Amino acid dipepetide frequency for Dyadobacter luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.365AlaAla: 6.365 ± 0.074
0.6AlaCys: 0.6 ± 0.017
4.356AlaAsp: 4.356 ± 0.051
4.57AlaGlu: 4.57 ± 0.059
3.454AlaPhe: 3.454 ± 0.044
6.048AlaGly: 6.048 ± 0.067
1.328AlaHis: 1.328 ± 0.026
4.976AlaIle: 4.976 ± 0.05
4.121AlaLys: 4.121 ± 0.054
7.071AlaLeu: 7.071 ± 0.068
1.684AlaMet: 1.684 ± 0.029
3.498AlaAsn: 3.498 ± 0.055
2.488AlaPro: 2.488 ± 0.037
3.035AlaGln: 3.035 ± 0.043
3.076AlaArg: 3.076 ± 0.045
5.055AlaSer: 5.055 ± 0.064
4.25AlaThr: 4.25 ± 0.058
5.123AlaVal: 5.123 ± 0.06
0.845AlaTrp: 0.845 ± 0.022
2.8AlaTyr: 2.8 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.464CysAla: 0.464 ± 0.016
0.115CysCys: 0.115 ± 0.008
0.356CysAsp: 0.356 ± 0.014
0.397CysGlu: 0.397 ± 0.015
0.377CysPhe: 0.377 ± 0.015
0.553CysGly: 0.553 ± 0.019
0.201CysHis: 0.201 ± 0.011
0.533CysIle: 0.533 ± 0.017
0.394CysLys: 0.394 ± 0.017
0.687CysLeu: 0.687 ± 0.02
0.171CysMet: 0.171 ± 0.009
0.331CysAsn: 0.331 ± 0.014
0.283CysPro: 0.283 ± 0.012
0.236CysGln: 0.236 ± 0.011
0.302CysArg: 0.302 ± 0.013
0.52CysSer: 0.52 ± 0.018
0.385CysThr: 0.385 ± 0.015
0.431CysVal: 0.431 ± 0.015
0.083CysTrp: 0.083 ± 0.007
0.273CysTyr: 0.273 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.905AspAla: 3.905 ± 0.048
0.331AspCys: 0.331 ± 0.013
2.416AspAsp: 2.416 ± 0.042
3.147AspGlu: 3.147 ± 0.048
3.124AspPhe: 3.124 ± 0.039
3.999AspGly: 3.999 ± 0.048
1.031AspHis: 1.031 ± 0.025
3.759AspIle: 3.759 ± 0.053
3.539AspLys: 3.539 ± 0.045
5.162AspLeu: 5.162 ± 0.054
1.172AspMet: 1.172 ± 0.022
2.512AspAsn: 2.512 ± 0.031
2.177AspPro: 2.177 ± 0.034
2.112AspGln: 2.112 ± 0.036
2.421AspArg: 2.421 ± 0.039
3.125AspSer: 3.125 ± 0.043
2.55AspThr: 2.55 ± 0.041
3.524AspVal: 3.524 ± 0.045
0.783AspTrp: 0.783 ± 0.018
2.417AspTyr: 2.417 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
4.254GluAla: 4.254 ± 0.056
0.297GluCys: 0.297 ± 0.011
2.76GluAsp: 2.76 ± 0.038
3.723GluGlu: 3.723 ± 0.058
2.426GluPhe: 2.426 ± 0.037
3.601GluGly: 3.601 ± 0.042
1.091GluHis: 1.091 ± 0.024
4.287GluIle: 4.287 ± 0.054
4.91GluLys: 4.91 ± 0.063
5.823GluLeu: 5.823 ± 0.067
1.533GluMet: 1.533 ± 0.029
3.485GluAsn: 3.485 ± 0.041
1.729GluPro: 1.729 ± 0.03
2.422GluGln: 2.422 ± 0.039
2.764GluArg: 2.764 ± 0.041
3.433GluSer: 3.433 ± 0.042
3.1GluThr: 3.1 ± 0.035
3.894GluVal: 3.894 ± 0.055
0.739GluTrp: 0.739 ± 0.02
2.117GluTyr: 2.117 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.36PheAla: 3.36 ± 0.044
0.437PheCys: 0.437 ± 0.014
2.889PheAsp: 2.889 ± 0.036
2.826PheGlu: 2.826 ± 0.045
2.433PhePhe: 2.433 ± 0.037
3.532PheGly: 3.532 ± 0.041
0.835PheHis: 0.835 ± 0.02
2.97PheIle: 2.97 ± 0.046
2.747PheLys: 2.747 ± 0.038
4.513PheLeu: 4.513 ± 0.061
1.088PheMet: 1.088 ± 0.023
2.554PheAsn: 2.554 ± 0.037
1.862PhePro: 1.862 ± 0.027
1.645PheGln: 1.645 ± 0.03
2.301PheArg: 2.301 ± 0.037
3.916PheSer: 3.916 ± 0.05
3.005PheThr: 3.005 ± 0.042
3.124PheVal: 3.124 ± 0.036
0.628PheTrp: 0.628 ± 0.02
1.971PheTyr: 1.971 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
4.897GlyAla: 4.897 ± 0.063
0.61GlyCys: 0.61 ± 0.02
3.376GlyAsp: 3.376 ± 0.043
3.598GlyGlu: 3.598 ± 0.04
3.746GlyPhe: 3.746 ± 0.044
5.015GlyGly: 5.015 ± 0.081
1.242GlyHis: 1.242 ± 0.023
5.443GlyIle: 5.443 ± 0.058
5.33GlyLys: 5.33 ± 0.056
6.497GlyLeu: 6.497 ± 0.067
1.737GlyMet: 1.737 ± 0.029
3.8GlyAsn: 3.8 ± 0.062
1.666GlyPro: 1.666 ± 0.029
2.536GlyGln: 2.536 ± 0.038
2.98GlyArg: 2.98 ± 0.039
4.921GlySer: 4.921 ± 0.061
4.391GlyThr: 4.391 ± 0.067
4.771GlyVal: 4.771 ± 0.053
1.06GlyTrp: 1.06 ± 0.023
3.148GlyTyr: 3.148 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.236HisAla: 1.236 ± 0.028
0.17HisCys: 0.17 ± 0.01
0.889HisAsp: 0.889 ± 0.02
1.01HisGlu: 1.01 ± 0.021
1.187HisPhe: 1.187 ± 0.026
1.199HisGly: 1.199 ± 0.032
0.518HisHis: 0.518 ± 0.014
1.354HisIle: 1.354 ± 0.03
0.93HisLys: 0.93 ± 0.022
1.808HisLeu: 1.808 ± 0.03
0.376HisMet: 0.376 ± 0.012
0.846HisAsn: 0.846 ± 0.021
0.956HisPro: 0.956 ± 0.024
0.809HisGln: 0.809 ± 0.022
0.85HisArg: 0.85 ± 0.022
1.125HisSer: 1.125 ± 0.024
1.029HisThr: 1.029 ± 0.022
1.093HisVal: 1.093 ± 0.021
0.257HisTrp: 0.257 ± 0.012
0.85HisTyr: 0.85 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.523IleAla: 5.523 ± 0.064
0.612IleCys: 0.612 ± 0.019
3.836IleAsp: 3.836 ± 0.051
4.09IleGlu: 4.09 ± 0.05
3.027IlePhe: 3.027 ± 0.041
4.798IleGly: 4.798 ± 0.053
1.292IleHis: 1.292 ± 0.027
4.189IleIle: 4.189 ± 0.056
3.822IleLys: 3.822 ± 0.048
6.168IleLeu: 6.168 ± 0.065
1.278IleMet: 1.278 ± 0.026
3.492IleAsn: 3.492 ± 0.046
3.184IlePro: 3.184 ± 0.032
2.433IleGln: 2.433 ± 0.036
3.416IleArg: 3.416 ± 0.04
5.255IleSer: 5.255 ± 0.051
4.288IleThr: 4.288 ± 0.047
4.26IleVal: 4.26 ± 0.046
0.763IleTrp: 0.763 ± 0.021
2.388IleTyr: 2.388 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.884LysAla: 4.884 ± 0.058
