Amino acid dipepetide frequency for Firmicutes bacterium CAG:313

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.848AlaAla: 2.848 ± 0.118
0.758AlaCys: 0.758 ± 0.045
2.42AlaAsp: 2.42 ± 0.077
2.97AlaGlu: 2.97 ± 0.119
2.598AlaPhe: 2.598 ± 0.093
3.322AlaGly: 3.322 ± 0.099
0.855AlaHis: 0.855 ± 0.046
5.92AlaIle: 5.92 ± 0.12
5.421AlaLys: 5.421 ± 0.135
5.469AlaLeu: 5.469 ± 0.13
1.594AlaMet: 1.594 ± 0.065
3.428AlaAsn: 3.428 ± 0.096
1.378AlaPro: 1.378 ± 0.063
1.254AlaGln: 1.254 ± 0.061
1.982AlaArg: 1.982 ± 0.075
3.928AlaSer: 3.928 ± 0.108
3.958AlaThr: 3.958 ± 0.107
3.356AlaVal: 3.356 ± 0.115
0.368AlaTrp: 0.368 ± 0.031
2.715AlaTyr: 2.715 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.043
0.214CysCys: 0.214 ± 0.023
0.807CysAsp: 0.807 ± 0.044
0.749CysGlu: 0.749 ± 0.046
0.622CysPhe: 0.622 ± 0.04
1.031CysGly: 1.031 ± 0.056
0.241CysHis: 0.241 ± 0.026
0.925CysIle: 0.925 ± 0.045
0.999CysLys: 0.999 ± 0.044
1.019CysLeu: 1.019 ± 0.042
0.201CysMet: 0.201 ± 0.022
0.71CysAsn: 0.71 ± 0.039
0.505CysPro: 0.505 ± 0.039
0.295CysGln: 0.295 ± 0.023
0.336CysArg: 0.336 ± 0.031
0.758CysSer: 0.758 ± 0.043
0.737CysThr: 0.737 ± 0.057
0.776CysVal: 0.776 ± 0.044
0.065CysTrp: 0.065 ± 0.011
0.67CysTyr: 0.67 ± 0.039
0.0CysXaa: 0.0 ± 0.0
Asp
3.236AspAla: 3.236 ± 0.095
0.627AspCys: 0.627 ± 0.038
3.241AspAsp: 3.241 ± 0.103
5.185AspGlu: 5.185 ± 0.124
2.794AspPhe: 2.794 ± 0.115
3.426AspGly: 3.426 ± 0.1
0.722AspHis: 0.722 ± 0.044
5.074AspIle: 5.074 ± 0.112
4.436AspLys: 4.436 ± 0.101
5.056AspLeu: 5.056 ± 0.128
1.195AspMet: 1.195 ± 0.061
3.482AspAsn: 3.482 ± 0.098
1.407AspPro: 1.407 ± 0.064
1.234AspGln: 1.234 ± 0.049
1.403AspArg: 1.403 ± 0.057
3.006AspSer: 3.006 ± 0.076
2.898AspThr: 2.898 ± 0.09
3.768AspVal: 3.768 ± 0.104
0.368AspTrp: 0.368 ± 0.03
3.268AspTyr: 3.268 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
3.958GluAla: 3.958 ± 0.151
0.661GluCys: 0.661 ± 0.036
3.509GluAsp: 3.509 ± 0.087
6.217GluGlu: 6.217 ± 0.174
2.702GluPhe: 2.702 ± 0.081
3.412GluGly: 3.412 ± 0.083
1.051GluHis: 1.051 ± 0.052
6.763GluIle: 6.763 ± 0.15
7.313GluLys: 7.313 ± 0.159
6.901GluLeu: 6.901 ± 0.159
1.879GluMet: 1.879 ± 0.071
5.094GluAsn: 5.094 ± 0.105
1.527GluPro: 1.527 ± 0.064
2.021GluGln: 2.021 ± 0.086
2.12GluArg: 2.12 ± 0.071
3.051GluSer: 3.051 ± 0.085
3.574GluThr: 3.574 ± 0.091
4.749GluVal: 4.749 ± 0.11
0.458GluTrp: 0.458 ± 0.038
3.716GluTyr: 3.716 ± 0.102
0.0GluXaa: 0.0 ± 0.0
Phe
2.735PheAla: 2.735 ± 0.092
0.543PheCys: 0.543 ± 0.039
2.945PheAsp: 2.945 ± 0.079
3.011PheGlu: 3.011 ± 0.078
1.951PhePhe: 1.951 ± 0.077
2.614PheGly: 2.614 ± 0.081
0.476PheHis: 0.476 ± 0.035
4.057PheIle: 4.057 ± 0.109
3.671PheLys: 3.671 ± 0.092
3.789PheLeu: 3.789 ± 0.113
0.999PheMet: 0.999 ± 0.051
2.706PheAsn: 2.706 ± 0.08
1.13PhePro: 1.13 ± 0.052
0.891PheGln: 0.891 ± 0.045
1.132PheArg: 1.132 ± 0.051
2.954PheSer: 2.954 ± 0.099
2.589PheThr: 2.589 ± 0.076
3.295PheVal: 3.295 ± 0.088
0.282PheTrp: 0.282 ± 0.028
1.966PheTyr: 1.966 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
3.347GlyAla: 3.347 ± 0.114
0.904GlyCys: 0.904 ± 0.046
2.72GlyAsp: 2.72 ± 0.071
3.466GlyGlu: 3.466 ± 0.095
2.614GlyPhe: 2.614 ± 0.076
3.55GlyGly: 3.55 ± 0.117
0.983GlyHis: 0.983 ± 0.047
5.859GlyIle: 5.859 ± 0.132
5.135GlyLys: 5.135 ± 0.105
4.991GlyLeu: 4.991 ± 0.113
1.446GlyMet: 1.446 ± 0.051
3.153GlyAsn: 3.153 ± 0.094
1.044GlyPro: 1.044 ± 0.051
1.394GlyGln: 1.394 ± 0.064
1.77GlyArg: 1.77 ± 0.076
3.579GlySer: 3.579 ± 0.107
3.644GlyThr: 3.644 ± 0.108
4.12GlyVal: 4.12 ± 0.117
0.593GlyTrp: 0.593 ± 0.056
3.182GlyTyr: 3.182 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
0.814HisAla: 0.814 ± 0.049
0.203HisCys: 0.203 ± 0.023
0.717HisAsp: 0.717 ± 0.04
0.934HisGlu: 0.934 ± 0.044
0.776HisPhe: 0.776 ± 0.043
0.875HisGly: 0.875 ± 0.051
0.37HisHis: 0.37 ± 0.044
1.299HisIle: 1.299 ± 0.062
0.981HisLys: 0.981 ± 0.052
1.414HisLeu: 1.414 ± 0.06
0.336HisMet: 0.336 ± 0.029
0.949HisAsn: 0.949 ± 0.051
0.674HisPro: 0.674 ± 0.044
0.53HisGln: 0.53 ± 0.038
0.516HisArg: 0.516 ± 0.034
0.864HisSer: 0.864 ± 0.041
0.774HisThr: 0.774 ± 0.043
0.85HisVal: 0.85 ± 0.044
0.065HisTrp: 0.065 ± 0.013
0.744HisTyr: 0.744 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.73IleAla: 5.73 ± 0.118
1.405IleCys: 1.405 ± 0.063
6.087IleAsp: 6.087 ± 0.134
6.535IleGlu: 6.535 ± 0.134
4.019IlePhe: 4.019 ± 0.121
5.8IleGly: 5.8 ± 0.139
1.209IleHis: 1.209 ± 0.051
9.278IleIle: 9.278 ± 0.197
7.884IleLys: 7.884 ± 0.146
8.087IleLeu: 8.087 ± 0.168
1.955IleMet: 1.955 ± 0.072
6.377IleAsn: 6.377 ± 0.144
2.905IlePro: 2.905 ± 0.092
1.87IleGln: 1.87 ± 0.066
2.618IleArg: 2.618 ± 0.086
6.134IleSer: 6.134 ± 0.125
5.798IleThr: 5.798 ± 0.142
7.115IleVal: 7.115 ± 0.135
0.422IleTrp: 0.422 ± 0.031
4.039IleTyr: 4.039 ± 0.099
0.0IleXaa: 0.0 ± 0.0
Lys
4.79LysAla: 4.79 ± 0.119
0.866LysCys: 0.866 ± 0.053
4.957LysAsp: 4.957 ± 0.115
7.812LysGlu: 7.812 ± 0.167
2.783LysPhe: 2.783 ± 0.092
3.892LysGly: 3.892 ± 0.102
1.164LysHis: 1.164 ± 0.055
8.152LysIle: 8.152 ± 0.159
8.682LysLys: 8.682 ± 0.174
7.697LysLeu: 7.697 ± 0.124
2.776LysMet: 2.776 ± 0.083
6.172LysAsn: 6.172 ± 0.123
2.181LysPro: 2.181 ± 0.075
2.39LysGln: 2.39 ± 0.079
2.9LysArg: 2.9 ± 0.078
4.145LysSer: 4.145 ± 0.119
4.995LysThr: 4.995 ± 0.117
5.924LysVal: 5.924 ± 0.13
0.627LysTrp: 0.627 ± 0.042
4.941LysTyr: 4.941 ± 0.131
0.0LysXaa: 0.0 ± 0.0
Leu
5.636LeuAla: 5.636 ± 0.135
0.976LeuCys: 0.976 ± 0.048
5.338LeuAsp: 5.338 ± 0.132
6.233LeuGlu: 6.233 ± 0.131
3.965LeuPhe: 3.965 ± 0.127
5.263LeuGly: 5.263 ± 0.109
1.195LeuHis: 1.195 ± 0.051
8.382LeuIle: 8.382 ± 0.185
7.719LeuLys: 7.719 ± 0.148
8.033LeuLeu: 8.033 ± 0.176
2.048LeuMet: 2.048 ± 0.067
6.001LeuAsn: 6.001 ± 0.118
3.062LeuPro: 3.062 ± 0.096
2.156LeuGln: 2.156 ± 0.073
2.609LeuArg: 2.609 ± 0.085
5.929LeuSer: 5.929 ± 0.119
5.457LeuThr: 5.457 ± 0.119
6.303LeuVal: 6.303 ± 0.135
0.478LeuTrp: 0.478 ± 0.036
3.583LeuTyr: 3.583 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
1.655MetAla: 1.655 ± 0.06
0.257MetCys: 0.257 ± 0.027
1.085MetAsp: 1.085 ± 0.048
1.303MetGlu: 1.303 ± 0.054
0.898MetPhe: 0.898 ± 0.055
1.405MetGly: 1.405 ± 0.054
0.379MetHis: 0.379 ± 0.025
2.163MetIle: 2.163 ± 0.071
2.318MetLys: 2.318 ± 0.075
2.246MetLeu: 2.246 ± 0.073
0.557MetMet: 0.557 ± 0.038
1.68MetAsn: 1.68 ± 0.052
0.839MetPro: 0.839 ± 0.05
0.717MetGln: 0.717 ± 0.04
0.753MetArg: 0.753 ± 0.043
1.427MetSer: 1.427 ± 0.051
1.231MetThr: 1.231 ± 0.054
1.545MetVal: 1.545 ± 0.054
0.138MetTrp: 0.138 ± 0.018
0.949MetTyr: 0.949 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.665AsnAla: 3.665 ± 0.11
0.87AsnCys: 0.87 ± 0.045
3.82AsnAsp: 3.82 ± 0.105
4.722AsnGlu: 4.722 ± 0.112
2.733AsnPhe: 2.733 ± 0.094
3.707AsnGly: 3.707 ± 0.089
1.143AsnHis: 1.143 ± 0.055
5.888AsnIle: 5.888 ± 0.13
5.766AsnLys: 5.766 ± 0.115
5.66AsnLeu: 5.66 ± 0.126
1.547AsnMet: 1.547 ± 0.053
5.162AsnAsn: 5.162 ± 0.14
2.215AsnPro: 2.215 ± 0.072
2.102AsnGln: 2.102 ± 0.077
1.91AsnArg: 1.91 ± 0.07
3.649AsnSer: 3.649 ± 0.105
3.103AsnThr: 3.103 ± 0.088
4.267AsnVal: 4.267 ± 0.095
0.458AsnTrp: 0.458 ± 0.036
3.789AsnTyr: 3.789 ± 0.107
0.0AsnXaa: 0.0 ± 0.0
Pro
1.342ProAla: 1.342 ± 0.062
0.286ProCys: 0.286 ± 0.026
1.387ProAsp: 1.387 ± 0.064
1.89ProGlu: 1.89 ± 0.058
1.439ProPhe: 1.439 ± 0.06
1.518ProGly: 1.518 ± 0.058
0.46ProHis: 0.46 ± 0.033
2.566ProIle: 2.566 ± 0.07
2.298ProLys: 2.298 ± 0.065
2.332ProLeu: 2.332 ± 0.069
0.546ProMet: 0.546 ± 0.041
1.953ProAsn: 1.953 ± 0.058
0.435ProPro: 0.435 ± 0.034
0.683ProGln: 0.683 ± 0.039
0.726ProArg: 0.726 ± 0.036
1.863ProSer: 1.863 ± 0.069
2.149ProThr: 2.149 ± 0.074
1.89ProVal: 1.89 ± 0.066
0.167ProTrp: 0.167 ± 0.017
1.349ProTyr: 1.349 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.567GlnAla: 1.567 ± 0.059
0.219GlnCys: 0.219 ± 0.024
1.254GlnAsp: 1.254 ± 0.056
1.752GlnGlu: 1.752 ± 0.069
1.058GlnPhe: 1.058 ± 0.048
1.306GlnGly: 1.306 ± 0.055
0.291GlnHis: 0.291 ± 0.028
2.623GlnIle: 2.623 ± 0.08
2.492GlnLys: 2.492 ± 0.069
2.395GlnLeu: 2.395 ± 0.079
0.76GlnMet: 0.76 ± 0.04
1.716GlnAsn: 1.716 ± 0.064
0.622GlnPro: 0.622 ± 0.044
0.74GlnGln: 0.74 ± 0.048
0.778GlnArg: 0.778 ± 0.045
1.245GlnSer: 1.245 ± 0.046
1.468GlnThr: 1.468 ± 0.054
1.678GlnVal: 1.678 ± 0.062
0.165GlnTrp: 0.165 ± 0.021
1.265GlnTyr: 1.265 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
1.617ArgAla: 1.617 ± 0.075
0.408ArgCys: 0.408 ± 0.032
1.425ArgAsp: 1.425 ± 0.062
1.962ArgGlu: 1.962 ± 0.082
1.441ArgPhe: 1.441 ± 0.059
1.685ArgGly: 1.685 ± 0.058
0.532ArgHis: 0.532 ± 0.037
2.972ArgIle: 2.972 ± 0.091
2.896ArgLys: 2.896 ± 0.091
2.86ArgLeu: 2.86 ± 0.08
0.783ArgMet: 0.783 ± 0.042
1.917ArgAsn: 1.917 ± 0.058
0.807ArgPro: 0.807 ± 0.046
0.895ArgGln: 0.895 ± 0.043
1.211ArgArg: 1.211 ± 0.059
1.502ArgSer: 1.502 ± 0.066
1.497ArgThr: 1.497 ± 0.06
1.989ArgVal: 1.989 ± 0.07
0.14ArgTrp: 0.14 ± 0.019
1.477ArgTyr: 1.477 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
2.866SerAla: 2.866 ± 0.084
0.848SerCys: 0.848 ± 0.044
3.356SerAsp: 3.356 ± 0.1
3.698SerGlu: 3.698 ± 0.1
3.067SerPhe: 3.067 ± 0.098
3.883SerGly: 3.883 ± 0.095
0.837SerHis: 0.837 ± 0.046
5.954SerIle: 5.954 ± 0.122
5.198SerLys: 5.198 ± 0.117
5.259SerLeu: 5.259 ± 0.126
1.279SerMet: 1.279 ± 0.05
3.748SerAsn: 3.748 ± 0.104
1.24SerPro: 1.24 ± 0.055
1.385SerGln: 1.385 ± 0.065
1.811SerArg: 1.811 ± 0.063
4.012SerSer: 4.012 ± 0.124
3.622SerThr: 3.622 ± 0.099
3.719SerVal: 3.719 ± 0.093
0.444SerTrp: 0.444 ± 0.034
3.094SerTyr: 3.094 ± 0.103
0.0SerXaa: 0.0 ± 0.0
Thr
2.657ThrAla: 2.657 ± 0.081
0.778ThrCys: 0.778 ± 0.059
2.864ThrAsp: 2.864 ± 0.081
3.241ThrGlu: 3.241 ± 0.097
2.681ThrPhe: 2.681 ± 0.079
3.683ThrGly: 3.683 ± 0.103
0.891ThrHis: 0.891 ± 0.041
6.411ThrIle: 6.411 ± 0.154
5.153ThrLys: 5.153 ± 0.117
5.475ThrLeu: 5.475 ± 0.116
1.22ThrMet: 1.22 ± 0.048
3.87ThrAsn: 3.87 ± 0.109
1.831ThrPro: 1.831 ± 0.074
1.053ThrGln: 1.053 ± 0.052
1.648ThrArg: 1.648 ± 0.058
3.944ThrSer: 3.944 ± 0.096
3.953ThrThr: 3.953 ± 0.131
3.789ThrVal: 3.789 ± 0.127
0.408ThrTrp: 0.408 ± 0.03
3.15ThrTyr: 3.15 ± 0.111
0.0ThrXaa: 0.0 ± 0.0
Val
4.314ValAla: 4.314 ± 0.111
0.855ValCys: 0.855 ± 0.049
4.17ValAsp: 4.17 ± 0.107
5.103ValGlu: 5.103 ± 0.112
2.814ValPhe: 2.814 ± 0.089
4.091ValGly: 4.091 ± 0.104
0.796ValHis: 0.796 ± 0.049
6.305ValIle: 6.305 ± 0.14
5.717ValLys: 5.717 ± 0.116
6.071ValLeu: 6.071 ± 0.127
1.441ValMet: 1.441 ± 0.061
4.179ValAsn: 4.179 ± 0.11
1.881ValPro: 1.881 ± 0.067
1.324ValGln: 1.324 ± 0.059
1.948ValArg: 1.948 ± 0.072
4.197ValSer: 4.197 ± 0.106
4.201ValThr: 4.201 ± 0.123
5.442ValVal: 5.442 ± 0.118
0.437ValTrp: 0.437 ± 0.032
2.855ValTyr: 2.855 ± 0.083
0.0ValXaa: 0.0 ± 0.0
Trp
0.356TrpAla: 0.356 ± 0.032
0.106TrpCys: 0.106 ± 0.017
0.381TrpAsp: 0.381 ± 0.037
0.345TrpGlu: 0.345 ± 0.032
0.336TrpPhe: 0.336 ± 0.027
0.354TrpGly: 0.354 ± 0.031
0.124TrpHis: 0.124 ± 0.018
0.546TrpIle: 0.546 ± 0.035
0.471TrpLys: 0.471 ± 0.036
0.595TrpLeu: 0.595 ± 0.037
0.167TrpMet: 0.167 ± 0.022
0.451TrpAsn: 0.451 ± 0.035
0.178TrpPro: 0.178 ± 0.02
0.248TrpGln: 0.248 ± 0.024
0.18TrpArg: 0.18 ± 0.021
0.372TrpSer: 0.372 ± 0.032
0.284TrpThr: 0.284 ± 0.029
0.408TrpVal: 0.408 ± 0.028
0.108TrpTrp: 0.108 ± 0.017
0.453TrpTyr: 0.453 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.097
0.609TyrCys: 0.609 ± 0.033
3.342TyrAsp: 3.342 ± 0.094
3.547TyrGlu: 3.547 ± 0.09
2.447TyrPhe: 2.447 ± 0.081
2.677TyrGly: 2.677 ± 0.095
0.967TyrHis: 0.967 ± 0.041
4.129TyrIle: 4.129 ± 0.1
3.297TyrLys: 3.297 ± 0.081
5.02TyrLeu: 5.02 ± 0.113
0.816TyrMet: 0.816 ± 0.043
3.428TyrAsn: 3.428 ± 0.109
1.416TyrPro: 1.416 ± 0.064
2.212TyrGln: 2.212 ± 0.087
1.662TyrArg: 1.662 ± 0.066
2.76TyrSer: 2.76 ± 0.085
2.767TyrThr: 2.767 ± 0.107
3.159TyrVal: 3.159 ± 0.079
0.275TyrTrp: 0.275 ± 0.028
2.932TyrTyr: 2.932 ± 0.107
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1321 proteins (443435 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski