Amino acid dipepetide frequency for Clostridium sp. CAG:780

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.56AlaAla: 2.56 ± 0.112
0.544AlaCys: 0.544 ± 0.041
2.85AlaAsp: 2.85 ± 0.102
3.999AlaGlu: 3.999 ± 0.123
2.018AlaPhe: 2.018 ± 0.079
3.761AlaGly: 3.761 ± 0.119
0.733AlaHis: 0.733 ± 0.05
5.839AlaIle: 5.839 ± 0.141
5.774AlaLys: 5.774 ± 0.159
4.66AlaLeu: 4.66 ± 0.131
1.493AlaMet: 1.493 ± 0.067
3.43AlaAsn: 3.43 ± 0.134
1.307AlaPro: 1.307 ± 0.056
1.838AlaGln: 1.838 ± 0.058
2.221AlaArg: 2.221 ± 0.087
3.137AlaSer: 3.137 ± 0.103
3.542AlaThr: 3.542 ± 0.132
3.659AlaVal: 3.659 ± 0.125
0.26AlaTrp: 0.26 ± 0.025
2.147AlaTyr: 2.147 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.047
0.15CysCys: 0.15 ± 0.021
0.61CysAsp: 0.61 ± 0.041
0.651CysGlu: 0.651 ± 0.043
0.432CysPhe: 0.432 ± 0.036
0.872CysGly: 0.872 ± 0.051
0.17CysHis: 0.17 ± 0.022
1.023CysIle: 1.023 ± 0.058
1.061CysLys: 1.061 ± 0.059
0.788CysLeu: 0.788 ± 0.049
0.227CysMet: 0.227 ± 0.027
0.645CysAsn: 0.645 ± 0.052
0.418CysPro: 0.418 ± 0.041
0.293CysGln: 0.293 ± 0.028
0.328CysArg: 0.328 ± 0.034
0.681CysSer: 0.681 ± 0.052
0.569CysThr: 0.569 ± 0.042
0.599CysVal: 0.599 ± 0.045
0.071CysTrp: 0.071 ± 0.018
0.487CysTyr: 0.487 ± 0.038
0.003CysXaa: 0.003 ± 0.003
Asp
2.869AspAla: 2.869 ± 0.099
0.637AspCys: 0.637 ± 0.045
2.896AspAsp: 2.896 ± 0.109
4.885AspGlu: 4.885 ± 0.133
2.382AspPhe: 2.382 ± 0.094
3.296AspGly: 3.296 ± 0.102
0.547AspHis: 0.547 ± 0.041
5.957AspIle: 5.957 ± 0.14
5.615AspLys: 5.615 ± 0.137
4.751AspLeu: 4.751 ± 0.116
1.501AspMet: 1.501 ± 0.068
3.473AspAsn: 3.473 ± 0.099
1.179AspPro: 1.179 ± 0.061
1.094AspGln: 1.094 ± 0.053
1.748AspArg: 1.748 ± 0.074
3.282AspSer: 3.282 ± 0.108
2.987AspThr: 2.987 ± 0.1
3.616AspVal: 3.616 ± 0.119
0.372AspTrp: 0.372 ± 0.033
2.661AspTyr: 2.661 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
4.332GluAla: 4.332 ± 0.101
0.697GluCys: 0.697 ± 0.05
4.592GluAsp: 4.592 ± 0.139
8.437GluGlu: 8.437 ± 0.212
2.872GluPhe: 2.872 ± 0.097
3.725GluGly: 3.725 ± 0.108
0.963GluHis: 0.963 ± 0.057
8.333GluIle: 8.333 ± 0.179
9.457GluLys: 9.457 ± 0.173
6.947GluLeu: 6.947 ± 0.152
2.245GluMet: 2.245 ± 0.075
6.608GluAsn: 6.608 ± 0.186
1.652GluPro: 1.652 ± 0.067
2.967GluGln: 2.967 ± 0.1
2.724GluArg: 2.724 ± 0.104
3.2GluSer: 3.2 ± 0.102
3.988GluThr: 3.988 ± 0.116
4.628GluVal: 4.628 ± 0.13
0.454GluTrp: 0.454 ± 0.05
3.736GluTyr: 3.736 ± 0.121
0.0GluXaa: 0.0 ± 0.0
Phe
2.464PheAla: 2.464 ± 0.089
0.421PheCys: 0.421 ± 0.034
2.333PheAsp: 2.333 ± 0.09
2.946PheGlu: 2.946 ± 0.096
1.491PhePhe: 1.491 ± 0.081
2.281PheGly: 2.281 ± 0.08
0.375PheHis: 0.375 ± 0.032
3.375PheIle: 3.375 ± 0.122
3.101PheLys: 3.101 ± 0.108
3.35PheLeu: 3.35 ± 0.113
0.851PheMet: 0.851 ± 0.047
2.265PheAsn: 2.265 ± 0.065
0.9PhePro: 0.9 ± 0.049
0.758PheGln: 0.758 ± 0.045
1.146PheArg: 1.146 ± 0.051
2.494PheSer: 2.494 ± 0.1
2.103PheThr: 2.103 ± 0.079
2.59PheVal: 2.59 ± 0.079
0.284PheTrp: 0.284 ± 0.024
1.537PheTyr: 1.537 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
3.375GlyAla: 3.375 ± 0.105
0.64GlyCys: 0.64 ± 0.052
2.861GlyAsp: 2.861 ± 0.088
4.288GlyGlu: 4.288 ± 0.113
2.267GlyPhe: 2.267 ± 0.075
3.41GlyGly: 3.41 ± 0.195
0.938GlyHis: 0.938 ± 0.053
6.126GlyIle: 6.126 ± 0.149
6.011GlyLys: 6.011 ± 0.15
4.379GlyLeu: 4.379 ± 0.122
1.441GlyMet: 1.441 ± 0.069
3.449GlyAsn: 3.449 ± 0.127
0.96GlyPro: 0.96 ± 0.059
1.608GlyGln: 1.608 ± 0.074
2.267GlyArg: 2.267 ± 0.08
3.025GlySer: 3.025 ± 0.124
3.93GlyThr: 3.93 ± 0.146
3.821GlyVal: 3.821 ± 0.102
0.394GlyTrp: 0.394 ± 0.036
2.954GlyTyr: 2.954 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
0.58HisAla: 0.58 ± 0.042
0.172HisCys: 0.172 ± 0.023
0.566HisAsp: 0.566 ± 0.033
0.656HisGlu: 0.656 ± 0.043
0.52HisPhe: 0.52 ± 0.041
0.766HisGly: 0.766 ± 0.048
0.265HisHis: 0.265 ± 0.027
1.217HisIle: 1.217 ± 0.054
0.955HisLys: 0.955 ± 0.05
0.963HisLeu: 0.963 ± 0.059
0.345HisMet: 0.345 ± 0.028
0.771HisAsn: 0.771 ± 0.05
0.547HisPro: 0.547 ± 0.039
0.353HisGln: 0.353 ± 0.031
0.457HisArg: 0.457 ± 0.036
0.793HisSer: 0.793 ± 0.05
0.714HisThr: 0.714 ± 0.046
0.566HisVal: 0.566 ± 0.037
0.082HisTrp: 0.082 ± 0.015
0.517HisTyr: 0.517 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.487IleAla: 6.487 ± 0.157
1.225IleCys: 1.225 ± 0.059
5.801IleAsp: 5.801 ± 0.148
7.765IleGlu: 7.765 ± 0.162
3.462IlePhe: 3.462 ± 0.113
5.604IleGly: 5.604 ± 0.146
1.083IleHis: 1.083 ± 0.059
9.911IleIle: 9.911 ± 0.245
9.23IleLys: 9.23 ± 0.17
8.834IleLeu: 8.834 ± 0.203
2.139IleMet: 2.139 ± 0.078
6.217IleAsn: 6.217 ± 0.157
3.178IlePro: 3.178 ± 0.091
2.497IleGln: 2.497 ± 0.081
3.044IleArg: 3.044 ± 0.091
6.381IleSer: 6.381 ± 0.151
5.886IleThr: 5.886 ± 0.129
6.37IleVal: 6.37 ± 0.157
0.484IleTrp: 0.484 ± 0.039
3.829IleTyr: 3.829 ± 0.118
0.0IleXaa: 0.0 ± 0.0
Lys
5.032LysAla: 5.032 ± 0.122
0.892LysCys: 0.892 ± 0.053
5.784LysAsp: 5.784 ± 0.13
10.119LysGlu: 10.119 ± 0.223
3.173LysPhe: 3.173 ± 0.11
4.628LysGly: 4.628 ± 0.127
1.064LysHis: 1.064 ± 0.056
9.939LysIle: 9.939 ± 0.194
9.499LysLys: 9.499 ± 0.186
7.926LysLeu: 7.926 ± 0.169
2.801LysMet: 2.801 ± 0.083
6.692LysAsn: 6.692 ± 0.143
2.166LysPro: 2.166 ± 0.081
3.498LysGln: 3.498 ± 0.111
3.173LysArg: 3.173 ± 0.098
4.37LysSer: 4.37 ± 0.101
5.659LysThr: 5.659 ± 0.133
5.97LysVal: 5.97 ± 0.16
0.558LysTrp: 0.558 ± 0.039
4.983LysTyr: 4.983 ± 0.133
0.0LysXaa: 0.0 ± 0.0
Leu
5.161LeuAla: 5.161 ± 0.114
0.944LeuCys: 0.944 ± 0.053
4.885LeuAsp: 4.885 ± 0.121
7.078LeuGlu: 7.078 ± 0.175
2.998LeuPhe: 2.998 ± 0.117
5.049LeuGly: 5.049 ± 0.123
1.009LeuHis: 1.009 ± 0.05
7.28LeuIle: 7.28 ± 0.199
8.065LeuLys: 8.065 ± 0.182
7.007LeuLeu: 7.007 ± 0.188
1.939LeuMet: 1.939 ± 0.073
5.292LeuAsn: 5.292 ± 0.129
2.62LeuPro: 2.62 ± 0.096
2.377LeuGln: 2.377 ± 0.078
2.814LeuArg: 2.814 ± 0.097
5.33LeuSer: 5.33 ± 0.117
4.472LeuThr: 4.472 ± 0.114
4.945LeuVal: 4.945 ± 0.128
0.479LeuTrp: 0.479 ± 0.038
3.413LeuTyr: 3.413 ± 0.116
0.003LeuXaa: 0.003 ± 0.003
Met
1.551MetAla: 1.551 ± 0.086
0.29MetCys: 0.29 ± 0.026
1.321MetAsp: 1.321 ± 0.05
1.917MetGlu: 1.917 ± 0.07
0.924MetPhe: 0.924 ± 0.053
1.321MetGly: 1.321 ± 0.066
0.287MetHis: 0.287 ± 0.029
2.046MetIle: 2.046 ± 0.089
2.505MetLys: 2.505 ± 0.091
2.382MetLeu: 2.382 ± 0.089
0.569MetMet: 0.569 ± 0.041
1.507MetAsn: 1.507 ± 0.067
0.965MetPro: 0.965 ± 0.05
1.149MetGln: 1.149 ± 0.052
0.812MetArg: 0.812 ± 0.048
1.551MetSer: 1.551 ± 0.066
1.285MetThr: 1.285 ± 0.059
1.307MetVal: 1.307 ± 0.052
0.137MetTrp: 0.137 ± 0.019
0.987MetTyr: 0.987 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.074AsnAla: 3.074 ± 0.107
0.829AsnCys: 0.829 ± 0.054
3.137AsnAsp: 3.137 ± 0.1
4.868AsnGlu: 4.868 ± 0.146
2.404AsnPhe: 2.404 ± 0.083
4.127AsnGly: 4.127 ± 0.14
0.656AsnHis: 0.656 ± 0.047
6.944AsnIle: 6.944 ± 0.166
6.764AsnLys: 6.764 ± 0.15
5.44AsnLeu: 5.44 ± 0.124
1.671AsnMet: 1.671 ± 0.061
4.803AsnAsn: 4.803 ± 0.153
2.117AsnPro: 2.117 ± 0.081
2.106AsnGln: 2.106 ± 0.088
2.114AsnArg: 2.114 ± 0.074
3.993AsnSer: 3.993 ± 0.132
3.624AsnThr: 3.624 ± 0.106
4.16AsnVal: 4.16 ± 0.129
0.459AsnTrp: 0.459 ± 0.037
2.866AsnTyr: 2.866 ± 0.091
0.0AsnXaa: 0.0 ± 0.0
Pro
1.354ProAla: 1.354 ± 0.067
0.306ProCys: 0.306 ± 0.032
1.592ProAsp: 1.592 ± 0.078
2.732ProGlu: 2.732 ± 0.102
1.113ProPhe: 1.113 ± 0.053
1.537ProGly: 1.537 ± 0.064
0.317ProHis: 0.317 ± 0.033
2.494ProIle: 2.494 ± 0.083
2.133ProLys: 2.133 ± 0.073
2.043ProLeu: 2.043 ± 0.08
0.629ProMet: 0.629 ± 0.038
1.646ProAsn: 1.646 ± 0.066
0.473ProPro: 0.473 ± 0.052
0.719ProGln: 0.719 ± 0.046
0.769ProArg: 0.769 ± 0.046
1.46ProSer: 1.46 ± 0.065
1.584ProThr: 1.584 ± 0.061
1.936ProVal: 1.936 ± 0.09
0.191ProTrp: 0.191 ± 0.026
1.19ProTyr: 1.19 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
1.745GlnAla: 1.745 ± 0.07
0.189GlnCys: 0.189 ± 0.024
1.832GlnAsp: 1.832 ± 0.075
3.011GlnGlu: 3.011 ± 0.093
0.87GlnPhe: 0.87 ± 0.045
1.553GlnGly: 1.553 ± 0.08
0.252GlnHis: 0.252 ± 0.029
3.252GlnIle: 3.252 ± 0.096
3.055GlnLys: 3.055 ± 0.094
2.286GlnLeu: 2.286 ± 0.081
0.831GlnMet: 0.831 ± 0.049
2.251GlnAsn: 2.251 ± 0.079
0.577GlnPro: 0.577 ± 0.038
0.894GlnGln: 0.894 ± 0.054
1.149GlnArg: 1.149 ± 0.062
1.359GlnSer: 1.359 ± 0.061
1.638GlnThr: 1.638 ± 0.071
1.753GlnVal: 1.753 ± 0.072
0.164GlnTrp: 0.164 ± 0.026
1.242GlnTyr: 1.242 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
1.802ArgAla: 1.802 ± 0.071
0.331ArgCys: 0.331 ± 0.034
1.797ArgAsp: 1.797 ± 0.074
2.987ArgGlu: 2.987 ± 0.114
1.357ArgPhe: 1.357 ± 0.057
1.726ArgGly: 1.726 ± 0.075
0.457ArgHis: 0.457 ± 0.036
3.175ArgIle: 3.175 ± 0.089
3.503ArgLys: 3.503 ± 0.111
2.751ArgLeu: 2.751 ± 0.098
1.004ArgMet: 1.004 ± 0.054
2.251ArgAsn: 2.251 ± 0.087
0.96ArgPro: 0.96 ± 0.063
1.058ArgGln: 1.058 ± 0.059
1.537ArgArg: 1.537 ± 0.073
1.37ArgSer: 1.37 ± 0.066
1.955ArgThr: 1.955 ± 0.075
2.125ArgVal: 2.125 ± 0.083
0.222ArgTrp: 0.222 ± 0.026
1.419ArgTyr: 1.419 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
3.0SerAla: 3.0 ± 0.102
0.468SerCys: 0.468 ± 0.036
3.088SerAsp: 3.088 ± 0.105
3.985SerGlu: 3.985 ± 0.097
2.245SerPhe: 2.245 ± 0.086
3.793SerGly: 3.793 ± 0.118
0.665SerHis: 0.665 ± 0.041
5.538SerIle: 5.538 ± 0.146
5.67SerLys: 5.67 ± 0.132
4.411SerLeu: 4.411 ± 0.124
1.225SerMet: 1.225 ± 0.062
3.818SerAsn: 3.818 ± 0.122
1.299SerPro: 1.299 ± 0.062
1.843SerGln: 1.843 ± 0.076
1.893SerArg: 1.893 ± 0.076
3.774SerSer: 3.774 ± 0.137
3.446SerThr: 3.446 ± 0.144
3.476SerVal: 3.476 ± 0.094
0.342SerTrp: 0.342 ± 0.032
2.595SerTyr: 2.595 ± 0.092
0.0SerXaa: 0.0 ± 0.0
Thr
3.383ThrAla: 3.383 ± 0.11
0.536ThrCys: 0.536 ± 0.036
3.279ThrAsp: 3.279 ± 0.091
3.84ThrGlu: 3.84 ± 0.11
2.232ThrPhe: 2.232 ± 0.084
3.878ThrGly: 3.878 ± 0.117
0.703ThrHis: 0.703 ± 0.043
6.009ThrIle: 6.009 ± 0.14
5.049ThrLys: 5.049 ± 0.121
4.83ThrLeu: 4.83 ± 0.112
1.242ThrMet: 1.242 ± 0.065
3.627ThrAsn: 3.627 ± 0.132
1.797ThrPro: 1.797 ± 0.077
1.709ThrGln: 1.709 ± 0.08
1.904ThrArg: 1.904 ± 0.077
3.52ThrSer: 3.52 ± 0.125
3.7ThrThr: 3.7 ± 0.142
3.84ThrVal: 3.84 ± 0.113
0.364ThrTrp: 0.364 ± 0.036
2.481ThrTyr: 2.481 ± 0.091
0.005ThrXaa: 0.005 ± 0.004
Val
3.936ValAla: 3.936 ± 0.123
0.738ValCys: 0.738 ± 0.049
3.659ValAsp: 3.659 ± 0.118
4.819ValGlu: 4.819 ± 0.126
2.344ValPhe: 2.344 ± 0.085
3.856ValGly: 3.856 ± 0.12
0.689ValHis: 0.689 ± 0.04
6.036ValIle: 6.036 ± 0.131
5.784ValLys: 5.784 ± 0.162
5.292ValLeu: 5.292 ± 0.132
1.417ValMet: 1.417 ± 0.066
3.542ValAsn: 3.542 ± 0.088
1.813ValPro: 1.813 ± 0.069
1.685ValGln: 1.685 ± 0.078
1.977ValArg: 1.977 ± 0.073
3.788ValSer: 3.788 ± 0.105
3.884ValThr: 3.884 ± 0.141
4.258ValVal: 4.258 ± 0.125
0.402ValTrp: 0.402 ± 0.036
2.554ValTyr: 2.554 ± 0.088
0.0ValXaa: 0.0 ± 0.0
Trp
0.315TrpAla: 0.315 ± 0.033
0.09TrpCys: 0.09 ± 0.017
0.32TrpAsp: 0.32 ± 0.037
0.427TrpGlu: 0.427 ± 0.031
0.249TrpPhe: 0.249 ± 0.028
0.375TrpGly: 0.375 ± 0.037
0.123TrpHis: 0.123 ± 0.018
0.536TrpIle: 0.536 ± 0.037
0.49TrpLys: 0.49 ± 0.048
0.563TrpLeu: 0.563 ± 0.048
0.145TrpMet: 0.145 ± 0.018
0.495TrpAsn: 0.495 ± 0.035
0.142TrpPro: 0.142 ± 0.021
0.235TrpGln: 0.235 ± 0.023
0.232TrpArg: 0.232 ± 0.024
0.35TrpSer: 0.35 ± 0.031
0.284TrpThr: 0.284 ± 0.029
0.342TrpVal: 0.342 ± 0.032
0.096TrpTrp: 0.096 ± 0.027
0.323TrpTyr: 0.323 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.177TyrAla: 2.177 ± 0.082
0.552TyrCys: 0.552 ± 0.043
2.544TyrAsp: 2.544 ± 0.077
3.148TyrGlu: 3.148 ± 0.104
1.712TyrPhe: 1.712 ± 0.08
2.587TyrGly: 2.587 ± 0.109
0.509TyrHis: 0.509 ± 0.035
4.395TyrIle: 4.395 ± 0.127
4.204TyrLys: 4.204 ± 0.135
3.555TyrLeu: 3.555 ± 0.121
1.094TyrMet: 1.094 ± 0.048
3.372TyrAsn: 3.372 ± 0.1
1.149TyrPro: 1.149 ± 0.062
1.223TyrGln: 1.223 ± 0.058
1.477TyrArg: 1.477 ± 0.069
2.716TyrSer: 2.716 ± 0.078
2.678TyrThr: 2.678 ± 0.091
2.513TyrVal: 2.513 ± 0.088
0.317TyrTrp: 0.317 ± 0.033
1.802TyrTyr: 1.802 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.003XaaLys: 0.003 ± 0.003
0.0XaaLeu: 0.0 ± 0.0
0.003XaaMet: 0.003 ± 0.003
0.003XaaAsn: 0.003 ± 0.003
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.003XaaArg: 0.003 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.022XaaXaa: 0.022 ± 0.013
Statistics based on 1194 proteins (365637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski