379 ± 0.859
0.81AspHis: 0.81 ± 0.279
4.354AspIle: 4.354 ± 0.729
4.253AspLys: 4.253 ± 0.566
3.949AspLeu: 3.949 ± 0.501
1.215AspMet: 1.215 ± 0.3
1.823AspAsn: 1.823 ± 0.42
2.025AspPro: 2.025 ± 0.478
1.823AspGln: 1.823 ± 0.394
3.341AspArg: 3.341 ± 0.61
3.443AspSer: 3.443 ± 0.58
3.949AspThr: 3.949 ± 0.629
3.645AspVal: 3.645 ± 0.629
0.81AspTrp: 0.81 ± 0.275
1.924AspTyr: 1.924 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
5.974GluAla: 5.974 ± 0.814
1.114GluCys: 1.114 ± 0.316
2.633GluAsp: 2.633 ± 0.519
3.443GluGlu: 3.443 ± 0.601
1.823GluPhe: 1.823 ± 0.417
3.544GluGly: 3.544 ± 0.86
1.215GluHis: 1.215 ± 0.336
4.151GluIle: 4.151 ± 0.763
3.848GluLys: 3.848 ± 0.63
7.999GluLeu: 7.999 ± 0.893
2.936GluMet: 2.936 ± 0.472
3.341GluAsn: 3.341 ± 0.638
2.633GluPro: 2.633 ± 0.582
2.228GluGln: 2.228 ± 0.527
3.949GluArg: 3.949 ± 0.614
4.05GluSer: 4.05 ± 0.54
3.24GluThr: 3.24 ± 0.6
3.139GluVal: 3.139 ± 0.551
0.81GluTrp: 0.81 ± 0.272
2.43GluTyr: 2.43 ± 0.64
0.0GluXaa: 0.0 ± 0.0
Phe
3.645PheAla: 3.645 ± 0.587
0.709PheCys: 0.709 ± 0.246
1.924PheAsp: 1.924 ± 0.402
2.228PheGlu: 2.228 ± 0.473
1.215PhePhe: 1.215 ± 0.4
1.519PheGly: 1.519 ± 0.315
0.81PheHis: 0.81 ± 0.237
1.823PheIle: 1.823 ± 0.525
2.329PheLys: 2.329 ± 0.519
2.126PheLeu: 2.126 ± 0.406
0.81PheMet: 0.81 ± 0.235
1.62PheAsn: 1.62 ± 0.409
1.62PhePro: 1.62 ± 0.414
1.62PheGln: 1.62 ± 0.332
1.721PheArg: 1.721 ± 0.432
3.24PheSer: 3.24 ± 0.579
2.43PheThr: 2.43 ± 0.558
2.025PheVal: 2.025 ± 0.53
0.709PheTrp: 0.709 ± 0.292
0.709PheTyr: 0.709 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
6.177GlyAla: 6.177 ± 0.733
1.62GlyCys: 1.62 ± 0.442
4.557GlyAsp: 4.557 ± 0.876
5.367GlyGlu: 5.367 ± 0.837
3.139GlyPhe: 3.139 ± 0.612
6.582GlyGly: 6.582 ± 1.201
1.114GlyHis: 1.114 ± 0.278
4.253GlyIle: 4.253 ± 0.65
4.151GlyLys: 4.151 ± 0.599
5.063GlyLeu: 5.063 ± 0.702
2.329GlyMet: 2.329 ± 0.499
3.038GlyAsn: 3.038 ± 0.644
0.405GlyPro: 0.405 ± 0.186
1.924GlyGln: 1.924 ± 0.393
3.645GlyArg: 3.645 ± 0.584
3.746GlySer: 3.746 ± 0.561
3.949GlyThr: 3.949 ± 0.872
6.177GlyVal: 6.177 ± 0.844
1.316GlyTrp: 1.316 ± 0.351
1.823GlyTyr: 1.823 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
1.721HisAla: 1.721 ± 0.403
0.608HisCys: 0.608 ± 0.267
1.013HisAsp: 1.013 ± 0.299
1.114HisGlu: 1.114 ± 0.444
0.506HisPhe: 0.506 ± 0.253
1.418HisGly: 1.418 ± 0.4
0.911HisHis: 0.911 ± 0.329
0.81HisIle: 0.81 ± 0.214
0.709HisLys: 0.709 ± 0.258
1.215HisLeu: 1.215 ± 0.273
0.506HisMet: 0.506 ± 0.218
1.013HisAsn: 1.013 ± 0.322
1.114HisPro: 1.114 ± 0.292
0.81HisGln: 0.81 ± 0.272
1.215HisArg: 1.215 ± 0.285
