Amino acid dipepetide frequency for Great Island virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.529AlaAla: 7.529 ± 1.244
1.027AlaCys: 1.027 ± 0.435
4.107AlaAsp: 4.107 ± 0.64
4.791AlaGlu: 4.791 ± 1.061
2.396AlaPhe: 2.396 ± 0.807
6.502AlaGly: 6.502 ± 0.794
2.225AlaHis: 2.225 ± 0.626
5.305AlaIle: 5.305 ± 1.48
2.225AlaLys: 2.225 ± 0.502
12.32AlaLeu: 12.32 ± 0.99
2.225AlaMet: 2.225 ± 0.937
2.738AlaAsn: 2.738 ± 0.787
5.647AlaPro: 5.647 ± 0.464
3.422AlaGln: 3.422 ± 0.875
10.096AlaArg: 10.096 ± 1.033
5.305AlaSer: 5.305 ± 0.856
4.791AlaThr: 4.791 ± 0.949
6.674AlaVal: 6.674 ± 0.956
1.711AlaTrp: 1.711 ± 0.482
2.909AlaTyr: 2.909 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
1.369CysAla: 1.369 ± 0.552
0.342CysCys: 0.342 ± 0.22
0.513CysAsp: 0.513 ± 0.261
0.684CysGlu: 0.684 ± 0.243
0.856CysPhe: 0.856 ± 0.528
0.856CysGly: 0.856 ± 0.292
0.171CysHis: 0.171 ± 0.182
0.342CysIle: 0.342 ± 0.225
0.171CysLys: 0.171 ± 0.182
0.684CysLeu: 0.684 ± 0.401
0.684CysMet: 0.684 ± 0.27
1.027CysAsn: 1.027 ± 0.344
0.342CysPro: 0.342 ± 0.166
0.513CysGln: 0.513 ± 0.345
1.198CysArg: 1.198 ± 0.423
0.513CysSer: 0.513 ± 0.273
1.027CysThr: 1.027 ± 0.576
1.027CysVal: 1.027 ± 0.495
0.0CysTrp: 0.0 ± 0.0
0.856CysTyr: 0.856 ± 0.407
0.0CysXaa: 0.0 ± 0.0
Asp
5.647AspAla: 5.647 ± 0.738
0.513AspCys: 0.513 ± 0.178
5.476AspAsp: 5.476 ± 0.889
4.107AspGlu: 4.107 ± 0.779
1.54AspPhe: 1.54 ± 0.427
3.08AspGly: 3.08 ± 0.643
1.198AspHis: 1.198 ± 0.468
3.765AspIle: 3.765 ± 0.739
1.027AspLys: 1.027 ± 0.395
6.16AspLeu: 6.16 ± 1.292
1.027AspMet: 1.027 ± 0.264
0.856AspAsn: 0.856 ± 0.386
3.251AspPro: 3.251 ± 0.568
2.225AspGln: 2.225 ± 0.476
3.765AspArg: 3.765 ± 0.764
3.251AspSer: 3.251 ± 0.628
3.422AspThr: 3.422 ± 0.783
5.818AspVal: 5.818 ± 0.899
0.342AspTrp: 0.342 ± 0.242
1.54AspTyr: 1.54 ± 0.292
0.0AspXaa: 0.0 ± 0.0
Glu
7.529GluAla: 7.529 ± 1.223
0.513GluCys: 0.513 ± 0.259
2.567GluAsp: 2.567 ± 0.505
4.278GluGlu: 4.278 ± 0.586
2.738GluPhe: 2.738 ± 0.873
3.422GluGly: 3.422 ± 0.812
1.54GluHis: 1.54 ± 0.427
4.107GluIle: 4.107 ± 0.843
1.882GluLys: 1.882 ± 0.557
3.765GluLeu: 3.765 ± 0.678
1.882GluMet: 1.882 ± 0.51
1.369GluAsn: 1.369 ± 0.608
2.225GluPro: 2.225 ± 0.585
1.711GluGln: 1.711 ± 0.27
6.845GluArg: 6.845 ± 0.947
4.62GluSer: 4.62 ± 0.703
3.251GluThr: 3.251 ± 0.87
4.962GluVal: 4.962 ± 0.507