0.278LysCys: 0.278 ± 0.013
3.572LysAsp: 3.572 ± 0.044
4.237LysGlu: 4.237 ± 0.055
2.289LysPhe: 2.289 ± 0.031
4.384LysGly: 4.384 ± 0.044
1.117LysHis: 1.117 ± 0.025
4.408LysIle: 4.408 ± 0.055
4.63LysLys: 4.63 ± 0.054
5.765LysLeu: 5.765 ± 0.054
1.674LysMet: 1.674 ± 0.031
3.649LysAsn: 3.649 ± 0.043
2.599LysPro: 2.599 ± 0.039
2.506LysGln: 2.506 ± 0.033
2.675LysArg: 2.675 ± 0.035
4.153LysSer: 4.153 ± 0.052
3.814LysThr: 3.814 ± 0.047
4.259LysVal: 4.259 ± 0.05
0.84LysTrp: 0.84 ± 0.021
2.449LysTyr: 2.449 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
7.161LeuAla: 7.161 ± 0.069
0.728LeuCys: 0.728 ± 0.021
4.833LeuAsp: 4.833 ± 0.049
5.006LeuGlu: 5.006 ± 0.059
4.594LeuPhe: 4.594 ± 0.058
6.048LeuGly: 6.048 ± 0.065
1.753LeuHis: 1.753 ± 0.032
6.416LeuIle: 6.416 ± 0.066
6.367LeuLys: 6.367 ± 0.059
9.53LeuLeu: 9.53 ± 0.095
2.096LeuMet: 2.096 ± 0.035
4.988LeuAsn: 4.988 ± 0.056
4.353LeuPro: 4.353 ± 0.047
3.494LeuGln: 3.494 ± 0.043
4.267LeuArg: 4.267 ± 0.049
7.436LeuSer: 7.436 ± 0.067
5.886LeuThr: 5.886 ± 0.053
5.803LeuVal: 5.803 ± 0.063
1.034LeuTrp: 1.034 ± 0.028
3.264LeuTyr: 3.264 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.767MetAla: 1.767 ± 0.026
0.137MetCys: 0.137 ± 0.008
1.118MetAsp: 1.118 ± 0.023
1.318MetGlu: 1.318 ± 0.028
0.792MetPhe: 0.792 ± 0.021
1.523MetGly: 1.523 ± 0.028
0.433MetHis: 0.433 ± 0.014
1.494MetIle: 1.494 ± 0.031
1.885MetLys: 1.885 ± 0.032
2.217MetLeu: 2.217 ± 0.034
0.572MetMet: 0.572 ± 0.017
1.264MetAsn: 1.264 ± 0.026
1.003MetPro: 1.003 ± 0.023
0.91MetGln: 0.91 ± 0.023
1.012MetArg: 1.012 ± 0.022
1.43MetSer: 1.43 ± 0.027
1.208MetThr: 1.208 ± 0.022
1.381MetVal: 1.381 ± 0.026
0.21MetTrp: 0.21 ± 0.011
0.695MetTyr: 0.695 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.78AsnAla: 3.78 ± 0.051
0.304AsnCys: 0.304 ± 0.015
2.555AsnAsp: 2.555 ± 0.035
2.772AsnGlu: 2.772 ± 0.039
2.471AsnPhe: 2.471 ± 0.04
3.939AsnGly: 3.939 ± 0.054
0.947AsnHis: 0.947 ± 0.022
3.585AsnIle: 3.585 ± 0.045
3.017AsnLys: 3.017 ± 0.041
4.778AsnLeu: 4.778 ± 0.059
1.081AsnMet: 1.081 ± 0.024
2.75AsnAsn: 2.75 ± 0.048
2.832AsnPro: 2.832 ± 0.039
2.128AsnGln: 2.128 ± 0.035
2.47AsnArg: 2.47 ± 0.038
3.349AsnSer: 3.349 ± 0.052
3.106AsnThr: 3.106 ± 0.041
3.285AsnVal: 3.285 ± 0.05
0.779AsnTrp: 0.779 ± 0.022
2.263AsnTyr: 2.263 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.367ProAla: 3.367 ± 0.046
0.202ProCys: 0.202 ± 0.011
2.801ProAsp: 2.801 ± 0.033
3.095ProGlu: 3.095 ± 0.051
1.941ProPhe: 1.941 ± 0.035
2.995ProGly: 2.995 ± 0.041
0.67ProHis: 0.67 ± 0.018
2.24ProIle: 2.24 ± 0.035
2.07ProLys: 2.07 ± 0.034
3.373ProLeu: 3.373 ± 0.042
0.774ProMet: 0.774 ± 0.02
1.829ProAsn: 1.829 ± 0.033
0.997ProPro: 0.997 ± 0.028
1.363ProGln: 1.363 ± 0.024
1.241ProArg: 1.241 ± 0.026
2.52ProSer: 2.52 ± 0.038
2.029ProThr: 2.029 ± 0.033
3.521ProVal: 3.521 ± 0.055
0.449ProTrp: 0.449 ± 0.017
1.51ProTyr: 1.51 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
2.652GlnAla: 2.652 ± 0.039
0.185GlnCys: 0.185 ± 0.009
1.768GlnAsp: 1.768 ± 0.035
2.191GlnGlu: 2.191 ± 0.037
1.736GlnPhe: 1.736 ± 0.03
2.164GlnGly: 2.164 ± 0.035
0.775GlnHis: 0.775 ± 0.019
2.757GlnIle: 2.757 ± 0.036
2.76GlnLys: 2.76 ± 0.04
3.921GlnLeu: 3.921 ± 0.05
0.917GlnMet: 0.917 ± 0.023
2.128GlnAsn: 2.128 ± 0.035
1.528GlnPro: 1.528 ± 0.024
1.964GlnGln: 1.964 ± 0.038
1.722GlnArg: 1.722 ± 0.032
2.447GlnSer: 2.447 ± 0.042
2.349GlnThr: 2.349 ± 0.034
2.493GlnVal: 2.493 ± 0.038
0.489GlnTrp: 0.489 ± 0.016
1.532GlnTyr: 1.532 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
2.839ArgAla: 2.839 ± 0.041
0.248ArgCys: 0.248 ± 0.011
2.167ArgAsp: 2.167 ± 0.035
2.704ArgGlu: 2.704 ± 0.041
2.38ArgPhe: 2.38 ± 0.037
2.492ArgGly: 2.492 ± 0.04
0.799ArgHis: 0.799 ± 0.022
3.484ArgIle: 3.484 ± 0.044
3.123ArgLys: 3.123 ± 0.036
4.309ArgLeu: 4.309 ± 0.044
1.147ArgMet: 1.147 ± 0.023
2.564ArgAsn: 2.564 ± 0.038
1.598ArgPro: 1.598 ± 0.032
1.824ArgGln: 1.824 ± 0.035
1.915ArgArg: 1.915 ± 0.034
2.767ArgSer: 2.767 ± 0.042
2.434ArgThr: 2.434 ± 0.033
2.735ArgVal: 2.735 ± 0.04
0.616ArgTrp: 0.616 ± 0.017
2.029ArgTyr: 2.029 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.121SerAla: 5.121 ± 0.057
0.568SerCys: 0.568 ± 0.021
3.719SerAsp: 3.719 ± 0.041
4.013SerGlu: 4.013 ± 0.045
3.838SerPhe: 3.838 ± 0.051
5.558SerGly: 5.558 ± 0.068
1.217SerHis: 1.217 ± 0.028
4.456SerIle: 4.456 ± 0.051
3.931SerLys: 3.931 ± 0.044
6.629SerLeu: 6.629 ± 0.063
1.404SerMet: 1.404 ± 0.028
3.135SerAsn: 3.135 ± 0.051
2.53SerPro: 2.53 ± 0.04
2.533SerGln: 2.533 ± 0.035
2.965SerArg: 2.965 ± 0.043
4.627SerSer: 4.627 ± 0.058
3.63SerThr: 3.63 ± 0.047
4.955SerVal: 4.955 ± 0.054
0.878SerTrp: 0.878 ± 0.025
2.864SerTyr: 2.864 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.617ThrAla: 4.617 ± 0.058
0.31ThrCys: 0.31 ± 0.012
3.436ThrAsp: 3.436 ± 0.043
3.348ThrGlu: 3.348 ± 0.043
2.787ThrPhe: 2.787 ± 0.035
5.022ThrGly: 5.022 ± 0.06
1.015ThrHis: 1.015 ± 0.022
4.004ThrIle: 4.004 ± 0.044
3.008ThrLys: 3.008 ± 0.039
5.402ThrLeu: 5.402 ± 0.061
1.036ThrMet: 1.036 ± 0.023
2.809ThrAsn: 2.809 ± 0.044
2.61ThrPro: 2.61 ± 0.041
1.961ThrGln: 1.961 ± 0.033
2.235ThrArg: 2.235 ± 0.031
3.979ThrSer: 3.979 ± 0.049
3.457ThrThr: 3.457 ± 0.049
4.019ThrVal: 4.019 ± 0.057
0.643ThrTrp: 0.643 ± 0.019
2.359ThrTyr: 2.359 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.033ValAla: 5.033 ± 0.053
0.56ValCys: 0.56 ± 0.017
3.388ValAsp: 3.388 ± 0.045
3.577ValGlu: 3.577 ± 0.046
3.253ValPhe: 3.253 ± 0.04
4.144ValGly: 4.144 ± 0.052
1.146ValHis: 1.146 ± 0.022
4.623ValIle: 4.623 ± 0.055
4.348ValLys: 4.348 ± 0.053
6.299ValLeu: 6.299 ± 0.06
1.5ValMet: 1.5 ± 0.029
3.567ValAsn: 3.567 ± 0.047
2.585ValPro: 2.585 ± 0.039
2.244ValGln: 2.244 ± 0.035
3.007ValArg: 3.007 ± 0.043
5.033ValSer: 5.033 ± 0.053
4.06ValThr: 4.06 ± 0.051
4.588ValVal: 4.588 ± 0.049
0.792ValTrp: 0.792 ± 0.018
2.49ValTyr: 2.49 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.825TrpAla: 0.825 ± 0.022
0.09TrpCys: 0.09 ± 0.007
0.705TrpAsp: 0.705 ± 0.019
0.75TrpGlu: 0.75 ± 0.021
0.598TrpPhe: 0.598 ± 0.017
0.924TrpGly: 0.924 ± 0.025
0.27TrpHis: 0.27 ± 0.013
0.827TrpIle: 0.827 ± 0.02
0.881TrpLys: 0.881 ± 0.025
1.273TrpLeu: 1.273 ± 0.033
0.35TrpMet: 0.35 ± 0.013
0.725TrpAsn: 0.725 ± 0.018
0.378TrpPro: 0.378 ± 0.014
0.584TrpGln: 0.584 ± 0.02
0.555TrpArg: 0.555 ± 0.018
0.748TrpSer: 0.748 ± 0.024
0.712TrpThr: 0.712 ± 0.02
0.744TrpVal: 0.744 ± 0.02
0.203TrpTrp: 0.203 ± 0.011
0.495TrpTyr: 0.495 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.693TyrAla: 2.693 ± 0.039
0.308TyrCys: 0.308 ± 0.013
2.264TyrAsp: 2.264 ± 0.037
2.015TyrGlu: 2.015 ± 0.032
2.183TyrPhe: 2.183 ± 0.038
2.824TyrGly: 2.824 ± 0.036
0.812TyrHis: 0.812 ± 0.02
2.31TyrIle: 2.31 ± 0.039
2.37TyrLys: 2.37 ± 0.035
3.83TyrLeu: 3.83 ± 0.043
0.779TyrMet: 0.779 ± 0.021
2.268TyrAsn: 2.268 ± 0.038
1.629TyrPro: 1.629 ± 0.03
1.742TyrGln: 1.742 ± 0.032
1.999TyrArg: 1.999 ± 0.032
2.733TyrSer: 2.733 ± 0.04
2.376TyrThr: 2.376 ± 0.041
2.233TyrVal: 2.233 ± 0.033
0.546TyrTrp: 0.546 ± 0.019
1.723TyrTyr: 1.723 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5642 proteins (2023372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski