Amino acid dipepetide frequency for Leptospirillum ferrodiazotrophum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.092AlaAla: 7.092 ± 0.109	0.788AlaCys: 0.788 ± 0.036	3.77AlaAsp: 3.77 ± 0.067	4.781AlaGlu: 4.781 ± 0.089	3.54AlaPhe: 3.54 ± 0.067	7.631AlaGly: 7.631 ± 0.115	1.839AlaHis: 1.839 ± 0.048	4.548AlaIle: 4.548 ± 0.079	2.98AlaLys: 2.98 ± 0.072	10.995AlaLeu: 10.995 ± 0.131	2.179AlaMet: 2.179 ± 0.058	1.926AlaAsn: 1.926 ± 0.054	4.609AlaPro: 4.609 ± 0.076	2.424AlaGln: 2.424 ± 0.057	7.126AlaArg: 7.126 ± 0.121	5.481AlaSer: 5.481 ± 0.079	4.073AlaThr: 4.073 ± 0.076	5.507AlaVal: 5.507 ± 0.091	0.936AlaTrp: 0.936 ± 0.033	1.9AlaTyr: 1.9 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.608CysAla: 0.608 ± 0.029	0.072CysCys: 0.072 ± 0.011	0.401CysAsp: 0.401 ± 0.025	0.354CysGlu: 0.354 ± 0.024	0.308CysPhe: 0.308 ± 0.023	0.837CysGly: 0.837 ± 0.04	0.332CysHis: 0.332 ± 0.022	0.21CysIle: 0.21 ± 0.015	0.179CysLys: 0.179 ± 0.016	0.934CysLeu: 0.934 ± 0.037	0.107CysMet: 0.107 ± 0.012	0.168CysAsn: 0.168 ± 0.015	0.572CysPro: 0.572 ± 0.029	0.337CysGln: 0.337 ± 0.021	0.867CysArg: 0.867 ± 0.032	0.495CysSer: 0.495 ± 0.026	0.297CysThr: 0.297 ± 0.019	0.481CysVal: 0.481 ± 0.026	0.076CysTrp: 0.076 ± 0.01	0.176CysTyr: 0.176 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.448AspAla: 3.448 ± 0.067	0.395AspCys: 0.395 ± 0.023	1.996AspAsp: 1.996 ± 0.052	2.642AspGlu: 2.642 ± 0.07	2.31AspPhe: 2.31 ± 0.06	3.735AspGly: 3.735 ± 0.073	1.221AspHis: 1.221 ± 0.04	2.409AspIle: 2.409 ± 0.06	1.534AspLys: 1.534 ± 0.05	6.781AspLeu: 6.781 ± 0.097	0.954AspMet: 0.954 ± 0.035	1.149AspAsn: 1.149 ± 0.042	4.384AspPro: 4.384 ± 0.082	1.384AspGln: 1.384 ± 0.047	5.037AspArg: 5.037 ± 0.083	2.916AspSer: 2.916 ± 0.065	1.94AspThr: 1.94 ± 0.048	2.771AspVal: 2.771 ± 0.059	0.676AspTrp: 0.676 ± 0.028	1.31AspTyr: 1.31 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.448GluAla: 6.448 ± 0.113	0.407GluCys: 0.407 ± 0.022	2.905GluAsp: 2.905 ± 0.07	5.695GluGlu: 5.695 ± 0.111	1.961GluPhe: 1.961 ± 0.048	6.076GluGly: 6.076 ± 0.1	1.1GluHis: 1.1 ± 0.04	5.086GluIle: 5.086 ± 0.086	4.315GluLys: 4.315 ± 0.078	4.779GluLeu: 4.779 ± 0.084	1.586GluMet: 1.586 ± 0.042	1.982GluAsn: 1.982 ± 0.051	2.248GluPro: 2.248 ± 0.061	1.378GluGln: 1.378 ± 0.047	5.459GluArg: 5.459 ± 0.09	4.474GluSer: 4.474 ± 0.085	4.012GluThr: 4.012 ± 0.075	4.189GluVal: 4.189 ± 0.08	0.869GluTrp: 0.869 ± 0.036	1.124GluTyr: 1.124 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.893PheAla: 2.893 ± 0.06	0.456PheCys: 0.456 ± 0.027	2.311PheAsp: 2.311 ± 0.055	2.199PheGlu: 2.199 ± 0.053	2.3PhePhe: 2.3 ± 0.068	3.339PheGly: 3.339 ± 0.076	1.061PheHis: 1.061 ± 0.036	1.568PheIle: 1.568 ± 0.047	1.046PheLys: 1.046 ± 0.04	5.312PheLeu: 5.312 ± 0.1	0.868PheMet: 0.868 ± 0.037	0.902PheAsn: 0.902 ± 0.036	2.491PhePro: 2.491 ± 0.067	1.131PheGln: 1.131 ± 0.036	3.312PheArg: 3.312 ± 0.062	3.781PheSer: 3.781 ± 0.073	1.629PheThr: 1.629 ± 0.045	2.912PheVal: 2.912 ± 0.064	0.659PheTrp: 0.659 ± 0.026	1.149PheTyr: 1.149 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.685GlyAla: 6.685 ± 0.11	0.716GlyCys: 0.716 ± 0.033	3.732GlyAsp: 3.732 ± 0.067	6.126GlyGlu: 6.126 ± 0.092	3.477GlyPhe: 3.477 ± 0.071	7.716GlyGly: 7.716 ± 0.151	1.992GlyHis: 1.992 ± 0.05	5.356GlyIle: 5.356 ± 0.091	4.043GlyLys: 4.043 ± 0.072	8.243GlyLeu: 8.243 ± 0.107	2.264GlyMet: 2.264 ± 0.063	2.183GlyAsn: 2.183 ± 0.07	3.583GlyPro: 3.583 ± 0.076	2.578GlyGln: 2.578 ± 0.06	6.388GlyArg: 6.388 ± 0.108	5.785GlySer: 5.785 ± 0.101	4.815GlyThr: 4.815 ± 0.095	5.962GlyVal: 5.962 ± 0.083	1.138GlyTrp: 1.138 ± 0.043	2.296GlyTyr: 2.296 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.741HisAla: 1.741 ± 0.05	0.202HisCys: 0.202 ± 0.016	0.968HisAsp: 0.968 ± 0.034	1.155HisGlu: 1.155 ± 0.04	0.998HisPhe: 0.998 ± 0.036	1.672HisGly: 1.672 ± 0.043	0.68HisHis: 0.68 ± 0.032	1.079HisIle: 1.079 ± 0.037	0.664HisLys: 0.664 ± 0.026	2.738HisLeu: 2.738 ± 0.064	0.501HisMet: 0.501 ± 0.024	0.519HisAsn: 0.519 ± 0.025	1.924HisPro: 1.924 ± 0.047	0.67HisGln: 0.67 ± 0.028	1.831HisArg: 1.831 ± 0.044	1.306HisSer: 1.306 ± 0.042	0.867HisThr: 0.867 ± 0.037	1.489HisVal: 1.489 ± 0.049	0.296HisTrp: 0.296 ± 0.02	0.64HisTyr: 0.64 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.485IleAla: 4.485 ± 0.075	0.39IleCys: 0.39 ± 0.021	3.169IleAsp: 3.169 ± 0.069	3.313IleGlu: 3.313 ± 0.068	2.079IlePhe: 2.079 ± 0.052	3.988IleGly: 3.988 ± 0.077	1.334IleHis: 1.334 ± 0.042	1.946IleIle: 1.946 ± 0.055	1.625IleLys: 1.625 ± 0.056	7.048IleLeu: 7.048 ± 0.093	0.862IleMet: 0.862 ± 0.029	1.275IleAsn: 1.275 ± 0.047	3.603IlePro: 3.603 ± 0.071	1.367IleGln: 1.367 ± 0.043	4.583IleArg: 4.583 ± 0.081	3.656IleSer: 3.656 ± 0.074	2.207IleThr: 2.207 ± 0.059	4.001IleVal: 4.001 ± 0.089	0.466IleTrp: 0.466 ± 0.027	1.07IleTyr: 1.07 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.706LysAla: 3.706 ± 0.082	0.188LysCys: 0.188 ± 0.016	2.253LysAsp: 2.253 ± 0.051	3.215LysGlu: 3.215 ± 0.087	0.869LysPhe: 0.869 ± 0.033	3.644LysGly: 3.644 ± 0.075	0.602LysHis: 0.602 ± 0.031	2.888LysIle: 2.888 ± 0.067	3.569LysLys: 3.569 ± 0.096	2.631LysLeu: 2.631 ± 0.058	0.982LysMet: 0.982 ± 0.036	1.784LysAsn: 1.784 ± 0.055	1.527LysPro: 1.527 ± 0.048	0.791LysGln: 0.791 ± 0.036	2.686LysArg: 2.686 ± 0.058	2.724LysSer: 2.724 ± 0.068	2.844LysThr: 2.844 ± 0.069	2.806LysVal: 2.806 ± 0.062	0.344LysTrp: 0.344 ± 0.021	0.695LysTyr: 0.695 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.832LeuAla: 10.832 ± 0.133	0.849LeuCys: 0.849 ± 0.039	5.808LeuAsp: 5.808 ± 0.1	6.871LeuGlu: 6.871 ± 0.095	5.305LeuPhe: 5.305 ± 0.101	8.228LeuGly: 8.228 ± 0.138	2.312LeuHis: 2.312 ± 0.059	4.273LeuIle: 4.273 ± 0.076	4.024LeuLys: 4.024 ± 0.083	13.717LeuLeu: 13.717 ± 0.194	2.161LeuMet: 2.161 ± 0.056	2.144LeuAsn: 2.144 ± 0.057	7.646LeuPro: 7.646 ± 0.1	2.355LeuGln: 2.355 ± 0.057	7.732LeuArg: 7.732 ± 0.114	11.422LeuSer: 11.422 ± 0.134	5.392LeuThr: 5.392 ± 0.088	7.637LeuVal: 7.637 ± 0.117	1.492LeuTrp: 1.492 ± 0.049	2.616LeuTyr: 2.616 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.773MetAla: 2.773 ± 0.059	0.106MetCys: 0.106 ± 0.011	1.178MetAsp: 1.178 ± 0.035	1.677MetGlu: 1.677 ± 0.042	0.534MetPhe: 0.534 ± 0.025	2.225MetGly: 2.225 ± 0.055	0.289MetHis: 0.289 ± 0.021	1.351MetIle: 1.351 ± 0.042	1.327MetLys: 1.327 ± 0.039	1.508MetLeu: 1.508 ± 0.045	0.606MetMet: 0.606 ± 0.032	0.867MetAsn: 0.867 ± 0.035	0.985MetPro: 0.985 ± 0.036	0.462MetGln: 0.462 ± 0.023	1.299MetArg: 1.299 ± 0.035	1.49MetSer: 1.49 ± 0.043	1.739MetThr: 1.739 ± 0.044	1.702MetVal: 1.702 ± 0.05	0.155MetTrp: 0.155 ± 0.015	0.296MetTyr: 0.296 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.199AsnAla: 2.199 ± 0.054	0.204AsnCys: 0.204 ± 0.017	1.177AsnAsp: 1.177 ± 0.041	1.207AsnGlu: 1.207 ± 0.044	0.954AsnPhe: 0.954 ± 0.035	2.077AsnGly: 2.077 ± 0.063	0.613AsnHis: 0.613 ± 0.029	1.545AsnIle: 1.545 ± 0.047	0.775AsnLys: 0.775 ± 0.031	2.977AsnLeu: 2.977 ± 0.062	0.637AsnMet: 0.637 ± 0.03	0.729AsnAsn: 0.729 ± 0.039	2.155AsnPro: 2.155 ± 0.057	0.791AsnGln: 0.791 ± 0.03	2.078AsnArg: 2.078 ± 0.047	1.398AsnSer: 1.398 ± 0.047	1.279AsnThr: 1.279 ± 0.051	1.673AsnVal: 1.673 ± 0.049	0.281AsnTrp: 0.281 ± 0.018	0.651AsnTyr: 0.651 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.8ProAla: 4.8 ± 0.073	0.432ProCys: 0.432 ± 0.023	3.697ProAsp: 3.697 ± 0.071	5.139ProGlu: 5.139 ± 0.096	2.68ProPhe: 2.68 ± 0.06	5.459ProGly: 5.459 ± 0.078	1.269ProHis: 1.269 ± 0.039	2.236ProIle: 2.236 ± 0.053	1.923ProLys: 1.923 ± 0.055	6.544ProLeu: 6.544 ± 0.118	1.225ProMet: 1.225 ± 0.033	1.182ProAsn: 1.182 ± 0.046	4.13ProPro: 4.13 ± 0.089	1.468ProGln: 1.468 ± 0.039	3.386ProArg: 3.386 ± 0.074	4.659ProSer: 4.659 ± 0.09	2.506ProThr: 2.506 ± 0.065	4.775ProVal: 4.775 ± 0.077	0.706ProTrp: 0.706 ± 0.027	1.256ProTyr: 1.256 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.684GlnAla: 2.684 ± 0.065	0.181GlnCys: 0.181 ± 0.016	1.207GlnAsp: 1.207 ± 0.035	2.159GlnGlu: 2.159 ± 0.054	0.832GlnPhe: 0.832 ± 0.032	2.545GlnGly: 2.545 ± 0.053	0.403GlnHis: 0.403 ± 0.02	1.796GlnIle: 1.796 ± 0.052	1.772GlnLys: 1.772 ± 0.056	1.704GlnLeu: 1.704 ± 0.049	0.672GlnMet: 0.672 ± 0.028	0.965GlnAsn: 0.965 ± 0.034	0.966GlnPro: 0.966 ± 0.036	0.682GlnGln: 0.682 ± 0.037	1.636GlnArg: 1.636 ± 0.054	1.923GlnSer: 1.923 ± 0.05	1.699GlnThr: 1.699 ± 0.043	1.877GlnVal: 1.877 ± 0.048	0.379GlnTrp: 0.379 ± 0.02	0.53GlnTyr: 0.53 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.534ArgAla: 5.534 ± 0.099	0.494ArgCys: 0.494 ± 0.026	3.547ArgAsp: 3.547 ± 0.073	6.827ArgGlu: 6.827 ± 0.116	3.161ArgPhe: 3.161 ± 0.062	5.107ArgGly: 5.107 ± 0.073	1.937ArgHis: 1.937 ± 0.048	5.316ArgIle: 5.316 ± 0.081	3.789ArgLys: 3.789 ± 0.075	8.784ArgLeu: 8.784 ± 0.13	2.004ArgMet: 2.004 ± 0.048	1.953ArgAsn: 1.953 ± 0.051	3.91ArgPro: 3.91 ± 0.069	2.587ArgGln: 2.587 ± 0.054	5.755ArgArg: 5.755 ± 0.106	4.985ArgSer: 4.985 ± 0.087	4.04ArgThr: 4.04 ± 0.072	4.846ArgVal: 4.846 ± 0.078	1.05ArgTrp: 1.05 ± 0.038	1.932ArgTyr: 1.932 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.277SerAla: 5.277 ± 0.09	0.686SerCys: 0.686 ± 0.031	3.399SerAsp: 3.399 ± 0.072	3.86SerGlu: 3.86 ± 0.079	3.437SerPhe: 3.437 ± 0.076	7.244SerGly: 7.244 ± 0.117	1.58SerHis: 1.58 ± 0.047	2.927SerIle: 2.927 ± 0.064	2.034SerLys: 2.034 ± 0.054	9.445SerLeu: 9.445 ± 0.124	1.588SerMet: 1.588 ± 0.049	1.527SerAsn: 1.527 ± 0.054	5.452SerPro: 5.452 ± 0.105	2.156SerGln: 2.156 ± 0.059	6.216SerArg: 6.216 ± 0.105	5.405SerSer: 5.405 ± 0.121	2.871SerThr: 2.871 ± 0.061	4.608SerVal: 4.608 ± 0.081	0.904SerTrp: 0.904 ± 0.032	1.696SerTyr: 1.696 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.937ThrAla: 3.937 ± 0.066	0.386ThrCys: 0.386 ± 0.023	2.149ThrAsp: 2.149 ± 0.056	2.509ThrGlu: 2.509 ± 0.053	2.115ThrPhe: 2.115 ± 0.051	5.113ThrGly: 5.113 ± 0.105	1.142ThrHis: 1.142 ± 0.038	2.875ThrIle: 2.875 ± 0.065	1.532ThrLys: 1.532 ± 0.044	6.761ThrLeu: 6.761 ± 0.119	1.065ThrMet: 1.065 ± 0.037	1.206ThrAsn: 1.206 ± 0.04	3.49ThrPro: 3.49 ± 0.075	1.309ThrGln: 1.309 ± 0.039	3.313ThrArg: 3.313 ± 0.068	2.945ThrSer: 2.945 ± 0.071	2.819ThrThr: 2.819 ± 0.068	4.076ThrVal: 4.076 ± 0.083	0.489ThrTrp: 0.489 ± 0.023	1.129ThrTyr: 1.129 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.302ValAla: 6.302 ± 0.087	0.565ValCys: 0.565 ± 0.028	3.611ValAsp: 3.611 ± 0.073	4.183ValGlu: 4.183 ± 0.08	2.923ValPhe: 2.923 ± 0.071	5.572ValGly: 5.572 ± 0.088	1.398ValHis: 1.398 ± 0.039	3.246ValIle: 3.246 ± 0.073	2.212ValLys: 2.212 ± 0.06	7.956ValLeu: 7.956 ± 0.114	1.578ValMet: 1.578 ± 0.044	1.74ValAsn: 1.74 ± 0.059	3.857ValPro: 3.857 ± 0.065	1.429ValGln: 1.429 ± 0.042	5.729ValArg: 5.729 ± 0.1	5.231ValSer: 5.231 ± 0.077	3.722ValThr: 3.722 ± 0.075	5.63ValVal: 5.63 ± 0.093	0.803ValTrp: 0.803 ± 0.031	1.524ValTyr: 1.524 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.035	0.104TrpCys: 0.104 ± 0.011	0.531TrpAsp: 0.531 ± 0.026	0.852TrpGlu: 0.852 ± 0.031	0.517TrpPhe: 0.517 ± 0.027	1.062TrpGly: 1.062 ± 0.034	0.245TrpHis: 0.245 ± 0.02	0.844TrpIle: 0.844 ± 0.032	0.674TrpLys: 0.674 ± 0.028	1.186TrpLeu: 1.186 ± 0.036	0.304TrpMet: 0.304 ± 0.019	0.473TrpAsn: 0.473 ± 0.026	0.544TrpPro: 0.544 ± 0.024	0.388TrpGln: 0.388 ± 0.022	0.762TrpArg: 0.762 ± 0.029	0.826TrpSer: 0.826 ± 0.032	0.67TrpThr: 0.67 ± 0.03	0.873TrpVal: 0.873 ± 0.037	0.138TrpTrp: 0.138 ± 0.012	0.266TrpTyr: 0.266 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.795TyrAla: 1.795 ± 0.046	0.19TyrCys: 0.19 ± 0.015	1.181TyrAsp: 1.181 ± 0.043	1.33TyrGlu: 1.33 ± 0.044	1.02TyrPhe: 1.02 ± 0.038	1.807TyrGly: 1.807 ± 0.05	0.593TyrHis: 0.593 ± 0.028	0.967TyrIle: 0.967 ± 0.035	0.733TyrLys: 0.733 ± 0.029	2.773TyrLeu: 2.773 ± 0.063	0.423TyrMet: 0.423 ± 0.022	0.726TyrAsn: 0.726 ± 0.044	1.397TyrPro: 1.397 ± 0.043	0.926TyrGln: 0.926 ± 0.036	2.364TyrArg: 2.364 ± 0.053	1.41TyrSer: 1.41 ± 0.047	0.939TyrThr: 0.939 ± 0.036	1.397TyrVal: 1.397 ± 0.043	0.285TyrTrp: 0.285 ± 0.02	0.716TyrTyr: 0.716 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2653 proteins (828293 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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