0.513GluTrp: 0.513 ± 0.492
2.053GluTyr: 2.053 ± 0.589
0.0GluXaa: 0.0 ± 0.0
Phe
1.882PheAla: 1.882 ± 0.427
0.513PheCys: 0.513 ± 0.251
2.225PheAsp: 2.225 ± 0.367
1.54PheGlu: 1.54 ± 0.442
1.54PhePhe: 1.54 ± 0.409
2.396PheGly: 2.396 ± 0.685
1.369PheHis: 1.369 ± 0.401
1.54PheIle: 1.54 ± 0.472
0.684PheLys: 0.684 ± 0.284
2.909PheLeu: 2.909 ± 0.682
1.027PheMet: 1.027 ± 0.296
0.856PheAsn: 0.856 ± 0.297
2.053PhePro: 2.053 ± 0.367
1.54PheGln: 1.54 ± 0.617
4.278PheArg: 4.278 ± 0.625
3.422PheSer: 3.422 ± 0.813
1.027PheThr: 1.027 ± 0.329
3.422PheVal: 3.422 ± 0.616
0.171PheTrp: 0.171 ± 0.199
0.513PheTyr: 0.513 ± 0.29
0.0PheXaa: 0.0 ± 0.0
Gly
5.305GlyAla: 5.305 ± 1.314
0.342GlyCys: 0.342 ± 0.365
4.278GlyAsp: 4.278 ± 0.996
3.936GlyGlu: 3.936 ± 0.788
1.882GlyPhe: 1.882 ± 0.491
2.909GlyGly: 2.909 ± 0.967
2.396GlyHis: 2.396 ± 0.449
3.08GlyIle: 3.08 ± 0.451
1.882GlyLys: 1.882 ± 0.516
4.62GlyLeu: 4.62 ± 1.002
2.738GlyMet: 2.738 ± 0.77
1.369GlyAsn: 1.369 ± 0.363
3.422GlyPro: 3.422 ± 0.66
2.396GlyGln: 2.396 ± 0.572
4.278GlyArg: 4.278 ± 0.86
4.449GlySer: 4.449 ± 1.087
3.08GlyThr: 3.08 ± 0.622
3.422GlyVal: 3.422 ± 0.787
1.027GlyTrp: 1.027 ± 0.338
2.053GlyTyr: 2.053 ± 0.745
0.0GlyXaa: 0.0 ± 0.0
His
2.053HisAla: 2.053 ± 0.504
0.342HisCys: 0.342 ± 0.227
0.856HisAsp: 0.856 ± 0.27
1.369HisGlu: 1.369 ± 0.304
0.856HisPhe: 0.856 ± 0.308
3.251HisGly: 3.251 ± 1.03
1.198HisHis: 1.198 ± 0.422
1.027HisIle: 1.027 ± 0.385
0.513HisLys: 0.513 ± 0.222
2.738HisLeu: 2.738 ± 0.535
0.684HisMet: 0.684 ± 0.272
1.198HisAsn: 1.198 ± 0.443
1.54HisPro: 1.54 ± 0.45
1.198HisGln: 1.198 ± 0.486
2.567HisArg: 2.567 ± 0.613
1.54HisSer: 1.54 ± 0.445
1.54HisThr: 1.54 ± 0.785
2.396HisVal: 2.396 ± 0.429
0.342HisTrp: 0.342 ± 0.185
0.684HisTyr: 0.684 ± 0.413
0.0HisXaa: 0.0 ± 0.0
Ile
3.422IleAla: 3.422 ± 0.622
0.684IleCys: 0.684 ± 0.297
3.765IleAsp: 3.765 ± 0.712
3.251IleGlu: 3.251 ± 0.866
1.54IlePhe: 1.54 ± 0.395
2.738IleGly: 2.738 ± 0.496
2.053IleHis: 2.053 ± 0.677
1.882IleIle: 1.882 ± 0.57
1.369IleLys: 1.369 ± 0.44
4.107IleLeu: 4.107 ± 0.657
1.027IleMet: 1.027 ± 0.356
0.856IleAsn: 0.856 ± 0.424
3.08IlePro: 3.08 ± 0.574
2.225IleGln: 2.225 ± 0.367
5.647IleArg: 5.647 ± 0.724
2.909IleSer: 2.909 ± 0.584
2.909IleThr: 2.909 ± 0.859
2.909IleVal: 2.909 ± 0.735
0.513IleTrp: 0.513 ± 0.251
1.198IleTyr: 1.198 ± 0.348
0.0IleXaa: 0.0 ± 0.0
Lys
1.711LysAla: 1.711 ± 0.672
0.0LysCys: 0.0 ± 0.0
2.225LysAsp: 2.225 ± 0.776
2.053LysGlu: 2.053 ± 0.568
0.342LysPhe: 0.342 ± 0.185
0.342LysGly: 0.342 ± 0.234
0.513LysHis: 0.513 ± 0.493
1.54LysIle: 1.54 ± 0.466
1.027LysLys: 1.027 ± 0.355
1.711LysLeu: 1.711 ± 0.574
1.369LysMet: 1.369 ± 0.367
0.684LysAsn: 0.684 ± 0.332
1.027LysPro: 1.027 ± 0.534
0.513LysGln: 0.513 ± 0.218
3.593LysArg: 3.593 ± 0.989
1.54LysSer: 1.54 ± 0.525
2.053LysThr: 2.053 ± 0.622
2.053LysVal: 2.053 ± 0.731
0.0LysTrp: 0.0 ± 0.0
0.856LysTyr: 0.856 ± 0.454
0.0LysXaa: 0.0 ± 0.0
Leu
10.438LeuAla: 10.438 ± 1.873
1.54LeuCys: 1.54 ± 0.398
4.449LeuAsp: 4.449 ± 0.96
4.791LeuGlu: 4.791 ± 0.927
3.936LeuPhe: 3.936 ± 0.801
5.305LeuGly: 5.305 ± 0.71
3.251LeuHis: 3.251 ± 0.554
2.738LeuIle: 2.738 ± 0.869
3.08LeuLys: 3.08 ± 0.942
10.096LeuLeu: 10.096 ± 1.545
2.396LeuMet: 2.396 ± 0.509
3.08LeuAsn: 3.08 ± 0.566
4.278LeuPro: 4.278 ± 0.929
2.396LeuGln: 2.396 ± 0.876
11.465LeuArg: 11.465 ± 1.451
6.16LeuSer: 6.16 ± 0.572
4.962LeuThr: 4.962 ± 0.828
5.989LeuVal: 5.989 ± 0.737
1.369LeuTrp: 1.369 ± 0.657
3.08LeuTyr: 3.08 ± 0.62
0.0LeuXaa: 0.0 ± 0.0
Met
3.422MetAla: 3.422 ± 0.716
0.513MetCys: 0.513 ± 0.26
1.54MetAsp: 1.54 ± 0.432
1.54MetGlu: 1.54 ± 0.386
0.513MetPhe: 0.513 ± 0.276
1.027MetGly: 1.027 ± 0.314
0.513MetHis: 0.513 ± 0.25
1.54MetIle: 1.54 ± 0.461
0.513MetLys: 0.513 ± 0.259
3.593MetLeu: 3.593 ± 0.572
0.856MetMet: 0.856 ± 0.402
0.171MetAsn: 0.171 ± 0.164
0.513MetPro: 0.513 ± 0.444
1.711MetGln: 1.711 ± 0.377
3.251MetArg: 3.251 ± 0.548
2.567MetSer: 2.567 ± 0.376
0.856MetThr: 0.856 ± 0.315
0.513MetVal: 0.513 ± 0.258
0.342MetTrp: 0.342 ± 0.225
1.027MetTyr: 1.027 ± 0.424
0.0MetXaa: 0.0 ± 0.0
Asn
3.765AsnAla: 3.765 ± 0.885
0.0AsnCys: 0.0 ± 0.0
0.684AsnAsp: 0.684 ± 0.342
1.711AsnGlu: 1.711 ± 0.588
1.198AsnPhe: 1.198 ± 0.37
1.882AsnGly: 1.882 ± 0.412
0.342AsnHis: 0.342 ± 0.185
0.856AsnIle: 0.856 ± 0.308
0.342AsnLys: 0.342 ± 0.243
2.225AsnLeu: 2.225 ± 0.429
1.027AsnMet: 1.027 ± 0.301
1.027AsnAsn: 1.027 ± 0.464
1.711AsnPro: 1.711 ± 0.709
1.027AsnGln: 1.027 ± 0.439
1.882AsnArg: 1.882 ± 0.541
1.711AsnSer: 1.711 ± 0.364
1.54AsnThr: 1.54 ± 0.474
2.053AsnVal: 2.053 ± 0.667
0.171AsnTrp: 0.171 ± 0.128
1.027AsnTyr: 1.027 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
4.278ProAla: 4.278 ± 1.057
0.342ProCys: 0.342 ± 0.219
3.08ProAsp: 3.08 ± 0.734
4.449ProGlu: 4.449 ± 0.832
2.225ProPhe: 2.225 ± 0.392
4.107ProGly: 4.107 ± 0.93
1.198ProHis: 1.198 ± 0.275
2.225ProIle: 2.225 ± 0.643
0.684ProLys: 0.684 ± 0.273
3.936ProLeu: 3.936 ± 0.711
1.369ProMet: 1.369 ± 0.314
1.027ProAsn: 1.027 ± 0.487
3.936ProPro: 3.936 ± 1.423
2.225ProGln: 2.225 ± 0.354
5.305ProArg: 5.305 ± 1.203
2.225ProSer: 2.225 ± 0.441
3.765ProThr: 3.765 ± 0.823
4.107ProVal: 4.107 ± 0.726
0.513ProTrp: 0.513 ± 0.213
1.711ProTyr: 1.711 ± 0.443
0.0ProXaa: 0.0 ± 0.0
Gln
3.08GlnAla: 3.08 ± 0.558
0.684GlnCys: 0.684 ± 0.373
2.053GlnAsp: 2.053 ± 0.565
1.882GlnGlu: 1.882 ± 0.528
1.027GlnPhe: 1.027 ± 0.298
2.053GlnGly: 2.053 ± 0.471
1.711GlnHis: 1.711 ± 0.623
2.567GlnIle: 2.567 ± 0.658
0.856GlnLys: 0.856 ± 0.306
2.567GlnLeu: 2.567 ± 0.692
1.711GlnMet: 1.711 ± 0.478
1.711GlnAsn: 1.711 ± 0.585
1.369GlnPro: 1.369 ± 0.476
1.711GlnGln: 1.711 ± 0.491
4.107GlnArg: 4.107 ± 0.894
2.225GlnSer: 2.225 ± 0.662
3.593GlnThr: 3.593 ± 0.613
1.711GlnVal: 1.711 ± 0.318
0.856GlnTrp: 0.856 ± 0.33
1.027GlnTyr: 1.027 ± 0.466
0.0GlnXaa: 0.0 ± 0.0
Arg
10.096ArgAla: 10.096 ± 1.107
2.053ArgCys: 2.053 ± 0.293
7.7ArgAsp: 7.7 ± 1.199
8.042ArgGlu: 8.042 ± 0.705
3.936ArgPhe: 3.936 ± 0.879
4.791ArgGly: 4.791 ± 0.945
2.225ArgHis: 2.225 ± 0.758
5.647ArgIle: 5.647 ± 0.884
2.738ArgLys: 2.738 ± 0.483
8.385ArgLeu: 8.385 ± 0.984
2.738ArgMet: 2.738 ± 0.697
3.08ArgAsn: 3.08 ± 0.437
3.765ArgPro: 3.765 ± 0.826
2.909ArgGln: 2.909 ± 0.712
10.438ArgArg: 10.438 ± 2.05
6.674ArgSer: 6.674 ± 0.814
5.647ArgThr: 5.647 ± 1.143
8.385ArgVal: 8.385 ± 1.218
0.856ArgTrp: 0.856 ± 0.335
1.882ArgTyr: 1.882 ± 0.55
0.0ArgXaa: 0.0 ± 0.0
Ser
8.042SerAla: 8.042 ± 1.336
0.856SerCys: 0.856 ± 0.407
3.936SerAsp: 3.936 ± 0.882
3.251SerGlu: 3.251 ± 0.597
2.567SerPhe: 2.567 ± 1.067
3.251SerGly: 3.251 ± 0.515
2.053SerHis: 2.053 ± 0.377
1.711SerIle: 1.711 ± 0.425
1.711SerLys: 1.711 ± 0.579
6.674SerLeu: 6.674 ± 1.088
1.198SerMet: 1.198 ± 0.343
1.369SerAsn: 1.369 ± 0.413
3.422SerPro: 3.422 ± 0.604
2.225SerGln: 2.225 ± 0.69
4.791SerArg: 4.791 ± 0.739
3.936SerSer: 3.936 ± 1.013
4.449SerThr: 4.449 ± 1.167
4.278SerVal: 4.278 ± 0.873
1.198SerTrp: 1.198 ± 0.44
2.567SerTyr: 2.567 ± 0.51
0.0SerXaa: 0.0 ± 0.0
Thr
4.278ThrAla: 4.278 ± 0.993
1.198ThrCys: 1.198 ± 0.606
2.225ThrAsp: 2.225 ± 0.426
2.567ThrGlu: 2.567 ± 0.56
2.053ThrPhe: 2.053 ± 0.461
2.909ThrGly: 2.909 ± 0.953
1.54ThrHis: 1.54 ± 0.558
2.567ThrIle: 2.567 ± 0.45
2.225ThrLys: 2.225 ± 1.004
6.502ThrLeu: 6.502 ± 1.145
1.198ThrMet: 1.198 ± 0.302
1.027ThrAsn: 1.027 ± 0.466
4.449ThrPro: 4.449 ± 0.807
3.08ThrGln: 3.08 ± 0.625
6.674ThrArg: 6.674 ± 1.128
5.133ThrSer: 5.133 ± 1.145
3.936ThrThr: 3.936 ± 0.695
2.909ThrVal: 2.909 ± 0.713
0.684ThrTrp: 0.684 ± 0.359
2.396ThrTyr: 2.396 ± 0.53
0.0ThrXaa: 0.0 ± 0.0
Val
5.647ValAla: 5.647 ± 0.879
0.684ValCys: 0.684 ± 0.244
3.936ValAsp: 3.936 ± 1.001
4.962ValGlu: 4.962 ± 0.555
2.396ValPhe: 2.396 ± 0.445
4.791ValGly: 4.791 ± 0.849
1.882ValHis: 1.882 ± 0.369
3.593ValIle: 3.593 ± 0.733
1.027ValLys: 1.027 ± 0.471
8.042ValLeu: 8.042 ± 1.265
0.856ValMet: 0.856 ± 0.279
1.54ValAsn: 1.54 ± 0.405
4.962ValPro: 4.962 ± 0.829
3.593ValGln: 3.593 ± 0.505
7.358ValArg: 7.358 ± 0.928
3.765ValSer: 3.765 ± 0.947
4.278ValThr: 4.278 ± 0.656
4.791ValVal: 4.791 ± 0.686
0.342ValTrp: 0.342 ± 0.234
3.251ValTyr: 3.251 ± 0.751
0.0ValXaa: 0.0 ± 0.0
Trp
0.513TrpAla: 0.513 ± 0.353
0.513TrpCys: 0.513 ± 0.343
0.856TrpAsp: 0.856 ± 0.273
0.513TrpGlu: 0.513 ± 0.234
0.513TrpPhe: 0.513 ± 0.206
0.684TrpGly: 0.684 ± 0.228
0.171TrpHis: 0.171 ± 0.164
0.513TrpIle: 0.513 ± 0.367
0.342TrpLys: 0.342 ± 0.229
1.369TrpLeu: 1.369 ± 0.694
0.0TrpMet: 0.0 ± 0.0
0.342TrpAsn: 0.342 ± 0.257
0.513TrpPro: 0.513 ± 0.31
0.684TrpGln: 0.684 ± 0.255
1.198TrpArg: 1.198 ± 0.29
0.684TrpSer: 0.684 ± 0.313
0.684TrpThr: 0.684 ± 0.326
0.856TrpVal: 0.856 ± 0.342
0.0TrpTrp: 0.0 ± 0.0
0.171TrpTyr: 0.171 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.936TyrAla: 3.936 ± 0.677
0.513TyrCys: 0.513 ± 0.422
1.54TyrAsp: 1.54 ± 0.344
2.053TyrGlu: 2.053 ± 0.501
0.856TyrPhe: 0.856 ± 0.245
2.567TyrGly: 2.567 ± 0.663
0.342TyrHis: 0.342 ± 0.223
1.54TyrIle: 1.54 ± 0.398
0.856TyrLys: 0.856 ± 0.234
2.396TyrLeu: 2.396 ± 0.595
0.342TyrMet: 0.342 ± 0.166
0.856TyrAsn: 0.856 ± 0.34
1.369TyrPro: 1.369 ± 0.754
1.198TyrGln: 1.198 ± 0.318
3.251TyrArg: 3.251 ± 0.729
0.856TyrSer: 0.856 ± 0.386
2.738TyrThr: 2.738 ± 0.666
3.422TyrVal: 3.422 ± 0.43
0.171TyrTrp: 0.171 ± 0.199
0.856TyrTyr: 0.856 ± 0.306
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5845 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski