Amino acid dipepetide frequency for Verminephrobacter eiseniae (strain EF01-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.306AlaAla: 18.306 ± 0.233	1.682AlaCys: 1.682 ± 0.033	6.585AlaAsp: 6.585 ± 0.075	5.652AlaGlu: 5.652 ± 0.079	3.846AlaPhe: 3.846 ± 0.062	11.77AlaGly: 11.77 ± 0.145	3.087AlaHis: 3.087 ± 0.053	5.615AlaIle: 5.615 ± 0.055	3.431AlaLys: 3.431 ± 0.057	16.273AlaLeu: 16.273 ± 0.137	3.461AlaMet: 3.461 ± 0.058	2.909AlaAsn: 2.909 ± 0.063	6.869AlaPro: 6.869 ± 0.089	6.739AlaGln: 6.739 ± 0.08	10.178AlaArg: 10.178 ± 0.122	6.965AlaSer: 6.965 ± 0.078	6.151AlaThr: 6.151 ± 0.104	8.709AlaVal: 8.709 ± 0.091	1.865AlaTrp: 1.865 ± 0.043	2.422AlaTyr: 2.422 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.772CysAla: 1.772 ± 0.037	0.176CysCys: 0.176 ± 0.011	0.616CysAsp: 0.616 ± 0.021	0.468CysGlu: 0.468 ± 0.017	0.336CysPhe: 0.336 ± 0.016	1.172CysGly: 1.172 ± 0.031	0.338CysHis: 0.338 ± 0.012	0.543CysIle: 0.543 ± 0.017	0.266CysLys: 0.266 ± 0.012	0.98CysLeu: 0.98 ± 0.024	0.291CysMet: 0.291 ± 0.014	0.265CysAsn: 0.265 ± 0.013	0.602CysPro: 0.602 ± 0.02	0.362CysGln: 0.362 ± 0.018	0.782CysArg: 0.782 ± 0.021	0.581CysSer: 0.581 ± 0.02	0.577CysThr: 0.577 ± 0.019	0.816CysVal: 0.816 ± 0.023	0.155CysTrp: 0.155 ± 0.01	0.228CysTyr: 0.228 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.186AspAla: 7.186 ± 0.089	0.539AspCys: 0.539 ± 0.022	2.381AspAsp: 2.381 ± 0.05	2.802AspGlu: 2.802 ± 0.044	1.995AspPhe: 1.995 ± 0.034	4.706AspGly: 4.706 ± 0.086	0.966AspHis: 0.966 ± 0.026	2.654AspIle: 2.654 ± 0.05	1.715AspLys: 1.715 ± 0.045	5.234AspLeu: 5.234 ± 0.064	1.357AspMet: 1.357 ± 0.025	1.28AspAsn: 1.28 ± 0.056	3.006AspPro: 3.006 ± 0.043	1.591AspGln: 1.591 ± 0.036	3.159AspArg: 3.159 ± 0.057	2.355AspSer: 2.355 ± 0.043	2.553AspThr: 2.553 ± 0.117	3.315AspVal: 3.315 ± 0.038	0.885AspTrp: 0.885 ± 0.022	1.284AspTyr: 1.284 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.197GluAla: 5.197 ± 0.07	0.391GluCys: 0.391 ± 0.015	1.825GluAsp: 1.825 ± 0.041	1.811GluGlu: 1.811 ± 0.039	1.621GluPhe: 1.621 ± 0.037	3.1GluGly: 3.1 ± 0.045	1.309GluHis: 1.309 ± 0.032	2.457GluIle: 2.457 ± 0.042	1.545GluLys: 1.545 ± 0.036	5.032GluLeu: 5.032 ± 0.069	1.174GluMet: 1.174 ± 0.023	1.233GluAsn: 1.233 ± 0.027	2.371GluPro: 2.371 ± 0.041	2.539GluGln: 2.539 ± 0.042	4.666GluArg: 4.666 ± 0.057	2.309GluSer: 2.309 ± 0.057	2.273GluThr: 2.273 ± 0.043	3.287GluVal: 3.287 ± 0.06	0.596GluTrp: 0.596 ± 0.021	0.927GluTyr: 0.927 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.241PheAla: 4.241 ± 0.072	0.442PheCys: 0.442 ± 0.019	2.465PheAsp: 2.465 ± 0.041	1.77PheGlu: 1.77 ± 0.034	1.282PhePhe: 1.282 ± 0.035	3.274PheGly: 3.274 ± 0.054	0.726PheHis: 0.726 ± 0.022	1.583PheIle: 1.583 ± 0.033	1.081PheLys: 1.081 ± 0.035	2.76PheLeu: 2.76 ± 0.051	0.789PheMet: 0.789 ± 0.023	0.995PheAsn: 0.995 ± 0.026	1.427PhePro: 1.427 ± 0.038	1.073PheGln: 1.073 ± 0.027	1.744PheArg: 1.744 ± 0.033	2.108PheSer: 2.108 ± 0.069	1.896PheThr: 1.896 ± 0.09	2.584PheVal: 2.584 ± 0.047	0.479PheTrp: 0.479 ± 0.018	0.741PheTyr: 0.741 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.427GlyAla: 10.427 ± 0.092	1.096GlyCys: 1.096 ± 0.027	3.518GlyAsp: 3.518 ± 0.054	3.571GlyGlu: 3.571 ± 0.057	3.22GlyPhe: 3.22 ± 0.057	6.705GlyGly: 6.705 ± 0.084	2.177GlyHis: 2.177 ± 0.038	4.331GlyIle: 4.331 ± 0.054	3.299GlyLys: 3.299 ± 0.052	9.342GlyLeu: 9.342 ± 0.1	2.506GlyMet: 2.506 ± 0.053	2.472GlyAsn: 2.472 ± 0.111	3.346GlyPro: 3.346 ± 0.047	4.314GlyGln: 4.314 ± 0.056	5.919GlyArg: 5.919 ± 0.073	4.918GlySer: 4.918 ± 0.059	4.44GlyThr: 4.44 ± 0.128	6.166GlyVal: 6.166 ± 0.059	1.357GlyTrp: 1.357 ± 0.032	2.326GlyTyr: 2.326 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	3.027HisAla: 3.027 ± 0.054	0.384HisCys: 0.384 ± 0.014	1.21HisAsp: 1.21 ± 0.028	1.081HisGlu: 1.081 ± 0.029	0.892HisPhe: 0.892 ± 0.026	2.428HisGly: 2.428 ± 0.044	0.645HisHis: 0.645 ± 0.018	1.039HisIle: 1.039 ± 0.03	0.597HisLys: 0.597 ± 0.02	2.407HisLeu: 2.407 ± 0.038	0.577HisMet: 0.577 ± 0.021	0.514HisAsn: 0.514 ± 0.02	1.673HisPro: 1.673 ± 0.036	0.943HisGln: 0.943 ± 0.023	1.732HisArg: 1.732 ± 0.035	1.189HisSer: 1.189 ± 0.027	1.086HisThr: 1.086 ± 0.024	1.511HisVal: 1.511 ± 0.033	0.523HisTrp: 0.523 ± 0.021	0.61HisTyr: 0.61 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.694IleAla: 6.694 ± 0.073	0.525IleCys: 0.525 ± 0.02	3.443IleAsp: 3.443 ± 0.05	3.047IleGlu: 3.047 ± 0.051	1.344IlePhe: 1.344 ± 0.026	4.574IleGly: 4.574 ± 0.061	0.945IleHis: 0.945 ± 0.02	1.695IleIle: 1.695 ± 0.04	1.306IleLys: 1.306 ± 0.032	3.364IleLeu: 3.364 ± 0.055	0.825IleMet: 0.825 ± 0.023	1.327IleAsn: 1.327 ± 0.027	2.081IlePro: 2.081 ± 0.037	1.312IleGln: 1.312 ± 0.035	2.971IleArg: 2.971 ± 0.055	2.474IleSer: 2.474 ± 0.063	2.737IleThr: 2.737 ± 0.06	3.608IleVal: 3.608 ± 0.047	0.514IleTrp: 0.514 ± 0.019	0.956IleTyr: 0.956 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.539LysAla: 3.539 ± 0.067	0.176LysCys: 0.176 ± 0.01	1.477LysAsp: 1.477 ± 0.033	1.344LysGlu: 1.344 ± 0.033	0.792LysPhe: 0.792 ± 0.022	2.267LysGly: 2.267 ± 0.05	0.59LysHis: 0.59 ± 0.016	1.481LysIle: 1.481 ± 0.037	1.252LysLys: 1.252 ± 0.032	3.036LysLeu: 3.036 ± 0.058	0.766LysMet: 0.766 ± 0.023	0.939LysAsn: 0.939 ± 0.033	1.885LysPro: 1.885 ± 0.042	1.021LysGln: 1.021 ± 0.024	1.947LysArg: 1.947 ± 0.038	1.726LysSer: 1.726 ± 0.034	2.041LysThr: 2.041 ± 0.037	2.155LysVal: 2.155 ± 0.042	0.339LysTrp: 0.339 ± 0.014	0.643LysTyr: 0.643 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.664LeuAla: 15.664 ± 0.126	1.268LeuCys: 1.268 ± 0.029	5.681LeuAsp: 5.681 ± 0.068	4.623LeuGlu: 4.623 ± 0.061	3.231LeuPhe: 3.231 ± 0.065	8.848LeuGly: 8.848 ± 0.087	2.667LeuHis: 2.667 ± 0.041	4.454LeuIle: 4.454 ± 0.062	2.996LeuLys: 2.996 ± 0.056	11.743LeuLeu: 11.743 ± 0.163	2.38LeuMet: 2.38 ± 0.042	2.513LeuAsn: 2.513 ± 0.038	6.28LeuPro: 6.28 ± 0.078	4.672LeuGln: 4.672 ± 0.067	8.457LeuArg: 8.457 ± 0.086	6.198LeuSer: 6.198 ± 0.074	5.145LeuThr: 5.145 ± 0.08	7.538LeuVal: 7.538 ± 0.076	1.321LeuTrp: 1.321 ± 0.034	1.993LeuTyr: 1.993 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.463MetAla: 3.463 ± 0.05	0.188MetCys: 0.188 ± 0.011	1.052MetAsp: 1.052 ± 0.029	0.937MetGlu: 0.937 ± 0.023	0.654MetPhe: 0.654 ± 0.024	1.956MetGly: 1.956 ± 0.041	0.61MetHis: 0.61 ± 0.02	1.04MetIle: 1.04 ± 0.029	0.948MetLys: 0.948 ± 0.023	2.769MetLeu: 2.769 ± 0.045	0.568MetMet: 0.568 ± 0.023	0.87MetAsn: 0.87 ± 0.021	1.572MetPro: 1.572 ± 0.039	1.262MetGln: 1.262 ± 0.032	1.821MetArg: 1.821 ± 0.034	1.506MetSer: 1.506 ± 0.025	1.53MetThr: 1.53 ± 0.031	1.793MetVal: 1.793 ± 0.034	0.214MetTrp: 0.214 ± 0.011	0.391MetTyr: 0.391 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.307AsnAla: 3.307 ± 0.062	0.267AsnCys: 0.267 ± 0.012	1.351AsnAsp: 1.351 ± 0.045	1.09AsnGlu: 1.09 ± 0.026	0.93AsnPhe: 0.93 ± 0.048	2.312AsnGly: 2.312 ± 0.057	0.578AsnHis: 0.578 ± 0.022	1.147AsnIle: 1.147 ± 0.022	0.765AsnLys: 0.765 ± 0.028	2.687AsnLeu: 2.687 ± 0.081	0.542AsnMet: 0.542 ± 0.02	0.709AsnAsn: 0.709 ± 0.034	1.885AsnPro: 1.885 ± 0.032	0.998AsnGln: 0.998 ± 0.033	1.588AsnArg: 1.588 ± 0.032	1.107AsnSer: 1.107 ± 0.042	1.368AsnThr: 1.368 ± 0.055	1.71AsnVal: 1.71 ± 0.029	0.397AsnTrp: 0.397 ± 0.018	0.672AsnTyr: 0.672 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.754ProAla: 7.754 ± 0.102	0.539ProCys: 0.539 ± 0.018	3.296ProAsp: 3.296 ± 0.053	2.998ProGlu: 2.998 ± 0.04	1.701ProPhe: 1.701 ± 0.035	5.469ProGly: 5.469 ± 0.068	1.215ProHis: 1.215 ± 0.025	2.058ProIle: 2.058 ± 0.036	1.398ProLys: 1.398 ± 0.036	5.268ProLeu: 5.268 ± 0.067	1.546ProMet: 1.546 ± 0.033	1.148ProAsn: 1.148 ± 0.036	2.971ProPro: 2.971 ± 0.064	2.248ProGln: 2.248 ± 0.046	3.229ProArg: 3.229 ± 0.051	2.773ProSer: 2.773 ± 0.048	2.524ProThr: 2.524 ± 0.045	4.259ProVal: 4.259 ± 0.057	0.844ProTrp: 0.844 ± 0.025	1.271ProTyr: 1.271 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	6.666GlnAla: 6.666 ± 0.103	0.37GlnCys: 0.37 ± 0.015	1.932GlnAsp: 1.932 ± 0.041	1.85GlnGlu: 1.85 ± 0.035	1.28GlnPhe: 1.28 ± 0.033	3.471GlnGly: 3.471 ± 0.041	1.071GlnHis: 1.071 ± 0.026	1.965GlnIle: 1.965 ± 0.032	1.084GlnLys: 1.084 ± 0.032	4.267GlnLeu: 4.267 ± 0.058	1.119GlnMet: 1.119 ± 0.022	0.803GlnAsn: 0.803 ± 0.027	2.481GlnPro: 2.481 ± 0.039	2.135GlnGln: 2.135 ± 0.041	3.905GlnArg: 3.905 ± 0.063	2.082GlnSer: 2.082 ± 0.034	2.187GlnThr: 2.187 ± 0.037	3.121GlnVal: 3.121 ± 0.053	0.8GlnTrp: 0.8 ± 0.025	0.872GlnTyr: 0.872 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	8.702ArgAla: 8.702 ± 0.104	0.966ArgCys: 0.966 ± 0.03	3.308ArgAsp: 3.308 ± 0.045	3.394ArgGlu: 3.394 ± 0.047	2.654ArgPhe: 2.654 ± 0.046	4.458ArgGly: 4.458 ± 0.053	2.288ArgHis: 2.288 ± 0.042	3.828ArgIle: 3.828 ± 0.053	2.135ArgLys: 2.135 ± 0.045	8.203ArgLeu: 8.203 ± 0.081	2.091ArgMet: 2.091 ± 0.038	1.842ArgAsn: 1.842 ± 0.041	3.966ArgPro: 3.966 ± 0.073	3.735ArgGln: 3.735 ± 0.055	5.354ArgArg: 5.354 ± 0.073	4.091ArgSer: 4.091 ± 0.052	3.141ArgThr: 3.141 ± 0.048	4.91ArgVal: 4.91 ± 0.071	1.254ArgTrp: 1.254 ± 0.033	1.753ArgTyr: 1.753 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.393SerAla: 7.393 ± 0.127	0.562SerCys: 0.562 ± 0.02	2.691SerAsp: 2.691 ± 0.059	2.238SerGlu: 2.238 ± 0.036	2.101SerPhe: 2.101 ± 0.045	5.533SerGly: 5.533 ± 0.071	1.237SerHis: 1.237 ± 0.027	2.673SerIle: 2.673 ± 0.07	1.407SerLys: 1.407 ± 0.043	5.178SerLeu: 5.178 ± 0.077	1.429SerMet: 1.429 ± 0.033	1.405SerAsn: 1.405 ± 0.036	2.754SerPro: 2.754 ± 0.043	1.769SerGln: 1.769 ± 0.032	3.377SerArg: 3.377 ± 0.052	3.053SerSer: 3.053 ± 0.074	2.842SerThr: 2.842 ± 0.046	4.174SerVal: 4.174 ± 0.086	0.695SerTrp: 0.695 ± 0.018	1.345SerTyr: 1.345 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	6.076ThrAla: 6.076 ± 0.13	0.46ThrCys: 0.46 ± 0.015	2.559ThrAsp: 2.559 ± 0.058	2.199ThrGlu: 2.199 ± 0.054	1.693ThrPhe: 1.693 ± 0.121	5.064ThrGly: 5.064 ± 0.098	1.141ThrHis: 1.141 ± 0.026	2.324ThrIle: 2.324 ± 0.102	1.115ThrLys: 1.115 ± 0.037	6.232ThrLeu: 6.232 ± 0.083	1.192ThrMet: 1.192 ± 0.029	1.155ThrAsn: 1.155 ± 0.031	3.698ThrPro: 3.698 ± 0.087	1.86ThrGln: 1.86 ± 0.035	3.429ThrArg: 3.429 ± 0.054	2.576ThrSer: 2.576 ± 0.078	2.66ThrThr: 2.66 ± 0.065	4.279ThrVal: 4.279 ± 0.144	0.608ThrTrp: 0.608 ± 0.016	1.026ThrTyr: 1.026 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	9.094ValAla: 9.094 ± 0.079	0.824ValCys: 0.824 ± 0.024	3.693ValAsp: 3.693 ± 0.053	3.26ValGlu: 3.26 ± 0.047	2.502ValPhe: 2.502 ± 0.047	5.416ValGly: 5.416 ± 0.061	1.597ValHis: 1.597 ± 0.037	3.416ValIle: 3.416 ± 0.061	2.013ValLys: 2.013 ± 0.04	8.457ValLeu: 8.457 ± 0.071	1.696ValMet: 1.696 ± 0.035	2.077ValAsn: 2.077 ± 0.09	3.713ValPro: 3.713 ± 0.051	3.197ValGln: 3.197 ± 0.044	4.902ValArg: 4.902 ± 0.064	3.836ValSer: 3.836 ± 0.06	4.189ValThr: 4.189 ± 0.204	5.53ValVal: 5.53 ± 0.074	0.912ValTrp: 0.912 ± 0.037	1.463ValTyr: 1.463 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.361TrpAla: 1.361 ± 0.042	0.189TrpCys: 0.189 ± 0.011	0.578TrpAsp: 0.578 ± 0.018	0.53TrpGlu: 0.53 ± 0.018	0.536TrpPhe: 0.536 ± 0.02	0.957TrpGly: 0.957 ± 0.026	0.393TrpHis: 0.393 ± 0.014	0.616TrpIle: 0.616 ± 0.021	0.45TrpLys: 0.45 ± 0.016	2.041TrpLeu: 2.041 ± 0.046	0.398TrpMet: 0.398 ± 0.018	0.443TrpAsn: 0.443 ± 0.014	0.779TrpPro: 0.779 ± 0.022	0.801TrpGln: 0.801 ± 0.026	1.224TrpArg: 1.224 ± 0.029	0.919TrpSer: 0.919 ± 0.025	0.696TrpThr: 0.696 ± 0.036	0.922TrpVal: 0.922 ± 0.027	0.255TrpTrp: 0.255 ± 0.013	0.293TrpTyr: 0.293 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.643TyrAla: 2.643 ± 0.044	0.282TyrCys: 0.282 ± 0.01	1.303TyrAsp: 1.303 ± 0.042	1.0TyrGlu: 1.0 ± 0.028	0.852TyrPhe: 0.852 ± 0.027	1.972TyrGly: 1.972 ± 0.044	0.485TyrHis: 0.485 ± 0.019	0.825TyrIle: 0.825 ± 0.024	0.613TyrLys: 0.613 ± 0.022	2.399TyrLeu: 2.399 ± 0.055	0.437TyrMet: 0.437 ± 0.016	0.509TyrAsn: 0.509 ± 0.023	1.15TyrPro: 1.15 ± 0.027	0.89TyrGln: 0.89 ± 0.025	1.686TyrArg: 1.686 ± 0.031	1.093TyrSer: 1.093 ± 0.024	1.309TyrThr: 1.309 ± 0.06	1.401TyrVal: 1.401 ± 0.033	0.369TyrTrp: 0.369 ± 0.016	0.533TyrTyr: 0.533 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4911 proteins (1646448 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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