0.81HisSer: 0.81 ± 0.327
0.81HisThr: 0.81 ± 0.314
1.418HisVal: 1.418 ± 0.3
0.203HisTrp: 0.203 ± 0.116
0.709HisTyr: 0.709 ± 0.238
0.0HisXaa: 0.0 ± 0.0
Ile
5.367IleAla: 5.367 ± 0.724
0.81IleCys: 0.81 ± 0.33
4.86IleAsp: 4.86 ± 0.68
3.746IleGlu: 3.746 ± 0.48
1.823IlePhe: 1.823 ± 0.432
4.05IleGly: 4.05 ± 0.558
0.709IleHis: 0.709 ± 0.333
2.734IleIle: 2.734 ± 0.657
2.329IleLys: 2.329 ± 0.566
3.443IleLeu: 3.443 ± 0.586
0.81IleMet: 0.81 ± 0.255
2.228IleAsn: 2.228 ± 0.446
1.519IlePro: 1.519 ± 0.456
2.43IleGln: 2.43 ± 0.429
4.557IleArg: 4.557 ± 0.689
4.455IleSer: 4.455 ± 0.72
3.848IleThr: 3.848 ± 0.627
3.746IleVal: 3.746 ± 0.586
0.405IleTrp: 0.405 ± 0.231
1.013IleTyr: 1.013 ± 0.408
0.0IleXaa: 0.0 ± 0.0
Lys
5.265LysAla: 5.265 ± 0.691
0.203LysCys: 0.203 ± 0.141
3.038LysAsp: 3.038 ± 0.605
3.24LysGlu: 3.24 ± 0.692
1.013LysPhe: 1.013 ± 0.292
4.354LysGly: 4.354 ± 0.732
1.215LysHis: 1.215 ± 0.343
2.329LysIle: 2.329 ± 0.435
3.645LysLys: 3.645 ± 0.703
5.063LysLeu: 5.063 ± 0.823
0.911LysMet: 0.911 ± 0.37
2.633LysAsn: 2.633 ± 0.624
3.443LysPro: 3.443 ± 0.77
1.924LysGln: 1.924 ± 0.405
4.151LysArg: 4.151 ± 0.602
2.633LysSer: 2.633 ± 0.607
4.05LysThr: 4.05 ± 0.649
3.949LysVal: 3.949 ± 0.661
1.114LysTrp: 1.114 ± 0.382
2.126LysTyr: 2.126 ± 0.487
0.0LysXaa: 0.0 ± 0.0
Leu
9.822LeuAla: 9.822 ± 0.997
0.608LeuCys: 0.608 ± 0.362
5.873LeuAsp: 5.873 ± 0.839
5.468LeuGlu: 5.468 ± 0.686
2.633LeuPhe: 2.633 ± 0.493
5.67LeuGly: 5.67 ± 0.768
1.519LeuHis: 1.519 ± 0.372
4.354LeuIle: 4.354 ± 0.552
4.759LeuLys: 4.759 ± 0.69
5.367LeuLeu: 5.367 ± 0.672
2.633LeuMet: 2.633 ± 0.543
4.05LeuAsn: 4.05 ± 0.55
3.848LeuPro: 3.848 ± 0.547
4.05LeuGln: 4.05 ± 0.459
5.367LeuArg: 5.367 ± 0.826
6.177LeuSer: 6.177 ± 0.869
7.29LeuThr: 7.29 ± 1.055
4.151LeuVal: 4.151 ± 0.633
1.418LeuTrp: 1.418 ± 0.335
1.924LeuTyr: 1.924 ± 0.456
0.0LeuXaa: 0.0 ± 0.0
Met
3.341MetAla: 3.341 ± 0.539
0.101MetCys: 0.101 ± 0.092
0.911MetAsp: 0.911 ± 0.342
1.316MetGlu: 1.316 ± 0.391
1.215MetPhe: 1.215 ± 0.392
0.911MetGly: 0.911 ± 0.291
0.405MetHis: 0.405 ± 0.19
1.215MetIle: 1.215 ± 0.398
1.519MetLys: 1.519 ± 0.405
2.329MetLeu: 2.329 ± 0.509
0.405MetMet: 0.405 ± 0.205
1.418MetAsn: 1.418 ± 0.331
0.709MetPro: 0.709 ± 0.242
0.911MetGln: 0.911 ± 0.39
1.924MetArg: 1.924 ± 0.439
2.43MetSer: 2.43 ± 0.429
2.835MetThr: 2.835 ± 0.515
1.418MetVal: 1.418 ± 0.355
0.304MetTrp: 0.304 ± 0.258
0.81MetTyr: 0.81 ± 0.295
0.0MetXaa: 0.0 ± 0.0
Asn
3.139AsnAla: 3.139 ± 0.54
0.304AsnCys: 0.304 ± 0.174
1.721AsnAsp: 1.721 ± 0.412
2.734AsnGlu: 2.734 ± 0.538
1.519AsnPhe: 1.519 ± 0.321
3.848AsnGly: 3.848 ± 0.793
0.405AsnHis: 0.405 ± 0.206
2.633AsnIle: 2.633 ± 0.663
1.924AsnLys: 1.924 ± 0.448
3.24AsnLeu: 3.24 ± 0.451
1.418AsnMet: 1.418 ± 0.398
2.025AsnAsn: 2.025 ± 0.466
2.329AsnPro: 2.329 ± 0.491
1.114AsnGln: 1.114 ± 0.325
2.329AsnArg: 2.329 ± 0.522
2.025AsnSer: 2.025 ± 0.431
2.228AsnThr: 2.228 ± 0.504
2.228AsnVal: 2.228 ± 0.384
0.304AsnTrp: 0.304 ± 0.177
0.608AsnTyr: 0.608 ± 0.245
0.0AsnXaa: 0.0 ± 0.0
Pro
4.86ProAla: 4.86 ± 0.712
0.405ProCys: 0.405 ± 0.202
3.544ProAsp: 3.544 ± 0.659
3.443ProGlu: 3.443 ± 0.579
1.215ProPhe: 1.215 ± 0.379
2.329ProGly: 2.329 ± 0.474
1.013ProHis: 1.013 ± 0.372
2.126ProIle: 2.126 ± 0.5
2.228ProLys: 2.228 ± 0.438
3.645ProLeu: 3.645 ± 0.548
0.405ProMet: 0.405 ± 0.225
1.418ProAsn: 1.418 ± 0.401
2.025ProPro: 2.025 ± 0.369
1.013ProGln: 1.013 ± 0.369
2.43ProArg: 2.43 ± 0.532
2.228ProSer: 2.228 ± 0.574
1.316ProThr: 1.316 ± 0.4
4.557ProVal: 4.557 ± 0.683
0.506ProTrp: 0.506 ± 0.216
0.709ProTyr: 0.709 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
3.949GlnAla: 3.949 ± 1.06
0.608GlnCys: 0.608 ± 0.259
1.62GlnAsp: 1.62 ± 0.516
2.633GlnGlu: 2.633 ± 0.473
1.418GlnPhe: 1.418 ± 0.323
1.215GlnGly: 1.215 ± 0.31
0.405GlnHis: 0.405 ± 0.188
1.823GlnIle: 1.823 ± 0.534
2.734GlnLys: 2.734 ± 0.345
4.354GlnLeu: 4.354 ± 0.739
0.506GlnMet: 0.506 ± 0.195
1.013GlnAsn: 1.013 ± 0.365
1.721GlnPro: 1.721 ± 0.366
1.316GlnGln: 1.316 ± 0.454
3.848GlnArg: 3.848 ± 0.599
3.24GlnSer: 3.24 ± 0.585
2.228GlnThr: 2.228 ± 0.548
1.215GlnVal: 1.215 ± 0.312
0.81GlnTrp: 0.81 ± 0.291
1.013GlnTyr: 1.013 ± 0.353
0.0GlnXaa: 0.0 ± 0.0
Arg
5.367ArgAla: 5.367 ± 0.728
0.506ArgCys: 0.506 ± 0.175
2.936ArgAsp: 2.936 ± 0.407
5.063ArgGlu: 5.063 ± 0.768
1.924ArgPhe: 1.924 ± 0.434
3.544ArgGly: 3.544 ± 0.715
2.228ArgHis: 2.228 ± 0.407
4.151ArgIle: 4.151 ± 0.696
4.151ArgLys: 4.151 ± 0.668
6.885ArgLeu: 6.885 ± 0.836
1.721ArgMet: 1.721 ± 0.477
2.329ArgAsn: 2.329 ± 0.555
2.025ArgPro: 2.025 ± 0.466
2.228ArgGln: 2.228 ± 0.576
4.962ArgArg: 4.962 ± 0.888
3.341ArgSer: 3.341 ± 0.455
3.645ArgThr: 3.645 ± 0.726
5.367ArgVal: 5.367 ± 0.695
1.316ArgTrp: 1.316 ± 0.389
1.62ArgTyr: 1.62 ± 0.453
0.0ArgXaa: 0.0 ± 0.0
Ser
7.797SerAla: 7.797 ± 1.018
0.304SerCys: 0.304 ± 0.18
5.265SerAsp: 5.265 ± 0.627
3.443SerGlu: 3.443 ± 0.579
1.823SerPhe: 1.823 ± 0.432
3.544SerGly: 3.544 ± 0.703
1.013SerHis: 1.013 ± 0.376
3.139SerIle: 3.139 ± 0.437
2.531SerLys: 2.531 ± 0.55
6.278SerLeu: 6.278 ± 0.867
1.924SerMet: 1.924 ± 0.438
2.43SerAsn: 2.43 ± 0.519
2.228SerPro: 2.228 ± 0.52
2.835SerGln: 2.835 ± 0.346
4.455SerArg: 4.455 ± 0.714
2.228SerSer: 2.228 ± 0.55
3.341SerThr: 3.341 ± 0.671
4.86SerVal: 4.86 ± 0.559
0.81SerTrp: 0.81 ± 0.248
1.418SerTyr: 1.418 ± 0.431
0.0SerXaa: 0.0 ± 0.0
Thr
7.088ThrAla: 7.088 ± 1.305
0.709ThrCys: 0.709 ± 0.267
3.645ThrAsp: 3.645 ± 0.486
2.329ThrGlu: 2.329 ± 0.512
1.62ThrPhe: 1.62 ± 0.483
6.48ThrGly: 6.48 ± 0.715
0.81ThrHis: 0.81 ± 0.315
3.848ThrIle: 3.848 ± 0.573
3.341ThrLys: 3.341 ± 0.53
7.594ThrLeu: 7.594 ± 0.682
1.519ThrMet: 1.519 ± 0.363
1.721ThrAsn: 1.721 ± 0.372
2.329ThrPro: 2.329 ± 0.372
2.025ThrGln: 2.025 ± 0.545
3.443ThrArg: 3.443 ± 0.512
2.734ThrSer: 2.734 ± 0.648
3.848ThrThr: 3.848 ± 0.551
4.962ThrVal: 4.962 ± 0.688
1.013ThrTrp: 1.013 ± 0.274
1.62ThrTyr: 1.62 ± 0.515
0.0ThrXaa: 0.0 ± 0.0
Val
5.873ValAla: 5.873 ± 0.654
0.709ValCys: 0.709 ± 0.289
4.151ValAsp: 4.151 ± 0.636
4.455ValGlu: 4.455 ± 0.766
3.443ValPhe: 3.443 ± 0.519
4.151ValGly: 4.151 ± 0.814
0.911ValHis: 0.911 ± 0.277
4.354ValIle: 4.354 ± 0.696
4.253ValLys: 4.253 ± 0.689
4.253ValLeu: 4.253 ± 0.56
1.823ValMet: 1.823 ± 0.41
2.734ValAsn: 2.734 ± 0.568
3.139ValPro: 3.139 ± 0.534
2.531ValGln: 2.531 ± 0.542
3.24ValArg: 3.24 ± 0.515
4.455ValSer: 4.455 ± 0.529
5.265ValThr: 5.265 ± 0.571
4.05ValVal: 4.05 ± 0.688
1.316ValTrp: 1.316 ± 0.413
1.721ValTyr: 1.721 ± 0.498
0.0ValXaa: 0.0 ± 0.0
Trp
1.316TrpAla: 1.316 ± 0.315
0.101TrpCys: 0.101 ± 0.13
0.709TrpAsp: 0.709 ± 0.264
1.519TrpGlu: 1.519 ± 0.383
0.506TrpPhe: 0.506 ± 0.229
0.506TrpGly: 0.506 ± 0.381
0.709TrpHis: 0.709 ± 0.247
0.81TrpIle: 0.81 ± 0.28
0.709TrpLys: 0.709 ± 0.263
2.228TrpLeu: 2.228 ± 0.492
0.203TrpMet: 0.203 ± 0.132
0.304TrpAsn: 0.304 ± 0.183
1.114TrpPro: 1.114 ± 0.341
0.506TrpGln: 0.506 ± 0.17
1.519TrpArg: 1.519 ± 0.379
0.709TrpSer: 0.709 ± 0.244
0.405TrpThr: 0.405 ± 0.201
0.506TrpVal: 0.506 ± 0.285
0.304TrpTrp: 0.304 ± 0.142
0.608TrpTyr: 0.608 ± 0.237
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.633TyrAla: 2.633 ± 0.561
0.101TyrCys: 0.101 ± 0.111
1.823TyrAsp: 1.823 ± 0.369
1.62TyrGlu: 1.62 ± 0.363
1.215TyrPhe: 1.215 ± 0.397
1.924TyrGly: 1.924 ± 0.391
0.405TyrHis: 0.405 ± 0.219
1.62TyrIle: 1.62 ± 0.435
0.81TyrLys: 0.81 ± 0.246
1.924TyrLeu: 1.924 ± 0.399
0.81TyrMet: 0.81 ± 0.251
0.506TyrAsn: 0.506 ± 0.21
1.013TyrPro: 1.013 ± 0.372
1.721TyrGln: 1.721 ± 0.404
2.228TyrArg: 2.228 ± 0.459
1.215TyrSer: 1.215 ± 0.375
1.721TyrThr: 1.721 ± 0.392
2.228TyrVal: 2.228 ± 0.637
0.203TyrTrp: 0.203 ± 0.116
0.506TyrTyr: 0.506 ± 0.248
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (9877 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski