Amino acid dipepetide frequency for Enterobacteria phage I2-2 (Bacteriophage I2-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.91AlaAla: 3.91 ± 1.589
0.489AlaCys: 0.489 ± 0.366
4.399AlaAsp: 4.399 ± 1.101
1.955AlaGlu: 1.955 ± 0.748
1.955AlaPhe: 1.955 ± 0.933
5.376AlaGly: 5.376 ± 1.928
0.978AlaHis: 0.978 ± 0.548
3.421AlaIle: 3.421 ± 1.102
8.309AlaLys: 8.309 ± 1.266
9.286AlaLeu: 9.286 ± 2.845
0.978AlaMet: 0.978 ± 0.684
2.444AlaAsn: 2.444 ± 0.995
0.978AlaPro: 0.978 ± 0.548
3.421AlaGln: 3.421 ± 1.164
1.955AlaArg: 1.955 ± 0.835
7.82AlaSer: 7.82 ± 1.375
4.888AlaThr: 4.888 ± 2.052
6.354AlaVal: 6.354 ± 1.315
0.978AlaTrp: 0.978 ± 0.731
2.444AlaTyr: 2.444 ± 0.936
0.0AlaXaa: 0.0 ± 0.0
Cys
0.489CysAla: 0.489 ± 0.366
0.0CysCys: 0.0 ± 0.0
0.489CysAsp: 0.489 ± 0.366
2.444CysGlu: 2.444 ± 0.917
0.0CysPhe: 0.0 ± 0.0
0.978CysGly: 0.978 ± 0.543
0.978CysHis: 0.978 ± 0.706
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.978CysLeu: 0.978 ± 0.51
0.0CysMet: 0.0 ± 0.0
0.489CysAsn: 0.489 ± 0.366
0.489CysPro: 0.489 ± 0.476
0.489CysGln: 0.489 ± 0.366
0.978CysArg: 0.978 ± 0.951
0.0CysSer: 0.0 ± 0.0
0.489CysThr: 0.489 ± 0.366
1.466CysVal: 1.466 ± 0.743
0.978CysTrp: 0.978 ± 0.628
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.91AspAla: 3.91 ± 1.427
0.0AspCys: 0.0 ± 0.0
2.933AspAsp: 2.933 ± 1.154
4.888AspGlu: 4.888 ± 1.164
1.466AspPhe: 1.466 ± 0.799
6.354AspGly: 6.354 ± 2.005
0.978AspHis: 0.978 ± 0.706
4.888AspIle: 4.888 ± 0.935
2.933AspLys: 2.933 ± 2.315
5.865AspLeu: 5.865 ± 1.084
1.466AspMet: 1.466 ± 0.743
4.399AspAsn: 4.399 ± 1.569
0.0AspPro: 0.0 ± 0.0
1.955AspGln: 1.955 ± 1.092
2.444AspArg: 2.444 ± 0.742
4.399AspSer: 4.399 ± 1.736
4.888AspThr: 4.888 ± 2.003
5.865AspVal: 5.865 ± 1.426
0.978AspTrp: 0.978 ± 0.543
0.978AspTyr: 0.978 ± 0.721
0.0AspXaa: 0.0 ± 0.0
Glu
4.399GluAla: 4.399 ± 0.725
0.489GluCys: 0.489 ± 0.476
1.466GluAsp: 1.466 ± 0.767
2.444GluGlu: 2.444 ± 0.772
1.466GluPhe: 1.466 ± 0.856
2.933GluGly: 2.933 ± 1.404
0.489GluHis: 0.489 ± 0.476
1.466GluIle: 1.466 ± 0.713
0.489GluLys: 0.489 ± 0.366
3.91GluLeu: 3.91 ± 1.463
0.978GluMet: 0.978 ± 0.51
0.0GluAsn: 0.0 ± 0.0
0.978GluPro: 0.978 ± 0.447
3.421GluGln: 3.421 ± 0.886
0.978GluArg: 0.978 ± 0.721
5.865GluSer: 5.865 ± 2.154
1.466GluThr: 1.466 ± 0.894
1.466GluVal: 1.466 ± 0.713
0.978GluTrp: 0.978 ± 0.829
0.978GluTyr: 0.978 ± 0.51
0.0GluXaa: 0.0 ± 0.0
Phe
5.376PheAla: 5.376 ± 1.319
0.489PheCys: 0.489 ± 0.476
1.466PheAsp: 1.466 ± 0.676
1.466PheGlu: 1.466 ± 0.76
2.444PhePhe: 2.444 ± 1.061
3.421PheGly: 3.421 ± 1.069
0.0PheHis: 0.0 ± 0.0
1.955PheIle: 1.955 ± 0.985
4.399PheLys: 4.399 ± 1.483
2.444PheLeu: 2.444 ± 1.097
0.978PheMet: 0.978 ± 0.616
3.421PheAsn: 3.421 ± 1.415
0.489PhePro: 0.489 ± 0.476
1.955PheGln: 1.955 ± 0.711
1.955PheArg: 1.955 ± 0.69
2.933PheSer: 2.933 ± 0.977
0.978PheThr: 0.978 ± 0.511
2.933PheVal: 2.933 ± 1.597
0.489PheTrp: 0.489 ± 0.366
2.444PheTyr: 2.444 ± 0.865
0.0PheXaa: 0.0 ± 0.0
Gly
3.91GlyAla: 3.91 ± 1.779
1.466GlyCys: 1.466 ± 1.097
4.888GlyAsp: 4.888 ± 3.206
2.444GlyGlu: 2.444 ± 1.359
3.91GlyPhe: 3.91 ± 1.326
12.708GlyGly: 12.708 ± 4.789
1.466GlyHis: 1.466 ± 0.785
7.331GlyIle: 7.331 ± 1.951
6.843GlyLys: 6.843 ± 1.198
5.376GlyLeu: 5.376 ± 1.87
1.466GlyMet: 1.466 ± 0.665
6.354GlyAsn: 6.354 ± 2.059
0.0GlyPro: 0.0 ± 0.0
2.933GlyGln: 2.933 ± 1.589
3.421GlyArg: 3.421 ± 1.662
7.82GlySer: 7.82 ± 3.061
4.399GlyThr: 4.399 ± 1.265
5.865GlyVal: 5.865 ± 1.315
0.978GlyTrp: 0.978 ± 0.511
2.933GlyTyr: 2.933 ± 1.186
0.0GlyXaa: 0.0 ± 0.0
His
0.978HisAla: 0.978 ± 0.543
0.0HisCys: 0.0 ± 0.0
0.489HisAsp: 0.489 ± 0.366
0.0HisGlu: 0.0 ± 0.0
0.978HisPhe: 0.978 ± 0.951
2.444HisGly: 2.444 ± 0.944
0.978HisHis: 0.978 ± 0.543
1.466HisIle: 1.466 ± 0.91
0.0HisLys: 0.0 ± 0.0
0.978HisLeu: 0.978 ± 0.829
0.0HisMet: 0.0 ± 0.0
0.489HisAsn: 0.489 ± 0.414
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.978HisArg: 0.978 ± 0.628
0.978HisSer: 0.978 ± 0.703
0.978HisThr: 0.978 ± 0.706
1.955HisVal: 1.955 ± 0.761
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.91IleAla: 3.91 ± 1.081
1.466IleCys: 1.466 ± 0.743
6.843IleAsp: 6.843 ± 0.846
1.466IleGlu: 1.466 ± 0.76
3.421IlePhe: 3.421 ± 1.145
4.399IleGly: 4.399 ± 1.46
0.978IleHis: 0.978 ± 0.733
1.955IleIle: 1.955 ± 0.794
2.933IleLys: 2.933 ± 0.692
2.444IleLeu: 2.444 ± 1.925
0.489IleMet: 0.489 ± 0.597
5.376IleAsn: 5.376 ± 1.774
3.91IlePro: 3.91 ± 0.756
3.91IleGln: 3.91 ± 1.703
2.933IleArg: 2.933 ± 1.08
4.399IleSer: 4.399 ± 1.053
4.399IleThr: 4.399 ± 1.209
3.91IleVal: 3.91 ± 1.36
0.489IleTrp: 0.489 ± 0.366
2.933IleTyr: 2.933 ± 1.828
0.0IleXaa: 0.0 ± 0.0
Lys
4.888LysAla: 4.888 ± 1.721
0.0LysCys: 0.0 ± 0.0
4.399LysAsp: 4.399 ± 1.148
2.444LysGlu: 2.444 ± 1.107
1.466LysPhe: 1.466 ± 0.694
3.91LysGly: 3.91 ± 0.889
0.0LysHis: 0.0 ± 0.0
4.399LysIle: 4.399 ± 1.326
2.933LysLys: 2.933 ± 0.976
4.399LysLeu: 4.399 ± 1.51
0.978LysMet: 0.978 ± 0.706
2.933LysAsn: 2.933 ± 1.397
2.444LysPro: 2.444 ± 0.9
2.444LysGln: 2.444 ± 1.327
2.444LysArg: 2.444 ± 0.961
5.376LysSer: 5.376 ± 1.46
5.376LysThr: 5.376 ± 0.65
3.91LysVal: 3.91 ± 1.465
0.978LysTrp: 0.978 ± 0.543
1.466LysTyr: 1.466 ± 0.933
0.0LysXaa: 0.0 ± 0.0
Leu
5.376LeuAla: 5.376 ± 1.78
0.489LeuCys: 0.489 ± 0.61
2.444LeuAsp: 2.444 ± 1.447
3.421LeuGlu: 3.421 ± 1.165
2.933LeuPhe: 2.933 ± 1.477
6.354LeuGly: 6.354 ± 1.768
1.955LeuHis: 1.955 ± 1.086
7.331LeuIle: 7.331 ± 2.267
2.933LeuLys: 2.933 ± 0.826
3.91LeuLeu: 3.91 ± 1.256
4.399LeuMet: 4.399 ± 1.538
3.91LeuAsn: 3.91 ± 1.102
4.399LeuPro: 4.399 ± 1.326
1.466LeuGln: 1.466 ± 0.87
4.399LeuArg: 4.399 ± 1.304
9.286LeuSer: 9.286 ± 1.521
7.331LeuThr: 7.331 ± 1.846
3.91LeuVal: 3.91 ± 1.215
0.0LeuTrp: 0.0 ± 0.0
1.955LeuTyr: 1.955 ± 0.816
0.0LeuXaa: 0.0 ± 0.0
Met
1.955MetAla: 1.955 ± 1.22
0.0MetCys: 0.0 ± 0.0
0.978MetAsp: 0.978 ± 0.523
0.0MetGlu: 0.0 ± 0.0
1.955MetPhe: 1.955 ± 0.806
2.444MetGly: 2.444 ± 0.86
0.489MetHis: 0.489 ± 0.61
1.466MetIle: 1.466 ± 0.983
2.444MetLys: 2.444 ± 0.648
0.489MetLeu: 0.489 ± 0.414
0.0MetMet: 0.0 ± 0.0
1.955MetAsn: 1.955 ± 1.172
1.466MetPro: 1.466 ± 0.676
0.489MetGln: 0.489 ± 0.366
1.955MetArg: 1.955 ± 1.026
2.933MetSer: 2.933 ± 1.172
1.955MetThr: 1.955 ± 0.841
0.978MetVal: 0.978 ± 0.628
0.0MetTrp: 0.0 ± 0.0
0.489MetTyr: 0.489 ± 0.366
0.0MetXaa: 0.0 ± 0.0
Asn
1.955AsnAla: 1.955 ± 1.203
0.489AsnCys: 0.489 ± 0.414
2.444AsnAsp: 2.444 ± 1.828
1.466AsnGlu: 1.466 ± 0.676
1.466AsnPhe: 1.466 ± 0.519
5.865AsnGly: 5.865 ± 1.802
0.0AsnHis: 0.0 ± 0.0
2.933AsnIle: 2.933 ± 1.257
0.978AsnLys: 0.978 ± 0.681
3.91AsnLeu: 3.91 ± 1.572
0.978AsnMet: 0.978 ± 0.706
2.933AsnAsn: 2.933 ± 1.628
2.444AsnPro: 2.444 ± 1.158
2.933AsnGln: 2.933 ± 1.217
2.444AsnArg: 2.444 ± 1.014
6.354AsnSer: 6.354 ± 1.277
2.444AsnThr: 2.444 ± 0.723
4.399AsnVal: 4.399 ± 0.967
1.466AsnTrp: 1.466 ± 0.546
1.955AsnTyr: 1.955 ± 0.662
0.0AsnXaa: 0.0 ± 0.0
Pro
3.421ProAla: 3.421 ± 1.703
0.489ProCys: 0.489 ± 0.414
2.444ProAsp: 2.444 ± 0.772
1.466ProGlu: 1.466 ± 0.785
1.955ProPhe: 1.955 ± 1.202
0.489ProGly: 0.489 ± 0.431
0.489ProHis: 0.489 ± 0.414
1.466ProIle: 1.466 ± 0.702
0.489ProLys: 0.489 ± 0.476
3.421ProLeu: 3.421 ± 0.948
0.0ProMet: 0.0 ± 0.0
0.0ProAsn: 0.0 ± 0.0
0.978ProPro: 0.978 ± 0.523
1.955ProGln: 1.955 ± 0.99
1.466ProArg: 1.466 ± 0.676
5.376ProSer: 5.376 ± 2.165
1.466ProThr: 1.466 ± 0.546
4.888ProVal: 4.888 ± 1.113
0.0ProTrp: 0.0 ± 0.0
0.489ProTyr: 0.489 ± 0.476
0.0ProXaa: 0.0 ± 0.0
Gln
3.421GlnAla: 3.421 ± 0.93
0.489GlnCys: 0.489 ± 0.476
1.955GlnAsp: 1.955 ± 0.845
0.489GlnGlu: 0.489 ± 0.61
0.978GlnPhe: 0.978 ± 0.447
2.444GlnGly: 2.444 ± 1.218
0.489GlnHis: 0.489 ± 0.61
2.933GlnIle: 2.933 ± 1.141
0.978GlnLys: 0.978 ± 0.641
3.421GlnLeu: 3.421 ± 0.581
1.955GlnMet: 1.955 ± 0.831
1.466GlnAsn: 1.466 ± 0.694
0.978GlnPro: 0.978 ± 0.511
0.978GlnGln: 0.978 ± 0.706
1.466GlnArg: 1.466 ± 0.435
4.888GlnSer: 4.888 ± 1.659
2.444GlnThr: 2.444 ± 1.204
4.888GlnVal: 4.888 ± 0.676
0.489GlnTrp: 0.489 ± 0.431
1.955GlnTyr: 1.955 ± 0.92
0.0GlnXaa: 0.0 ± 0.0
Arg
2.444ArgAla: 2.444 ± 0.843
0.0ArgCys: 0.0 ± 0.0
1.466ArgAsp: 1.466 ± 0.715
1.466ArgGlu: 1.466 ± 0.888
0.0ArgPhe: 0.0 ± 0.0
1.466ArgGly: 1.466 ± 0.702
1.466ArgHis: 1.466 ± 0.856
2.933ArgIle: 2.933 ± 1.059
3.91ArgLys: 3.91 ± 1.295
3.421ArgLeu: 3.421 ± 1.42
3.421ArgMet: 3.421 ± 1.197
1.955ArgAsn: 1.955 ± 0.99
0.978ArgPro: 0.978 ± 0.51
2.444ArgGln: 2.444 ± 0.914
1.466ArgArg: 1.466 ± 0.522
3.91ArgSer: 3.91 ± 1.652
1.466ArgThr: 1.466 ± 0.715
6.354ArgVal: 6.354 ± 2.23
0.489ArgTrp: 0.489 ± 0.414
0.489ArgTyr: 0.489 ± 0.476
0.0ArgXaa: 0.0 ± 0.0
Ser
7.331SerAla: 7.331 ± 1.769
0.978SerCys: 0.978 ± 0.706
7.331SerAsp: 7.331 ± 2.399
1.466SerGlu: 1.466 ± 1.097
8.309SerPhe: 8.309 ± 2.232
7.82SerGly: 7.82 ± 1.47
0.489SerHis: 0.489 ± 0.431
5.865SerIle: 5.865 ± 1.412
5.865SerLys: 5.865 ± 1.344
7.331SerLeu: 7.331 ± 1.439
0.489SerMet: 0.489 ± 0.61
6.354SerAsn: 6.354 ± 2.146
3.421SerPro: 3.421 ± 1.013
2.933SerGln: 2.933 ± 0.986
4.888SerArg: 4.888 ± 1.896
6.843SerSer: 6.843 ± 2.069
4.888SerThr: 4.888 ± 1.675
8.798SerVal: 8.798 ± 2.129
1.955SerTrp: 1.955 ± 0.877
2.444SerTyr: 2.444 ± 0.93
0.0SerXaa: 0.0 ± 0.0
Thr
5.376ThrAla: 5.376 ± 1.583
1.466ThrCys: 1.466 ± 0.682
4.888ThrAsp: 4.888 ± 1.569
1.955ThrGlu: 1.955 ± 0.921
1.466ThrPhe: 1.466 ± 0.694
10.753ThrGly: 10.753 ± 4.73
0.978ThrHis: 0.978 ± 0.543
1.955ThrIle: 1.955 ± 0.887
4.888ThrLys: 4.888 ± 1.382
6.354ThrLeu: 6.354 ± 1.658
0.489ThrMet: 0.489 ± 0.431
0.978ThrAsn: 0.978 ± 0.511
1.955ThrPro: 1.955 ± 1.203
2.933ThrGln: 2.933 ± 1.08
0.978ThrArg: 0.978 ± 0.548
4.399ThrSer: 4.399 ± 1.925
2.444ThrThr: 2.444 ± 0.69
5.376ThrVal: 5.376 ± 1.236
0.978ThrTrp: 0.978 ± 0.73
2.933ThrTyr: 2.933 ± 1.322
0.0ThrXaa: 0.0 ± 0.0
Val
6.354ValAla: 6.354 ± 2.216
1.955ValCys: 1.955 ± 0.989
5.865ValAsp: 5.865 ± 1.742
2.444ValGlu: 2.444 ± 1.08
2.444ValPhe: 2.444 ± 1.005
4.888ValGly: 4.888 ± 1.031
0.489ValHis: 0.489 ± 0.476
5.376ValIle: 5.376 ± 1.619
3.421ValLys: 3.421 ± 0.73
7.82ValLeu: 7.82 ± 2.037
3.421ValMet: 3.421 ± 0.916
3.421ValAsn: 3.421 ± 1.201
5.376ValPro: 5.376 ± 1.631
1.955ValGln: 1.955 ± 1.361
3.91ValArg: 3.91 ± 1.58
7.331ValSer: 7.331 ± 1.106
8.798ValThr: 8.798 ± 1.325
6.843ValVal: 6.843 ± 2.442
0.978ValTrp: 0.978 ± 0.706
1.955ValTyr: 1.955 ± 1.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.489TrpAsp: 0.489 ± 0.476
1.466TrpGlu: 1.466 ± 0.785
0.978TrpPhe: 0.978 ± 0.951
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.489TrpIle: 0.489 ± 0.476
1.466TrpLys: 1.466 ± 0.743
2.444TrpLeu: 2.444 ± 0.848
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.978TrpPro: 0.978 ± 0.684
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
2.933TrpSer: 2.933 ± 1.227
0.0TrpThr: 0.0 ± 0.0
0.978TrpVal: 0.978 ± 0.51
0.0TrpTrp: 0.0 ± 0.0
0.978TrpTyr: 0.978 ± 0.447
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.933TyrAla: 2.933 ± 1.515
0.978TyrCys: 0.978 ± 0.523
3.91TyrAsp: 3.91 ± 1.222
1.466TyrGlu: 1.466 ± 0.519
2.933TyrPhe: 2.933 ± 0.805
1.466TyrGly: 1.466 ± 0.766
0.0TyrHis: 0.0 ± 0.0
2.933TyrIle: 2.933 ± 0.844
0.978TyrLys: 0.978 ± 0.706
0.0TyrLeu: 0.0 ± 0.0
1.466TyrMet: 1.466 ± 0.841
0.978TyrAsn: 0.978 ± 0.731
0.489TyrPro: 0.489 ± 0.431
0.489TyrGln: 0.489 ± 0.366
0.489TyrArg: 0.489 ± 0.414
1.955TyrSer: 1.955 ± 0.645
2.444TyrThr: 2.444 ± 0.959
3.91TyrVal: 3.91 ± 1.122
0.0TyrTrp: 0.0 ± 0.0
2.444TyrTyr: 2.444 ± 1.447
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (2047 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski