Amino acid dipepetide frequency for Ruminococcus albus SY3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.675AlaAla: 7.675 ± 0.132	1.094AlaCys: 1.094 ± 0.035	5.605AlaAsp: 5.605 ± 0.088	6.688AlaGlu: 6.688 ± 0.099	3.106AlaPhe: 3.106 ± 0.073	5.442AlaGly: 5.442 ± 0.101	1.145AlaHis: 1.145 ± 0.036	4.561AlaIle: 4.561 ± 0.066	5.002AlaLys: 5.002 ± 0.095	6.392AlaLeu: 6.392 ± 0.093	2.155AlaMet: 2.155 ± 0.047	2.717AlaAsn: 2.717 ± 0.058	2.156AlaPro: 2.156 ± 0.054	2.069AlaGln: 2.069 ± 0.041	2.709AlaArg: 2.709 ± 0.064	3.865AlaSer: 3.865 ± 0.062	2.861AlaThr: 2.861 ± 0.062	7.059AlaVal: 7.059 ± 0.1	0.524AlaTrp: 0.524 ± 0.027	2.791AlaTyr: 2.791 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.314CysAla: 1.314 ± 0.034	0.338CysCys: 0.338 ± 0.019	1.178CysAsp: 1.178 ± 0.031	1.202CysGlu: 1.202 ± 0.038	0.76CysPhe: 0.76 ± 0.028	1.722CysGly: 1.722 ± 0.049	0.321CysHis: 0.321 ± 0.018	1.218CysIle: 1.218 ± 0.037	0.956CysLys: 0.956 ± 0.037	1.166CysLeu: 1.166 ± 0.035	0.443CysMet: 0.443 ± 0.02	0.605CysAsn: 0.605 ± 0.027	0.61CysPro: 0.61 ± 0.023	0.273CysGln: 0.273 ± 0.017	0.78CysArg: 0.78 ± 0.029	1.158CysSer: 1.158 ± 0.04	1.065CysThr: 1.065 ± 0.04	1.029CysVal: 1.029 ± 0.033	0.131CysTrp: 0.131 ± 0.012	0.657CysTyr: 0.657 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.138AspAla: 4.138 ± 0.08	1.039AspCys: 1.039 ± 0.038	4.479AspAsp: 4.479 ± 0.085	5.543AspGlu: 5.543 ± 0.091	2.879AspPhe: 2.879 ± 0.052	5.287AspGly: 5.287 ± 0.084	1.055AspHis: 1.055 ± 0.035	5.949AspIle: 5.949 ± 0.077	5.087AspLys: 5.087 ± 0.075	4.663AspLeu: 4.663 ± 0.07	2.204AspMet: 2.204 ± 0.053	3.191AspAsn: 3.191 ± 0.068	2.18AspPro: 2.18 ± 0.052	1.04AspGln: 1.04 ± 0.034	2.634AspArg: 2.634 ± 0.051	4.027AspSer: 4.027 ± 0.077	4.016AspThr: 4.016 ± 0.078	3.959AspVal: 3.959 ± 0.065	0.57AspTrp: 0.57 ± 0.026	3.029AspTyr: 3.029 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.591GluAla: 4.591 ± 0.095	1.073GluCys: 1.073 ± 0.035	4.514GluAsp: 4.514 ± 0.08	5.849GluGlu: 5.849 ± 0.114	2.791GluPhe: 2.791 ± 0.055	4.109GluGly: 4.109 ± 0.062	1.266GluHis: 1.266 ± 0.041	5.358GluIle: 5.358 ± 0.083	6.548GluLys: 6.548 ± 0.101	6.898GluLeu: 6.898 ± 0.1	2.153GluMet: 2.153 ± 0.042	4.366GluAsn: 4.366 ± 0.078	1.928GluPro: 1.928 ± 0.049	2.266GluGln: 2.266 ± 0.054	3.098GluArg: 3.098 ± 0.058	3.568GluSer: 3.568 ± 0.071	3.6GluThr: 3.6 ± 0.066	4.153GluVal: 4.153 ± 0.072	0.678GluTrp: 0.678 ± 0.029	3.418GluTyr: 3.418 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	3.147PheAla: 3.147 ± 0.063	0.828PheCys: 0.828 ± 0.029	3.487PheAsp: 3.487 ± 0.071	2.959PheGlu: 2.959 ± 0.061	1.788PhePhe: 1.788 ± 0.05	3.298PheGly: 3.298 ± 0.061	0.59PheHis: 0.59 ± 0.024	2.974PheIle: 2.974 ± 0.052	2.427PheLys: 2.427 ± 0.054	3.13PheLeu: 3.13 ± 0.072	1.203PheMet: 1.203 ± 0.034	1.802PheAsn: 1.802 ± 0.043	1.313PhePro: 1.313 ± 0.041	0.778PheGln: 0.778 ± 0.031	1.854PheArg: 1.854 ± 0.048	3.22PheSer: 3.22 ± 0.064	2.751PheThr: 2.751 ± 0.05	2.73PheVal: 2.73 ± 0.058	0.384PheTrp: 0.384 ± 0.02	1.792PheTyr: 1.792 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.862GlyAla: 4.862 ± 0.105	1.452GlyCys: 1.452 ± 0.054	4.489GlyAsp: 4.489 ± 0.07	4.893GlyGlu: 4.893 ± 0.07	3.356GlyPhe: 3.356 ± 0.06	5.066GlyGly: 5.066 ± 0.092	1.188GlyHis: 1.188 ± 0.035	5.414GlyIle: 5.414 ± 0.091	5.59GlyLys: 5.59 ± 0.088	5.471GlyLeu: 5.471 ± 0.084	2.267GlyMet: 2.267 ± 0.052	3.102GlyAsn: 3.102 ± 0.07	0.866GlyPro: 0.866 ± 0.036	1.69GlyGln: 1.69 ± 0.044	3.005GlyArg: 3.005 ± 0.056	4.516GlySer: 4.516 ± 0.082	4.27GlyThr: 4.27 ± 0.12	4.78GlyVal: 4.78 ± 0.079	0.739GlyTrp: 0.739 ± 0.036	3.39GlyTyr: 3.39 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.886HisAla: 0.886 ± 0.031	0.31HisCys: 0.31 ± 0.017	1.048HisAsp: 1.048 ± 0.039	1.08HisGlu: 1.08 ± 0.036	0.817HisPhe: 0.817 ± 0.026	1.213HisGly: 1.213 ± 0.037	0.405HisHis: 0.405 ± 0.034	1.362HisIle: 1.362 ± 0.041	1.027HisLys: 1.027 ± 0.033	1.175HisLeu: 1.175 ± 0.036	0.42HisMet: 0.42 ± 0.02	0.746HisAsn: 0.746 ± 0.026	0.659HisPro: 0.659 ± 0.027	0.413HisGln: 0.413 ± 0.018	0.722HisArg: 0.722 ± 0.025	1.056HisSer: 1.056 ± 0.035	0.952HisThr: 0.952 ± 0.034	0.828HisVal: 0.828 ± 0.029	0.191HisTrp: 0.191 ± 0.014	0.693HisTyr: 0.693 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.621IleAla: 5.621 ± 0.074	1.443IleCys: 1.443 ± 0.04	4.928IleAsp: 4.928 ± 0.069	4.758IleGlu: 4.758 ± 0.062	2.976IlePhe: 2.976 ± 0.06	4.752IleGly: 4.752 ± 0.09	1.082IleHis: 1.082 ± 0.036	5.227IleIle: 5.227 ± 0.094	4.787IleLys: 4.787 ± 0.073	5.332IleLeu: 5.332 ± 0.085	1.973IleMet: 1.973 ± 0.047	3.616IleAsn: 3.616 ± 0.06	3.068IlePro: 3.068 ± 0.069	1.551IleGln: 1.551 ± 0.041	3.192IleArg: 3.192 ± 0.062	5.604IleSer: 5.604 ± 0.087	4.748IleThr: 4.748 ± 0.077	4.673IleVal: 4.673 ± 0.071	0.547IleTrp: 0.547 ± 0.026	2.725IleTyr: 2.725 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.598LysAla: 5.598 ± 0.09	0.997LysCys: 0.997 ± 0.037	4.213LysAsp: 4.213 ± 0.072	5.046LysGlu: 5.046 ± 0.082	2.275LysPhe: 2.275 ± 0.047	4.444LysGly: 4.444 ± 0.072	1.08LysHis: 1.08 ± 0.035	4.784LysIle: 4.784 ± 0.07	5.753LysLys: 5.753 ± 0.08	6.412LysLeu: 6.412 ± 0.079	2.102LysMet: 2.102 ± 0.046	3.953LysAsn: 3.953 ± 0.066	2.229LysPro: 2.229 ± 0.046	2.002LysGln: 2.002 ± 0.048	3.081LysArg: 3.081 ± 0.06	3.818LysSer: 3.818 ± 0.065	4.057LysThr: 4.057 ± 0.075	4.488LysVal: 4.488 ± 0.072	0.762LysTrp: 0.762 ± 0.031	3.272LysTyr: 3.272 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.23LeuAla: 6.23 ± 0.088	1.644LeuCys: 1.644 ± 0.04	5.178LeuAsp: 5.178 ± 0.085	5.235LeuGlu: 5.235 ± 0.087	3.424LeuPhe: 3.424 ± 0.079	5.397LeuGly: 5.397 ± 0.082	1.284LeuHis: 1.284 ± 0.032	5.648LeuIle: 5.648 ± 0.088	5.853LeuLys: 5.853 ± 0.081	6.677LeuLeu: 6.677 ± 0.096	2.505LeuMet: 2.505 ± 0.054	3.631LeuAsn: 3.631 ± 0.062	3.199LeuPro: 3.199 ± 0.063	1.706LeuGln: 1.706 ± 0.04	3.52LeuArg: 3.52 ± 0.06	5.929LeuSer: 5.929 ± 0.081	5.515LeuThr: 5.515 ± 0.09	4.602LeuVal: 4.602 ± 0.074	0.663LeuTrp: 0.663 ± 0.028	3.053LeuTyr: 3.053 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.186MetAla: 2.186 ± 0.057	0.425MetCys: 0.425 ± 0.021	1.551MetAsp: 1.551 ± 0.039	1.725MetGlu: 1.725 ± 0.044	1.286MetPhe: 1.286 ± 0.053	1.926MetGly: 1.926 ± 0.049	0.422MetHis: 0.422 ± 0.019	2.064MetIle: 2.064 ± 0.049	2.272MetLys: 2.272 ± 0.045	2.745MetLeu: 2.745 ± 0.053	0.887MetMet: 0.887 ± 0.033	1.511MetAsn: 1.511 ± 0.041	1.125MetPro: 1.125 ± 0.034	0.859MetGln: 0.859 ± 0.03	1.295MetArg: 1.295 ± 0.037	1.977MetSer: 1.977 ± 0.045	1.919MetThr: 1.919 ± 0.046	1.584MetVal: 1.584 ± 0.039	0.213MetTrp: 0.213 ± 0.014	0.998MetTyr: 0.998 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.654AsnAla: 3.654 ± 0.064	0.843AsnCys: 0.843 ± 0.031	3.123AsnAsp: 3.123 ± 0.057	3.117AsnGlu: 3.117 ± 0.064	1.813AsnPhe: 1.813 ± 0.045	4.49AsnGly: 4.49 ± 0.091	0.641AsnHis: 0.641 ± 0.026	3.887AsnIle: 3.887 ± 0.061	2.969AsnLys: 2.969 ± 0.063	2.989AsnLeu: 2.989 ± 0.052	1.287AsnMet: 1.287 ± 0.037	2.577AsnAsn: 2.577 ± 0.082	1.581AsnPro: 1.581 ± 0.04	0.907AsnGln: 0.907 ± 0.037	1.816AsnArg: 1.816 ± 0.046	3.169AsnSer: 3.169 ± 0.068	2.912AsnThr: 2.912 ± 0.069	3.137AsnVal: 3.137 ± 0.059	0.468AsnTrp: 0.468 ± 0.022	2.11AsnTyr: 2.11 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.676ProAla: 2.676 ± 0.065	0.476ProCys: 0.476 ± 0.022	2.952ProAsp: 2.952 ± 0.06	3.226ProGlu: 3.226 ± 0.066	1.441ProPhe: 1.441 ± 0.044	1.45ProGly: 1.45 ± 0.04	0.521ProHis: 0.521 ± 0.023	1.945ProIle: 1.945 ± 0.04	2.032ProLys: 2.032 ± 0.05	2.374ProLeu: 2.374 ± 0.055	0.88ProMet: 0.88 ± 0.028	1.379ProAsn: 1.379 ± 0.045	0.805ProPro: 0.805 ± 0.032	0.981ProGln: 0.981 ± 0.036	1.049ProArg: 1.049 ± 0.031	1.816ProSer: 1.816 ± 0.043	1.678ProThr: 1.678 ± 0.041	2.734ProVal: 2.734 ± 0.06	0.282ProTrp: 0.282 ± 0.018	1.312ProTyr: 1.312 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.889GlnAla: 1.889 ± 0.046	0.338GlnCys: 0.338 ± 0.019	1.14GlnAsp: 1.14 ± 0.033	1.493GlnGlu: 1.493 ± 0.043	1.014GlnPhe: 1.014 ± 0.029	1.553GlnGly: 1.553 ± 0.049	0.406GlnHis: 0.406 ± 0.019	1.852GlnIle: 1.852 ± 0.048	1.868GlnLys: 1.868 ± 0.046	2.205GlnLeu: 2.205 ± 0.049	0.794GlnMet: 0.794 ± 0.029	1.341GlnAsn: 1.341 ± 0.045	0.848GlnPro: 0.848 ± 0.038	0.91GlnGln: 0.91 ± 0.038	1.175GlnArg: 1.175 ± 0.034	1.453GlnSer: 1.453 ± 0.038	1.454GlnThr: 1.454 ± 0.041	1.399GlnVal: 1.399 ± 0.039	0.217GlnTrp: 0.217 ± 0.013	1.157GlnTyr: 1.157 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.646ArgAla: 2.646 ± 0.056	0.643ArgCys: 0.643 ± 0.027	2.408ArgAsp: 2.408 ± 0.054	3.097ArgGlu: 3.097 ± 0.061	1.966ArgPhe: 1.966 ± 0.046	2.533ArgGly: 2.533 ± 0.059	0.753ArgHis: 0.753 ± 0.024	3.244ArgIle: 3.244 ± 0.059	2.984ArgLys: 2.984 ± 0.051	3.763ArgLeu: 3.763 ± 0.065	1.285ArgMet: 1.285 ± 0.036	1.966ArgAsn: 1.966 ± 0.045	1.28ArgPro: 1.28 ± 0.038	1.274ArgGln: 1.274 ± 0.036	2.188ArgArg: 2.188 ± 0.051	2.53ArgSer: 2.53 ± 0.048	2.256ArgThr: 2.256 ± 0.048	2.581ArgVal: 2.581 ± 0.049	0.381ArgTrp: 0.381 ± 0.018	1.952ArgTyr: 1.952 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.465SerAla: 5.465 ± 0.088	1.03SerCys: 1.03 ± 0.033	4.462SerAsp: 4.462 ± 0.073	4.641SerGlu: 4.641 ± 0.071	2.943SerPhe: 2.943 ± 0.05	5.533SerGly: 5.533 ± 0.108	0.923SerHis: 0.923 ± 0.032	4.155SerIle: 4.155 ± 0.069	3.995SerLys: 3.995 ± 0.073	4.981SerLeu: 4.981 ± 0.09	1.708SerMet: 1.708 ± 0.042	2.675SerAsn: 2.675 ± 0.067	1.961SerPro: 1.961 ± 0.04	1.582SerGln: 1.582 ± 0.044	2.631SerArg: 2.631 ± 0.053	4.448SerSer: 4.448 ± 0.11	3.181SerThr: 3.181 ± 0.065	4.557SerVal: 4.557 ± 0.08	0.607SerTrp: 0.607 ± 0.031	2.732SerTyr: 2.732 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	5.507ThrAla: 5.507 ± 0.096	0.674ThrCys: 0.674 ± 0.023	4.367ThrAsp: 4.367 ± 0.088	4.216ThrGlu: 4.216 ± 0.068	2.387ThrPhe: 2.387 ± 0.051	4.465ThrGly: 4.465 ± 0.077	0.855ThrHis: 0.855 ± 0.028	4.09ThrIle: 4.09 ± 0.083	3.232ThrLys: 3.232 ± 0.07	4.714ThrLeu: 4.714 ± 0.073	1.369ThrMet: 1.369 ± 0.038	2.279ThrAsn: 2.279 ± 0.052	2.219ThrPro: 2.219 ± 0.051	1.284ThrGln: 1.284 ± 0.032	1.844ThrArg: 1.844 ± 0.045	3.653ThrSer: 3.653 ± 0.103	3.112ThrThr: 3.112 ± 0.078	5.087ThrVal: 5.087 ± 0.1	0.484ThrTrp: 0.484 ± 0.024	2.382ThrTyr: 2.382 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.121ValAla: 4.121 ± 0.083	1.343ValCys: 1.343 ± 0.041	3.873ValAsp: 3.873 ± 0.067	4.022ValGlu: 4.022 ± 0.069	3.059ValPhe: 3.059 ± 0.06	3.926ValGly: 3.926 ± 0.058	1.037ValHis: 1.037 ± 0.032	5.335ValIle: 5.335 ± 0.069	4.738ValLys: 4.738 ± 0.076	5.623ValLeu: 5.623 ± 0.08	2.105ValMet: 2.105 ± 0.049	3.272ValAsn: 3.272 ± 0.059	2.458ValPro: 2.458 ± 0.053	1.599ValGln: 1.599 ± 0.046	2.842ValArg: 2.842 ± 0.055	4.854ValSer: 4.854 ± 0.067	4.763ValThr: 4.763 ± 0.108	4.159ValVal: 4.159 ± 0.083	0.606ValTrp: 0.606 ± 0.02	2.9ValTyr: 2.9 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.537TrpAla: 0.537 ± 0.021	0.189TrpCys: 0.189 ± 0.013	0.67TrpAsp: 0.67 ± 0.028	0.563TrpGlu: 0.563 ± 0.028	0.424TrpPhe: 0.424 ± 0.02	0.716TrpGly: 0.716 ± 0.03	0.216TrpHis: 0.216 ± 0.015	0.502TrpIle: 0.502 ± 0.024	0.564TrpLys: 0.564 ± 0.028	0.846TrpLeu: 0.846 ± 0.027	0.206TrpMet: 0.206 ± 0.014	0.548TrpAsn: 0.548 ± 0.025	0.098TrpPro: 0.098 ± 0.011	0.337TrpGln: 0.337 ± 0.018	0.422TrpArg: 0.422 ± 0.021	0.506TrpSer: 0.506 ± 0.024	0.487TrpThr: 0.487 ± 0.02	0.522TrpVal: 0.522 ± 0.022	0.103TrpTrp: 0.103 ± 0.01	0.458TrpTyr: 0.458 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.87TyrAla: 2.87 ± 0.063	0.745TyrCys: 0.745 ± 0.03	3.305TyrAsp: 3.305 ± 0.063	2.874TyrGlu: 2.874 ± 0.057	1.95TyrPhe: 1.95 ± 0.051	3.084TyrGly: 3.084 ± 0.064	0.811TyrHis: 0.811 ± 0.027	3.034TyrIle: 3.034 ± 0.058	2.684TyrLys: 2.684 ± 0.053	3.335TyrLeu: 3.335 ± 0.068	1.02TyrMet: 1.02 ± 0.03	2.215TyrAsn: 2.215 ± 0.059	1.426TyrPro: 1.426 ± 0.038	0.984TyrGln: 0.984 ± 0.034	1.875TyrArg: 1.875 ± 0.044	3.04TyrSer: 3.04 ± 0.063	2.623TyrThr: 2.623 ± 0.075	2.575TyrVal: 2.575 ± 0.058	0.368TyrTrp: 0.368 ± 0.02	2.038TyrTyr: 2.038 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3322 proteins (1072678 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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