Amino acid dipepetide frequency for Streptococcus phage Javan503

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.406AlaAla: 2.406 ± 0.633
0.445AlaCys: 0.445 ± 0.221
4.544AlaAsp: 4.544 ± 0.605
6.237AlaGlu: 6.237 ± 1.041
2.762AlaPhe: 2.762 ± 0.391
3.92AlaGly: 3.92 ± 0.617
0.891AlaHis: 0.891 ± 0.322
6.593AlaIle: 6.593 ± 0.666
7.128AlaLys: 7.128 ± 0.905
4.9AlaLeu: 4.9 ± 0.651
2.049AlaMet: 2.049 ± 0.365
4.187AlaAsn: 4.187 ± 0.66
1.426AlaPro: 1.426 ± 0.336
1.693AlaGln: 1.693 ± 0.401
2.94AlaArg: 2.94 ± 0.539
4.9AlaSer: 4.9 ± 0.701
3.207AlaThr: 3.207 ± 0.715
3.475AlaVal: 3.475 ± 0.627
1.069AlaTrp: 1.069 ± 0.279
2.762AlaTyr: 2.762 ± 0.462
0.0AlaXaa: 0.0 ± 0.0
Cys
0.089CysAla: 0.089 ± 0.091
0.0CysCys: 0.0 ± 0.0
0.445CysAsp: 0.445 ± 0.195
0.535CysGlu: 0.535 ± 0.218
0.089CysPhe: 0.089 ± 0.104
0.178CysGly: 0.178 ± 0.13
0.0CysHis: 0.0 ± 0.0
0.445CysIle: 0.445 ± 0.256
0.356CysLys: 0.356 ± 0.18
0.267CysLeu: 0.267 ± 0.14
0.0CysMet: 0.0 ± 0.0
0.267CysAsn: 0.267 ± 0.152
0.267CysPro: 0.267 ± 0.161
0.089CysGln: 0.089 ± 0.094
0.535CysArg: 0.535 ± 0.264
0.445CysSer: 0.445 ± 0.159
0.089CysThr: 0.089 ± 0.092
0.178CysVal: 0.178 ± 0.125
0.0CysTrp: 0.0 ± 0.0
0.535CysTyr: 0.535 ± 0.228
0.0CysXaa: 0.0 ± 0.0
Asp
4.187AspAla: 4.187 ± 0.601
0.356AspCys: 0.356 ± 0.185
3.653AspAsp: 3.653 ± 0.548
4.9AspGlu: 4.9 ± 0.583
2.673AspPhe: 2.673 ± 0.483
5.969AspGly: 5.969 ± 0.814
0.713AspHis: 0.713 ± 0.302
3.831AspIle: 3.831 ± 0.434
5.88AspLys: 5.88 ± 0.773
4.989AspLeu: 4.989 ± 0.612
1.069AspMet: 1.069 ± 0.362
4.989AspAsn: 4.989 ± 0.623
1.426AspPro: 1.426 ± 0.318
1.426AspGln: 1.426 ± 0.331
2.94AspArg: 2.94 ± 0.488
3.207AspSer: 3.207 ± 0.547
4.722AspThr: 4.722 ± 0.645
4.811AspVal: 4.811 ± 0.631
0.802AspTrp: 0.802 ± 0.297
4.009AspTyr: 4.009 ± 0.451
0.0AspXaa: 0.0 ± 0.0
Glu
4.633GluAla: 4.633 ± 1.01
0.267GluCys: 0.267 ± 0.158
2.94GluAsp: 2.94 ± 0.69
5.078GluGlu: 5.078 ± 0.83
3.297GluPhe: 3.297 ± 0.533
1.96GluGly: 1.96 ± 0.386
1.069GluHis: 1.069 ± 0.302
4.9GluIle: 4.9 ± 0.619
6.593GluLys: 6.593 ± 0.95
7.573GluLeu: 7.573 ± 0.87
1.96GluMet: 1.96 ± 0.374
3.475GluAsn: 3.475 ± 0.729
1.515GluPro: 1.515 ± 0.46
3.564GluGln: 3.564 ± 0.642
3.831GluArg: 3.831 ± 0.92
3.118GluSer: 3.118 ± 0.511
4.009GluThr: 4.009 ± 0.723
4.544GluVal: 4.544 ± 0.646
1.069GluTrp: 1.069 ± 0.306
3.386GluTyr: 3.386 ± 0.454
0.0GluXaa: 0.0 ± 0.0
Phe
3.118PheAla: 3.118 ± 0.532
0.089PheCys: 0.089 ± 0.092
3.118PheAsp: 3.118 ± 0.49
2.762PheGlu: 2.762 ± 0.456
1.426PhePhe: 1.426 ± 0.366
2.94PheGly: 2.94 ± 0.396
0.178PheHis: 0.178 ± 0.11
2.673PheIle: 2.673 ± 0.516
3.475PheLys: 3.475 ± 0.619
2.049PheLeu: 2.049 ± 0.428
0.98PheMet: 0.98 ± 0.296
2.406PheAsn: 2.406 ± 0.525
1.158PhePro: 1.158 ± 0.341
1.158PheGln: 1.158 ± 0.353
1.515PheArg: 1.515 ± 0.337
2.762PheSer: 2.762 ± 0.584
2.584PheThr: 2.584 ± 0.432
2.316PheVal: 2.316 ± 0.43
0.535PheTrp: 0.535 ± 0.218
1.693PheTyr: 1.693 ± 0.339
0.0PheXaa: 0.0 ± 0.0
Gly
3.386GlyAla: 3.386 ± 0.735
0.445GlyCys: 0.445 ± 0.181
3.831GlyAsp: 3.831 ± 0.699
3.297GlyGlu: 3.297 ± 0.485
2.495GlyPhe: 2.495 ± 0.547
4.009GlyGly: 4.009 ± 0.876
1.336GlyHis: 1.336 ± 0.337
4.989GlyIle: 4.989 ± 0.747
5.613GlyLys: 5.613 ± 0.811
4.811GlyLeu: 4.811 ± 0.62
2.762GlyMet: 2.762 ± 0.539
3.386GlyAsn: 3.386 ± 0.43
0.802GlyPro: 0.802 ± 0.368
2.049GlyGln: 2.049 ± 0.483
2.138GlyArg: 2.138 ± 0.512
4.187GlySer: 4.187 ± 0.758
4.989GlyThr: 4.989 ± 1.007
4.277GlyVal: 4.277 ± 0.716
1.693GlyTrp: 1.693 ± 0.292
3.386GlyTyr: 3.386 ± 0.57
0.0GlyXaa: 0.0 ± 0.0
His
1.247HisAla: 1.247 ± 0.373
0.178HisCys: 0.178 ± 0.125
0.802HisAsp: 0.802 ± 0.294
0.713HisGlu: 0.713 ± 0.235
0.713HisPhe: 0.713 ± 0.239
0.713HisGly: 0.713 ± 0.283
0.178HisHis: 0.178 ± 0.121
1.247HisIle: 1.247 ± 0.277
1.158HisLys: 1.158 ± 0.321
0.98HisLeu: 0.98 ± 0.247
0.356HisMet: 0.356 ± 0.173
0.802HisAsn: 0.802 ± 0.322
0.445HisPro: 0.445 ± 0.172
0.089HisGln: 0.089 ± 0.084
0.713HisArg: 0.713 ± 0.254
0.624HisSer: 0.624 ± 0.253
0.535HisThr: 0.535 ± 0.223
1.069HisVal: 1.069 ± 0.273
0.089HisTrp: 0.089 ± 0.071
0.802HisTyr: 0.802 ± 0.274
0.0HisXaa: 0.0 ± 0.0
Ile
5.702IleAla: 5.702 ± 0.63
0.445IleCys: 0.445 ± 0.175
7.038IleAsp: 7.038 ± 0.77
5.078IleGlu: 5.078 ± 0.787
2.227IlePhe: 2.227 ± 0.468
4.811IleGly: 4.811 ± 0.726
0.802IleHis: 0.802 ± 0.283
4.455IleIle: 4.455 ± 0.633
5.435IleLys: 5.435 ± 0.768
5.078IleLeu: 5.078 ± 0.704
1.069IleMet: 1.069 ± 0.283
4.366IleAsn: 4.366 ± 0.557
2.406IlePro: 2.406 ± 0.526
2.316IleGln: 2.316 ± 0.631
2.316IleArg: 2.316 ± 0.394
4.277IleSer: 4.277 ± 0.573
4.989IleThr: 4.989 ± 0.662
4.9IleVal: 4.9 ± 0.792
0.98IleTrp: 0.98 ± 0.258
3.118IleTyr: 3.118 ± 0.489
0.0IleXaa: 0.0 ± 0.0
Lys
5.435LysAla: 5.435 ± 0.691
0.178LysCys: 0.178 ± 0.113
5.702LysAsp: 5.702 ± 0.849
5.524LysGlu: 5.524 ± 1.012
2.673LysPhe: 2.673 ± 0.426
4.722LysGly: 4.722 ± 0.695
1.336LysHis: 1.336 ± 0.332
6.771LysIle: 6.771 ± 0.975
6.86LysLys: 6.86 ± 1.07
6.682LysLeu: 6.682 ± 0.644
1.693LysMet: 1.693 ± 0.456
5.435LysAsn: 5.435 ± 0.507
3.297LysPro: 3.297 ± 0.609
4.366LysGln: 4.366 ± 0.669
3.742LysArg: 3.742 ± 0.694
6.326LysSer: 6.326 ± 0.862
6.058LysThr: 6.058 ± 0.92
4.989LysVal: 4.989 ± 0.746
1.069LysTrp: 1.069 ± 0.333
3.564LysTyr: 3.564 ± 0.572
0.0LysXaa: 0.0 ± 0.0
Leu
6.504LeuAla: 6.504 ± 0.84
0.267LeuCys: 0.267 ± 0.148
5.791LeuAsp: 5.791 ± 0.781
5.88LeuGlu: 5.88 ± 0.901
2.673LeuPhe: 2.673 ± 0.428
3.564LeuGly: 3.564 ± 0.755
0.624LeuHis: 0.624 ± 0.253
5.791LeuIle: 5.791 ± 0.708
7.217LeuLys: 7.217 ± 0.736
5.88LeuLeu: 5.88 ± 0.772
1.693LeuMet: 1.693 ± 0.386
5.078LeuAsn: 5.078 ± 0.629
1.96LeuPro: 1.96 ± 0.406
3.564LeuGln: 3.564 ± 0.531
3.475LeuArg: 3.475 ± 0.714
6.237LeuSer: 6.237 ± 0.737
5.257LeuThr: 5.257 ± 0.582
5.078LeuVal: 5.078 ± 0.785
1.069LeuTrp: 1.069 ± 0.337
2.495LeuTyr: 2.495 ± 0.429
0.0LeuXaa: 0.0 ± 0.0
Met
2.049MetAla: 2.049 ± 0.446
0.089MetCys: 0.089 ± 0.088
1.426MetAsp: 1.426 ± 0.429
0.98MetGlu: 0.98 ± 0.344
0.891MetPhe: 0.891 ± 0.247
0.445MetGly: 0.445 ± 0.197
0.178MetHis: 0.178 ± 0.121
1.336MetIle: 1.336 ± 0.299
1.158MetLys: 1.158 ± 0.229
2.316MetLeu: 2.316 ± 0.582
0.267MetMet: 0.267 ± 0.129
1.069MetAsn: 1.069 ± 0.301
0.98MetPro: 0.98 ± 0.259
0.891MetGln: 0.891 ± 0.298
1.069MetArg: 1.069 ± 0.277
1.782MetSer: 1.782 ± 0.312
2.406MetThr: 2.406 ± 0.424
1.158MetVal: 1.158 ± 0.265
0.356MetTrp: 0.356 ± 0.191
1.069MetTyr: 1.069 ± 0.308
0.0MetXaa: 0.0 ± 0.0
Asn
4.277AsnAla: 4.277 ± 0.586
0.178AsnCys: 0.178 ± 0.113
3.564AsnAsp: 3.564 ± 0.483
4.098AsnGlu: 4.098 ± 0.475
2.406AsnPhe: 2.406 ± 0.397
5.702AsnGly: 5.702 ± 0.597
1.158AsnHis: 1.158 ± 0.292
4.098AsnIle: 4.098 ± 0.666
5.167AsnLys: 5.167 ± 0.524
5.524AsnLeu: 5.524 ± 0.724
1.069AsnMet: 1.069 ± 0.365
4.009AsnAsn: 4.009 ± 0.643
2.406AsnPro: 2.406 ± 0.55
2.138AsnGln: 2.138 ± 0.366
2.138AsnArg: 2.138 ± 0.356
2.762AsnSer: 2.762 ± 0.43
2.584AsnThr: 2.584 ± 0.438
3.653AsnVal: 3.653 ± 0.491
0.624AsnTrp: 0.624 ± 0.269
1.871AsnTyr: 1.871 ± 0.267
0.0AsnXaa: 0.0 ± 0.0
Pro
1.426ProAla: 1.426 ± 0.437
0.0ProCys: 0.0 ± 0.0
2.316ProAsp: 2.316 ± 0.471
2.406ProGlu: 2.406 ± 0.594
1.515ProPhe: 1.515 ± 0.362
1.515ProGly: 1.515 ± 0.35
0.535ProHis: 0.535 ± 0.199
1.426ProIle: 1.426 ± 0.355
2.762ProLys: 2.762 ± 0.505
2.495ProLeu: 2.495 ± 0.396
0.356ProMet: 0.356 ± 0.171
1.515ProAsn: 1.515 ± 0.329
0.98ProPro: 0.98 ± 0.242
1.336ProGln: 1.336 ± 0.416
1.069ProArg: 1.069 ± 0.318
2.851ProSer: 2.851 ± 0.57
1.515ProThr: 1.515 ± 0.357
1.871ProVal: 1.871 ± 0.384
0.0ProTrp: 0.0 ± 0.0
1.247ProTyr: 1.247 ± 0.379
0.0ProXaa: 0.0 ± 0.0
Gln
3.653GlnAla: 3.653 ± 0.646
0.356GlnCys: 0.356 ± 0.18
2.138GlnAsp: 2.138 ± 0.389
2.138GlnGlu: 2.138 ± 0.403
0.891GlnPhe: 0.891 ± 0.287
2.316GlnGly: 2.316 ± 0.572
0.624GlnHis: 0.624 ± 0.221
2.316GlnIle: 2.316 ± 0.439
3.653GlnLys: 3.653 ± 0.556
3.029GlnLeu: 3.029 ± 0.456
0.713GlnMet: 0.713 ± 0.27
2.584GlnAsn: 2.584 ± 0.406
1.604GlnPro: 1.604 ± 0.4
1.426GlnGln: 1.426 ± 0.425
1.069GlnArg: 1.069 ± 0.273
3.207GlnSer: 3.207 ± 0.637
1.426GlnThr: 1.426 ± 0.359
2.851GlnVal: 2.851 ± 0.42
0.445GlnTrp: 0.445 ± 0.181
1.336GlnTyr: 1.336 ± 0.308
0.0GlnXaa: 0.0 ± 0.0
Arg
2.762ArgAla: 2.762 ± 0.513
0.178ArgCys: 0.178 ± 0.128
2.049ArgAsp: 2.049 ± 0.368
3.386ArgGlu: 3.386 ± 0.494
1.158ArgPhe: 1.158 ± 0.377
2.227ArgGly: 2.227 ± 0.449
0.535ArgHis: 0.535 ± 0.201
3.029ArgIle: 3.029 ± 0.546
4.544ArgLys: 4.544 ± 0.59
4.187ArgLeu: 4.187 ± 0.685
0.713ArgMet: 0.713 ± 0.202
1.693ArgAsn: 1.693 ± 0.364
1.069ArgPro: 1.069 ± 0.281
1.782ArgGln: 1.782 ± 0.376
2.138ArgArg: 2.138 ± 0.356
1.782ArgSer: 1.782 ± 0.517
2.495ArgThr: 2.495 ± 0.419
2.673ArgVal: 2.673 ± 0.469
0.98ArgTrp: 0.98 ± 0.392
1.693ArgTyr: 1.693 ± 0.459
0.0ArgXaa: 0.0 ± 0.0
Ser
5.078SerAla: 5.078 ± 0.845
0.267SerCys: 0.267 ± 0.158
4.9SerAsp: 4.9 ± 0.825
4.277SerGlu: 4.277 ± 0.64
3.029SerPhe: 3.029 ± 0.651
5.524SerGly: 5.524 ± 1.075
0.891SerHis: 0.891 ± 0.329
4.277SerIle: 4.277 ± 0.639
5.167SerLys: 5.167 ± 0.731
5.346SerLeu: 5.346 ± 0.534
1.515SerMet: 1.515 ± 0.378
3.118SerAsn: 3.118 ± 0.621
1.426SerPro: 1.426 ± 0.328
2.94SerGln: 2.94 ± 0.499
1.426SerArg: 1.426 ± 0.391
4.187SerSer: 4.187 ± 1.236
3.653SerThr: 3.653 ± 0.731
4.989SerVal: 4.989 ± 0.745
1.069SerTrp: 1.069 ± 0.278
1.782SerTyr: 1.782 ± 0.433
0.0SerXaa: 0.0 ± 0.0
Thr
3.564ThrAla: 3.564 ± 0.603
0.0ThrCys: 0.0 ± 0.0
3.207ThrAsp: 3.207 ± 0.636
3.742ThrGlu: 3.742 ± 0.583
3.386ThrPhe: 3.386 ± 0.633
5.257ThrGly: 5.257 ± 0.896
0.891ThrHis: 0.891 ± 0.275
6.237ThrIle: 6.237 ± 0.99
4.9ThrLys: 4.9 ± 0.609
4.544ThrLeu: 4.544 ± 0.778
0.98ThrMet: 0.98 ± 0.273
3.742ThrAsn: 3.742 ± 0.616
1.871ThrPro: 1.871 ± 0.426
2.138ThrGln: 2.138 ± 0.38
2.049ThrArg: 2.049 ± 0.37
3.742ThrSer: 3.742 ± 0.513
5.435ThrThr: 5.435 ± 0.922
4.366ThrVal: 4.366 ± 0.839
0.535ThrTrp: 0.535 ± 0.194
2.94ThrTyr: 2.94 ± 0.595
0.0ThrXaa: 0.0 ± 0.0
Val
4.455ValAla: 4.455 ± 0.599
0.445ValCys: 0.445 ± 0.226
5.167ValAsp: 5.167 ± 0.635
4.722ValGlu: 4.722 ± 0.777
2.316ValPhe: 2.316 ± 0.368
4.544ValGly: 4.544 ± 0.839
0.624ValHis: 0.624 ± 0.254
3.92ValIle: 3.92 ± 0.635
5.257ValLys: 5.257 ± 0.701
3.742ValLeu: 3.742 ± 0.503
1.426ValMet: 1.426 ± 0.395
4.098ValAsn: 4.098 ± 0.673
2.406ValPro: 2.406 ± 0.409
1.871ValGln: 1.871 ± 0.498
2.94ValArg: 2.94 ± 0.475
5.257ValSer: 5.257 ± 0.527
4.811ValThr: 4.811 ± 1.062
4.366ValVal: 4.366 ± 0.839
0.356ValTrp: 0.356 ± 0.193
2.049ValTyr: 2.049 ± 0.384
0.0ValXaa: 0.0 ± 0.0
Trp
0.535TrpAla: 0.535 ± 0.203
0.356TrpCys: 0.356 ± 0.192
0.891TrpAsp: 0.891 ± 0.354
0.98TrpGlu: 0.98 ± 0.27
0.178TrpPhe: 0.178 ± 0.127
1.247TrpGly: 1.247 ± 0.339
0.267TrpHis: 0.267 ± 0.147
1.069TrpIle: 1.069 ± 0.275
1.158TrpLys: 1.158 ± 0.335
1.426TrpLeu: 1.426 ± 0.454
0.089TrpMet: 0.089 ± 0.104
0.535TrpAsn: 0.535 ± 0.192
0.0TrpPro: 0.0 ± 0.0
0.713TrpGln: 0.713 ± 0.233
0.535TrpArg: 0.535 ± 0.197
1.336TrpSer: 1.336 ± 0.383
0.98TrpThr: 0.98 ± 0.324
0.713TrpVal: 0.713 ± 0.24
0.267TrpTrp: 0.267 ± 0.178
0.178TrpTyr: 0.178 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.029TyrAla: 3.029 ± 0.504
0.267TyrCys: 0.267 ± 0.147
3.029TyrAsp: 3.029 ± 0.513
2.049TyrGlu: 2.049 ± 0.408
2.138TyrPhe: 2.138 ± 0.542
2.316TyrGly: 2.316 ± 0.418
0.624TyrHis: 0.624 ± 0.224
2.406TyrIle: 2.406 ± 0.492
3.029TyrLys: 3.029 ± 0.539
4.277TyrLeu: 4.277 ± 0.546
1.069TyrMet: 1.069 ± 0.327
2.673TyrAsn: 2.673 ± 0.523
1.693TyrPro: 1.693 ± 0.449
2.227TyrGln: 2.227 ± 0.371
2.495TyrArg: 2.495 ± 0.369
1.871TyrSer: 1.871 ± 0.386
1.782TyrThr: 1.782 ± 0.389
2.495TyrVal: 2.495 ± 0.493
0.445TyrTrp: 0.445 ± 0.167
1.871TyrTyr: 1.871 ± 0.272
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski